Striking pattern of Purkinje cell loss in cerebellum of an ataxic
... observed in leaner mice (Herrup and Wilczynski 1982, Frank et al. 2003), but not reported in other Cav2.1 mutant mice. The present study examined histopathologically the cerebellum of tottering mice, and demonstrated an obvious Purkinje cell loss in the vermis but not in the hemispherical lobules. T ...
... observed in leaner mice (Herrup and Wilczynski 1982, Frank et al. 2003), but not reported in other Cav2.1 mutant mice. The present study examined histopathologically the cerebellum of tottering mice, and demonstrated an obvious Purkinje cell loss in the vermis but not in the hemispherical lobules. T ...
Complete Thyroxine-Binding Globulin (TBG) Deficiency Produced
... creates a new acceptor splice site one nucleotide upstream of the authentic acceptor splice site adding an intronic G to the downstream exon. This is in agreement with the majority of acceptor splice site mutations reported (15, 18). Exonic and intronic recognition sequences have an established role ...
... creates a new acceptor splice site one nucleotide upstream of the authentic acceptor splice site adding an intronic G to the downstream exon. This is in agreement with the majority of acceptor splice site mutations reported (15, 18). Exonic and intronic recognition sequences have an established role ...
Heredity and Math - Computer Science
... this ladder is about three million base pairs long. The two ends link together to form a ring, and then the ring gets wadded up so it can fit inside the cell. ...
... this ladder is about three million base pairs long. The two ends link together to form a ring, and then the ring gets wadded up so it can fit inside the cell. ...
- CSHL Institutional Repository
... Three of the spores undergo programmed cell death and the remaining one becomes the functional megaspore (Misra, 1962; Poliakova, 1964; Mansfield et al., 1991; Webb and Gunning, 1990). A large class of mutants that affect megasporogenesis has been identified in Arabidopsis, and shown to cause both m ...
... Three of the spores undergo programmed cell death and the remaining one becomes the functional megaspore (Misra, 1962; Poliakova, 1964; Mansfield et al., 1991; Webb and Gunning, 1990). A large class of mutants that affect megasporogenesis has been identified in Arabidopsis, and shown to cause both m ...
Hierarchical Text Categorization and Its Evaluation
... • to try global hierarchical approach with other learning algorithms • to extend the gene annotation training sets with similar documents from Medline • to perform similar task for other organisms • to use gene annotations in gene classification and clustering ...
... • to try global hierarchical approach with other learning algorithms • to extend the gene annotation training sets with similar documents from Medline • to perform similar task for other organisms • to use gene annotations in gene classification and clustering ...
Lampetra fluviatilis Neurotrophin Homolog, Descendant of a
... gene family that dates back more than 460 million years to the early vertebrate ancestors. The results show that the neurotrophin gene family was originally formed by two subsequent duplications. The duplication that formed nerve growth factor, neurotrophin-3, brain-derived neurotrophic factor, and ...
... gene family that dates back more than 460 million years to the early vertebrate ancestors. The results show that the neurotrophin gene family was originally formed by two subsequent duplications. The duplication that formed nerve growth factor, neurotrophin-3, brain-derived neurotrophic factor, and ...
pdf
... removal of up to 60 Tg of nitrogen annually, roughly an eighth of the global fixed nitrogen sink. Although denitrification has long been believed to be the major process responsible for fixed nitrogen loss from the oceans, recent studies show that anaerobic ammonium oxidation (anammox) is potentiall ...
... removal of up to 60 Tg of nitrogen annually, roughly an eighth of the global fixed nitrogen sink. Although denitrification has long been believed to be the major process responsible for fixed nitrogen loss from the oceans, recent studies show that anaerobic ammonium oxidation (anammox) is potentiall ...
Restriction Fragment Length Polymorphism of hsp70
... Previous studies from our laboratory have demonstrated that the intermediate phenotype of thermosensitivity is present in hypertensive mice and rats. Increased expression of hsp70 caused by increased transcription rate was demonstrated in vivo, in organs, and in cultured cells from spontaneously hyp ...
... Previous studies from our laboratory have demonstrated that the intermediate phenotype of thermosensitivity is present in hypertensive mice and rats. Increased expression of hsp70 caused by increased transcription rate was demonstrated in vivo, in organs, and in cultured cells from spontaneously hyp ...
unit 2: mechanisms of inheritance
... DNA extraction labs are available from many print and online sources and are relatively simple to perform. They use • inexpensive materials (e.g., dish soap, salt [NaCl], ethanol, plant or animal tissue) • simple equipment (e.g., beakers, test tubes, mortar and pestle, glass rods, stir sticks) The D ...
