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Chado: evolution of a biological database LONG VERSION
Chado: evolution of a biological database LONG VERSION

... Origins of Chado • Chado was originally developed for FlyBase – Integration of GadFly (Berkeley) and previous FlyBase database ...
DNA Sequencing Handbook
DNA Sequencing Handbook

... 5. Sample Drop off and Mailing Samples may be dropped off in room 147 of the Biotechnology Building from 8:00 am 4:00 pm, Monday through Friday. Samples can be sent Fed Ex overnight or via US Mail; no ice is necessary for DNA. Our mailing address is 147 Biotechnology Building, Ithaca, NY 14853. Note ...
FOXP2 in focus: what can genes tell us about speech and language?
FOXP2 in focus: what can genes tell us about speech and language?

... sometimes been taken as evidence for existence of genes specific to grammar. However, extensive work by Faraneh Vargha-Khadem and colleagues has made it clear that the impairment in the KE family is not restricted to selective aspects of grammar [17 –21]. In line with the original description of the ...
Putative GTPase Gtr1p genetically interacts with the RanGTPase
Putative GTPase Gtr1p genetically interacts with the RanGTPase

... Nishitani et al., 1991). Subsequently, ts mutants of the S. cerevisiae RCC1 homologue have been independently isolated from diverse viewpoints of cellular function such as mating pathway (srm1) (Clark and Sprague, 1989), mRNA splicing (prp20) (Aebi et al., 1990) and mRNA export (mtr1) (Kadowaki et a ...
PTC Genetics Lab Student Worksheet
PTC Genetics Lab Student Worksheet

... (sweet, salty, umami) or potentially harmful or toxic (bitter, sour). The ability to taste is due to the presence of chemically sensitive, specialized taste receptor cells on the surface of the tongue and throat. When we eat something sweet, the soluble molecules in the food dissolve in saliva and b ...
here - Genomes Unzipped
here - Genomes Unzipped

... these two types of artifact in this analysis, as both are non-biological. For the test of position bias, it is known that the error rate of Illumina sequencing depends on the position in the read [6]. Additionally, mapping errors around insertions/deletions relative to a reference genome can lead to ...
Validated preCRMs
Validated preCRMs

... the situation for protein-coding genes, systematic rules for encoding CRMs in genomic DNA are not yet elucidated (Wasserman and Sandelin 2004), although a variety of predictive methods are being explored. Methods that seek over-represented motifs in co-expressed genes have limited but improving succ ...
A newly discovered human -globin gene
A newly discovered human -globin gene

... The globin genes and their products have been intensively investigated for the past 50 years. Those studies led to the description of structural and regulatory elements that are useful for the recognition and comparison of hundreds of globin gene family members. The divergence of ancestral ␣- and ␤- ...
Example - Hivebench
Example - Hivebench

... association of a greater-than-17-base oligonucleotide with its target sequence is an extremely sequence-specific process, far more so than the specificity of monoclonal antibodies in binding to specific antigenic determinants. Consequently, 17-mer or longer primers are routinely used for amplificati ...
Genetics and Genomics of Core Short Tandem Repeat Loci
Genetics and Genomics of Core Short Tandem Repeat Loci

... ‘‘off-ladder’’ alleles can be variants with more or less of the core repeat unit than present in the common alleles found in the commercially available allelic ladder. these variant alleles may contain partial repeats or insertions/deletions in the flanking region close to the repeat ...
Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size
Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size

... gilts may be explained that there are variations in the genetic background. In addition, the observed effects might be caused by the linkage of this locus with other quantitative trait locus (QTLs) which contributed to the reproductive traits. Mutation of nucleotide can alter gene function, either b ...
(PPI) node degrees with SNP counts
(PPI) node degrees with SNP counts

... which contains information about the genes associated with each SNP. The Build 128 version of SNPContigLocusID contains about 13,129,868 rows (though about half of them specify “NW_” mRNA segments and were ignored). Here is a query that retrieves the records for 2 SNPs (among many others) that appea ...
Discovery of MLL1 binding units, their localization to CpG Islands
Discovery of MLL1 binding units, their localization to CpG Islands

