Role of lipids in sepsis - Critical Care and Shock
... by increasing the production of hydrogen peroxide (H2O2) (33). LPC facilitates elimination of bacteria. In patients with sepsis, plasma levels of LPC are low. LPC decreased TNF-α and IL-1β production and enhanced T1H (T helper type 1) cytokines interferon-γ (IFN-γ), IL-2 and IL-12. Deactivation of n ...
... by increasing the production of hydrogen peroxide (H2O2) (33). LPC facilitates elimination of bacteria. In patients with sepsis, plasma levels of LPC are low. LPC decreased TNF-α and IL-1β production and enhanced T1H (T helper type 1) cytokines interferon-γ (IFN-γ), IL-2 and IL-12. Deactivation of n ...
Blood products - Vula
... – Impaired LV function and vascular tone restricts oxygen delivery and blood redistribution – Infants have high resting heart rates, which limits the ability to increase cardiac output ...
... – Impaired LV function and vascular tone restricts oxygen delivery and blood redistribution – Infants have high resting heart rates, which limits the ability to increase cardiac output ...
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
... – March 2008 in which 101 samples was collectedand analyzed. Out of these, 51 samples yielded 6 genera of organisms placing the incidence rate of neonatal sepsis at the center at 51 (50.5%). This may be attributed to the poor obstetric care and unsterile delivery practices, it may also be attributed ...
... – March 2008 in which 101 samples was collectedand analyzed. Out of these, 51 samples yielded 6 genera of organisms placing the incidence rate of neonatal sepsis at the center at 51 (50.5%). This may be attributed to the poor obstetric care and unsterile delivery practices, it may also be attributed ...
here - Boston University Medical Campus
... cultures for organisms other than S. aureus Adapted from McCormick JK, Yarwood JM, Schlievert PM. Toxic shock syndrome and bacterial superantigens: An update. Annu Rev Microbiol. 2001;55:77-104. *Proposed revision of diagnostic criteria for staphylococcal toxic shock syndrome (TSS) includes: 1. isol ...
... cultures for organisms other than S. aureus Adapted from McCormick JK, Yarwood JM, Schlievert PM. Toxic shock syndrome and bacterial superantigens: An update. Annu Rev Microbiol. 2001;55:77-104. *Proposed revision of diagnostic criteria for staphylococcal toxic shock syndrome (TSS) includes: 1. isol ...
Bleeding and Shock - MyersParkSportsMed
... Venous Bleeding • Rupture of 1+ veins • Less severe than arterial • Steady blood flow • Bluish-red blood • Easier to control ...
... Venous Bleeding • Rupture of 1+ veins • Less severe than arterial • Steady blood flow • Bluish-red blood • Easier to control ...
infectious diseases
... were positive in 6 (17%) of 35 attempts. Cerebrospinal fluid (CSF) cultures were positive in 3 (9.4%) of 32 patients; one additional child whose CSF was not initially examined later developed meningitis. These data suggest that: (a) bacteremia is commonly present in BC, (b) the pathogenesis of BC do ...
... were positive in 6 (17%) of 35 attempts. Cerebrospinal fluid (CSF) cultures were positive in 3 (9.4%) of 32 patients; one additional child whose CSF was not initially examined later developed meningitis. These data suggest that: (a) bacteremia is commonly present in BC, (b) the pathogenesis of BC do ...
Infectious Diseases for Interns
... Severe communityacquired pneumonia Hospital-acquired pneumonia Intra-abdominal ...
... Severe communityacquired pneumonia Hospital-acquired pneumonia Intra-abdominal ...
Inflammatory Markers in the 21st Century
... of infection Sierra R, Rello J, Bailen MA, et al. C-reactive protein used as an early indicator of infection in patients with systemic inflammatory response syndrome. Intensive Care Med 2004;30:2038–45. Peres Bota D, Melot C, Lopes FF, et al. Infection probability score (IPS): a method to help asses ...
... of infection Sierra R, Rello J, Bailen MA, et al. C-reactive protein used as an early indicator of infection in patients with systemic inflammatory response syndrome. Intensive Care Med 2004;30:2038–45. Peres Bota D, Melot C, Lopes FF, et al. Infection probability score (IPS): a method to help asses ...
Lessons on Influenza and other infections
... “A woman in the second trimester collapsed at work with headache and loss of balance. The patient spoke to NHS 24 twice and was advised to take paracetamol. The patient also saw her GP and was given the same advice. Her symptoms deteriorated over the next 48 hours and she was taken again to see the ...
... “A woman in the second trimester collapsed at work with headache and loss of balance. The patient spoke to NHS 24 twice and was advised to take paracetamol. The patient also saw her GP and was given the same advice. Her symptoms deteriorated over the next 48 hours and she was taken again to see the ...
