Gene Prediction Techniques - Computational Biology of RNA
... usually caused by mutations in a single gene that makes the protein it encodes not to function properly or not to function at all. These are called Mendelian diseases or hereditary diseases, and can have different type of inheritance (Dominant, Recessive or X-linked). In this short practical we intr ...
... usually caused by mutations in a single gene that makes the protein it encodes not to function properly or not to function at all. These are called Mendelian diseases or hereditary diseases, and can have different type of inheritance (Dominant, Recessive or X-linked). In this short practical we intr ...
- Wiley Online Library
... the chromosomal background of -thalassemia mutations in several human populations. The eastern region of India is not well characterized in this regard. The Bengali population from the state of West Bengal has been the subject of our study. It is an admixture of native people with later migrants wh ...
... the chromosomal background of -thalassemia mutations in several human populations. The eastern region of India is not well characterized in this regard. The Bengali population from the state of West Bengal has been the subject of our study. It is an admixture of native people with later migrants wh ...
Tutorial: RNA-Seq Analysis Part II (Tracks): Non-Specific
... 11. You may wonder why there are so many non specific matches for this gene. To understand this, go to the table view of your experiment by clicking on the table icon at the bottom of the experiment editor (see the red arrow in figure 12). Type the name of the gene, "Rps13" in the "Filter" box and p ...
... 11. You may wonder why there are so many non specific matches for this gene. To understand this, go to the table view of your experiment by clicking on the table icon at the bottom of the experiment editor (see the red arrow in figure 12). Type the name of the gene, "Rps13" in the "Filter" box and p ...
Methods S1
... Wheat and rye lines which were used for Southern blot analysis, Pm8 cloning or were tested with the Pm8-marker sfr43(Pm8) for the presence or absence of the Pm8 gene are listed in Table S1. Wheat-rye recombinant lines T8, T9, T16, T18, 1B+14 and 1B+37 along with their parental lines Pavon 76 and Pav ...
... Wheat and rye lines which were used for Southern blot analysis, Pm8 cloning or were tested with the Pm8-marker sfr43(Pm8) for the presence or absence of the Pm8 gene are listed in Table S1. Wheat-rye recombinant lines T8, T9, T16, T18, 1B+14 and 1B+37 along with their parental lines Pavon 76 and Pav ...
ChromatinDB: a database of genome-wide
... specificity (Roth et al., 2001; Suka et al., 2001). In contrast, selection of a random set of 135 yeast promoter regions did not reveal a significant enrichment or depletion of any of the histone modification data sets (Supplementary Fig. S2). Intriguingly, we observe that acetylation of H2AZ K14 is ...
... specificity (Roth et al., 2001; Suka et al., 2001). In contrast, selection of a random set of 135 yeast promoter regions did not reveal a significant enrichment or depletion of any of the histone modification data sets (Supplementary Fig. S2). Intriguingly, we observe that acetylation of H2AZ K14 is ...
BIOINFORMATICS MODULE I - Tetrahymena Genome Database
... Write down the domains and their relative locations (near the middle, at the Cterminus, N-terminus, etc.). If there are no domains identified, go to step 5. 4. Predict your gene’s function: The functional domains in your protein are the best predictors of its function in Tetrahymena. Click on a doma ...
... Write down the domains and their relative locations (near the middle, at the Cterminus, N-terminus, etc.). If there are no domains identified, go to step 5. 4. Predict your gene’s function: The functional domains in your protein are the best predictors of its function in Tetrahymena. Click on a doma ...
Beyond the ABCs: ternary complex formation in the control of
... The final proof that the Im MADS-box genes are indeed essenC-function mutants and so the Im genes are unlikely to act as tial for the activity of the organ identity genes has now been essential downstream targets of the C-function genes. obtained in Arabidopsis. Individual loss-of-function mutants i ...
... The final proof that the Im MADS-box genes are indeed essenC-function mutants and so the Im genes are unlikely to act as tial for the activity of the organ identity genes has now been essential downstream targets of the C-function genes. obtained in Arabidopsis. Individual loss-of-function mutants i ...
Thinking of Biology - Oxford Academic
... multicellular organism all have the same genes, but particular cell types express only some of them" (Epp Figure 1. Schematicrepresentationof some transcription, editing, and translation 1997, p. 537). He went on to say that processes, highlighting the context dependencyof the expression of gene pro ...
... multicellular organism all have the same genes, but particular cell types express only some of them" (Epp Figure 1. Schematicrepresentationof some transcription, editing, and translation 1997, p. 537). He went on to say that processes, highlighting the context dependencyof the expression of gene pro ...
