A novel mutation of the Keratin 12 gene responsible for a severe
... form of Meesmann’s corneal dystrophy. Methods: A family with clinically identified Meesmann’s corneal dystrophy was recruited and studied. Electron microscopy was performed on scrapings of corneal epithelial cells from the proband. Mutations in the KRT12 gene were sought using direct genomic sequenc ...
... form of Meesmann’s corneal dystrophy. Methods: A family with clinically identified Meesmann’s corneal dystrophy was recruited and studied. Electron microscopy was performed on scrapings of corneal epithelial cells from the proband. Mutations in the KRT12 gene were sought using direct genomic sequenc ...
How to approach and treat viral infections in ICU
... studies in ICU patients, <5.5% of mechanically ventilated patients with VAP had a respiratory sample positive for respiratory viruses [6,72,78] and in many of these cases the mechanical ventilation duration before virus detection may have indicated carriage before ICU admission. Latent viruses such ...
... studies in ICU patients, <5.5% of mechanically ventilated patients with VAP had a respiratory sample positive for respiratory viruses [6,72,78] and in many of these cases the mechanical ventilation duration before virus detection may have indicated carriage before ICU admission. Latent viruses such ...
Evolutionary Patterns in the Sequence and Structure of
... Transfer RNAs (tRNAs) are ancient molecules that are central to translation. Since they probably carry evolutionary signatures that were left behind when the living world diversified, we reconstructed phylogenies directly from the sequence and structure of tRNA using well-established phylogenetic me ...
... Transfer RNAs (tRNAs) are ancient molecules that are central to translation. Since they probably carry evolutionary signatures that were left behind when the living world diversified, we reconstructed phylogenies directly from the sequence and structure of tRNA using well-established phylogenetic me ...
Grade 12 - Curriculum
... The following Grade 10, 11 and 12 Lesson Plans were developed by Subject Advisors during May 2009. Teachers are requested to look at them, modify them where necessary to suit their contexts and resources. It must be remembered that Lesson Plans are working documents, and any comments to improve the ...
... The following Grade 10, 11 and 12 Lesson Plans were developed by Subject Advisors during May 2009. Teachers are requested to look at them, modify them where necessary to suit their contexts and resources. It must be remembered that Lesson Plans are working documents, and any comments to improve the ...
Evaluation of genomic DNA from paraffin
... separated by a clear space with oedematous fluid and in some cases there is also a diffuse infiltration of subendocardial fibrosis (Tidholm & Jönsson 2005). In a study, 64 of 65 (98%) dogs with confirmed DCM were positive for attenuated wavy fibers. In 147 dogs with other heart disease than DCM only ...
... separated by a clear space with oedematous fluid and in some cases there is also a diffuse infiltration of subendocardial fibrosis (Tidholm & Jönsson 2005). In a study, 64 of 65 (98%) dogs with confirmed DCM were positive for attenuated wavy fibers. In 147 dogs with other heart disease than DCM only ...
Handout #2 - MSU Billings
... Norm. "Well you see, Norm, it's like this... A herd of buffalo can only move as fast as the slowest buffalo. And when the herd is hunted, it's the slowest and weakest ones at the back that are killed first. This natural selection is good for the herd as a whole, because the general speed and health ...
... Norm. "Well you see, Norm, it's like this... A herd of buffalo can only move as fast as the slowest buffalo. And when the herd is hunted, it's the slowest and weakest ones at the back that are killed first. This natural selection is good for the herd as a whole, because the general speed and health ...
Tumor metastasis-associated human MTA1 gene and its MTA1
... Using differential cDNA library screening techniques based on metastatic and nonmetastatic rat mammary adenocarcinoma cell lines, we previously cloned and sequenced the metastasis-associated gene mta1. Using homology to the rat mta1 gene, we cloned the human MTA1 gene and found it to be over-express ...
... Using differential cDNA library screening techniques based on metastatic and nonmetastatic rat mammary adenocarcinoma cell lines, we previously cloned and sequenced the metastasis-associated gene mta1. Using homology to the rat mta1 gene, we cloned the human MTA1 gene and found it to be over-express ...
Genetic Polymorphisms Underlying Lung Cancer - J
... together with millions of GWAS marker SNPs. This will provide a powerful method for analyzing these polymorphisms in populations that were tested in recent GWASs. SNPs in DNA repair genes and therapeutic responses: Genetic polymorphisms underlie inter-individual diŠerences in terms of susceptibility ...
... together with millions of GWAS marker SNPs. This will provide a powerful method for analyzing these polymorphisms in populations that were tested in recent GWASs. SNPs in DNA repair genes and therapeutic responses: Genetic polymorphisms underlie inter-individual diŠerences in terms of susceptibility ...
