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Sequencing genomes
Sequencing genomes

... Positive score – frequency of substitutions is greater than would have occurred by random chance. Zero score – frequency is equal to that expected by chance. ...
Agarose Gel Electrophoresis
Agarose Gel Electrophoresis

... - Migration and separation of DNA in agarose gels: - DNA is negatively charged and therefore migrates to the anode (positively charged electrode), if a voltage is applied - rate (speed) of migration depends on: - size of the DNA (length in base pairs, bp, or kilobase pairs, kb): large DNAs migrate s ...
evidence of evolution
evidence of evolution

... Paleontology: the study of fossils or extinct organisms, continues to provide new information and support current hypothesis about how evolution occurs. ...
TM Review Genetics
TM Review Genetics

... homozygous dominant father and a heterozygous mother. Describe the genotypes and phenotypes of the offspring, including the percentages of each. ...
Genome-wide association studies for microbial genomes
Genome-wide association studies for microbial genomes

... van Bokhorst-van de Veen et al. PLoS ONE 2012 ...
Genetics: Tour of the Basics
Genetics: Tour of the Basics

... 14. In this case, the “H” gene is called what? What is the masked “h” gene called? What does the term heterozygous mean? 15. The mom and dad each have how many alleles for the thumb trait? 16. How many do they pass on to their child? 17. What are the combinations of alleles that the child might get? ...
phenylketonuria (PKU): linked to genes on chromosome 12.
phenylketonuria (PKU): linked to genes on chromosome 12.

... BETWEEN THE M COPY AND THE P COPY ...
Diffusion and random walks - California Institute of
Diffusion and random walks - California Institute of

... The genomes of organisms A and B code for the same set of proteins but have different regulatory DNA. The two cells in the cartoon start in the same state, expressing the same proteins at stage 1, but step to quite different states at stage 2 because of their different arrangements of regulatory mod ...
Human Genome I - Open.Michigan
Human Genome I - Open.Michigan

... ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding ...
Analysis of immunoglobulin heavy chain V
Analysis of immunoglobulin heavy chain V

... the germ-line and generated throughout evolution (1-3). This basic diversity is extended by somatic processes such as combinatorial V-(D)-J joining (4), flexibility in the joining site (4-8) and point mutations (1, 2, 5, 9-17). As recently shown somatic diversity also may be generated by recombinati ...
Meiotic recombination
Meiotic recombination

DNA Replication Simulation WKST
DNA Replication Simulation WKST

... What do you think happens to the DNA on the other half of the strand? Remember, DNA can only be added after the primer and can only be added moving along the template strand in the 3’ to 5’ direction. Also, helicase is unwinding the DNA strands at the replication fork as Polymerase is adding nucleo ...
A Variable Number of Tandem Repeats Locus with!, the Human
A Variable Number of Tandem Repeats Locus with!, the Human

... large retroposon family mapped to a chromosomal rite. HERVK10 is a 9.2-kb genome present in ,v50 copies per haploid human genome, and is homologous to both type A retroviruses and to the type B mouse mammary tumor virus (11). Both SINE-R11 and the retroposon of the C2 gene (SINE-R.C2) are homologous ...
Metzenberg, R.L. and J. Grotelueschen
Metzenberg, R.L. and J. Grotelueschen

... (Berlin and Yanofsky 1985, Molec. Cell. Biol. 5:839-848; ibid. 849-855). Loci with names starting with LZ and DB are arbitrary DNA fragments of unknown function, studied in our laboratory by Ludwika Zagorska and David Butler, respectively. hbs is "homebase", studied in J. Kinsey's laboratory. Finall ...
Historic Heredity - Core Concepts: Biology
Historic Heredity - Core Concepts: Biology

... Hereditary will be examined as the transmission of the physical and genetic qualities of parents. The study of genetics includes the important role of genes in the development of human beings. Genes make up genetic codes. All living beings have DNA, which carries the genetic code. The structure and ...
Genetic Explanation 2: the role a specific gene defect
Genetic Explanation 2: the role a specific gene defect

... a mutation was identified in the eighth exon (section) of their MAO-A gene. This means they had the warrior gene. The men with the defective gene (and not all men in the family inherited it) showed aggressive, sometimes violent behaviour including arson and attempted rape. The men seemed unable to r ...
Topic guide 7.7: Genes and evolution
Topic guide 7.7: Genes and evolution

... code, many amino acids are coded for by more than one base triplet. However, molecular biologists now know that not all DNA codes for proteins and they are now finding that silent mutations may be involved with certain genetic diseases, such as Marfan’s syndrome, if they occur in a regulatory portio ...
DNA - K.T. Leung
DNA - K.T. Leung

... • The main goal of DNA in the cell is long-term storage of information. • Various enzymes act on DNA & copy its information into either more DNA, in DNA replication, or transcribe & translate it into protein. • Encodes the sequence of amino acid residues in protein. www.earthlife.net/images/eury-cel ...
ATP. The 32P-containing terminal nucleotide
ATP. The 32P-containing terminal nucleotide

... identified following hydrolysis by snake readily is 5'-end at the venom phosphodiesterase and separation of the resulting mononucleotide by electrophoresis. Methods generally employed for the identification of 3'terminal nucleotides require a quantity of DNA sufficient to permit detection of the 3'- ...
1. What are the four nitrogenous bases found in DNA? 1. Where in
1. What are the four nitrogenous bases found in DNA? 1. Where in

... 5. When converting DNA to RNA, there are rules about which bases pair together • Adenine pairs with Uracil A ---- U • Guanine pairs with Cytosine G ---- C • This means that an A on the DNA strand will result in or code for a U on the RNA strand. T’s in DNA get replaced by U’s in RNA! ...
2014.10.16論文評述心得報告 環醫所博士班研究生 黃建程 Detection
2014.10.16論文評述心得報告 環醫所博士班研究生 黃建程 Detection

... Genomic imprinting is an epigenetic phenomenon by which certain genes can be expressed in a parent-of-origin-specific manner. It may also ensure transposable elements remain epigenetically silenced throughout gametogenic reprogramming to maintain genome integrity. It is an inheritance process indepe ...
Cladogram: Amylase Activity
Cladogram: Amylase Activity

... scientists can often determine evolutionary relationships between the organisms that share that protein. A cladogram can be constructed to depict the evolutionary distance between the organisms. This method takes advantage of the predictable rate at which mutations occur in DNA. Those organisms with ...
DNA polymerase
DNA polymerase

... You will perform a BLAST search against a database of known proteins to determine which protein your sequence encodes. What will happen if this protein mutates or malfunctions? ...
No Slide Title
No Slide Title

... 7. Final report: 30 points Assignment 1 Pick an enzyme/organism combination • Try to convince the group in 5-10 minutes why yours is best ...
Zebra fish
Zebra fish

... Identification of retrovirus-induced mutations • DNA flanking the insert cloned by inverse PCR • If candidate gene was not found small chromosomal walk was used • RT-PCR and RACE was then used to obtain the rest of the cDNA • To confirm that the correct junction fragment (and gene) have been cloned ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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