Gene Section IKZF1 (Ikaros family zinc finger 1) in Oncology and Haematology
... Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Taniwaki M, Seto M. The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large Bcell lymphoma. Blood. 2000 Apr 15;95(8):2719-21 ...
... Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Taniwaki M, Seto M. The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large Bcell lymphoma. Blood. 2000 Apr 15;95(8):2719-21 ...
Changes in DNA-binding activity of transcription factors in the
... mon features: all of them are expressed only in mammary gland epithelium during late pregnancy and lactation, their transcription is induced by lactogenic hormones – insulin, prolactin and glucocorticoids, while repressed by progesterone. These features make mammary gland a good model for studying m ...
... mon features: all of them are expressed only in mammary gland epithelium during late pregnancy and lactation, their transcription is induced by lactogenic hormones – insulin, prolactin and glucocorticoids, while repressed by progesterone. These features make mammary gland a good model for studying m ...
Regulation of Gene Expression
... Hormones affect the regulation of gene expression in one of two ways. Steroid hormones interact directly with intracellular receptors that are DNA-binding regulatory proteins; binding of the hormone has either positive or negative effects on the transcription of genes targeted by the hormone. Nons ...
... Hormones affect the regulation of gene expression in one of two ways. Steroid hormones interact directly with intracellular receptors that are DNA-binding regulatory proteins; binding of the hormone has either positive or negative effects on the transcription of genes targeted by the hormone. Nons ...
A gain-of-function TBX20 mutation causes congenital atrial septal
... consequences for the variant. As shown in figure 2 the residue of Ile121 packs between side chains of Arg127 and Tyr267, which make important interactions with DNA.14 To investigate disease segregation in the family pedigree, we characterised relatives of the proband (figure 1C). The index patient (IV ...
... consequences for the variant. As shown in figure 2 the residue of Ile121 packs between side chains of Arg127 and Tyr267, which make important interactions with DNA.14 To investigate disease segregation in the family pedigree, we characterised relatives of the proband (figure 1C). The index patient (IV ...
Chapter 17 - Auburn University
... 1. process is somewhat similar to DNA synthesis, but no primer is needed 2. bacterial cells each only have one type of RNA polymerase 3. eukaryotic cells have three major types of RNA polymerase RNA polymerase I is used in making rRNA RNA polymerase II is used in making mRNA and some small RNA m ...
... 1. process is somewhat similar to DNA synthesis, but no primer is needed 2. bacterial cells each only have one type of RNA polymerase 3. eukaryotic cells have three major types of RNA polymerase RNA polymerase I is used in making rRNA RNA polymerase II is used in making mRNA and some small RNA m ...
RNA Polymerases
... regulation of their transcription. Some promoters such as the U6 small nuclear RNA (U6 snRNA ) and small RNA genes from the Epstein-Barr virus use only regulatory sequences upstream from their transcription start sites. The coding region of the U6 snRNA has a characteristic A box. However, this sequ ...
... regulation of their transcription. Some promoters such as the U6 small nuclear RNA (U6 snRNA ) and small RNA genes from the Epstein-Barr virus use only regulatory sequences upstream from their transcription start sites. The coding region of the U6 snRNA has a characteristic A box. However, this sequ ...
Long Noncoding RNAs Add Another Layer to Pre
... long ncRNAs remain largely unexplored. It seems unlikely that the long ncRNAs are just transcriptional noise, because many of them are conserved, their expression is developmentally regulated, and they have tissue-specific expression patterns (Mercer et al., 2009). Furthermore, several long ncRNAs a ...
... long ncRNAs remain largely unexplored. It seems unlikely that the long ncRNAs are just transcriptional noise, because many of them are conserved, their expression is developmentally regulated, and they have tissue-specific expression patterns (Mercer et al., 2009). Furthermore, several long ncRNAs a ...
A Comparative Genomic Method for Computational
... • DnaA regulation may couple lipid cellular processes to DNA replication – this may be accomplished by the transcription factor activity of DnaA upstream of phospholipid biosynthesis genes fadL, acpP, fabF, accD, plsC, psd, and pgsA – changes in expression of the phospholipid biosynthesis proteins a ...
