Chromosomes Carrying Meiotic Avoidance Loci
... et al., 2004; Conner et al., 2008). By contrast, two independent dominant loci control apomixis in Hieracium praealtum. Genetic markers linked to these loci have been determined using a deletion mapping approach (Catanach et al., 2006). The roles of these two loci and their interactions with the sex ...
... et al., 2004; Conner et al., 2008). By contrast, two independent dominant loci control apomixis in Hieracium praealtum. Genetic markers linked to these loci have been determined using a deletion mapping approach (Catanach et al., 2006). The roles of these two loci and their interactions with the sex ...
SPATULA, a bHLH carpel development gene
... within. These tissues usually develop from the carpel margins and include a stigma on which pollen alights, and transmitting tissues within the style and ovary through which the pollen tubes grow. In Arabidopsis, two congenitally joined carpels make up a central gynoecium. At the apex, stigmatic tis ...
... within. These tissues usually develop from the carpel margins and include a stigma on which pollen alights, and transmitting tissues within the style and ovary through which the pollen tubes grow. In Arabidopsis, two congenitally joined carpels make up a central gynoecium. At the apex, stigmatic tis ...
Endothelin signaling activates Mef2c expression in the neural crest
... strongly induced expression of the wild-type Mef2c-F1-lacZ transgene in neural crest cells but did not similarly induce expression of a version of the transgene with a mutated MEF2 site (Fig. 4B). Importantly, MEF2C was also required for the precocious activation of endogenous Mef2c in the neural cr ...
... strongly induced expression of the wild-type Mef2c-F1-lacZ transgene in neural crest cells but did not similarly induce expression of a version of the transgene with a mutated MEF2 site (Fig. 4B). Importantly, MEF2C was also required for the precocious activation of endogenous Mef2c in the neural cr ...
Autism-Associated Insertion Mutation (InsG) ofShank3 Exon 21
... an insertion mutation identified in two brothers with autism with an extra and 0.85 M sucrose, and centrifuged at 82,500 ⫻ g. The fraction between “G” inserted into exon 21 (Durand et al., 2007) and located at position 3728 1.15 M and 1 M sucrose layer was isolated, resuspended in buffer C (6 mM of ...
... an insertion mutation identified in two brothers with autism with an extra and 0.85 M sucrose, and centrifuged at 82,500 ⫻ g. The fraction between “G” inserted into exon 21 (Durand et al., 2007) and located at position 3728 1.15 M and 1 M sucrose layer was isolated, resuspended in buffer C (6 mM of ...
a complex voyage to the X chromosome
... molecular level. Together, these approaches are beginning to uncover a complex X chromosome targeting mechanism that involves the recognition of DNA elements and transcriptionally active genes. Here, we explore the relative contributions of sequence elements and transcriptional activity to the compl ...
... molecular level. Together, these approaches are beginning to uncover a complex X chromosome targeting mechanism that involves the recognition of DNA elements and transcriptionally active genes. Here, we explore the relative contributions of sequence elements and transcriptional activity to the compl ...
Gene Section EVI1 (ecotropic viral integration site 1 (EVI1) and
... Exon 3 of the human EVI1 gene contains two closely spaced ATG codons, either of which may serve as the translation initiation site. Depending on which ATG is used, proteins of 1051 or 1041 amino acids will be formed. EVI1 contains two domains of seven and three zinc finger motifs, respectively, a re ...
... Exon 3 of the human EVI1 gene contains two closely spaced ATG codons, either of which may serve as the translation initiation site. Depending on which ATG is used, proteins of 1051 or 1041 amino acids will be formed. EVI1 contains two domains of seven and three zinc finger motifs, respectively, a re ...
Hox patterning of the vertebrate rib cage
... affected in both the Hox5 and the Hox6 single mutants, colinearity is not immediately apparent for these genes; however, paralogous mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den A ...
... affected in both the Hox5 and the Hox6 single mutants, colinearity is not immediately apparent for these genes; however, paralogous mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den A ...
Hox patterning of the vertebrate rib cage
... affected in both the Hox5 and the Hox6 single mutants, colinearity is not immediately apparent for these genes; however, paralogous mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den A ...
... affected in both the Hox5 and the Hox6 single mutants, colinearity is not immediately apparent for these genes; however, paralogous mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den A ...
Common Quantitative Trait Loci for Alcohol
... to differ up to 1.6- and 1.9-fold, respectively, among the LSXSS RI strains (Erwin et al., 1993). These differences are continuously and normally distributed and show a significant effect of RI strain (genetic effect) on NT receptor density in all brain regions. Estimates indicate a minimum of six a ...