WHAT IS A GENE? - Electronic Scholarly Publishing
... when the effect of x-rays on genes was discovered by Muller 16 the methods available to geneticists for direct studies of gene properties were highly unsatisfactory. High stability of the great majority of genes and inability to produce changes experimentally on any of the known genes made direct ap ...
... when the effect of x-rays on genes was discovered by Muller 16 the methods available to geneticists for direct studies of gene properties were highly unsatisfactory. High stability of the great majority of genes and inability to produce changes experimentally on any of the known genes made direct ap ...
Gene Section RBL2 (retinoblastoma-like 2) Atlas of Genetics and Cytogenetics
... Recent studies show a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of estrogen receptor-alpha transcription. pRb2/p130 expression predicts outcome in squamous cell carcinoma of the esophagus, lung, mouth and endometrium carcinomas. Analyses of gene expression profiles ide ...
... Recent studies show a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of estrogen receptor-alpha transcription. pRb2/p130 expression predicts outcome in squamous cell carcinoma of the esophagus, lung, mouth and endometrium carcinomas. Analyses of gene expression profiles ide ...
Microarray Analysis -- Image Processing and Filter Design
... The relative abundance of the corresponding mRNA from the two sources will be assessed by the mesured signal. ...
... The relative abundance of the corresponding mRNA from the two sources will be assessed by the mesured signal. ...
here - FasterDB
... heart and muscle tissues where exon 13 has high global Si values. B- Expression table of the exon 15 in the HSN2 gene (orthologous of the human exon 13 in the WNK1 gene) among mouse tissues. Red rectangles correspond to heart and muscle tissues where exon 15 has also high global Si values. ...
... heart and muscle tissues where exon 13 has high global Si values. B- Expression table of the exon 15 in the HSN2 gene (orthologous of the human exon 13 in the WNK1 gene) among mouse tissues. Red rectangles correspond to heart and muscle tissues where exon 15 has also high global Si values. ...
Investigation of the role of the Inflammasome triggering HIN200
... AIM2, a unique cytosolic DNA sensor which instigates the formation of the inflammasome yielding cell death via IL-1β and IL-182. This project sought to develop a novel subcongenic mouse model containing the HIN 200 locus, B10.Yaa.Bxs3.Ifi to investigate the potential role of this gene family in SLE ...
... AIM2, a unique cytosolic DNA sensor which instigates the formation of the inflammasome yielding cell death via IL-1β and IL-182. This project sought to develop a novel subcongenic mouse model containing the HIN 200 locus, B10.Yaa.Bxs3.Ifi to investigate the potential role of this gene family in SLE ...
Nyholt and colleagues provided compelling evidence for the
... (rs502434), and a -1952T/C SNP (rs3761555) in the promoter region. The two GRIA3-SNPs (rs502434 and rs3761555), were analyzed for association with migraine in the case-control population of Australia Caucasians. The distribution of rs502434 and rs3761555 genotypes in the studied population did not d ...
... (rs502434), and a -1952T/C SNP (rs3761555) in the promoter region. The two GRIA3-SNPs (rs502434 and rs3761555), were analyzed for association with migraine in the case-control population of Australia Caucasians. The distribution of rs502434 and rs3761555 genotypes in the studied population did not d ...
Chromosomal insertion of foreign DNA
... Summary ― The main route and, in most species, the only reliable route to the generation of transgenic animals is by microinjecting DNA into an early embryo, generally one of the pronuclei of a newly fertilized egg (a one-cell embryo). In most cases, a small number (perhaps 100) of identical ...
... Summary ― The main route and, in most species, the only reliable route to the generation of transgenic animals is by microinjecting DNA into an early embryo, generally one of the pronuclei of a newly fertilized egg (a one-cell embryo). In most cases, a small number (perhaps 100) of identical ...
Several recent reports have suggested a relationship between
... imprinting errors. Angelman’s, and Prader-Willi syndromes are serious conditions that involve multiple developmental abnormalities and Beckwith-Wiedemann syndrome mimics to some extent a fetal overgrowth phenotype. While the complete genetic basis of these diseases is as yet unclear, they all appare ...
... imprinting errors. Angelman’s, and Prader-Willi syndromes are serious conditions that involve multiple developmental abnormalities and Beckwith-Wiedemann syndrome mimics to some extent a fetal overgrowth phenotype. While the complete genetic basis of these diseases is as yet unclear, they all appare ...
Chromosome 21 Scan in Down Syndrome Reveals DSCAM as a
... Hirschsprung disease (HSCR) genetics is a paradigm for the study and understanding of multigenic disorders. Association between Down syndrome and HSCR suggests that genetic factors that predispose to HSCR map to chromosome 21. To identify these additional factors, we performed a dose-dependent assoc ...