... • DnaA regulation may couple lipid cellular processes to DNA replication – this may be accomplished by the transcription factor activity of DnaA upstream of phospholipid biosynthesis genes fadL, acpP, fabF, accD, plsC, psd, and pgsA – changes in expression of the phospholipid biosynthesis proteins a ...
Chapter 17 Notes
... • Some introns contain sequences that may regulate gene expression • Some genes can encode more than one kind of polypeptide, depending on which segments are treated as exons during splicing • This is called alternative RNA splicing • Consequently, the number of different proteins an organism can pr ...
... • Some introns contain sequences that may regulate gene expression • Some genes can encode more than one kind of polypeptide, depending on which segments are treated as exons during splicing • This is called alternative RNA splicing • Consequently, the number of different proteins an organism can pr ...
Yeast Two-Hybrid Screen
... labeled promoter region and mutated as-1like element AHBP-1b can specifically bind the PR-1 promoter region in vitro ...
... labeled promoter region and mutated as-1like element AHBP-1b can specifically bind the PR-1 promoter region in vitro ...
Ch. 17 From Gene to Protein
... Is the actual synthesis of a polypeptide, which occurs under the direction of mRNA Occurs on ribosomes Involves mRNA, tRNA and rRNA http://www.youtube.com/watch?v=D5vH4Q_tAkY&feature=rela ted ...
... Is the actual synthesis of a polypeptide, which occurs under the direction of mRNA Occurs on ribosomes Involves mRNA, tRNA and rRNA http://www.youtube.com/watch?v=D5vH4Q_tAkY&feature=rela ted ...
1 How DNA Makes Stuff
... It can be misleading to think of DNA as a blueprint, but it works sometimes, like now. (But only just for now—see the box on the next page.) You don't bring the master plans for a building to the job site, where things are messy and windy. You make a copy of the plans, and bring them instead. (And i ...
... It can be misleading to think of DNA as a blueprint, but it works sometimes, like now. (But only just for now—see the box on the next page.) You don't bring the master plans for a building to the job site, where things are messy and windy. You make a copy of the plans, and bring them instead. (And i ...
DNA transcription 3.lecture ENG OK
... Alternative splicing allows production of a large variety of proteins from a limited amount of DNA. It is now thought that between 30 and 60% of human genes undergo alternative splicing. Many human diseases (15%) may be connected to problems with splicing. Explains how 25000 genes of the hum ...
... Alternative splicing allows production of a large variety of proteins from a limited amount of DNA. It is now thought that between 30 and 60% of human genes undergo alternative splicing. Many human diseases (15%) may be connected to problems with splicing. Explains how 25000 genes of the hum ...
My favourite flowering image: floral organs with trichomes SUPPLEMENT PAPER
... targets (O Maoileidigh et al., 2013; Wuest et al., 2012). These included genes involved in the formation of trichomes, which in Arabidopsis are mainly present on leaves and on the inflorescence stem. We then asked whether the floral organ identity factors are involved in directly repressing trichome ...
... targets (O Maoileidigh et al., 2013; Wuest et al., 2012). These included genes involved in the formation of trichomes, which in Arabidopsis are mainly present on leaves and on the inflorescence stem. We then asked whether the floral organ identity factors are involved in directly repressing trichome ...
doc BIOL 200 Notes up to Midterm
... TFIIH is a helicase which locally unwinds DNA and allows Pol II to form the open complex Another subunit of TFIIH is a kinase that phosphorylates CTD, promoting elongation TFIIA: associated to promoter at same time as TFIID As elongation starts, all general factors EXCEPT TBP is released TBP s ...
... TFIIH is a helicase which locally unwinds DNA and allows Pol II to form the open complex Another subunit of TFIIH is a kinase that phosphorylates CTD, promoting elongation TFIIA: associated to promoter at same time as TFIID As elongation starts, all general factors EXCEPT TBP is released TBP s ...
Mechanisms of Nucleolar Dominance in Animals and Plants
... ribosomal genes of the other species. This phenomenon has been called "nucleolar dominance" and has been reported in such diverse organisms as frogs (Xenopus), Drosophila, many genera of plants, and mammalian somatic cell hybrids. Recent advances in our knowledge of the structure of ribosomal genes ...