... DNA extraction labs are available from many print and online sources and are relatively simple to perform. They use • inexpensive materials (e.g., dish soap, salt [NaCl], ethanol, plant or animal tissue) • simple equipment (e.g., beakers, test tubes, mortar and pestle, glass rods, stir sticks) The D ...
345 - Timstar
... SNPs may fall within any region of the genome – the coding sequences of genes, the noncoding sequences of genes, or regions in-between genes (the intergenic regions). When an SNP falls within a coding sequence, that alteration may not necessarily change the amino acid sequence of the subsequent prot ...
... SNPs may fall within any region of the genome – the coding sequences of genes, the noncoding sequences of genes, or regions in-between genes (the intergenic regions). When an SNP falls within a coding sequence, that alteration may not necessarily change the amino acid sequence of the subsequent prot ...
Expression of p53 Target Genes in the Early Phase of Long
... by shifting the balance between proapoptotic (Bax, Noxa, and Puma) and antiapoptotic (Bcl2, Birc5) proteins of the Bcl2 family, which regulate the activity of proteolytic enzymes called caspases. In addition, p53 can induce the expression of “death receptors,” which initiate apoptosis by the binding ...
... by shifting the balance between proapoptotic (Bax, Noxa, and Puma) and antiapoptotic (Bcl2, Birc5) proteins of the Bcl2 family, which regulate the activity of proteolytic enzymes called caspases. In addition, p53 can induce the expression of “death receptors,” which initiate apoptosis by the binding ...
Exon skipping and reading through stop codons
... influence the progress of the disease with drug-like substances. But, with the exception of steroids, all this has not been done in living boys, but in their isolated muscle cells in the laboratory or in animals. However, clinical trials are being planned now for the near future, mainly trials with ...
... influence the progress of the disease with drug-like substances. But, with the exception of steroids, all this has not been done in living boys, but in their isolated muscle cells in the laboratory or in animals. However, clinical trials are being planned now for the near future, mainly trials with ...
docx
... for an interrogating base position includes five probes: one probe to hybridise to the WT, three probes to detect three possible single base-pair mutations, and one probe to detect single deletion. There are at least 24 probe sets for each nucleotide position, including both sense and anti-sense pro ...
... for an interrogating base position includes five probes: one probe to hybridise to the WT, three probes to detect three possible single base-pair mutations, and one probe to detect single deletion. There are at least 24 probe sets for each nucleotide position, including both sense and anti-sense pro ...
Genetics of Hemophilia
... hemophilia. This allows family members to make informed decisions about their care, and obtain the proper treatment and information. »» If you are a carrier, but do not have a known family history of hemophilia, it is still possible that there are other women in your family who carry the gene for he ...
... hemophilia. This allows family members to make informed decisions about their care, and obtain the proper treatment and information. »» If you are a carrier, but do not have a known family history of hemophilia, it is still possible that there are other women in your family who carry the gene for he ...
Functional SNPs in the SCGB3A2 promoter are
... autoimmune diseases with recent data estimating frequencies of up to 1.3% (0.5% clinical and 0.7% subclinical) in the USA (1) and 0.25– 1.09% in China (2). The hallmark of GD is the production of thyroid-stimulating hormone receptor (TSHR)-stimulating antibodies, leading to hyperthyroidism. GD is a ...
... autoimmune diseases with recent data estimating frequencies of up to 1.3% (0.5% clinical and 0.7% subclinical) in the USA (1) and 0.25– 1.09% in China (2). The hallmark of GD is the production of thyroid-stimulating hormone receptor (TSHR)-stimulating antibodies, leading to hyperthyroidism. GD is a ...
TILLING. Traditional Mutagenesis Meets
... On the one hand, mutations in genes expected to impact a phenotypic trait controlled by many genes, such as plant height or size or leaf shape, may be subject to epistatic interactions, and outcrossing to the wild type may be necessary. On the other hand, mutations in genes expected to impact a phen ...
... On the one hand, mutations in genes expected to impact a phenotypic trait controlled by many genes, such as plant height or size or leaf shape, may be subject to epistatic interactions, and outcrossing to the wild type may be necessary. On the other hand, mutations in genes expected to impact a phen ...
Meiosis
... occurs prior to meiosis. However, in many other organisms such as maize, oat, humans, and mice, homologous chromosomes are not associated with each other until zygotene. Regardless of when chromosomes pair, a major question in meiosis is, how do the homologous chromosomes identify and associate with ...
... occurs prior to meiosis. However, in many other organisms such as maize, oat, humans, and mice, homologous chromosomes are not associated with each other until zygotene. Regardless of when chromosomes pair, a major question in meiosis is, how do the homologous chromosomes identify and associate with ...
A molecular method for assessing meiofauna diversity in marine
... PCR products from multiple reactions prior to cloning will reduce biases introduced through PCR, such as PCR drift (Wagner, et al. 1994). Combining and mixing individual sediment samples collected at each site prior to molecular analysis can reduce biases introduced by patchiness of meiofauna in the ...