Case # 31 MC, a 60y/o male, has already been
... Dx: Pneumonia (but hospital acquired type in Hx) Gram(-) GIT ?Endotracheal Intubation, nasogastric tubing or enteral feeding ASPIRATION P.:Indwelling catheter Gram(+) nose,Skin ?Bacteria,Viral,Fungi COMMUNITY ACQUIRED P. Other organism 21%P.Aeroginosa,9%Enterob acter or 8%K.Pneumonia ...
... Dx: Pneumonia (but hospital acquired type in Hx) Gram(-) GIT ?Endotracheal Intubation, nasogastric tubing or enteral feeding ASPIRATION P.:Indwelling catheter Gram(+) nose,Skin ?Bacteria,Viral,Fungi COMMUNITY ACQUIRED P. Other organism 21%P.Aeroginosa,9%Enterob acter or 8%K.Pneumonia ...
The Spleen
... The risk is greatest in children younger than four years of age The risk of sepsis is higher among patients requiring splenectomy for inherited diseases The risk of sepsis after splenectomy is lowest after ...
... The risk is greatest in children younger than four years of age The risk of sepsis is higher among patients requiring splenectomy for inherited diseases The risk of sepsis after splenectomy is lowest after ...
Illuminating Neonatal Sepsis as Age-Specific Systemic Inflammatory
... neonatal patient group is hyperinflammatory immune responses. These are poorly explained and typically cited as immaturity reporting functional deficiencies in neonatal immune cells. In a murine model of neonatal sepsis, it was shown that the main difference between the neonatal and adult course of ...
... neonatal patient group is hyperinflammatory immune responses. These are poorly explained and typically cited as immaturity reporting functional deficiencies in neonatal immune cells. In a murine model of neonatal sepsis, it was shown that the main difference between the neonatal and adult course of ...
Pressure Ulcers (Bed Sores)
... III) Crater (bowl shaped depression on surface) IV) Damage to muscle or bone I) ...
... III) Crater (bowl shaped depression on surface) IV) Damage to muscle or bone I) ...
SF 10.2-2 Sepsis & Surgical Infections 2 - Postsurgical Infection Session Objectives
... SF 10.2-2 Sepsis & Surgical Infections 2 - Postsurgical Infection Session Objectives After this session you will be able to: 1. Discuss the approach to fever in the postoperative patient. 2. Outline the presentation, diagnosis, management and common pathogens for common post-surgical infections incl ...
... SF 10.2-2 Sepsis & Surgical Infections 2 - Postsurgical Infection Session Objectives After this session you will be able to: 1. Discuss the approach to fever in the postoperative patient. 2. Outline the presentation, diagnosis, management and common pathogens for common post-surgical infections incl ...
Defense against Disease
... Treat all blood/soiled linens as potentially infectious Wear gloves if contact with blood/body fluids Place used syringes in sharps container ▪ Don’t recap or manipulate needles/sharps ...
... Treat all blood/soiled linens as potentially infectious Wear gloves if contact with blood/body fluids Place used syringes in sharps container ▪ Don’t recap or manipulate needles/sharps ...
HeartWare HVAD: Risk Factors for Adverse Outcomes
... Freedom from any ICVA: 6 months = 96%; 1 year = 93%; 2 years = 88% Freedom from HCVA: 6 months = 95%; 1 year = 90%; 2 years = 86% ...
... Freedom from any ICVA: 6 months = 96%; 1 year = 93%; 2 years = 88% Freedom from HCVA: 6 months = 95%; 1 year = 90%; 2 years = 86% ...
septicemia, sepsis, septic shock
... fever, over the 38oC or hypothermia less than 36oC; tachypneea more than 20 breaths/min; tachycardia more than 90 beats/min.; leucocytosis more than 12000/mmc; leucopenia less than 4000/mmc or more than 10 percents immature forms. ...
... fever, over the 38oC or hypothermia less than 36oC; tachypneea more than 20 breaths/min; tachycardia more than 90 beats/min.; leucocytosis more than 12000/mmc; leucopenia less than 4000/mmc or more than 10 percents immature forms. ...
Presenting problems in infectious diseases
... and any patients with eosinophil count more than 400 cell/ml. should be investigated for possible parasitic infection which include: Strongyloidosis, Hook warm, Ascariasis, Schistosomiasis, Cysticercosis, hydatid disease,…… ...
... and any patients with eosinophil count more than 400 cell/ml. should be investigated for possible parasitic infection which include: Strongyloidosis, Hook warm, Ascariasis, Schistosomiasis, Cysticercosis, hydatid disease,…… ...
