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encode 2012
encode 2012

... thousands of quiescent regions. • It is possible to correlate quantitatively RNA sequence production and processing with both chromatin marks and transcription factor binding at promoters, indicating that promoter functionality can explain most of the variation in RNA expression. ...
Quick Unit Summary A gene is a stretch of DNA that codes for a
Quick Unit Summary A gene is a stretch of DNA that codes for a

... A gene is a stretch of DNA that codes for a specific characteristic or physical trait. Organisms always have 2 copies of each gene- the one they inherited from their biological mother and the one they inherited from their biological father. Genes have varying levels of expression, referred to as dom ...
Lecture#7 - Eukaryote gene structure and regulation.
Lecture#7 - Eukaryote gene structure and regulation.

... Proximal cis-acting elements - The Promoter Region Fig beta-globin promoter Mutations have been used to define the essential promoter sequences. Many nucleotides can be changed with no effect on transcription. DNA sequences in the promoter region of the gene: |-----> mRNA ...
Genetics in Glaucoma- The Importance and The Interpretation
Genetics in Glaucoma- The Importance and The Interpretation

... Strong family history is a risk factor A single gene susceptibility gene is unlikely Multiple genes and environmental factors are involved Associated with mutations in a novel gene OPTN. Optineurin is expressed in many ocular tissues as well as nonocular ...
INBREEDING Definition
INBREEDING Definition

... Heterosis and Out-breeding depression  Heterosis is strong in F1 generation and weak in F2-F3  Out-breeding is weak in F1 and Strong in F2 and F3 ...
Gene Section SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein)
Gene Section SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein)

... interacts with the cancer-testis antigen SSX2. It is thought that SSX2IP regulates the function of SSX2 in the testes and malignant cells. The rodent equivalent is known as afadin DIL domain-interacting protein (ADIP) and the chicken orthologue is called clockcontrolled gene (LCG) (Breslin et al., 2 ...
Fine Structure and Analysis of Eukaryotic Genes
Fine Structure and Analysis of Eukaryotic Genes

... • Many metabolic functions are carried out by proteins conserved from bacteria or yeast to humans - one may find a homolog with a known function. • Many sequence motifs are associated with a specific biochemical function (e.g. kinase, ATPase). A match to such a motif identifies a potential class of ...
Slide 1
Slide 1

... something. • Could be in charge of making a protein (like the gene for the molecule keratin has its nucleotides in an order such that the amino acid sequence that is made from those directions will make keratin) • Could be a ‘regulatory’ gene – like a foreman in a factory who produces nothing direct ...
You Light Up My Life - Lakefield District Secondary School
You Light Up My Life - Lakefield District Secondary School

... “bald” but rather thin ...
What is gene testing
What is gene testing

... missing, or altered chemical base. Genes can be overexpressed (too many copies), inactivated, or lost altogether. Sometimes, pieces of chromosomes become switched, so that a gene ends up in a location where it is permanently and inappropriately turned on or off. In addition to studying chromosomes o ...
Bacterial Transformation with (pGLO Plasmid)
Bacterial Transformation with (pGLO Plasmid)

... DNA in the form of a plasmid • Reinforce the following process: DNA  RNA  Protein  Trait • Observe how genes are regulated ...
ppt
ppt

... A series of values of variables taken in successive periods of time ...
It turns out that cultures with a history of dairy farming and milk
It turns out that cultures with a history of dairy farming and milk

... the sickle-cell gene can actually protect against malaria. So in parts of the world where malaria infection rates are extremely high, like Africa, natural selection may actually favour the sickle-shaped cells. In the gamble of life, protection against malaria may be preferable, even at the potential ...
221_exam_2_2002
221_exam_2_2002

... ____ In two-component regulatory systems a signal is relayed to the regulator protein by A. phosphorylation B. adenylation C. autoinducer D. a peptide ____ Promoter strength is determined by A. the DNA sequence of the promoter region B. the number of operators C. how close the promoter is to the sta ...
Sex & Death: Introduction to the Philosophy of Biology
Sex & Death: Introduction to the Philosophy of Biology

... 2) Excludes impostors like individual nucleotides 3) The phenotypic effect of genes makes them more likely to be replicated ...
Methyl methanesulphonate (MMS, Fig
Methyl methanesulphonate (MMS, Fig

... the original species. In the mouse L5178Y cells, the set of MMS-induced transcripts did not at all overlap with those upregulated by bleomycin (with a single exception). Also in TK6 culture were most genes possessing differential activity treatment-specific. Anyway, there were 2 genes induced by bot ...
Gene Ontology (GO) - The Linnaeus Centre for Bioinformatics
Gene Ontology (GO) - The Linnaeus Centre for Bioinformatics

... The bioinformatics group research is a reflection of the field: on one hand we develop algorithms and build tools and software systems that enable answering complex questions in Life Sciences, on the other hand we try to come with answers to these questions. Our modus of work is distinguished by col ...
4.1 Intro to Genetics
4.1 Intro to Genetics

... A child has brown hair and brown eyes. His father has brown hair and blue eyes. His mother has red hair and brown eyes. The best explanation for the child having brown hair and brown eyes is that (A) A gene mutation occurred that resulted in brown hair and brown eyes (B) Gene expression must change ...
Law of Independent Assortment
Law of Independent Assortment

... Law of Dominance: if the two alleles at a locus differ, then one, the dominant allele, determines the organism′s appearance; the other, the recessive allele, has no noticeable effect on the organism′s appearance Law of Segregation: the two alleles for a heritable character separate (segregate) durin ...
Gene Section NKX2-2 (NK2 homeobox 2) Atlas of Genetics and Cytogenetics
Gene Section NKX2-2 (NK2 homeobox 2) Atlas of Genetics and Cytogenetics

... Cytogenetics Ewing's sarcoma cells harbor the characteristic translocation t(11;22)(q24;q12) in roughly 90% of ...
Microarray Data Analysis
Microarray Data Analysis

... • Fold change is often much greater for low intensity samples (absolute amount of RNA is small) • If you normalize by dividing all samples by the mean, then genes that express at this level will have their variation suppressed ...
sign - GVI.cz
sign - GVI.cz

... signs appear in various qualities (forms)  the colour of petals can be white, yellow, ….  so the colour is:  a qualitative sign  a monogenous sign > hereditary determined by just one gene ...
Aim: What is positive feedback of bacterial operons?
Aim: What is positive feedback of bacterial operons?

... (lactose metabolism).  Both repressible and inducible operons demonstrate negative control because active repressors can only have negative effects on transcription. ...
Integrating Gene Expression Analysis into Genome-Wide
Integrating Gene Expression Analysis into Genome-Wide

... causative genetic variation or the mechanism by which ...
Recombinant DNA Simulation
Recombinant DNA Simulation

... Investigation 6: Recombinant DNA Simulation Introduction: One of the most important processes developed by biotechnologists was the procedure where a gene is removed from the DNA of one organism and inserted into the DNA of another organism. This technique is called Recombinant DNA. The entire proce ...
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Epigenetics of diabetes Type 2

In recent years it has become apparent that the environment and underlying mechanisms affect gene expression and the genome outside of the central dogma of biology. It has been found that many Epigenetic mechanisms are involved in the regulation and expression of genes such as DNA methylation and chromatin remodeling. These epigenetic mechanisms are believed to be a contributing factor to pathological diseases such as Diabetes type II. An understanding of the epigenome of Diabetes patients may help to elucidate otherwise hidden causes of this disease.
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