... to differ up to 1.6- and 1.9-fold, respectively, among the LSXSS RI strains (Erwin et al., 1993). These differences are continuously and normally distributed and show a significant effect of RI strain (genetic effect) on NT receptor density in all brain regions. Estimates indicate a minimum of six a ...
RESULTATS Capítol 1 __________________________________________________________________________ 71
... (OML) of the dentate gyrus (DG). Conversely, the commissural/associational afferents terminate in the stratum radiatum (SR), stratum oriens(SO), and inner molecular layer (IML) (Blackstad, 1956; Ruth et al., 1982; Steward, 1976; Steward and Scoville, 1976; Swanson and Cowan, 1977; Swanson et al., 19 ...
... (OML) of the dentate gyrus (DG). Conversely, the commissural/associational afferents terminate in the stratum radiatum (SR), stratum oriens(SO), and inner molecular layer (IML) (Blackstad, 1956; Ruth et al., 1982; Steward, 1976; Steward and Scoville, 1976; Swanson and Cowan, 1977; Swanson et al., 19 ...
Testing the ABC floral-organ identity model: expression of
... Clone and sequence the ABC genes. Look for similarities with sequenced genes already in the database. ...
... Clone and sequence the ABC genes. Look for similarities with sequenced genes already in the database. ...
PPT
... but rare in population; may not be reflective of common disease. Also, hard to collect family data. ...
... but rare in population; may not be reflective of common disease. Also, hard to collect family data. ...
Endogenous Cerberus activity is required for anterior head
... injection of the CerMo does not cause visible head defects in the Xenopus embryo. In contrast, targeted increase of BMP, Nodal or Wnt activity in the ADE resulted specifically in the loss of head, but not trunk-tail structures. These factors synergistically inhibited head structures when simultaneou ...
... injection of the CerMo does not cause visible head defects in the Xenopus embryo. In contrast, targeted increase of BMP, Nodal or Wnt activity in the ADE resulted specifically in the loss of head, but not trunk-tail structures. These factors synergistically inhibited head structures when simultaneou ...
Syntabulin, a motor protein linker, controls dorsal
... disorganized vegetal microtubule array formation, and subsequently displays ventralization (Mei et al., 2009). Furthermore, a ubiquitin ligase, tripartite motif-containing 36 (trim36), is localized to the vegetal cortex of Xenopus oocytes, and when depleted causes defective vegetal microtubule array ...
... disorganized vegetal microtubule array formation, and subsequently displays ventralization (Mei et al., 2009). Furthermore, a ubiquitin ligase, tripartite motif-containing 36 (trim36), is localized to the vegetal cortex of Xenopus oocytes, and when depleted causes defective vegetal microtubule array ...
Dysfunction of Wild-Type Huntingtin in Huntington
... hypothesis indicate that huntingtin is a substrate for caspases. Huntingtin cleavage by caspases occurs in a poly-Gln-dependent manner, i.e., the longer the poly-Gln in huntingtin, the more efficient is the cleavage, which then generates NH2-terminal fragments of mutant huntingtin endowed with cell ...
... hypothesis indicate that huntingtin is a substrate for caspases. Huntingtin cleavage by caspases occurs in a poly-Gln-dependent manner, i.e., the longer the poly-Gln in huntingtin, the more efficient is the cleavage, which then generates NH2-terminal fragments of mutant huntingtin endowed with cell ...
View our poster (1.1 MB PDF)
... Figure 1. RNA interference (RNAi) is a highly evolutionarily conserved mechanism of gene regulation. RNAi occurs at the post-transcriptional level and is triggered by short double-stranded RNA (dsRNA), known as short interfering RNA (siRNA), which is endogenously processed from long dsRNA by the RNa ...
... Figure 1. RNA interference (RNAi) is a highly evolutionarily conserved mechanism of gene regulation. RNAi occurs at the post-transcriptional level and is triggered by short double-stranded RNA (dsRNA), known as short interfering RNA (siRNA), which is endogenously processed from long dsRNA by the RNa ...
Induction of the hair growth phase in postnatal mice by localized
... hedgehog (Shh) appears to play a central role. Shh, one of 3 vertebrate homologues of Drosophila hedgehog (Hh), is involved in pattern formation of vertebrate organs including brain, heart, lung, skeleton, and skin (9–20). Shh functions in association with a complex signaling pathway that includes P ...
... hedgehog (Shh) appears to play a central role. Shh, one of 3 vertebrate homologues of Drosophila hedgehog (Hh), is involved in pattern formation of vertebrate organs including brain, heart, lung, skeleton, and skin (9–20). Shh functions in association with a complex signaling pathway that includes P ...
