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MUTATIONS
MUTATIONS

... Substitutions are the most common form of mutation. They involve the replacement of one base by another. One codon may be altered so that it now codes for one different amino acid in the protein sequence. The most detrimental substitution mutations seem to be when the 1st or 2nd base of a codon is a ...
Prokaryotic Gene Regulation
Prokaryotic Gene Regulation

... quote -- 'I'm always for less regulation.' " – Sen. Barack Obama “Senator Obama was silent on the regulation of Fannie Mae and Freddie Mac, and his Democratic allies in Congress opposed every effort to rein them in…last year he said that subprime loans had been, quote, “a good idea.””- Sen. John McC ...
Integrated genome sequence and linkage map of physic nut
Integrated genome sequence and linkage map of physic nut

... iodide, is about 416 Mbp (Carvalho et al., 2008). A large proportion of the heterochromatic DNA, such as centromeric and pericentromeric DNA, was probably not assembled by the WGS process, but more than 94% of the available ESTcDNA data for physic nut and about 87% of that for J. integerrima was cov ...
LDheatmap (Version 0.9-1): Example of Adding Tracks
LDheatmap (Version 0.9-1): Example of Adding Tracks

... give information on the SNPs, such as their alleles and genomic location. The help file help("GIMAP5.CEU") gives full details. In addition to GIMAP5.CEU, you should have the LDheatmap objects llGenes and llGenesRecomb in your workspace. These objects are the heatmap with tracks for genes and recombi ...
Reconstruction of a 450-My-old ancestral vertebrate protokaryotype
Reconstruction of a 450-My-old ancestral vertebrate protokaryotype

... applied only with an X chromosome probe in marsupials [28]. It was immediately evident that most mammalian species show a much greater degree of karyotype conservation than expected from the human–mouse comparison [29]. Shared ancestral chromosome characteristics in the form of associations and fiss ...
An interspecific plant hybrid shows novel changes in
An interspecific plant hybrid shows novel changes in

... PtSR34a.1 is not associated with any of the three AS isoforms common between the two parents and the hybrid. The conceptual translation of the hybrid-specific AS forms revealed a premature termination codon in both cases (Figure 3). If the transcripts are translated they would result in truncated pr ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... This suggests that many TFs can be regulated simply by the abundance (expression levels) of the TF. However, across 1000 microarray expression experiments for yeast, the correlation between a TF’s expression and that of its ChIP-based targets was typically very low (only between 0 and 0.25). Conside ...
We`re on the brink of a DNA revolution – where your genetic code
We`re on the brink of a DNA revolution – where your genetic code

... in looking for genetic links, there’s been a tidal wave of announcements proclaiming that a given condition’s genetic source has been unmasked. The difficulty for any company that wants to offer predictive tests is sorting the scientific wheat from the chaff, the true genetic links with disease from ...
Wide Crosses - University of Illinois Archives
Wide Crosses - University of Illinois Archives

... for a particular species, and even to insert custom-designed genes that do not exist in nature. As a result we can create what can be regarded as synthetic life forms, something which could not be done by conventional breeding. It is interesting to compare this advance to the advances that led to cr ...
MitoP2, an integrated database on mitochondrial proteins in yeast
MitoP2, an integrated database on mitochondrial proteins in yeast

... the mitochondrial proteome of yeast and man. Extensions to mouse, Caenorhabditis elegans and Arabidopsis thaliana will be added soon. The aim of the database is to provide a comprehensive reference list of mitochondrial proteins and to link individual entries with databases containing information ab ...
Analysis of the Brassica oleracea genome by the generation of B
Analysis of the Brassica oleracea genome by the generation of B

... somic addition Jines. respectively (Fig. I a. b). The rest were diploids. The B. a/eroceo extra chromosomes could not be distinguished from the B. compeslris chromo­ somes by the acetocarmine technique. All the 2n = 22 plants derived either from 2n = 21 plants or from higher hyperploids were tentall ...
Phylogeny of Euphydryas Checkerspot Butterflies (Lepidoptera
Phylogeny of Euphydryas Checkerspot Butterflies (Lepidoptera