... Response Elements (TREs). However, despite their functional importance, nothing is known about sequence features that may act as TREs in mammalian genomic DNA. Results: By analyzing results of reported DNA binding assays, we identified several CpG rich motifs as potential MLL1 binding units (defined ...
The causes and molecular consequences of polyploidy in
The causes and molecular consequences of polyploidy in

... may exist to create a post-zygotic reproductive barrier for gene flow between species, naturally ...
Ionic distribution around simple DNA models. I
Ionic distribution around simple DNA models. I

... preclude field lines from escaping so that the estimates correspond to zero boundary conditions in the finite difference Poisson–Boltzmann terminology.28 Furthermore, Tanford and Kirwood, in their application of Kirwood’s discrete charge model of proteins to titration curve calculations, found that ...
Phylogenetic Affinity of Mitochondria of Euglena
Phylogenetic Affinity of Mitochondria of Euglena

... RNA molecules called guide RNAs mediate the uridine insertion/deletion type of RNA editing (Simpson et al. 1993). It is known that these guide RNA molecules can be capped in vitro with guanylyl transferase and GTP (Blum and Simpson 1990). To search for similar RNA species in E. gracilis mitochondria ...
Chapter 10 - McGraw Hill Higher Education
Chapter 10 - McGraw Hill Higher Education

... The sequence of the entire human genome was reported on June 26, 2000 It consists of 3.2 billion base pairs If the human genome were a book It would be 500,000 pages long It would take about 60 years to read at the rate of 8 hours a day, every day, at five bases a second ...
here
here

... The neuropilin-2 (NRP2) gene is localized to 2q34, an autism susceptibility locus. NRP2 has been demonstrated to both guide axons and to control neuronal migration in the central nervous system. It has been reported that NRP2 may be required in vivo for sorting migrating cortical and ...
Using a Single Nucleotide Polymorphism to Predict Bitter
Using a Single Nucleotide Polymorphism to Predict Bitter

... repeat is a short sequence of DNA that is repeated in a headto-tail fashion at a specific chromosomal locus. Tandem repeats are interspersed throughout the human genome. Some sequences are found at only one site -- a single locus - in the human genome. For many tandem repeats, the number of repeated ...
Origin of New Genes: Evidence from Experimental
Origin of New Genes: Evidence from Experimental

Original Article Accurate quantification standards of DNA via
Original Article Accurate quantification standards of DNA via

... highly acidic absorption solution is not suitable for use with the IC columns. Further, the conventional loading of sample in the quartz holder [18] as pressed pellets was modified to load aqueous DNA stock solution directly on ashless filter paper through sequential pipetting and drying under infra ...
Positional dependence of transcriptional inhibition by DNA torsional
Positional dependence of transcriptional inhibition by DNA torsional

... We also considered that, because gene activity and gene density in subtelomeric regions could be lower than the chromosomal average, these regions could have less potential to generate DNA helical tension, leading to little change in their transcription output. To examine this possibility, we compar ...
SM 2 Gen Evn
SM 2 Gen Evn

... In eukaryotes - control of metabolic pathways by gene expression includes enhancers and transcription factors. Students should understand the role of control elements, including the promoter region, enhancer region, the transcription factors (proteins) that must bind to both regions before transcrip ...
Cryptochrome 1 controls tomato development
Cryptochrome 1 controls tomato development

... Cryptochrome control of tomato development 555 elongation, stem growth and internode elongation, leaf and cotyledon expansion, B-dependent gene expression, and anthocyanin accumulation (Ahmad and Cashmore, 1993; Ahmad and Cashmore, 1996; Fuglevand et al., 1996; Koornneef et al., 1980) and, in combi ...
2 Genetic Epidemiology - How to quantify, localize and identify
2 Genetic Epidemiology - How to quantify, localize and identify

... Environmental factors can range from intrauterine environment to the influence of the family environment, school, friends and many other unidentified nongenetic factors. In this chapter we will provide an overview of methods used to model the contribution of genes and environment to variance in a tr ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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