Plant Functional Genomics Plant Functional Genomics
... of two or more DNA fragments, are beyond the cloning capacity of the BAC system or are much less efficiently cloned. In 1994, our laboratory was the first to construct a BAC library for plants using Sorghum bicolor (5). Since then, we have constructed a substantial number of deep coverage BAC librar ...
... of two or more DNA fragments, are beyond the cloning capacity of the BAC system or are much less efficiently cloned. In 1994, our laboratory was the first to construct a BAC library for plants using Sorghum bicolor (5). Since then, we have constructed a substantial number of deep coverage BAC librar ...
Organelle division: From coli to chloroplasts
... bacterial-like systems. The components of the mitochondrial division system are unknown, but they might be related to some other process characteristic of eukaryotic cells, such as vesicle budding. Another example of where chloroplasts are more ‘bacteria-like’ than mitochondria involves protein tran ...
... bacterial-like systems. The components of the mitochondrial division system are unknown, but they might be related to some other process characteristic of eukaryotic cells, such as vesicle budding. Another example of where chloroplasts are more ‘bacteria-like’ than mitochondria involves protein tran ...
PPT - UCLA Health
... Smith-Magenis syndrome is caused by a microdeletion in chromosome 17, is associated with mild to moderate mental retardation; mild dysmorphic features such as broad feet and hands; peripheral neuropathy; hearing loss associated with recurrent otitis media; a disturbed pattern of sleep that can be ve ...
... Smith-Magenis syndrome is caused by a microdeletion in chromosome 17, is associated with mild to moderate mental retardation; mild dysmorphic features such as broad feet and hands; peripheral neuropathy; hearing loss associated with recurrent otitis media; a disturbed pattern of sleep that can be ve ...
Gene Section ALK (anaplastic lymphoma kinase) Atlas of Genetics and Cytogenetics
... Present a favourable prognosis comparable to the one found in t(2;5) ALK+ ALCL. Cytogenetics Either t(X;2)(q11;p23), t(1;2)(q25;p23), inv(2)(p23q35), t(2;3)(p23;q21), t(2;17)(p23;q23), t(2;17)(p23;q25) or t(2;22)(p23;q11.2); hidden translocation is frequently found. Hybrid/Mutated gene 5' MSN, TPM3, ...
... Present a favourable prognosis comparable to the one found in t(2;5) ALK+ ALCL. Cytogenetics Either t(X;2)(q11;p23), t(1;2)(q25;p23), inv(2)(p23q35), t(2;3)(p23;q21), t(2;17)(p23;q23), t(2;17)(p23;q25) or t(2;22)(p23;q11.2); hidden translocation is frequently found. Hybrid/Mutated gene 5' MSN, TPM3, ...
A G to C mutation in the CRYGD gamma crystallin gene associated
... with nuclear cataracts which is common and suggests an abnormality of gene expression in early development. Some children did not show this mutation. The g.248 G>C is one of the mutations in exon 1, there is a possibility that other mutations in exon 1 might be involved in development of the disease ...
... with nuclear cataracts which is common and suggests an abnormality of gene expression in early development. Some children did not show this mutation. The g.248 G>C is one of the mutations in exon 1, there is a possibility that other mutations in exon 1 might be involved in development of the disease ...
Genetic Disorders Brochures
... characteristics. The autosomal traits mentioned in this lab are found on one of the first 22 chromosome pairs in the nuclei of each of your cells. PURPOSE: To investigate the inheritance of human characteristics. PROCEDURE: Autosomal Traits. Use the following information to determine which of the fo ...
... characteristics. The autosomal traits mentioned in this lab are found on one of the first 22 chromosome pairs in the nuclei of each of your cells. PURPOSE: To investigate the inheritance of human characteristics. PROCEDURE: Autosomal Traits. Use the following information to determine which of the fo ...
NeuroGeM, a knowledgebase of genetic modifiers
... involved in protein quality control are likely to modify disease progression [3]. For this reason, the disease-modifying effect of heat shock proteins (HSP) has been widely studied in model organisms [4–7]. In addition to HSPs, transcription factors regulating the expression of HSPs have also been i ...
... involved in protein quality control are likely to modify disease progression [3]. For this reason, the disease-modifying effect of heat shock proteins (HSP) has been widely studied in model organisms [4–7]. In addition to HSPs, transcription factors regulating the expression of HSPs have also been i ...
13-3
... beneficial variations. Some negatively disrupt gene function. Many if not most mutations are neutral; they have little or no effect on the expression of genes or the function of the proteins for which they code. Whether a mutation is negative or beneficial depends on how its DNA changes relative to th ...
... beneficial variations. Some negatively disrupt gene function. Many if not most mutations are neutral; they have little or no effect on the expression of genes or the function of the proteins for which they code. Whether a mutation is negative or beneficial depends on how its DNA changes relative to th ...