... Hirschsprung disease (HSCR) genetics is a paradigm for the study and understanding of multigenic disorders. Association between Down syndrome and HSCR suggests that genetic factors that predispose to HSCR map to chromosome 21. To identify these additional factors, we performed a dose-dependent assoc ...
Amsterdam Molecular Therapeutics to Develop AAV
... percent of the general population. At least 11 percent of NAFLD patients will develop NASH, a very serious inflammatory liver disease for which there is no therapy and affects many millions in the developed world. AMT-011, NAFLD, NASH and the metabolic syndrome AMT-011 is currently in its last phase ...
... percent of the general population. At least 11 percent of NAFLD patients will develop NASH, a very serious inflammatory liver disease for which there is no therapy and affects many millions in the developed world. AMT-011, NAFLD, NASH and the metabolic syndrome AMT-011 is currently in its last phase ...
MHC2TA Single Nucleotide Polymorphism and Genetic Risk for
... Department of Clinical Pathology and Cytology (M.G.), Karolinska University Hospital, SE-141 86 Stockholm, Sweden; Department of Internal Medicine (G.G., C.T., A.B., A.F.), Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy; Division of Bio ...
... Department of Clinical Pathology and Cytology (M.G.), Karolinska University Hospital, SE-141 86 Stockholm, Sweden; Department of Internal Medicine (G.G., C.T., A.B., A.F.), Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy; Division of Bio ...
shERWOOD-UltramiR shRNA
... UltramiR - Increased small RNA processing = Increased Knockdown The miR-30 scaffold has been further optimized based on conserved domains shown to be important determinants of primary microRNA processing by Drosha (Auyeung et al., 2013). This enhanced microRNA scaffold increases small RNA levels pr ...
... UltramiR - Increased small RNA processing = Increased Knockdown The miR-30 scaffold has been further optimized based on conserved domains shown to be important determinants of primary microRNA processing by Drosha (Auyeung et al., 2013). This enhanced microRNA scaffold increases small RNA levels pr ...
Inhibition of NF-kB by ZAS3, a zinc-finger protein that also binds to
... and mitosis of germ cells • Down-regulation of ZAS is associated with accelerated growth of cell lines and growth of multinucleated giant cells • ZAS3 required maturation (prevents apoptosis) • In ZAS-/- cells, developmental abnormalities resulted including tumorigenesis, polydactyly, and hydronephr ...
... and mitosis of germ cells • Down-regulation of ZAS is associated with accelerated growth of cell lines and growth of multinucleated giant cells • ZAS3 required maturation (prevents apoptosis) • In ZAS-/- cells, developmental abnormalities resulted including tumorigenesis, polydactyly, and hydronephr ...
ASCO_2009_files/Blanke GIST PD ASCO2009
... signatures and response on RTOG 0132: Background and Importance • 01321: Phase II neoadjuvant trial imatinib in KIT + potentially resectable GIST (primary or metastatic) ...
... signatures and response on RTOG 0132: Background and Importance • 01321: Phase II neoadjuvant trial imatinib in KIT + potentially resectable GIST (primary or metastatic) ...
Gene Section FSTL3 (follistatin-like 3 (secreted glycoprotein)) Atlas of Genetics and Cytogenetics
... In contrast to follistatin, FSTL3 does not contain a heparin binding motif and does not bind cell surface heparan-sulfate proteoglycans (Sidis et al., 2002). In addition to binding TGF beta family ligands, FSTL3 was demonstrated to interact with ADAM12 (a disintegrin and metalloprotease 12), an extr ...
... In contrast to follistatin, FSTL3 does not contain a heparin binding motif and does not bind cell surface heparan-sulfate proteoglycans (Sidis et al., 2002). In addition to binding TGF beta family ligands, FSTL3 was demonstrated to interact with ADAM12 (a disintegrin and metalloprotease 12), an extr ...
Molecular basis of the adult i phenotype and the gene responsible
... cDNA encoding an I-branching 6GlcNAc-T. The gene, designated IGnT, is located on chromosome 6p24.19,20 Another gene, located on chromosome 15q21-22 and designated C2GnT-M19 or C2/4GnT,20 was identified and shown to encode another Ibranching–forming enzyme.19 The blood group I locus has not been con ...
... cDNA encoding an I-branching 6GlcNAc-T. The gene, designated IGnT, is located on chromosome 6p24.19,20 Another gene, located on chromosome 15q21-22 and designated C2GnT-M19 or C2/4GnT,20 was identified and shown to encode another Ibranching–forming enzyme.19 The blood group I locus has not been con ...
