Rapid divergence and diversification of mammalian duplicate gene
... While small Ne is also thought to result in a higher prevalence of subfunctionalization [34], this process does not appear to play a major role in the retention of duplicate genes in either lineage. One possible reason for this observation is that subfunctionalization may be more common in duplicate ...
... While small Ne is also thought to result in a higher prevalence of subfunctionalization [34], this process does not appear to play a major role in the retention of duplicate genes in either lineage. One possible reason for this observation is that subfunctionalization may be more common in duplicate ...
Cloning and Expression of Endoglucanase genes from Trichoderma
... members of the class Oomycetes, which contain β-1, 3glucan and cellulose [4 ]. Thus, chitinases (EC 3.2.1.14) and β-1, 3-glucanases (EC 3.2.1.39), proteins secreted by Trichoderma spp., have been suggested as the key enzymes in the lysis of phytopathogenic fungal cell walls during mycoparasitic acti ...
... members of the class Oomycetes, which contain β-1, 3glucan and cellulose [4 ]. Thus, chitinases (EC 3.2.1.14) and β-1, 3-glucanases (EC 3.2.1.39), proteins secreted by Trichoderma spp., have been suggested as the key enzymes in the lysis of phytopathogenic fungal cell walls during mycoparasitic acti ...
Influence of industrial contamination on mobile genetic elements
... detected MGEs including plasmids, transposons and integrons across a wide variety of habitats (for example, Sobecky, 1999; Smalla and Sobecky, 2002; van Elsas and Bailey, 2002; Frost et al., 2005), but rarely in a quantitative manner due to previous methodological constraints. In those studies that ...
... detected MGEs including plasmids, transposons and integrons across a wide variety of habitats (for example, Sobecky, 1999; Smalla and Sobecky, 2002; van Elsas and Bailey, 2002; Frost et al., 2005), but rarely in a quantitative manner due to previous methodological constraints. In those studies that ...
Identification of a Novel Streptococcal Gene
... an SOS response that increases mutations and accelerates the evolution of antibiotic resistance in E. coli (14). Furthermore, it has been shown that the prevention of induction of the LexA-regulated SOS response inhibits the evolution of antibiotic resistance in E. coli (14). Thus, inhibitors of SOS ...
... an SOS response that increases mutations and accelerates the evolution of antibiotic resistance in E. coli (14). Furthermore, it has been shown that the prevention of induction of the LexA-regulated SOS response inhibits the evolution of antibiotic resistance in E. coli (14). Thus, inhibitors of SOS ...
Evolution of genetic and genomic features unique to the human
... varying size and gene copy number differences. The differences can affect coding regions, non-coding regulatory regions and repetitive sequence content. Strategies for identifying small-scale changes often involve scanning the genome for signatures of positive selection when comparing humans with no ...
... varying size and gene copy number differences. The differences can affect coding regions, non-coding regulatory regions and repetitive sequence content. Strategies for identifying small-scale changes often involve scanning the genome for signatures of positive selection when comparing humans with no ...
University of Groningen Characterization of the lytic-lysogenic
... protein. Within the central protected region of OR, an inverted repeat CCACGAAAAGTGG is present. A second copy of this repeat, though imperfect, is also located over the 35 box of the lysogenic promoter, PL, at OL (CCACGTTTTGCAA) (see Fig. 1B). Binding of CI2009 to the inverted repeat at OR is also ...
... protein. Within the central protected region of OR, an inverted repeat CCACGAAAAGTGG is present. A second copy of this repeat, though imperfect, is also located over the 35 box of the lysogenic promoter, PL, at OL (CCACGTTTTGCAA) (see Fig. 1B). Binding of CI2009 to the inverted repeat at OR is also ...
Keywords : LGMD2I, FKRP gene, novel mutations
... The limb-girdle muscular dystrophies (LGMD) are a heterogeneous group of genetically determined progressive disorders of the muscle with a primary or predominant involvement of the pelvic or shoulder girdle musculature. The clinical course in this group is characterized by normal intelligence and gr ...
... The limb-girdle muscular dystrophies (LGMD) are a heterogeneous group of genetically determined progressive disorders of the muscle with a primary or predominant involvement of the pelvic or shoulder girdle musculature. The clinical course in this group is characterized by normal intelligence and gr ...
Virus-mediated reprogramming of gene expression in plants John A
... (cRNA) molecules. These cRNAs could diffuse through the cytoplasm, anneal to their complementary sequence and serve as a guide for an RNA-degrading enzyme activity. Among the genes now known to be involved in PTGS-like activities are genes encoding proteins with similarities to an RdRP ([18•,19], a ...