Mechanisms of Transcription-Replication
... plasmid carrying the lacIq gene (Fig. 4C), it was completely repressed in the absence of IPTG, while being strongly activated in its presence (20). Figure 4C shows that replication stalling in this case was evident only when transcription from the head-on–oriented trc promoter was active. We have al ...
... plasmid carrying the lacIq gene (Fig. 4C), it was completely repressed in the absence of IPTG, while being strongly activated in its presence (20). Figure 4C shows that replication stalling in this case was evident only when transcription from the head-on–oriented trc promoter was active. We have al ...
Insulin-like growth factor (IGF) signalling is required for early dorso
... IGF-1R signalling is required for normal anterior and CNS development in zebrafish To further characterise the phenotype of DN-IGF-1R expressing embryos, we examined the expression of a number of genes that are critical for normal neural development and for notochord and somite formation. We initial ...
... IGF-1R signalling is required for normal anterior and CNS development in zebrafish To further characterise the phenotype of DN-IGF-1R expressing embryos, we examined the expression of a number of genes that are critical for normal neural development and for notochord and somite formation. We initial ...
Dynamic Changes in Aromatic Hydrocarbon Associated Catabolic
... pure cultures from environmental samples and allow studies of complex communities and their interactions with specific substrates to be performed. Previous studies have focused upon qualitative PCR approaches using catabolic genes as indicators of microbial degradation of compounds [9] or qPCR looki ...
... pure cultures from environmental samples and allow studies of complex communities and their interactions with specific substrates to be performed. Previous studies have focused upon qualitative PCR approaches using catabolic genes as indicators of microbial degradation of compounds [9] or qPCR looki ...
Conservation and diversification of gene function during mouthpart
... two lobes: the distal incisor lobe and the inner median molar lobe, which are linked by a flexible area (Fig. 5Ai to iv). The setae on the inner periphery of the incisor lobe delimit the comb and distal fringe of the incisor lobe (Fig. 5Ai). Remarkably, the molar area of the mandibles is asymmetric. ...
... two lobes: the distal incisor lobe and the inner median molar lobe, which are linked by a flexible area (Fig. 5Ai to iv). The setae on the inner periphery of the incisor lobe delimit the comb and distal fringe of the incisor lobe (Fig. 5Ai). Remarkably, the molar area of the mandibles is asymmetric. ...
Gene Section WWC1 (WW and C2 domain containing 1)
... and 783 is implied to be involved in binding phospholipids under assistance of two or three calcium ions. In addition to the WW and C2 domain, a glutamic acid-rich region can be found between amino acids 845 and 873 (Kremerskothen et al., 2003; Rayala et al., 2006) and a PDZ-binding motif is located ...
... and 783 is implied to be involved in binding phospholipids under assistance of two or three calcium ions. In addition to the WW and C2 domain, a glutamic acid-rich region can be found between amino acids 845 and 873 (Kremerskothen et al., 2003; Rayala et al., 2006) and a PDZ-binding motif is located ...
C3H/HeJ
... 2 Center for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada ...
... 2 Center for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada ...
Early Onset of Severe Familial Amyotrophic Lateral Sclerosis with a
... Motoneuron disease in mice with combined CNTF and SOD-1 gene defects. A, CNTF genotyping of mice. Ethidium bromide–stained 2% agarose gel reveals bands of 97 bp for the wild-type allele (CNTF⫹/⫹) and 1.197 bp for the mutated allele (CNTF⫺/⫺). Heterozygous mice (CNTF⫹/⫺) show both bands. “M” denotes ...
... Motoneuron disease in mice with combined CNTF and SOD-1 gene defects. A, CNTF genotyping of mice. Ethidium bromide–stained 2% agarose gel reveals bands of 97 bp for the wild-type allele (CNTF⫹/⫹) and 1.197 bp for the mutated allele (CNTF⫺/⫺). Heterozygous mice (CNTF⫹/⫺) show both bands. “M” denotes ...
of Lactobacillus pentosus
... Davis et al., 1984, Davis and Henderson, 1987). This xylE gene was not found within the cluster of xyl genes but is present on a separate locus on theE. coli chromosome. The xylR gene codes for a regulatory protein involved in the activation of expression of the xylose genes in the presence of D-xyl ...
... Davis et al., 1984, Davis and Henderson, 1987). This xylE gene was not found within the cluster of xyl genes but is present on a separate locus on theE. coli chromosome. The xylR gene codes for a regulatory protein involved in the activation of expression of the xylose genes in the presence of D-xyl ...