Polar auxin transport – old questions and new concepts?
... A subunit. RCN1 may control the level of phosphorylation and thereby the activity of a component involved in PAT (Garbers et al., 1996). This hypothesis was corroborated by recent findings that the rcn mutant displays enhanced basipetal auxin transport, a phenotype feature, which was also observed i ...
... A subunit. RCN1 may control the level of phosphorylation and thereby the activity of a component involved in PAT (Garbers et al., 1996). This hypothesis was corroborated by recent findings that the rcn mutant displays enhanced basipetal auxin transport, a phenotype feature, which was also observed i ...
Molecular Mechanisms of Light Stress Protection in Higher Plants
... production of reactive oxygen radicals. These radicals cause the oxidation and thus damage of all kinds of cell components. Plants have evolved several mechanisms to prevent or at least minimize this damage. In the present work some of the molecular mechanisms of photoprotection were investigated. I ...
... production of reactive oxygen radicals. These radicals cause the oxidation and thus damage of all kinds of cell components. Plants have evolved several mechanisms to prevent or at least minimize this damage. In the present work some of the molecular mechanisms of photoprotection were investigated. I ...
Type I Factor XI11 Deficiency Is Caused By a
... is a plasma transglutaminase consisting of two catalytic a and two noncatalytic b s~bunits.’.~.~ The a subunit contains an active site region of transglutaminases, and the b subunit is composed of 10 tandem repeats called “Sushi domain^"^ because of their shape, or “short consensus repeats (SCRs)”, ...
... is a plasma transglutaminase consisting of two catalytic a and two noncatalytic b s~bunits.’.~.~ The a subunit contains an active site region of transglutaminases, and the b subunit is composed of 10 tandem repeats called “Sushi domain^"^ because of their shape, or “short consensus repeats (SCRs)”, ...
The control of shoot branching: an example of plant information
... – the existing stem transport pathway. The polar transport stream in the stem is a good sink because of its ability to transport auxin away down the stem. This can be seen in a simple experiment where auxin is applied to the side of an isolated pea stem segment (Sachs 1981). A vascular strand will b ...
... – the existing stem transport pathway. The polar transport stream in the stem is a good sink because of its ability to transport auxin away down the stem. This can be seen in a simple experiment where auxin is applied to the side of an isolated pea stem segment (Sachs 1981). A vascular strand will b ...
Inverse correlation between SMN1 and SMN2 copy numbers
... population, indicating the presence of chromosome 5s with two copies of SMN1.4,10 We meta-analyzed published data,3,4,8,10,13,14 and updated deduced SMN1 allele frequencies5 as follows: ‘zero-copy allele’ (chromosome 5 lacking SMN1 exon 7), 9.83 10 3; ‘one-copy allele’, 9.57 10 1; ‘two-copy alle ...
... population, indicating the presence of chromosome 5s with two copies of SMN1.4,10 We meta-analyzed published data,3,4,8,10,13,14 and updated deduced SMN1 allele frequencies5 as follows: ‘zero-copy allele’ (chromosome 5 lacking SMN1 exon 7), 9.83 10 3; ‘one-copy allele’, 9.57 10 1; ‘two-copy alle ...
19. - 21. März 2014 in Essen - Deutsche Gesellschaft für
... Prof. Dr. med. Klaus Zerres, Aachen Prof. Dr. rer. nat. Kerstin Kutsche, Hamburg Prof. Dr. med. Jürgen Kohlhase, Freiburg Prof. Dr. med. Michael Speicher, Graz Prof. Dr. med. Wolfgang Berger, Zürich Prof. Dr. med. Gerd Utermann, Innsbruck Dr. rer. nat. Michael Bonin, Tübingen Prof. Dr. med. Gabriele ...
... Prof. Dr. med. Klaus Zerres, Aachen Prof. Dr. rer. nat. Kerstin Kutsche, Hamburg Prof. Dr. med. Jürgen Kohlhase, Freiburg Prof. Dr. med. Michael Speicher, Graz Prof. Dr. med. Wolfgang Berger, Zürich Prof. Dr. med. Gerd Utermann, Innsbruck Dr. rer. nat. Michael Bonin, Tübingen Prof. Dr. med. Gabriele ...
An N-terminally truncated envelope protein encoded
... patients with MS than from controls [12,16,17,19]. A monoclonal anti-HERV-W Env antibody (mAb 6A2B2) detects an antigen expressed in actively demyelinating brain lesions from patients with MS [12,16,18]. Importantly, expression of Syncytin-1 in astrocytes induces release of mediators that are cytoto ...
... patients with MS than from controls [12,16,17,19]. A monoclonal anti-HERV-W Env antibody (mAb 6A2B2) detects an antigen expressed in actively demyelinating brain lesions from patients with MS [12,16,18]. Importantly, expression of Syncytin-1 in astrocytes induces release of mediators that are cytoto ...