... (cRNA) molecules. These cRNAs could diffuse through the cytoplasm, anneal to their complementary sequence and serve as a guide for an RNA-degrading enzyme activity. Among the genes now known to be involved in PTGS-like activities are genes encoding proteins with similarities to an RdRP ([18•,19], a ...
Structure and evolution of Apetala3, a sex
... To reveal activity (expression) of individual repetitive elements linked to SlAP3Y and their domains, we conducted RT-PCR experiments (figure 4). Retroelement A (its LTR part) and LINE were expressed in both males and females in different tissues (leaves and buds). Surprisingly, retroelement B had a ...
... To reveal activity (expression) of individual repetitive elements linked to SlAP3Y and their domains, we conducted RT-PCR experiments (figure 4). Retroelement A (its LTR part) and LINE were expressed in both males and females in different tissues (leaves and buds). Surprisingly, retroelement B had a ...
separation of single gene effects from additive
... use of molecular markers, this method provides the opportunity to include cases with multiple linked or unlinked qualitative genes (or markers). If more generations are included, the model can also be extended to other more complex polygenic models (Cockerham, 1980, Zhu, 1994). A free copy of this s ...
... use of molecular markers, this method provides the opportunity to include cases with multiple linked or unlinked qualitative genes (or markers). If more generations are included, the model can also be extended to other more complex polygenic models (Cockerham, 1980, Zhu, 1994). A free copy of this s ...
Characterization of the metacaspase gene family in Arabidopsis
... Another role model I am honoured to have met during my academic career is my Michigan Tech co-adviser, Victor Busov. I would first like to thank him for providing me with the initial opportunity to work in his lab, an opportunity which helped me to find my direction in life, and for helping to furth ...
... Another role model I am honoured to have met during my academic career is my Michigan Tech co-adviser, Victor Busov. I would first like to thank him for providing me with the initial opportunity to work in his lab, an opportunity which helped me to find my direction in life, and for helping to furth ...
Seed-Specific Gene Activation Mediated by the Cre//ox Site
... activation of a 8-glucuronidase marker gene, by removal of a loxbounded blocking fragment, allowed the visualization of the activation process. By using seed-specific promoters, the timing and efficiency of gene activation could be followed within the developing tobacco (Nicotiana tabacum) embryo. T ...
... activation of a 8-glucuronidase marker gene, by removal of a loxbounded blocking fragment, allowed the visualization of the activation process. By using seed-specific promoters, the timing and efficiency of gene activation could be followed within the developing tobacco (Nicotiana tabacum) embryo. T ...
especially b-lymphocytes from patients with sjögren´s syndrome
... Immunologie, Berlin, (5) Harvard Medical School/Massachusetts General Hospital, Immunobiology Laboratory, Charlestown Zielsetzung Some components of the proteasome system has been shown to be dysregulated in total peripheral blood mononuclear cells (PBMCs) from patients with primary Sjögren's syndro ...
... Immunologie, Berlin, (5) Harvard Medical School/Massachusetts General Hospital, Immunobiology Laboratory, Charlestown Zielsetzung Some components of the proteasome system has been shown to be dysregulated in total peripheral blood mononuclear cells (PBMCs) from patients with primary Sjögren's syndro ...
Gene Section HMGA2 (high mobility group AT-hook 2) in Oncology and Haematology
... Architectural factor, non histone, preferential binding to AT rich sequences in the minor groove of DNA helix; the precise function remains to be elucidated; probable role in regulation of cell proliferation. ...
... Architectural factor, non histone, preferential binding to AT rich sequences in the minor groove of DNA helix; the precise function remains to be elucidated; probable role in regulation of cell proliferation. ...
Using gene networks to drug target identification
... Drug target identification involves acquiring a molecular level understanding of the function of drug targets. On the molecular level, function is manifested in the behaviour of complex networks. It is necessary to know the cellular context of the drug target and the impact of its inhibition or acti ...
... Drug target identification involves acquiring a molecular level understanding of the function of drug targets. On the molecular level, function is manifested in the behaviour of complex networks. It is necessary to know the cellular context of the drug target and the impact of its inhibition or acti ...
Case Report Section
... with fever, and chest infection was diagnosed with acute myeloid leukemia FAB M4 in February 2010. His biochemistry was significant for GGT (8 IU/L; normal 9-40) and LDH 350 (normal 90-225). Chromosomal studies performed at diagnosis revealed the karyotype 46,Y,t(X;11)(q22;q23) in 25 out of 30 metap ...
