Molecular characterization of glutathione peroxidase
... cyanobacteria. Liver is the major site in fish and other vertebrates for the detoxification of ingested toxic materials by oxidation, and ROS is known to be involved in the process (5, 30). As one of primary antioxidant enzymes, GPx plays an important role in protecting membrane from being oxidated. ...
... cyanobacteria. Liver is the major site in fish and other vertebrates for the detoxification of ingested toxic materials by oxidation, and ROS is known to be involved in the process (5, 30). As one of primary antioxidant enzymes, GPx plays an important role in protecting membrane from being oxidated. ...
The Plasmodium 6-cysteine protein family in sexual and sporozoite
... and end up in the liver sinusoid where they migrate through Kupffer cells and traverse through hepatocytes before colonizing inside a hepatocyte. During the invasion process a host derived membrane is formed around the parasite, the parasitophorous vacuole membrane (PVM), and the parasite remains in ...
... and end up in the liver sinusoid where they migrate through Kupffer cells and traverse through hepatocytes before colonizing inside a hepatocyte. During the invasion process a host derived membrane is formed around the parasite, the parasitophorous vacuole membrane (PVM), and the parasite remains in ...
Warren, ST and Ashley, CT: Triplet repeat expansion mutations: The example of fragile X syndrome. Annual Review of Neuroscience 18:77-99 (1995).
... might result from the inherent instability of this reiterated trinucleotide repeat, which would be reminiscent of other tandemly repeated sequences such as the highly polymorphic dinucleotide repeats (Weber 1990). Indeed, analysis of the eGG repeat of FMRl across normal populations revealed that it ...
... might result from the inherent instability of this reiterated trinucleotide repeat, which would be reminiscent of other tandemly repeated sequences such as the highly polymorphic dinucleotide repeats (Weber 1990). Indeed, analysis of the eGG repeat of FMRl across normal populations revealed that it ...
The P53 pathway and metabolism: implications in tissue
... WHY DO WE AGE AND GET CANCER? ARE THESE 2 PROCESSES INTRINSICALLY LINKED? p53 ...
... WHY DO WE AGE AND GET CANCER? ARE THESE 2 PROCESSES INTRINSICALLY LINKED? p53 ...
Laboratory testing of CYP2D6 alleles in relation to tamoxifen therapy
... with either (i) a well-defined influence on enzyme function or (ii) a clear relationship between the variant and an observable influence on drug pharmacokinetics, pharmacodynamics, or toxicology.8 The rationale is that, when there is a clear, mechanistic, cause–effect relationship between the varia ...
... with either (i) a well-defined influence on enzyme function or (ii) a clear relationship between the variant and an observable influence on drug pharmacokinetics, pharmacodynamics, or toxicology.8 The rationale is that, when there is a clear, mechanistic, cause–effect relationship between the varia ...
Gene Expression Profiles of Cold
... were divided into five categories according to the nature of deduced amino acid sequences: 17% are involved in cell wall metabolism, 12% are various transporters, 6% participate in signaling pathways, 34% are components of other cellular processes and 30% are hypothetical proteins or clones with no ...
... were divided into five categories according to the nature of deduced amino acid sequences: 17% are involved in cell wall metabolism, 12% are various transporters, 6% participate in signaling pathways, 34% are components of other cellular processes and 30% are hypothetical proteins or clones with no ...
The one-eyed pinhead gene functions in mesoderm and endoderm
... and Hogan, 1993) family are expressed as an early response to endoderm formation. Genetic analysis has not yet identified any mutants that disrupt the development of the entire endoderm. In genetic screens for additional genes that function during vertebrate pattern formation, we have discovered the ...
... and Hogan, 1993) family are expressed as an early response to endoderm formation. Genetic analysis has not yet identified any mutants that disrupt the development of the entire endoderm. In genetic screens for additional genes that function during vertebrate pattern formation, we have discovered the ...
C57BL/6 - Envigo
... Genetic drift is the change in frequency in which a gene appears in a population, through mutation, regardless of the adaptive value of the mutation. In an inbred population, natural random mutation occurs rather infrequently. Genetic drift is a normal process for any breeding population and thus ca ...
... Genetic drift is the change in frequency in which a gene appears in a population, through mutation, regardless of the adaptive value of the mutation. In an inbred population, natural random mutation occurs rather infrequently. Genetic drift is a normal process for any breeding population and thus ca ...
