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LeDoux outlines his theory of emotions and memory
LeDoux outlines his theory of emotions and memory

... making the tone a harbinger of threat. The tone alone then triggers a fear response: It activates the autonomic nervous system, which controls heart rate and blood pressure, and the sensory motor system, which controls muscle movement. LeDoux and his colleagues sought to find out where the brain sto ...
What is so memorable about CREBBP?
What is so memorable about CREBBP?

... CREB turns on other genes to store in long term memory. Switched on to create new connections between nerve cells Turning off and on genes by the act of remembering. In other words, CREB is a gene that mediates long-term memory. It acts as a master gene that turns on other genes, assisted by CREBBP ...
Supplemental Information - Molecular Cancer Research
Supplemental Information - Molecular Cancer Research

... Fisher's exact test computes a 2-tailed p-value = 0.000261. The gene universe used in this calculation (~22,000) is not an exact known number. However, running the test with a smaller gene universe (20,000) or a larger gene universe (30,000) still generates a significant p-value (20,000 p-value = 0. ...
MGG330 L1-2007
MGG330 L1-2007

... As name suggests for measuring expression Most genes in Genome covered From a variety of organisms ...
The relationship between genes and traits is often complex
The relationship between genes and traits is often complex

... Homework #4 is due 12/3/07 (only if needed) Bonus #2 posted Year End Topics: •mtDNA •Mapping •Probability •Evolution and the Origin of Humans ...
introduction to molecular genetics
introduction to molecular genetics

... chromosomes, by which hereditary characters are transmitted and determined, and each is regarded as a particular state of organization of the chromatin in the chromosome, consisting primarily DNA and protein ...
Microarray_module_lecture_(both_courses)
Microarray_module_lecture_(both_courses)

... Null hypothesis: treatment and control show equal gene expression (M=0) ...
Sex bias in gene expression is not the same as dosage
Sex bias in gene expression is not the same as dosage

... compensation (DC) in a male hypermethylated region than that in a previous report by Melamed and Arnold (2007). In their criticism, they state ‘a major issue is that the two studies differ in their view of the process of DC’ and we can do nothing but agree. They judged that ‘genes with low (female-b ...
Morphological Basis of Learning and Memory: Vertebrates
Morphological Basis of Learning and Memory: Vertebrates

...

A separate developmental approach that was very fruitful in understanding brain substrates of learning and memory involved enriching the lives of young animals with additional stimulation. Donald Hebb (psychobiologist, 19041985) proposed ways in which synaptic change could be incorporated mea ...

Glimmer and GeneMark
Glimmer and GeneMark

... Glimmer • Glimmer is a system for finding genes in microbial DNA http://ccb.jhu.edu/software/glimmer/index.shtml • The system works by creating a variable-length Markov model from a training set of genes and then using that model to attempt to identify all genes in a given DNA sequence. ...
emboj2009336-sup
emboj2009336-sup

... in Fig.1. Bars represent results from 5 independent experiments. Error bars denote SEM. * P<0.05. Fig. S2 Anti-HA-ChIP in G1E-ER4 cells stably expressing HA-tagged Mi-2ß before and after treatment with estradiol at the repressed GATA-1 target genes Kit (A), Gata2 (B), Myc and Lyl1 promoter (C) and t ...
BL220
BL220

... or transmission genetics, molecular biology, and population genetics. During the section on Mendelian genetics, we will cover mitosis and meiosis, traditional genetics problems, modes of inheritance, and chromosomal structure. The section on molecular biology will include information on DNA structur ...
PG1007 Lecture 7 Anterior-Posterior Patterning, HOX Genes and
PG1007 Lecture 7 Anterior-Posterior Patterning, HOX Genes and

... "for their discoveries concerning the genetic control of early embryonic development". ...
PowerPoint 簡報
PowerPoint 簡報

... their charges • DEAE-Sephadex chromotography uses an ionexchange resin that contains positively charged diethylaminorthyl (DEAE) group. • These positive charges attract negatively charged substances, including proteins. • Phosphocellular is commonly used negatively charged resin. ...
Where do pumpkins come from?
Where do pumpkins come from?

... •Regulatory sequences which increase the rate of transcription are called enhancers - those which decrease the rate of transcription are called silencers •Enhancers can function if their normal 5' -- 3' orientation is flipped. ...
Slide 1
Slide 1

... physico-chemical phenomena: 1. Cooperative binding 2. Steric hindrance ...
Active repressors
Active repressors

... specific regulatory sequences that can bind repression factors ...
Heritable genome-wide variation of gene expression and promoter methylation between
Heritable genome-wide variation of gene expression and promoter methylation between

... DE genes among the top 100 DM promoters when compared to a random sample of 100 DM genes (c2 = 2.1, P > 0.05). This is contrary to the common notion that methylation causes down-regulation of gene expression, but similar findings have recently been reported from other species, for example humans [16 ...
How do organisms grow and heal themselves? What instructions do
How do organisms grow and heal themselves? What instructions do

... Even though they did not know what the chemical (ultimately DNA) looked like they knew some of the mechanisms by which it acted. ...
Activity #3a - Center for Occupational Research and Development
Activity #3a - Center for Occupational Research and Development

... In Activities #1 and #2, you learned the scientific basis for how DNA microarray technology works and how it can be used to illustrate variations in gene expression by examining the gene expression data from two mythological creatures. Different gene expression results in different characteristics. ...
introduction modeling gene expression profiles kl
introduction modeling gene expression profiles kl

... components are utilized in the KL divergence approximation based on their mixture weights. ...
Name
Name

... (5) Define and distinguish between heterochromatin and euchromatin. heterochromatin is the condensed, gene poor DNA found mainly near centromeres and telomeres euchromatin is the less condensed, gene rich DNA where most genes are transcribed (5) Define and distinguish between centromere and telomere ...
What is a gene?
What is a gene?

... Transcription factors, defined here specifically as proteins containing domains that suggest sequencespecific DNA-binding activities, are classified based on the presence of 50+ conserved domains. Links to resources that provide information on mutants available, map positions or putative functions f ...
supplementary materials and methods
supplementary materials and methods

... Analysis of the LMNB1 duplication by quantitative real-time PCR. Amplification was performed in a total of 20 µl containing 10 µl of Taqman Universal PCR Master mix (P/N 4324018, Applied Biosystems), 1 µl of RNase P kit (20X, VIC dye, P/N 4316844), 2 µl of forward (5’-gccaaaaaacagttagcagatgaa) and r ...
Scientists have found that memories might be passed down through
Scientists have found that memories might be passed down through

... translational perspective, our results allow us to appreciate how the experiences of a parent, before even conceiving offspring, markedly influence both structure and function in the nervous system of subsequent generations. “Such a phenomenon may contribute to the etiology and potential intergenera ...
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Epigenetics in learning and memory

While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.
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