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Inferring genetic regulatory logic from expression data
Inferring genetic regulatory logic from expression data

... System and methods ...
Gene Section CITED4 (Cbp/p300 interacting transactivator, with Glu/Asp
Gene Section CITED4 (Cbp/p300 interacting transactivator, with Glu/Asp

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... subtype centroid and the global centroid. These genes are therefore not useful for discrimination in the case of comparing two subtypes. However, when there are more than two subtypes, a zero score may be reported as long as it is not zero for the shrunken centroids of all subtypes. A ...
Clark: Biotechnology, 2nd Edition Chapter 2: DNA, RNA, and Protein
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... 1) missing correlations between genes. 2) Predictor set size must be specified. • Data Sets used for the GA: – NCI60: expression profiles of 64 cancer cell lines containing 9703 cDNA sequences. – GCM: expression profiles for 198 tumor samples, 90 normal samples, and 20 unknowns containing 16063 gene ...
Chapter 21: The Genetic Basis of Development
Chapter 21: The Genetic Basis of Development

... a. What can one conclude from the fact that some mammalian apoptosis proteins are homologous to the Ced-3, Ced-4, and Ced-9 proteins of nematodes? The basic mechanism for programmed cell death evolved early in animal evolution. Unicorns! b. Give some examples of programmed cell death in humans. Prog ...
Chapter 21 The Genetic Control of Animal Development
Chapter 21 The Genetic Control of Animal Development

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Chapter 11 PowerPoint – Genetics

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... replication will be passed on to offspring as mutations. However, RNA's have very short life spans in the cytoplasm therefore mistakes are not permanent. The lack of proofreading allows for faster transcription. The prokaryotic promoter has two distinct elements that are not identical. How is this i ...
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... degree of complementarity to their targets, and the scarcity of microRNA lossof-function phenotypes in plants implies that redundancy exists between microRNA family members. Now, two papers provide new insights into this redundancy and into microRNA-regulated shoot development in Arabidopsis. Elliot ...
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Fish sampling - BioMed Central

... were originally done with an automatic pipeline, simultaneously running BLASTX (protein), BLASTN (core nucleotide) and BLASTN (EST), but annotation of the studied genes was also evaluated manually. The primer pairs amplify PCR products between 69-134 basepairs (bp) long. Since some of the assays did ...
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Sex bias in gene expression is not the same as dosage

... demonstration (Mank and Ellegren, 2009) of how male and female expression levels vary along the chicken Z chromosome, a study that arrived at a slightly different conclusion when it comes to the interpretation of dosage compensation (DC) in a male hypermethylated region than that in a previous repor ...
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... A regulator gene is a prokaryotic gene that codes for the production of a repressor protein An operator is a DNA segment that controls transcription by blocking RNA polymerase with a repressor protein; it is part of the operon. An intron is a section of a gene that is transcribed but not translated. ...
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Developmental Gene Expression Part II

from Chapter 11: Gene Regulation
from Chapter 11: Gene Regulation

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Messenger RNA profiling: a prototype method to supplant

... resembling mRNA structure but located in DNA Control: amplify DNA, look for ...
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My Slides - people.vcu.edu

... • Most gene regulatory roles unknown • A gene whose variants affect levels of a variety of other genes in a function regulates that process ...
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Genome DNA (deoxyribonucleic acid) Chromosome Gene Allele

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Long non-coding RNA

Long non-coding RNAs (long ncRNAs, lncRNA) are non-protein coding transcripts longer than 200 nucleotides. This somewhat arbitrary limit distinguishes long ncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs.
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