Transcription regulation of the Escherichia coli pcnB gene coding for
... There are two major eVectors of the stringent response. The Wrst one is a couple of two speciWc nucleotides, guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), collectively called (p)ppGpp and rapidly produced in response to variety of physico-chemical and nutritional stresses ( ...
... There are two major eVectors of the stringent response. The Wrst one is a couple of two speciWc nucleotides, guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), collectively called (p)ppGpp and rapidly produced in response to variety of physico-chemical and nutritional stresses ( ...
Replication timing as an epigenetic mark
... timing, chromatin structure and transcriptional activity. By the mid 1970’s it was already known that late-replicating DNA coincided with AT-rich, Giemsa-dark, G-bands on metaphase chromosomes with low transcriptional activity, while early-replicating DNA coincided with GC-rich, R-bands with high tr ...
... timing, chromatin structure and transcriptional activity. By the mid 1970’s it was already known that late-replicating DNA coincided with AT-rich, Giemsa-dark, G-bands on metaphase chromosomes with low transcriptional activity, while early-replicating DNA coincided with GC-rich, R-bands with high tr ...
Polymorphisms in the pfcrt and pfmdr1 genes in Plasmodium
... have been associated with chloroquine resistance.10,16 The K76T mutation is strongly associated with the chloroquine resistance phenotypes in field and clinical studies.15-17 Mutation in codon 76 have been found in CQR P. falciparum strains all over the world and become the principal determinant of ...
... have been associated with chloroquine resistance.10,16 The K76T mutation is strongly associated with the chloroquine resistance phenotypes in field and clinical studies.15-17 Mutation in codon 76 have been found in CQR P. falciparum strains all over the world and become the principal determinant of ...
****Disclaimer- This is not an exhaustive list of everything that may
... How does DNA packaging regulate gene expression? Describe X chromosome inactivation. Describe activators and repressors and their role in transcription. Describe alternative splicing. Be able to name and describe the mechanisms for regulation of translation and later stages of gene expression. 7. De ...
... How does DNA packaging regulate gene expression? Describe X chromosome inactivation. Describe activators and repressors and their role in transcription. Describe alternative splicing. Be able to name and describe the mechanisms for regulation of translation and later stages of gene expression. 7. De ...
Review Molecular pathogenesis of H5N1 influenza virus infections
... Given that the ability of an influenza virus to cause disease probably depends on its ability to replicate efficiently to produce high virus loads and outpace cellular antiviral responses, it is not surprising that the components of the viral replication complex are involved in viral pathogenicity. ...
... Given that the ability of an influenza virus to cause disease probably depends on its ability to replicate efficiently to produce high virus loads and outpace cellular antiviral responses, it is not surprising that the components of the viral replication complex are involved in viral pathogenicity. ...
Supplementary Information
... DNA and RNA fractions were isolated from the tissue using an AllPrep DNA/RNA mini kit (Qiagen) per the manufacturer’s procedure. Approximately 120 mg of frozen GBM tissue was lysed in a buffer containing guanidine-isothiocyanate to inactivate DNases and RNases and to ensure isolation of intact DNA a ...
... DNA and RNA fractions were isolated from the tissue using an AllPrep DNA/RNA mini kit (Qiagen) per the manufacturer’s procedure. Approximately 120 mg of frozen GBM tissue was lysed in a buffer containing guanidine-isothiocyanate to inactivate DNases and RNases and to ensure isolation of intact DNA a ...
Multiple Barriers to Nonhomologous DNA End Joining
... mutants retain the ability to phosphorylate H2AV in late pachytene. These results suggest that DSBs are being repaired in the mei-218; spn-D double mutant with nearwild-type efficiency, even though repair is not resulting in crossovers and may not involve HR. Since spn-D and spn-B encode homologs of ...
... mutants retain the ability to phosphorylate H2AV in late pachytene. These results suggest that DSBs are being repaired in the mei-218; spn-D double mutant with nearwild-type efficiency, even though repair is not resulting in crossovers and may not involve HR. Since spn-D and spn-B encode homologs of ...
Manitoba Institute of Cell Biology The Lyonel G. Israels Laboratories
... majority of cells in a tumour they might not eliminate the more relevant and rare stem cells which slowly but eventually can regenerate new tumours. This concept also reinforces the hypothesis that normal stem and progenitor cells are important cellular targets in the initiation and recurrence of hu ...
... majority of cells in a tumour they might not eliminate the more relevant and rare stem cells which slowly but eventually can regenerate new tumours. This concept also reinforces the hypothesis that normal stem and progenitor cells are important cellular targets in the initiation and recurrence of hu ...
