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Whole Exome Sequencing
Whole Exome Sequencing

... – History of heart defects or GI problems ...
Neonatal Cardiology
Neonatal Cardiology

... Open versus Closed  Palliative versus Corrective – Trend towards early, corrective surgery, even in ...
Sample Letter of Medical Necessity
Sample Letter of Medical Necessity

... The FAMILION genetic test is a CLIA-certified test designed to identify mutations in ion channel genes in patients and their family members with inherited cardiac channelopathies such as Long QT Syndrome (LQTS) and Brugada Syndrome. The test is performed in a commercial laboratory that meets all app ...
Ledbetter Presentation 8/15/05
Ledbetter Presentation 8/15/05

... Phenotypically normal mother has same duplication. ...
Human Genetics - Biology Department
Human Genetics - Biology Department

...  Remember:  Have 23 pairs  1 of each pair came from mom  1 of each pair came from dad ...
Long QT Syndrome
Long QT Syndrome

... Medications to be Avoided ...
Sex- Linked Traits
Sex- Linked Traits

... trait is present on his X chromosome, because Y chromosome cannot hide the trait. ...
A Rare Case of a Patient with Hypoplastic Left Heart Syndrome and
A Rare Case of a Patient with Hypoplastic Left Heart Syndrome and

... The embryologic cause of HLHS remains to be fully understood. There is also little evidence to show that HLHS is genetically linked to one chromosome. This is not surprising given the fact that multiple anomalies are present in this disorder. In one study, however, there was found to be a link in ch ...
File
File

... • This results in gametes with either missing or extra chromosomes • If an abnormal gamete produced by a nondisjunction event unites with a normal gamete in fertilization, the result is a zygote that contains an atypical number of chromosomes • Mitosis will then carry this number of chromosomes to ...
Basics of Genetic Assessment and Counseling
Basics of Genetic Assessment and Counseling

... • Charcot-Marie-Tooth - also known as hereditary motor and sensory neuropathy type I (HMSN I) has been shown to result from a small duplication on short arm of chromosome ...
Genetic Disorder`s Project Get into groups of 2 or 3 people. There
Genetic Disorder`s Project Get into groups of 2 or 3 people. There

... Genetic Disorder’s Project Get into groups of 2 or 3 people. There are many types of genetic disorders. Your group will pick one disorder to become experts on so you may teach the rest of the class. It cannot be the same as another’s group disorder. So once you decide on a disorder, get it approved ...
Writing Assignment: Genetic Diseases
Writing Assignment: Genetic Diseases

... Down syndrome is a chromosome abnormality, usually due to an extra copy of the 21st chromosome. This syndrome usually, although not always, results in mental retardation and other conditions. The muscular dystrophies are a group of genetic diseases characterized by progressive weakness and degenerat ...
chromosome - TeacherWeb
chromosome - TeacherWeb

... syndrome are male because they have at least one copy of the Y chromosome. About 1 in 500 to 1 in 1000 males is born with XXY chromosomes. It is the most common chromosome change in men with very low or absent sperm counts. ...
human genetics - local.brookings.k12.sd.us
human genetics - local.brookings.k12.sd.us

... AUTOSOMAL DOMINANT • Achondroplasia (Dwarfism) • Huntington’s ...
Chromosome Mutations
Chromosome Mutations

... to breakage A piece of a chromosome is lost ...
brushfield spot
brushfield spot

... Interphase FISH test for trisomy 21 The chromosome 21 probe is labelled with a red fluorochrome and a control probe (for  chromosome 18) is labelled in green.  The two green dots show that the hybridization  has worked for this cell, and the three red dots show that there are three copies of  chrom ...
Presentation Slides - Genetics in Primary Care Institute
Presentation Slides - Genetics in Primary Care Institute

... • Not all genetic changes cause disease! • There are many, many polymorphisms in the genome, in both dosage and sequence. • 46,XY, inv(9)(p11q13) sounds significant but is found in many people and doesn’t cause problems – this is not a chromosome abnormality! • If not previously reported as disease ...
Patient with “Lobster Claw” Hands and Feet: Ectrodactyly
Patient with “Lobster Claw” Hands and Feet: Ectrodactyly

... fungal agents could also be involved. Although many published reports of the syndrome are of sporadic cases with no family history, prenatal detection of specific chromosomal abnormalities of this type of syndrome marks an important step forward for those patients wishing to have children. Prenatal ...
What is a Karyotype?
What is a Karyotype?

... Doctors can also run tests on fetuses to check for chromosomal errors. This test is called an amniocentesis. ...
CHAPTER OUTLINE
CHAPTER OUTLINE

... so named because they differ between the sexes. In humans, males have the sex chromosomes X and Y, and females have two X chromosomes. Traits controlled by genes on the sex chromosomes are said to be sex-linked. The Y chromosome from the father often does not carry an allele for a trait found on the ...
Document
Document

... Chromosome Disorders Are A Major Category of Genetic Disease • Specific chromosomal abnormalities are: – Responsible for >100 identifiable syndromes – Collectively more common than all of the ...
Dr. Fern Tsien, Dept. of Genetics, LSUHSC, NO, LA
Dr. Fern Tsien, Dept. of Genetics, LSUHSC, NO, LA

... rather than complete loss. For example, one X-chromosome may be broken, have portions deleted or other structural problems such as ring formation. The clinical consequences of having one normal and one structurally defective X-chromosome vary widely. ...
Chromosome mutations
Chromosome mutations

... • almost always lethal when homozygous • often also lethal when heterozygous • example of a viable deletion in humans: Cris-du-chat syndrome • terminal deletion of short arm of one chromosome #5 • can be seen in karyotype analysis as loss of bands/interbands • leads to mental retardation ...
Chronic Fatigue no longer seen as `Yuppie Flu`
Chronic Fatigue no longer seen as `Yuppie Flu`

... survey in Georgia, using a less restrictive methodology to identify cases, found that about 1 in 40 adults ages 18 to 59 met the diagnostic criteria — an estimate 6 to 10 times higher than previously reported rates. However, many patients and researchers fear that the expanded prevalence rate could ...
Genetic Mutations
Genetic Mutations

... characterized by the presence of an additional X chromosome in each of a female's cells. Although females with this condition may be taller than average, this chromosomal change typically causes no unusual physical features. Most females with triple X syndrome have normal sexual development and are ...
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DiGeorge syndrome



DiGeorge syndrome is also known as 22q11.2 deletion syndrome,DiGeorge anomaly, velocardiofacial syndrome (VCFS), Shprintzen syndrome, conotruncal anomaly face syndrome (CTAF) or Takao syndrome, Sedlackova syndrome, Cayler cardiofacial syndrome,Strong syndrome, congenital thymic aplasia, and thymic hypoplasia. This syndrome is caused by the deletion of a small piece of chromosome 22. As such, it is recommended that the name ""22q11.2 deletion syndrome (22q11.2DS)"" be used.22q11.2DS is the most common microdeletion syndrome characterized by low copy repeats and the deletion occurs near the middle of the chromosome at a location designated 22q11.2—signifying its location on the long arm of one of the pair of chromosomes 22, on region 1, band 1, sub-band 2. The inheritance pattern is autosomal dominant and it has a prevalence estimated at 1:4000. The syndrome was described in 1968 by the pediatric endocrinologist Angelo DiGeorge. 22q11 deletion is also associated with truncus arteriosus and tetralogy of Fallot.
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