... PCR products from multiple reactions prior to cloning will reduce biases introduced through PCR, such as PCR drift (Wagner, et al. 1994). Combining and mixing individual sediment samples collected at each site prior to molecular analysis can reduce biases introduced by patchiness of meiofauna in the ...
Multiple Avirulence Loci and Allele-Specific Effector
... Ravensdale et al., 2012), a domain involved in specificity and direct AVR protein binding (Dodds et al., 2006; Krasileva et al., 2010). Their allelic variants recognize naturally occurring variants of their cognate AVRs, ATR13 and AVRL567, respectively, where differences in recognition specificity bet ...
... Ravensdale et al., 2012), a domain involved in specificity and direct AVR protein binding (Dodds et al., 2006; Krasileva et al., 2010). Their allelic variants recognize naturally occurring variants of their cognate AVRs, ATR13 and AVRL567, respectively, where differences in recognition specificity bet ...
The Old World monkey DAZ (Deleted in
... loci (AZFa, -b and -c). Microdeletions of AZFa–c could be detected in 5–15% of the infertile men, suggesting that the deleted regions of the Y chromosome contain genes essential for spermatogenesis (4,5). One candidate gene in the AZFc region is the recently described DAZ gene (Deleted in AZoospermi ...
... loci (AZFa, -b and -c). Microdeletions of AZFa–c could be detected in 5–15% of the infertile men, suggesting that the deleted regions of the Y chromosome contain genes essential for spermatogenesis (4,5). One candidate gene in the AZFc region is the recently described DAZ gene (Deleted in AZoospermi ...
Characterization and regulation of the bovine stearoyl-CoA desaturase gene promoter
... each primer, 10% DMSO, and 1 U Taq polymerase (Invitrogen) in a final volume of 50 ll. PCR conditions were 94 C for 2 min, followed by 35 cycles of denaturing at 95 C for 1 min, 58 C for 20 s, and elongation at 72 C for 1 min. Promoter fragments were cloned into a promoter-less luciferase reporte ...
... each primer, 10% DMSO, and 1 U Taq polymerase (Invitrogen) in a final volume of 50 ll. PCR conditions were 94 C for 2 min, followed by 35 cycles of denaturing at 95 C for 1 min, 58 C for 20 s, and elongation at 72 C for 1 min. Promoter fragments were cloned into a promoter-less luciferase reporte ...
Effect of Proliferating Cell Nuclear Antigen
... when PCNA is ubiquitinated, its affinity for these polymerases is increased by virtue of these motifs, and this facilitates their binding to the stalled forks. This mechanism, deduced from in vivo studies, has recently been demonstrated for pol in a reconstituted in vitro system (Zhuang et al., 200 ...
... when PCNA is ubiquitinated, its affinity for these polymerases is increased by virtue of these motifs, and this facilitates their binding to the stalled forks. This mechanism, deduced from in vivo studies, has recently been demonstrated for pol in a reconstituted in vitro system (Zhuang et al., 200 ...
A String-based Model for Simple Gene Assembly
... Also, the model has an interesting confluence property that does not hold in the general model, see [9]. The simple model for gene assembly has been investigated in [9] as a process of sorting signed permutations. A major shortcoming of this formalization is that the ld operations are not explicitly ...
... Also, the model has an interesting confluence property that does not hold in the general model, see [9]. The simple model for gene assembly has been investigated in [9] as a process of sorting signed permutations. A major shortcoming of this formalization is that the ld operations are not explicitly ...
Isolation, Characterization, and Annotation: The Search for Novel
... to the host, penetrates the cell membrane and injects its DNA. The genetic information can then follow two potential paths. In the lysogenic cycle, the DNA is incorporated into the host genome as a prophage and remains a part of the host’s genome as long as conditions remain stable for the prophage. ...
... to the host, penetrates the cell membrane and injects its DNA. The genetic information can then follow two potential paths. In the lysogenic cycle, the DNA is incorporated into the host genome as a prophage and remains a part of the host’s genome as long as conditions remain stable for the prophage. ...
A Fine Physical Map of Arabidopsis thaliana Chromosome 5
... A fine physical map of Arabidopsis thaliana chromosome 5 was constructed by ordering the clones from YAC, PI, TAC and BAC libraries of the genome using the sequences of a variety of genetic and EST markers and terminal sequences of clones. The markers used were 88 genetic markers, 13 EST markers, 87 ...
... A fine physical map of Arabidopsis thaliana chromosome 5 was constructed by ordering the clones from YAC, PI, TAC and BAC libraries of the genome using the sequences of a variety of genetic and EST markers and terminal sequences of clones. The markers used were 88 genetic markers, 13 EST markers, 87 ...