... present an interesting case. The pair of E. maturna have exactly the same sequence over 1,614 characters (bp ⫹ indels) of the combined data set. The protein coding sequences (COI and ND1) of E. intermedia differ from the E. maturna sequence by only 1 bp in the COI gene. However, the supposedly more ...
Ensembl Introduction
Ensembl Introduction

... • Pilot project completed in 2007: 1% of human genome • Discovered promoter elements are on either side of the transcription start site ...
Document
Document

The landscape of microbial phenotypic traits and associated genes
The landscape of microbial phenotypic traits and associated genes

... resistance (11,12) and relevance to biotechnological applications (13,14). The amount of prokaryotic genomes is increasing rapidly (15), aided by single-cell sequencing (16) and metagenomics (17). However, efforts to obtain systematic, high-quality phenotype annotation of microbes are not keeping pa ...
生物信息学主要英文术语及释义
生物信息学主要英文术语及释义

... than S that are expected to occur in a database search by chance. The lower the E value, the more significant the score. In a database similarity search, the probability that an alignment score as good as the one found between a query sequence and a database sequence would be found in as many compar ...
cis667-10
cis667-10

... to another location  It can also move from one chromosome to another  We call these movements genome rearrangments ...
Recovery of DNA for Forensic Analysis from Lip Cosmetics*
Recovery of DNA for Forensic Analysis from Lip Cosmetics*

... while many of the extracts were pigmented, not all such extracts resulted in fluorescent artefacts occurring in the DNA profile, and artifacts in the DNA profiles were also observed from extracts that appeared colorless. The Blue and Green wavelengths were the most commonly affected, but artifacts w ...
DNA Replication Replication begins simultaneously on several
DNA Replication Replication begins simultaneously on several

... Each nucleotide strand serves as a template for building a new complementary strand. Occurs at the replication fork ...
12859_2006_1447_MOESM4_ESM
12859_2006_1447_MOESM4_ESM

... novel splice forms, the transcripts have not been experimentally verified. Data mining repositories (e.g., EVDB), on the other hand, are based on defined standards in which the transcripts are more likely to have been verified. We obtained a wide range of results in our tests such as submission of t ...
Cloning and expression of proteins from Mycobacterium smegmatis
Cloning and expression of proteins from Mycobacterium smegmatis

... . According to the United States National Institute of Allergy and Infectious Diseases (NIAID) some two billion people are believed to be infected with M. tuberculosis [14]. An infected host with a fully functional immune system can carry latent TB for a very long time. Not only the developing count ...
BEACONHILLS COLLEGE
BEACONHILLS COLLEGE

... hypotheses that explain how changes to species have come about. In addition to observable similarities and differences between organisms, students explore the universality of DNA, and conversation of genes as evidence for ancestral lines of life that have given rise to the present biodiversity of ou ...
Detecting a Transposon in Corn
Detecting a Transposon in Corn

... Thus, McClintock explained color variegations, such as speckled kernels, that had intrigued botanists for centuries. (See Concept 32 of DNA From the Beginning, www.dnaftb.org, for an animation explaining McClintock’s elucidation of the Ac/Ds system.) Today the Ac/Ds system is an important tool in ge ...
Extraordinary Sequence Divergence at Tsga8, an X
Extraordinary Sequence Divergence at Tsga8, an X

... genome build 36 (release 46, August 2007; www.ensembl. org). For two genes (Magea9 and 4933436I01Rik), a single amplicon containing the entire protein-coding domain was polymerase chain reaction (PCR) amplified and sequenced. For Tsga8, we used several combinations of three forward and three reverse ...
Document
Document

... immunoprecipitation followed by sequencing a popular strategy to study transcriptome-wide RNA modifications, while creating challenges for analysis , especially in peak-finding. However, there have been no any available tools or softwares for MeRIP-Seq data analysis yet. Here, we present a high-effi ...
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Genomics

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism). Advances in genomics have triggered a revolution in discovery-based research to understand even the most complex biological systems such as the brain. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.
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