... ribosomal genes of the other species. This phenomenon has been called "nucleolar dominance" and has been reported in such diverse organisms as frogs (Xenopus), Drosophila, many genera of plants, and mammalian somatic cell hybrids. Recent advances in our knowledge of the structure of ribosomal genes ...
Novel domains and orthologues of eukaryotic
... and Caenorhabditis elegans ZK973.1 are signi®cantly more sequence similar to bacterial Tex (~35% pairwise sequence identity) than are Spt6p homologues (~25%). Moreover, these three eukaryotic proteins share the same CSZ and S1 domain architecture and predicted catalytic residues in their YqgF domain ...
... and Caenorhabditis elegans ZK973.1 are signi®cantly more sequence similar to bacterial Tex (~35% pairwise sequence identity) than are Spt6p homologues (~25%). Moreover, these three eukaryotic proteins share the same CSZ and S1 domain architecture and predicted catalytic residues in their YqgF domain ...
NEW EMBO MEMBER`S REVIEW Nuclear and cytosolic events of
... transcription of specific plant genes invited a search for a molecular mechanism that mediates communication between cytosol and nucleus. In animal systems, the communication between cytosolic or membrane-localized receptors and the nucleus is often achieved by regulating, via different mechanisms, ...
... transcription of specific plant genes invited a search for a molecular mechanism that mediates communication between cytosol and nucleus. In animal systems, the communication between cytosolic or membrane-localized receptors and the nucleus is often achieved by regulating, via different mechanisms, ...
Gene Section MYST3 (MYST histone acetyltransferase (monocytic leukemia) 3
... ZNF220; RUNXBP2 Location: 8p11 ...
... ZNF220; RUNXBP2 Location: 8p11 ...
Brooker Chapter 14
... 1. High levels of tryptophan 2. Medium levels of tryptophan – high trp-tRNA 3. Low levels of tryptophan – med-low trp-tRNA ...
... 1. High levels of tryptophan 2. Medium levels of tryptophan – high trp-tRNA 3. Low levels of tryptophan – med-low trp-tRNA ...
Effect of Flik mutation on the transcriptional activity
... • Helicobacter pylori is a bacterium that may cause a variety of gastrointestinal disorders • The FliK protein plays an important role in H. pylori motility • Microarrays constructed and confirmed with Comparative genomic hybridization • Results indicate that mutations in FliK affect transcription • ...
... • Helicobacter pylori is a bacterium that may cause a variety of gastrointestinal disorders • The FliK protein plays an important role in H. pylori motility • Microarrays constructed and confirmed with Comparative genomic hybridization • Results indicate that mutations in FliK affect transcription • ...
Chpt19_TxnlRegEuk.doc
... a. Recall from Part One of the course that most genes in eukaryotes are not expressed in any given tissue. Of the approximately 30,000 genes in humans, any particular tissue will express a few at high abundance (these are frequently tissue specific, e.g. globin genes in red cells) and up to a few th ...
... a. Recall from Part One of the course that most genes in eukaryotes are not expressed in any given tissue. Of the approximately 30,000 genes in humans, any particular tissue will express a few at high abundance (these are frequently tissue specific, e.g. globin genes in red cells) and up to a few th ...
Modulation of CTCF Insulator Function by
... of Molecular Cell reveals a novel mechanism in which noncoding RNA transcription and nucleosome repositioning evicts CTCF from a regulatory element to facilitate induction of a nearby gene. The zinc finger protein CTCF binds directly to specific DNA sequences and plays multiple roles in the regulati ...
... of Molecular Cell reveals a novel mechanism in which noncoding RNA transcription and nucleosome repositioning evicts CTCF from a regulatory element to facilitate induction of a nearby gene. The zinc finger protein CTCF binds directly to specific DNA sequences and plays multiple roles in the regulati ...
Transcription factor
In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes.A defining feature of transcription factors is that they contain one or more DNA-binding domains (DBDs), which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA-binding domains, and, therefore, are not classified as transcription factors.