The novel cytochrome c6 of chloroplasts
... the cytochrome b6 f complex, consistent with the loss of plastocyanin function. This study was carried out using a different ecotype from that used by Gupta et al. (2002a), but Weigel et al. (2003b) argued that the role of cytochrome c6A was unlikely to be fundamentally different between the two eco ...
... the cytochrome b6 f complex, consistent with the loss of plastocyanin function. This study was carried out using a different ecotype from that used by Gupta et al. (2002a), but Weigel et al. (2003b) argued that the role of cytochrome c6A was unlikely to be fundamentally different between the two eco ...
Multiple Functions for Actin during Filamentous Growth of Saccharomyces cerevisiae .
... Tpm1p (tropomyosin), Srv2p (cyclase-associated protein), and the formin homology domain protein Bni1p. Deletion of SLA2, which encodes a protein with homology to the focal adhesion protein talin, was also shown to block filamentation (Yang et al., 1997). Here we have investigated the functional requ ...
... Tpm1p (tropomyosin), Srv2p (cyclase-associated protein), and the formin homology domain protein Bni1p. Deletion of SLA2, which encodes a protein with homology to the focal adhesion protein talin, was also shown to block filamentation (Yang et al., 1997). Here we have investigated the functional requ ...
Prof. Kamakaka`s Lecture 12 Notes
... To understand the complete biological role of p53 protein and its mutant phenotype we need to study the gene at multiple levels: Genetics- mutant gene- mutant phenotype Now what? Genetics will relate specific mutation to specific phenotype It usually provides No Information about how the protein gen ...
... To understand the complete biological role of p53 protein and its mutant phenotype we need to study the gene at multiple levels: Genetics- mutant gene- mutant phenotype Now what? Genetics will relate specific mutation to specific phenotype It usually provides No Information about how the protein gen ...
Genetic Codes with No Dedicated Stop Codon: Context
... exist before the ribosome translates into poly(A) tails (on average approximately five codons intervene between the primary and additional downstream non-primary stops). As a consequence, if extensions result from readthrough they are typically expected to be very short. Even though multiple possibl ...
... exist before the ribosome translates into poly(A) tails (on average approximately five codons intervene between the primary and additional downstream non-primary stops). As a consequence, if extensions result from readthrough they are typically expected to be very short. Even though multiple possibl ...
Resveratrol Opportunism: What Is the Science Behind the Claims?
... bioavailability is somewhat misleading in that the glucuronide and sulfate forms of resveratrol also stay in the blood for some time. The question that recently has been raised is whether higher blood levels of the glucuronide and sulfate forms of resveratrol themselves have benefit, perhaps serving ...
... bioavailability is somewhat misleading in that the glucuronide and sulfate forms of resveratrol also stay in the blood for some time. The question that recently has been raised is whether higher blood levels of the glucuronide and sulfate forms of resveratrol themselves have benefit, perhaps serving ...
genomebiology.com
... exons/introns from previously intronic/exonic sequences, respectively), and insertion into first and last exons. However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates. Results: We analyzed the influence of TEs on ...
... exons/introns from previously intronic/exonic sequences, respectively), and insertion into first and last exons. However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates. Results: We analyzed the influence of TEs on ...
Alternatively Spliced Genes
... Evolutionarily, the basic machinery for pre-mRNA splicing appears to be highly conserved among different species of metazoans. In Saccharomyces cerevisiae, although only a small percentage of genes undergo splicing, more than 100 genes have been identified that are either dedicated to or involved in ...
... Evolutionarily, the basic machinery for pre-mRNA splicing appears to be highly conserved among different species of metazoans. In Saccharomyces cerevisiae, although only a small percentage of genes undergo splicing, more than 100 genes have been identified that are either dedicated to or involved in ...
Interactions between the otitis media gene, Fbxo11, and p53 in the
... (Cordenonsi et al., 2003). Mutant p53 can attenuate the ability of TGF-β1 to induce the expression of genes encoding p21, PAI-1 (plasminogen activator inhibitor), MMP2 (matrix metalloproteinase) and SM22 (smooth muscle specific 22 kDa protein) (Kalo et al., 2007). It has also been found that Ras sig ...
... (Cordenonsi et al., 2003). Mutant p53 can attenuate the ability of TGF-β1 to induce the expression of genes encoding p21, PAI-1 (plasminogen activator inhibitor), MMP2 (matrix metalloproteinase) and SM22 (smooth muscle specific 22 kDa protein) (Kalo et al., 2007). It has also been found that Ras sig ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... Marschalek R. MLL (myeloid/lymphoid or mixed lineage leukemia). Atlas Genet Cytogenet Oncol Haematol.2003;7(1):16-18. Hess JL, Huret JL. MLL (myeloid/lymphoid or mixed lineage leukemia). Atlas Genet Cytogenet Oncol Haematol.2001;5(1):12-14. Huret JL. MLL (myeloid/lymphoid or mixed lineage leukemia). ...