Plasmodium malariae and P. ovale genomes provide insights into
... human parasite P. falciparum than in its chimpanzee-infective relative P. reichenowi8. In both cases, the lack of diversity in human-infective species suggests recent population expansions. However, we found that a species that infects New World primates termed P. brasilianum was indistinguishable f ...
... human parasite P. falciparum than in its chimpanzee-infective relative P. reichenowi8. In both cases, the lack of diversity in human-infective species suggests recent population expansions. However, we found that a species that infects New World primates termed P. brasilianum was indistinguishable f ...
DNA methylation profiling identifies epigenetic dysregulation in
... comparatively high frequency of CpG dinucleotides. They usually harbour low levels of DNA methylation but can become hypermethylated; this CGI hypermethylation was demonstrated to abrogate transcription of tumour suppressor genes during tumourigenesis (Jones and Baylin, 2007). Lately, DNA methylatio ...
... comparatively high frequency of CpG dinucleotides. They usually harbour low levels of DNA methylation but can become hypermethylated; this CGI hypermethylation was demonstrated to abrogate transcription of tumour suppressor genes during tumourigenesis (Jones and Baylin, 2007). Lately, DNA methylatio ...
Engineered Cpf1 Enzymes with Altered PAM Specificities
... The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells1-5. Compared to other genome editing platforms, Cpf1 offers distinct advantages, such as the ability to easily target multiple genes simultaneously3, as well as low rates of off-target activity4, 5. However, ...
... The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells1-5. Compared to other genome editing platforms, Cpf1 offers distinct advantages, such as the ability to easily target multiple genes simultaneously3, as well as low rates of off-target activity4, 5. However, ...
INTRODUCTION - Mount Holyoke College
... weak how mutant allele has to be used for the flies to survive to metamorphosis. The howr17 allele is an appropriate weak allele since most flies survive to metamorphosis and some form viable adult flies. The howr17 mutation was induced by imprecise excision of a transposable Pelement {Baehrecke, 19 ...
... weak how mutant allele has to be used for the flies to survive to metamorphosis. The howr17 allele is an appropriate weak allele since most flies survive to metamorphosis and some form viable adult flies. The howr17 mutation was induced by imprecise excision of a transposable Pelement {Baehrecke, 19 ...
Genome Mapping in the Horse
... groups to chromosomes as well as to assign syntenic groups (see below) of markers established from somatic cell hybrid mapping to chromosomes. It enables the visualisation of a probe of interest on the chromosome. The probe is usually a particular segment of cloned DNA which is labelled to allow det ...
... groups to chromosomes as well as to assign syntenic groups (see below) of markers established from somatic cell hybrid mapping to chromosomes. It enables the visualisation of a probe of interest on the chromosome. The probe is usually a particular segment of cloned DNA which is labelled to allow det ...
On Periodicity in the Occurrence of Nucleotides in Protein Coding
... + Then we form a set of “potential genes” and “potential non-genes” by classifying each ORF sequence into the first set if it exhibits significant evidence of 3-periodicity with respect to some DNA word(s) (i.e., if the value of R(3) is below some appropriate threshold), and by classifying it into t ...
... + Then we form a set of “potential genes” and “potential non-genes” by classifying each ORF sequence into the first set if it exhibits significant evidence of 3-periodicity with respect to some DNA word(s) (i.e., if the value of R(3) is below some appropriate threshold), and by classifying it into t ...
Molecualr Biology and Evolution
... lies within the proteobacterial clade with bootstrap sup- smaller subclones of the n$K region in pUCl19. port of 80%. Normand et al. ( 1992) provided an additional test of the horizontal transfer hypothesis by ex- Sequencing amining the phylogeny of another nf gene, n$D. Initial sequencing was done ...
... lies within the proteobacterial clade with bootstrap sup- smaller subclones of the n$K region in pUCl19. port of 80%. Normand et al. ( 1992) provided an additional test of the horizontal transfer hypothesis by ex- Sequencing amining the phylogeny of another nf gene, n$D. Initial sequencing was done ...
A strategy for extracting and analyzing large
... more severe phenotype than either single mutant and still represent a synthetic, neutral, or alleviating interaction. Typically, large-scale studies have scored gene-gene interactions in a binary manner (synthetic sick/lethal or noninteracting) [3,4,6,7]; however, synthetic lethal interactions are o ...
... more severe phenotype than either single mutant and still represent a synthetic, neutral, or alleviating interaction. Typically, large-scale studies have scored gene-gene interactions in a binary manner (synthetic sick/lethal or noninteracting) [3,4,6,7]; however, synthetic lethal interactions are o ...