Supplementary Table 1 Entrez Gene (http://www.ncbi.nlm.nih.gov
... suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.(provided by RefSeq, Jun 2010) The protein encoded by this gene contains a bromodomain and several WD r ...
... suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.(provided by RefSeq, Jun 2010) The protein encoded by this gene contains a bromodomain and several WD r ...
Rabbit Genetics and Transgenic Models
... True or False: Retinitis pigmentosa is characterized by a progressive loss of rod, but not cone Which one of the following regarding retinitis pigmentosa is INCORRECT? a. Retinitis pigmentosa (RP) is genetically heterogenous b. RP is associated with mutations in several photoreceptor-specific and so ...
... True or False: Retinitis pigmentosa is characterized by a progressive loss of rod, but not cone Which one of the following regarding retinitis pigmentosa is INCORRECT? a. Retinitis pigmentosa (RP) is genetically heterogenous b. RP is associated with mutations in several photoreceptor-specific and so ...
Analysis of 16S ribosomal RNA gene segments for the diagnosis of
... combine nucleic acid amplification and a sequencespecific probe of the amplified product. These approaches are usually only able to query short DNA sequences; therefore, it is important to identify the regions within the target gene that supply the most taxonomic information in the smallest stretch ...
... combine nucleic acid amplification and a sequencespecific probe of the amplified product. These approaches are usually only able to query short DNA sequences; therefore, it is important to identify the regions within the target gene that supply the most taxonomic information in the smallest stretch ...
PubMed - Institute for Immunity, Transplantation and Infection
... Department of Chemistry, Stanford University, Stanford, California 94305, USA. The multiscale coarse-graining (MS-CG) method is a method for constructing a coarse-grained (CG) model of a system using data obtained from molecular dynamics simulations of the corresponding atomically detailed model. Th ...
... Department of Chemistry, Stanford University, Stanford, California 94305, USA. The multiscale coarse-graining (MS-CG) method is a method for constructing a coarse-grained (CG) model of a system using data obtained from molecular dynamics simulations of the corresponding atomically detailed model. Th ...
3-Hodgkin lymphoma
... account for about five percent of all cases of cancer in the United States, and Hodgkin's lymphoma in particular accounts for less than one percent of all cases of cancer in the United States. ...
... account for about five percent of all cases of cancer in the United States, and Hodgkin's lymphoma in particular accounts for less than one percent of all cases of cancer in the United States. ...
Introduction To Genetics- Chapter 11
... 2. The principle of independent assortment states that genes for different traits can segregate independently during the formation of gametes. 3. Independent assortment helps account for the many genetic variations observed in plants, animals and other organisms. ...
... 2. The principle of independent assortment states that genes for different traits can segregate independently during the formation of gametes. 3. Independent assortment helps account for the many genetic variations observed in plants, animals and other organisms. ...
Engineered bacteriophage-defence systems in bioprocessing
... groups, they displayed similar gene-expression patterns. Phage DT1 possesses 18 early-, 12 middle- and 12 late-expressed genes, whereas phage 2972 has 16 early-, 11 middle- and 14 late-expressed genes. In both phages, all of the early-expressed genes were adjacent to one another and comprised the pu ...
... groups, they displayed similar gene-expression patterns. Phage DT1 possesses 18 early-, 12 middle- and 12 late-expressed genes, whereas phage 2972 has 16 early-, 11 middle- and 14 late-expressed genes. In both phages, all of the early-expressed genes were adjacent to one another and comprised the pu ...
Secondary Leukemia Associated With The Anti-Cancer Agent
... secondary leukemia. In 1987, Ratain et al. first propounded the relationship between etoposide and secondary leukemia when it was used as a therapy for advanced non-small-cell lung cancer [2]. Subsequently, several investigators reported secondary leukemias, particularly acute myelogenous leukemia ( ...
... secondary leukemia. In 1987, Ratain et al. first propounded the relationship between etoposide and secondary leukemia when it was used as a therapy for advanced non-small-cell lung cancer [2]. Subsequently, several investigators reported secondary leukemias, particularly acute myelogenous leukemia ( ...
Characterization of the trans-spliced transcriptome and polycistronic
... In nematodes, spliced leader (SL) trans-splicing is associated with processing of polycistronic transcription units (PTU) into translatable mRNAs. Although SL trans-splicing is employed by all major lineages of flatworms, extensive information on the trans-spliced transcriptome in these organisms or ...
... In nematodes, spliced leader (SL) trans-splicing is associated with processing of polycistronic transcription units (PTU) into translatable mRNAs. Although SL trans-splicing is employed by all major lineages of flatworms, extensive information on the trans-spliced transcriptome in these organisms or ...