... with fever, and chest infection was diagnosed with acute myeloid leukemia FAB M4 in February 2010. His biochemistry was significant for GGT (8 IU/L; normal 9-40) and LDH 350 (normal 90-225). Chromosomal studies performed at diagnosis revealed the karyotype 46,Y,t(X;11)(q22;q23) in 25 out of 30 metap ...
Biol115_2014_Lecture 10_Prokaryotic Gene Regulation
... Operons: The basic concept" • A cluster of functionally related genes can be under coordinated control by a single on-off “switch”" • An operon is the entire stretch of DNA that includes the operator, the promoter, and the genes that they control" • The regulatory “switch” is a segment of DNA ca ...
... Operons: The basic concept" • A cluster of functionally related genes can be under coordinated control by a single on-off “switch”" • An operon is the entire stretch of DNA that includes the operator, the promoter, and the genes that they control" • The regulatory “switch” is a segment of DNA ca ...
LightCycler® 480 System - Gene Scanning
... signals of all samples are set to uniform, relative values from 100% to 0%. 2. Temperature shifting: the temperature axis of the normalized melting curves is shifted to the point where the entire double-stranded DNA is completely denatured. Samples with heterozygous SNPs can then be easily be distin ...
... signals of all samples are set to uniform, relative values from 100% to 0%. 2. Temperature shifting: the temperature axis of the normalized melting curves is shifted to the point where the entire double-stranded DNA is completely denatured. Samples with heterozygous SNPs can then be easily be distin ...
Comparison of Statistical Models for Affymetrix GeneChip
... Model-based estimators are superior to simple averaging Full model superior to reduced this does not necessarily mean that the mismatch probes are a good idea - but if they are present we should use them we have demonstrated this using both analytic considerations and experimental data a carefully d ...
... Model-based estimators are superior to simple averaging Full model superior to reduced this does not necessarily mean that the mismatch probes are a good idea - but if they are present we should use them we have demonstrated this using both analytic considerations and experimental data a carefully d ...
Genetics
... List the 3 Principles of Heredity • Traits are controlled by alleles on chromosomes • An allele’s effect is dominant or recessive • When a pair of chromosomes separate during meiosis the different alleles for a trait move into separate sex cells ...
... List the 3 Principles of Heredity • Traits are controlled by alleles on chromosomes • An allele’s effect is dominant or recessive • When a pair of chromosomes separate during meiosis the different alleles for a trait move into separate sex cells ...
93134006蔡家妮 期中作業二
... absence of a Dcm homologue in V. cholerae, analysis of the genome sequence indicated the presence of a gene, designated in this study as vchM, which encodes a DNA (cytosine-5-)-methyltransferase (m5C-MTase) designated M.Vch. M.Vch is not associated with a restriction endonuclease or a mismatch very ...
... absence of a Dcm homologue in V. cholerae, analysis of the genome sequence indicated the presence of a gene, designated in this study as vchM, which encodes a DNA (cytosine-5-)-methyltransferase (m5C-MTase) designated M.Vch. M.Vch is not associated with a restriction endonuclease or a mismatch very ...
Tumor suppressor genes as negative growth regulators in
... Non.nuclear tumor suppressor genes Another class of tumor suppressor genes encodes proteins whose locus of action resides outside the nucleus, The way these proteins function is not nearly as clear as that described for their nuclear counterparts. Non-nuclear tumor suppressor proteins probably exert ...
... Non.nuclear tumor suppressor genes Another class of tumor suppressor genes encodes proteins whose locus of action resides outside the nucleus, The way these proteins function is not nearly as clear as that described for their nuclear counterparts. Non-nuclear tumor suppressor proteins probably exert ...
1 An Introduction - ResearchOnline@JCU
... the Drosophila aristaless gene, are frequently involved in the development of the embryonic brain and specification of the CNS. Originally it was thought that the cnidarian ‘head’, with its mouth-like opening and surrounding tentacles, could not reflect the ancestral complexity of the vertebrate or ...
... the Drosophila aristaless gene, are frequently involved in the development of the embryonic brain and specification of the CNS. Originally it was thought that the cnidarian ‘head’, with its mouth-like opening and surrounding tentacles, could not reflect the ancestral complexity of the vertebrate or ...
What is a gene, post-ENCODE? History and updated definition
... The classical view of a gene as a discrete element in the genome has been shaken by ENCODE The ENCODE consortium recently completed its characterization of 1% of the human genome by various high-throughput experimental and computational techniques designed to characterize functional elements (The EN ...
... The classical view of a gene as a discrete element in the genome has been shaken by ENCODE The ENCODE consortium recently completed its characterization of 1% of the human genome by various high-throughput experimental and computational techniques designed to characterize functional elements (The EN ...