Specification of unique neuronal sub-types by integration of positional and temporal cues
... that ultimately result in the unique combinatorial expression of cell fate determinants in the different Ap neurons, which in turn ultimately lead to the activation of unique terminal differentiation genes. In addition, I have identified three different mechanisms by which the NB 5-6 lineage is modu ...
... that ultimately result in the unique combinatorial expression of cell fate determinants in the different Ap neurons, which in turn ultimately lead to the activation of unique terminal differentiation genes. In addition, I have identified three different mechanisms by which the NB 5-6 lineage is modu ...
Mechanisms of fast and stringent search in homologous pairing of
... experiments have shown that dsDNA fragments in solution are capable of pairing in a homology-dependent manner even in the absence of proteins [2–8]. This protein-free mode of pairing, which can also occur in the presence of nucleosomes [7], is robust to salt concentration, PH, and shear force, sugge ...
... experiments have shown that dsDNA fragments in solution are capable of pairing in a homology-dependent manner even in the absence of proteins [2–8]. This protein-free mode of pairing, which can also occur in the presence of nucleosomes [7], is robust to salt concentration, PH, and shear force, sugge ...
Nucleotide sequence and taxonomic value of the
... Preparation of C . pneumoniae from infected yolk sacs. Embryonated eggs were used to overcome the difficulties associated with the bulk growth of C . pneumoniae in tissue culture. Yolk sacs were harvested aseptically and examined for the presence of chlamydial EBs. Four positive yolk sacs were suspe ...
... Preparation of C . pneumoniae from infected yolk sacs. Embryonated eggs were used to overcome the difficulties associated with the bulk growth of C . pneumoniae in tissue culture. Yolk sacs were harvested aseptically and examined for the presence of chlamydial EBs. Four positive yolk sacs were suspe ...
The linear chromosome of the plant
... has evolved from Gram-positive bacteria [3]. Mycoplasmas are among the smallest self-replicating organisms known, and are characterized by a small genome with a low G+C content, and a lack of a firm cell wall. The genome sizes of phytoplasmas are estimated to range from 0.53 to 1.35 Mb [4] with a GC ...
... has evolved from Gram-positive bacteria [3]. Mycoplasmas are among the smallest self-replicating organisms known, and are characterized by a small genome with a low G+C content, and a lack of a firm cell wall. The genome sizes of phytoplasmas are estimated to range from 0.53 to 1.35 Mb [4] with a GC ...
the role of viral, bacterial, parasitic and human sialidases in disease
... nutrition, invasion, immunosuppression and in the spread of pathogens within the host. In some cases, they play an essential role in biofilm formation. Degradation of human sialic acids by pathogen sialidases is involved in infectious diseases such as periodontitis, cystic fibrosis, pneumonia, vagin ...
... nutrition, invasion, immunosuppression and in the spread of pathogens within the host. In some cases, they play an essential role in biofilm formation. Degradation of human sialic acids by pathogen sialidases is involved in infectious diseases such as periodontitis, cystic fibrosis, pneumonia, vagin ...
Increased HbF in Sickle Cell Anemia is Determined by a Factor
... Data from large families HbF are limited, but we have ...
... Data from large families HbF are limited, but we have ...
Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells
... affected embryos, a valuable resource that is accessible to only a small number of stem cell deriving laboratories and requires teamwork with a preimplantation genetic diagnosis (PGD) performing center. An alternative approach to generating diseased pluripotent stem cells (PSCs) entails the de-diffe ...
... affected embryos, a valuable resource that is accessible to only a small number of stem cell deriving laboratories and requires teamwork with a preimplantation genetic diagnosis (PGD) performing center. An alternative approach to generating diseased pluripotent stem cells (PSCs) entails the de-diffe ...
Biological Molecules
... Meiosis is the type of cell division that occurs in reproductive tissues. During meiosis two cellular divisions occur. In the first division, homologous chromosomes with two sister chromatids are separated, reducing the number of chromosomes. In the second division, sister chromatids are separated, ...
... Meiosis is the type of cell division that occurs in reproductive tissues. During meiosis two cellular divisions occur. In the first division, homologous chromosomes with two sister chromatids are separated, reducing the number of chromosomes. In the second division, sister chromatids are separated, ...
Seed-Specific Gene Activation Mediated by the Cre//ox Site
... altering Cre expression. Efficient Cre expression ultimately directed gene activation throughout the model tissue, whereas inefficient Cre expression resulted in mosaic tissue. limited gene activation provides a system for cell lineage and developmental analyses. ...
... altering Cre expression. Efficient Cre expression ultimately directed gene activation throughout the model tissue, whereas inefficient Cre expression resulted in mosaic tissue. limited gene activation provides a system for cell lineage and developmental analyses. ...