A RETROSPECTIVE STUDY OF BACTERIAL INFECTIONS IN
... findings were collected from medical records. Standard criteria were used to define all specific types of infections. Results: 140 patients were included: male/female: 122/18; mean age = 55.92 (SD = 7.96). The prevalence of bacterial infection was 34.28%. The most frequent infections were: urinary t ...
... findings were collected from medical records. Standard criteria were used to define all specific types of infections. Results: 140 patients were included: male/female: 122/18; mean age = 55.92 (SD = 7.96). The prevalence of bacterial infection was 34.28%. The most frequent infections were: urinary t ...
Document
... TNF + IL1→ fever + vasodilation Arachidonic acid metabolites →fever, tachypnea, V/Q abnormalities, lactic acidosis Nitric oxide →hypotention Myocardial depressant factors→ myocardial depression ...
... TNF + IL1→ fever + vasodilation Arachidonic acid metabolites →fever, tachypnea, V/Q abnormalities, lactic acidosis Nitric oxide →hypotention Myocardial depressant factors→ myocardial depression ...
Toxic Shock Syndrome
... The incidence of both TSS and STSS appeared to increase through the 1980s and 1990s but has now stabilised. A UK series showed an incidence of STSS increasing from 1 to 9.5 per million population per year in the 1990s. [3] Infections not associated with menstruation have become more common as menstr ...
... The incidence of both TSS and STSS appeared to increase through the 1980s and 1990s but has now stabilised. A UK series showed an incidence of STSS increasing from 1 to 9.5 per million population per year in the 1990s. [3] Infections not associated with menstruation have become more common as menstr ...
Dr Yaser Gad
... • PCT levels do not increase in some of the disease entities that cause the FUO syndrome, e.g., Still's disease, systemic lupus erythematosus, and inflammatory ...
... • PCT levels do not increase in some of the disease entities that cause the FUO syndrome, e.g., Still's disease, systemic lupus erythematosus, and inflammatory ...
Sepsis
Sepsis (/ˈsɛpsɨs/) is a whole-body inflammatory response to an infection. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. There may also be symptoms related to a specific infection, such as a cough with pneumonia, or painful urination with a kidney infection. In the very young, old, and people with a weakened immune system, there may be no symptoms of a specific infection and the body temperature may be low or normal rather than high. Severe sepsis is sepsis causing poor organ function or insufficient blood flow. Insufficient blood flow may be evident by low blood pressure, high blood lactate, or low urine output. Septic shock is low blood pressure due to sepsis that does not improve after reasonable amounts of intravenous fluids are given.Sepsis is caused by an immune response triggered by an infection. The infection is most commonly by bacteria, but can also be by fungi, viruses, or parasites. Common locations for the primary infection include: lungs, brain, urinary tract, skin, and abdominal organs. Risk factors include young or old age, a weakened immune system from conditions such as cancer or diabetes, and major trauma or burns. Diagnosis is based on meeting at least two systemic inflammatory response syndrome (SIRS) criteria due to a presumed infection. Blood cultures are recommended preferably before antibiotics are started; however, infection of the blood is not required for the diagnosis. Medical imaging should be done looking for the possible location of infection. Other potential causes of similar signs and symptoms include: anaphylaxis, adrenal insufficiency, low blood volume, heart failure, and pulmonary embolism among others.Sepsis is usually treated with intravenous fluids and antibiotics. This is often done in an intensive care unit. If fluid replacement is not enough to maintain blood pressure, medications that raise blood pressure can be used. Mechanical ventilation and dialysis may be needed to support the function of the lungs and kidneys, respectively. To guide treatment, a central venous catheter and an arterial catheter may be placed. Other measurements such as cardiac output and superior vena cava oxygen saturation may also be used. People with sepsis need preventive measures for deep vein thrombosis, stress ulcers and pressure ulcers, unless other conditions prevent such interventions. Some might benefit from tight control of blood sugar levels with insulin. The use of corticosteroids is controversial. Activated drotrecogin alfa, originally marketed for severe sepsis, has not been found to be helpful, and was withdrawn from sale in 2011.Disease severity partly determines the outcome with the risk of death from sepsis being as high as 30%, severe sepsis as high as 50%, and septic shock as high as 80%. The total number of cases worldwide is unknown as there is little data from the developing world. Estimates suggest sepsis affects millions of people a year. In the developed world about 0.2 to 3 per 1000 people gets sepsis yearly or about a million cases per year in the United States. Rates of disease have been increasing. Sepsis is more common among males than females. The terms septicemia and blood poisoning referred to the microorganisms or their toxins in the blood and are no longer commonly used. The condition has been described at least since the time of Hippocrates.