Robust systems persist in response to mutations
... one binding site. Payne and Wagner found that the more sites a transcription factor can bind to—and the more one can "hop" from one compatible site to the next through single mutations—the more robust the transcription factor's function. What's more, that robustness makes it easier for a population ...
... one binding site. Payne and Wagner found that the more sites a transcription factor can bind to—and the more one can "hop" from one compatible site to the next through single mutations—the more robust the transcription factor's function. What's more, that robustness makes it easier for a population ...
FROM DNA TO PROTEINS: gene expression Chapter 14 LECTURE
... Drosophila; E. coli; Neurospora crassa (common bread mold) BEADLE & TATUM EXPERIMENT one-gene, one-polypeptide relationship. The gene-enzyme relationship has since been revised to the Example: In hemoglobin, each polypeptide chain is specified by a separate gene. Other genes code for RNA are not tra ...
... Drosophila; E. coli; Neurospora crassa (common bread mold) BEADLE & TATUM EXPERIMENT one-gene, one-polypeptide relationship. The gene-enzyme relationship has since been revised to the Example: In hemoglobin, each polypeptide chain is specified by a separate gene. Other genes code for RNA are not tra ...
triplex-forming oligonucleotide (TFO)
... • Hydroxyurea – However, many patients cannot achieve increased HbF with these treatments! – With hydroxyurea treatment, for example, only about 60% of patients were found to ...
... • Hydroxyurea – However, many patients cannot achieve increased HbF with these treatments! – With hydroxyurea treatment, for example, only about 60% of patients were found to ...
X-Chromosome Inactivation: The Case of the Calico Cat1
... genome, led by Carolyn Brown and Huntington Willard of Case Western Reserve University in Cleveland. The key player in the story is a gene on the X-chromosome designated the “X-inactive-specific-transcript” gene, or Xist, as it is called in the mouse genome (pronounced “exist”.) In humans, this gene ...
... genome, led by Carolyn Brown and Huntington Willard of Case Western Reserve University in Cleveland. The key player in the story is a gene on the X-chromosome designated the “X-inactive-specific-transcript” gene, or Xist, as it is called in the mouse genome (pronounced “exist”.) In humans, this gene ...
Plant Gravitational and Space Genomics Tour
... SUC2, and a lipidtransfer protein-like gene (At2g18370) in ...
... SUC2, and a lipidtransfer protein-like gene (At2g18370) in ...
Supplementary methods
... first tested. Specifically, approximately 25% of the primers were tested on each species. If a primer pair successfully amplified a unique PCR product of the expected size in the leading species, we obtained the product for this gene from the other three species as well. If not, this primer set was ...
... first tested. Specifically, approximately 25% of the primers were tested on each species. If a primer pair successfully amplified a unique PCR product of the expected size in the leading species, we obtained the product for this gene from the other three species as well. If not, this primer set was ...
hox genes
... vitripennis [6], Hox genes are organized in a contiguous, single-copy cluster in the leafcutter ant Atta cephalotes. However, only 9 of the 10 genes usually found in the cluster were identified here (Figure1). Despite sequence similarity analyses against the entire genome, a homolog for Hox3-A was n ...
... vitripennis [6], Hox genes are organized in a contiguous, single-copy cluster in the leafcutter ant Atta cephalotes. However, only 9 of the 10 genes usually found in the cluster were identified here (Figure1). Despite sequence similarity analyses against the entire genome, a homolog for Hox3-A was n ...
Cancer-inducing genes
... • a large proportion are misexpressed in human cancer • for 47 out of 75 CRGs tested, co-regulation is found in primary human colon cancer and our murine colon cancer cell model • altered expression of 29 CRGs has been reported in a variety of human cancer types ...
... • a large proportion are misexpressed in human cancer • for 47 out of 75 CRGs tested, co-regulation is found in primary human colon cancer and our murine colon cancer cell model • altered expression of 29 CRGs has been reported in a variety of human cancer types ...
A Statistical Approach to Literature
... Problem • Gene List: Eisen K cluster (15 genes) – Mainly respiratory chain complex (13), one mitochondrial membrane pore (por1 or VDAC) ...
... Problem • Gene List: Eisen K cluster (15 genes) – Mainly respiratory chain complex (13), one mitochondrial membrane pore (por1 or VDAC) ...
Document
... -Integrative team of geneticists, breeders, genomicists, bioinformaticists, biologists to be poised to tackle important issues in translational genomics as it pertains to the Solanaeae (done) -Ready to move to more applications in the field, breeding, ...
... -Integrative team of geneticists, breeders, genomicists, bioinformaticists, biologists to be poised to tackle important issues in translational genomics as it pertains to the Solanaeae (done) -Ready to move to more applications in the field, breeding, ...
Supplementary Information
... The lasso was computed using the sixteen genes associated with survival in the 67 R-CHOP patients in univariate analysis, starting from an initial model that included the International Prognostic Index. The Lambda parameter controls the penalty applied to the regression coefficients and the gene ent ...
... The lasso was computed using the sixteen genes associated with survival in the 67 R-CHOP patients in univariate analysis, starting from an initial model that included the International Prognostic Index. The Lambda parameter controls the penalty applied to the regression coefficients and the gene ent ...
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... Although many of the brain-specific miRNAs have been identified, the functions of only a few are known. Nonetheless, the effects of miRNA-mediated modulation on gene expression during normal development, differentiation, and homeostasis, as well as related pathological conditions, are widely accepte ...
... Although many of the brain-specific miRNAs have been identified, the functions of only a few are known. Nonetheless, the effects of miRNA-mediated modulation on gene expression during normal development, differentiation, and homeostasis, as well as related pathological conditions, are widely accepte ...
11_Lecture_Presen - Bishop Conaty
... 11.5 Complex assemblies of proteins control eukaryotic transcription Regulatory proteins that bind to control sequences – Transcription factors promote RNA polymerase binding to the promoter – Activator proteins bind to DNA enhancers and interact with other transcription factors – Silencers are r ...
... 11.5 Complex assemblies of proteins control eukaryotic transcription Regulatory proteins that bind to control sequences – Transcription factors promote RNA polymerase binding to the promoter – Activator proteins bind to DNA enhancers and interact with other transcription factors – Silencers are r ...
Gene Section TRIM37 (tripartite motif-containing 37) Atlas of Genetics and Cytogenetics
... In situ hybridization suggests TRIM37 expression patterns in multiple tissues during mouse and human embryogenesis. No Trim37 expression is detected up to E9.5. At E11.5, Trim37 expression is detected in cells lining the esophagus and bronchias well as the innermost cells of the optic cup adjacent t ...
... In situ hybridization suggests TRIM37 expression patterns in multiple tissues during mouse and human embryogenesis. No Trim37 expression is detected up to E9.5. At E11.5, Trim37 expression is detected in cells lining the esophagus and bronchias well as the innermost cells of the optic cup adjacent t ...
H_Pylori_MicroArray_Data_Analysis
... • Statistical data was gathered to determine which genes in this experiment underwent the greatest changes • MAPPFinder was used to determine the most upregulated and downregulated genes • Data indicated that many of the top 10 most significant genes dealt with transcription • Data shows that RpoN d ...
... • Statistical data was gathered to determine which genes in this experiment underwent the greatest changes • MAPPFinder was used to determine the most upregulated and downregulated genes • Data indicated that many of the top 10 most significant genes dealt with transcription • Data shows that RpoN d ...