... Marschalek R. MLL (myeloid/lymphoid or mixed lineage leukemia). Atlas Genet Cytogenet Oncol Haematol.2003;7(1):16-18. Hess JL, Huret JL. MLL (myeloid/lymphoid or mixed lineage leukemia). Atlas Genet Cytogenet Oncol Haematol.2001;5(1):12-14. Huret JL. MLL (myeloid/lymphoid or mixed lineage leukemia). ...
Facts About Spinal Muscular Atrophy
... However, increasingly, modern technology is being used to ensure that children have the best quality of life possible. Non-invasive mechanical ventilation (using a face mask rather than by inserting a tube into the wind pipe) and feeding tubes can assist natural breathing and eating functions. Menta ...
... However, increasingly, modern technology is being used to ensure that children have the best quality of life possible. Non-invasive mechanical ventilation (using a face mask rather than by inserting a tube into the wind pipe) and feeding tubes can assist natural breathing and eating functions. Menta ...
The presence of an RHD pseudogene containing a
... mixed race, referred to as ‘‘Coloured’’ in South Africa; and from African American donors, selected on the basis of appearance, from Shreveport, Louisiana. Blood samples from D-positive black South Africans were derived from another study.20 All blood samples were collected into a citrate-phosphate- ...
... mixed race, referred to as ‘‘Coloured’’ in South Africa; and from African American donors, selected on the basis of appearance, from Shreveport, Louisiana. Blood samples from D-positive black South Africans were derived from another study.20 All blood samples were collected into a citrate-phosphate- ...
Early Onset of Severe Familial Amyotrophic Lateral Sclerosis with a
... applied for confirmation of the underlying GrA point mutation at the intron-exon boundary of exon 2 of the CNTF gene, leading to a frameshift and subsequent truncation of the resultant protein, which lacks biological activity (fig. 1C). Each analysis was repeated at least once from patient DNA, to c ...
... applied for confirmation of the underlying GrA point mutation at the intron-exon boundary of exon 2 of the CNTF gene, leading to a frameshift and subsequent truncation of the resultant protein, which lacks biological activity (fig. 1C). Each analysis was repeated at least once from patient DNA, to c ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA, and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the ...
... 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA, and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the ...
Fulltext: english,
... Among the mediators released by keratinocytes in response to UV radiation, there is a small peptide endothelin-1 (ET-1), a ligand for the endothelin-B (ETB) receptor expressed on melanocytes, which can lead to an increase in tyrosinase activity followed by an increase in melanin production. A recent ...
... Among the mediators released by keratinocytes in response to UV radiation, there is a small peptide endothelin-1 (ET-1), a ligand for the endothelin-B (ETB) receptor expressed on melanocytes, which can lead to an increase in tyrosinase activity followed by an increase in melanin production. A recent ...
A gain of function mutation causing skeletal overgrowth in the
... Fig. 2. Cloning of rapunzelc14. (A) A meiotic map representing approximately 47 kb of the rapunzelc14 region on chromosome 16. The critical region contains three paralogous genes (rpz, rpz2 and rpz3). Two additional paralogues (rpz4 and rpz5) are also present on chromosome 16, outside of the critica ...
... Fig. 2. Cloning of rapunzelc14. (A) A meiotic map representing approximately 47 kb of the rapunzelc14 region on chromosome 16. The critical region contains three paralogous genes (rpz, rpz2 and rpz3). Two additional paralogues (rpz4 and rpz5) are also present on chromosome 16, outside of the critica ...
Genetic studies of psoriasis and psoriatic arthritis
... identified with linkage analysis, 3q21 and 5q31-32, with a special emphasis on the PSORS5 region on chromosome 3q21. Another purpose was to investigate whether several autoimmuneassociating genes and genomic regions are susceptibility factors for psoriasis/psoriatic arthritis. Association studies on ...
... identified with linkage analysis, 3q21 and 5q31-32, with a special emphasis on the PSORS5 region on chromosome 3q21. Another purpose was to investigate whether several autoimmuneassociating genes and genomic regions are susceptibility factors for psoriasis/psoriatic arthritis. Association studies on ...
Sample Questions for Hemoglobinopathies
... -thalassemias, which present as a microcytic, hemolytic anemia in neonates, are self-limited disorders. Alpha thalassemias are symptomatic in both fetal and adult life, because the globin is common to Hgb A, A2, and F. Beta-thalassemias are not apparent at birth, because Hgb F (22) is the predo ...
... -thalassemias, which present as a microcytic, hemolytic anemia in neonates, are self-limited disorders. Alpha thalassemias are symptomatic in both fetal and adult life, because the globin is common to Hgb A, A2, and F. Beta-thalassemias are not apparent at birth, because Hgb F (22) is the predo ...