Risk assessment - Office of the Gene Technology Regulator
... unintended changes in their biochemistry or physiology. In addition, consideration was given to the opportunity for gene flow to other organisms, and its effects if this occurred. All events were characterised in relation to both the magnitude and probability of harm in the context of the controls p ...
... unintended changes in their biochemistry or physiology. In addition, consideration was given to the opportunity for gene flow to other organisms, and its effects if this occurred. All events were characterised in relation to both the magnitude and probability of harm in the context of the controls p ...
Tracing the Thread of Plastid Diversity through the Tapestry of Life
... the gram-negative cyanobacterial cell. This view is bolstered by the recent determination that Toc75, a key component of the plant plastid’s protein import apparatus, is homologous to a cyanobacterial secretory protein, both localized to the outer plastid envelope (reported in two papers submitted w ...
... the gram-negative cyanobacterial cell. This view is bolstered by the recent determination that Toc75, a key component of the plant plastid’s protein import apparatus, is homologous to a cyanobacterial secretory protein, both localized to the outer plastid envelope (reported in two papers submitted w ...
Deletions of NF1 gene and exons detected by multiplex ligation
... (SSCP),26 or denaturing high-performance liquid chromatography (DHPLC)15 27 with varying degrees of sensitivity for each method. Direct DNA sequencing is then used to confirm and characterise mutations detected by each of these approaches, and fluorescence in situ hybridisation (FISH) is used to det ...
... (SSCP),26 or denaturing high-performance liquid chromatography (DHPLC)15 27 with varying degrees of sensitivity for each method. Direct DNA sequencing is then used to confirm and characterise mutations detected by each of these approaches, and fluorescence in situ hybridisation (FISH) is used to det ...
The Genetics of CFTR: Genotype – Phenotype Relationship
... The topic of mutational classes and personalized therapy is not devoid of problems. Some mutations produce multiple effects and should be classified in multiple classes. An emblematic example is the CFTR worldwide most common mutation, the F508del, a deletion of phenylalanine at position 508 of the ...
... The topic of mutational classes and personalized therapy is not devoid of problems. Some mutations produce multiple effects and should be classified in multiple classes. An emblematic example is the CFTR worldwide most common mutation, the F508del, a deletion of phenylalanine at position 508 of the ...
ontology design patterns for the formalisation of biological ontologies
... independent subontologies, describing the molecular function, cellular component and biological process of gene products of other biological databases. The structure of GO is simple: the terms5 are related by two types of relationships, IsA and PartOf, creating a tree-like structure. GO allows for t ...
... independent subontologies, describing the molecular function, cellular component and biological process of gene products of other biological databases. The structure of GO is simple: the terms5 are related by two types of relationships, IsA and PartOf, creating a tree-like structure. GO allows for t ...
Intrauterine Growth Restriction (IUGR)
... 3.1. METHYLATIONOFTHEPLAGL1/HYMAIDMRDOESNOTCORRELATEWITHTHE PRESENCEOFIUGR.......................................................................................................131 CONCLUSIONS............................................................................................. ...
... 3.1. METHYLATIONOFTHEPLAGL1/HYMAIDMRDOESNOTCORRELATEWITHTHE PRESENCEOFIUGR.......................................................................................................131 CONCLUSIONS............................................................................................. ...
Document
... Homogentisic acid is secreted in urine of these patients. This is an aromatic compound and so Garrod suggested that it was an intermediate that was accumulating in mutant individuals and was caused by lack of enzyme that splits aromatic rings of amino Acids. ...
... Homogentisic acid is secreted in urine of these patients. This is an aromatic compound and so Garrod suggested that it was an intermediate that was accumulating in mutant individuals and was caused by lack of enzyme that splits aromatic rings of amino Acids. ...
Lab Manual - GRCC Instructional Home Page
... definable, measurable and controllable to produce verifiable data. For example, one would have a tough time trying to test the following question; “Did a supernatural force such as God create all life on earth?” Moreover, since the concept of God has many different meanings and definitions, it is di ...
... definable, measurable and controllable to produce verifiable data. For example, one would have a tough time trying to test the following question; “Did a supernatural force such as God create all life on earth?” Moreover, since the concept of God has many different meanings and definitions, it is di ...
The Choline/Ethanolamine Kinase Family in
... these CEK isoforms may have redundant functions in glycerolipid metabolism and plant development. Knocking Out of CEK4 Caused an Embryo-Lethal Phenotype The siliques of cek4-1/+ frequently produced wrinkled seeds (Figure 4B, red asterisks), indicative of the embryonic lethality of cek4-1/-. Siliques ...
... these CEK isoforms may have redundant functions in glycerolipid metabolism and plant development. Knocking Out of CEK4 Caused an Embryo-Lethal Phenotype The siliques of cek4-1/+ frequently produced wrinkled seeds (Figure 4B, red asterisks), indicative of the embryonic lethality of cek4-1/-. Siliques ...
The KetelD Dominant-Negative Mutations Identify
... replicates; however, the daughter centrosomes cannot separate in absence of intact NE (Figure 1G). The chromosomes fail to segregate in absence of the gonomeric spindle and disintegrate within minutes (Figure 1, G and I). The centrosomes may replicate two to three times but instead of separation the ...
... replicates; however, the daughter centrosomes cannot separate in absence of intact NE (Figure 1G). The chromosomes fail to segregate in absence of the gonomeric spindle and disintegrate within minutes (Figure 1, G and I). The centrosomes may replicate two to three times but instead of separation the ...
Genetic analysis of the floral initiation process (FLIP) in Arabidopsis
... cence to floral program requires the suppression of internode elongation, the suppression of lateral shoot development, the loss of indeterminate growth, and the initiation of floralspecific organ type and arrangement. Recent molecular and genetic analysis in both Arabidop sis and Antirrhinum majus ...
... cence to floral program requires the suppression of internode elongation, the suppression of lateral shoot development, the loss of indeterminate growth, and the initiation of floralspecific organ type and arrangement. Recent molecular and genetic analysis in both Arabidop sis and Antirrhinum majus ...
a complex voyage to the X chromosome
... recognition of the X chromosome, the MSL complex may spread to active genes on the X chromosome by recognizing marks of transcription and possibly additional DNA elements. The roles of sequence elements and transcriptional marks in targeting the MSL complex to the X chromosome and in its spreading a ...
... recognition of the X chromosome, the MSL complex may spread to active genes on the X chromosome by recognizing marks of transcription and possibly additional DNA elements. The roles of sequence elements and transcriptional marks in targeting the MSL complex to the X chromosome and in its spreading a ...
Candidate gene scan for Single Nucleotide Polymorphisms involved
... striking resemblance of monozygotic twins as well as amongst first degree relatives, ...
... striking resemblance of monozygotic twins as well as amongst first degree relatives, ...
Optimality models of phage life history and parallels in
... previous studies allowed for an intrinsic cell death rate, independent of phage killing, and the cell death rate puts an upper limit on the lysis time optimum in a stable or growing phage population. A cell death rate might obtain for various reasons—washout in a chemostat, predation from non-phage ...
... previous studies allowed for an intrinsic cell death rate, independent of phage killing, and the cell death rate puts an upper limit on the lysis time optimum in a stable or growing phage population. A cell death rate might obtain for various reasons—washout in a chemostat, predation from non-phage ...
Virulence factors of Salmonella enterica serovar Enteritidis
... multitude of cell types encountered in the various hosts (20, 56). Detailed molecular analysis of the various adhesion events is necessary to identify the critical bacterial and host components that confer the interaction. This knowledge may provide novel attractive targets for infection interventio ...
... multitude of cell types encountered in the various hosts (20, 56). Detailed molecular analysis of the various adhesion events is necessary to identify the critical bacterial and host components that confer the interaction. This knowledge may provide novel attractive targets for infection interventio ...
Thalassaemia Information Leaflet
... system). A large spleen can make anaemia worse, so you may need an operation to remove the spleen. If your spleen is removed, you will need extra immunisations and daily penicillin, to protect against certain infections (pneumococcal infection and meningitis). Transfusions can cause blood reactions ...
... system). A large spleen can make anaemia worse, so you may need an operation to remove the spleen. If your spleen is removed, you will need extra immunisations and daily penicillin, to protect against certain infections (pneumococcal infection and meningitis). Transfusions can cause blood reactions ...