Survival protein anoctamin-6 controls multiple platelet
... with residual PS exposure were smaller in size than the 8 μm-ballooning structures seen with wild-type platelets. Image quantification further learned that platelet ballooning was essentially abolished in ANO6Avor-/- blood samples (Figure 1B). Discussion In the present paper, we compared the activat ...
... with residual PS exposure were smaller in size than the 8 μm-ballooning structures seen with wild-type platelets. Image quantification further learned that platelet ballooning was essentially abolished in ANO6Avor-/- blood samples (Figure 1B). Discussion In the present paper, we compared the activat ...
Finding differentially expressed genes
... Differences between batches are even stronger than between samples in the same batch Note: batch effects at several stages Normalization is not sufficient to remove batcheffects Methods available (comBat) but not perfect Best: avoid batch effects if possible ...
... Differences between batches are even stronger than between samples in the same batch Note: batch effects at several stages Normalization is not sufficient to remove batcheffects Methods available (comBat) but not perfect Best: avoid batch effects if possible ...
Gene Section PYY (peptide YY) Atlas of Genetics and Cytogenetics
... PYY exerts its inhibitory actions via various Y receptors, including Y1 receptor-mediated epithelial responses and Y2 receptor-mediated neuronal effects. It inhibits food intake via NPY-2 receptors expressed by neurons of the arcuate nucleus of the hypothalamus. Generally, it is considered to act in ...
... PYY exerts its inhibitory actions via various Y receptors, including Y1 receptor-mediated epithelial responses and Y2 receptor-mediated neuronal effects. It inhibits food intake via NPY-2 receptors expressed by neurons of the arcuate nucleus of the hypothalamus. Generally, it is considered to act in ...
RNAi Rescue using Precision LentiORF
... analysis. However, in addition to gene-specific silencing through perfect complementarity to the target transcript, siRNA-mediated silencing can also lead to regulation of unintended transcripts through seed-region complementarity. This off-targeted regulation can potentially cause phenotypic effect ...
... analysis. However, in addition to gene-specific silencing through perfect complementarity to the target transcript, siRNA-mediated silencing can also lead to regulation of unintended transcripts through seed-region complementarity. This off-targeted regulation can potentially cause phenotypic effect ...
ERF/AP2 Subfamily A3 and ER/AP2 Subfamily A6 Genes
... General Seed Coat/ Globular Stage General Seed coat/ Heart stage General seedcoat/ pre-globular stage ...
... General Seed Coat/ Globular Stage General Seed coat/ Heart stage General seedcoat/ pre-globular stage ...
Ding, Yi : Singular Value Decomposition applied to the building of class predictor
... expression data on a genomic scale (Spellman et. al 1998, Eisen et. al 1998, Golub et. al 1999). The outputs of the experiments are expression profiles either sampled at different times or from different sources (patients belonging to different phenotype). This has a profound impact on the study of ...
... expression data on a genomic scale (Spellman et. al 1998, Eisen et. al 1998, Golub et. al 1999). The outputs of the experiments are expression profiles either sampled at different times or from different sources (patients belonging to different phenotype). This has a profound impact on the study of ...
Answers to most Study Problems for Quiz 1
... A-B- wildtype aaB- wildtype A-bb wildtype aabb = piggy b. Hypothesis: piggy is a single gene trait with 2 alleles that have a simple dominance relationship where the wildtype allele is completely dominant to the mutant allele. Mendel’s principle of segregation (and random fertilization of gametes) p ...
... A-B- wildtype aaB- wildtype A-bb wildtype aabb = piggy b. Hypothesis: piggy is a single gene trait with 2 alleles that have a simple dominance relationship where the wildtype allele is completely dominant to the mutant allele. Mendel’s principle of segregation (and random fertilization of gametes) p ...
Meiosis II
... • The chromatid threads begin to twist and condense, creating chromosomal structures which are visible to the microscope. • Each chromosome then actively seeks out its homologous chromosome. • After the homologous chromosomes pair, the structure is referred to as a tetrad (four chromatids). • The po ...
... • The chromatid threads begin to twist and condense, creating chromosomal structures which are visible to the microscope. • Each chromosome then actively seeks out its homologous chromosome. • After the homologous chromosomes pair, the structure is referred to as a tetrad (four chromatids). • The po ...
lac
... over the mutated alleles. In two cases (Is18 and Is694) however, the mutated alleles turned out to be dominant over the wild allele. ...
... over the mutated alleles. In two cases (Is18 and Is694) however, the mutated alleles turned out to be dominant over the wild allele. ...
Disruption of Individual Members of Arabidopsis Syntaxin Gene
... the T7-SYP21. Binding sites for primers 1, 2, 3, 4, and T are indicated by the arrows. Note that the T7-SYP21 transgene lacks the binding site for primer 4. (B) PCR analysis of genomic DNA extracted from representative plants of the SYP21/SYP21 (lane 1), SYP21/SYP21::T7-SYP21 (lane 2), SYP21/syp21-1 ...
... the T7-SYP21. Binding sites for primers 1, 2, 3, 4, and T are indicated by the arrows. Note that the T7-SYP21 transgene lacks the binding site for primer 4. (B) PCR analysis of genomic DNA extracted from representative plants of the SYP21/SYP21 (lane 1), SYP21/SYP21::T7-SYP21 (lane 2), SYP21/syp21-1 ...
COMMENTARY: Why do pathogens carry avirulence genes?
... avirulence but with virulence …’’ [50 ]. In the only and classic textbook on the subject, Day’s ‘‘ Genetics of HostParasite Interactions ’’, avirulence as a phenotype is explicitly compared to microbial auxotrophy and to sensitivity to a poison [12 ]. In this widely accepted view, the avirulent path ...
... avirulence but with virulence …’’ [50 ]. In the only and classic textbook on the subject, Day’s ‘‘ Genetics of HostParasite Interactions ’’, avirulence as a phenotype is explicitly compared to microbial auxotrophy and to sensitivity to a poison [12 ]. In this widely accepted view, the avirulent path ...
Project Outline
... factors with the cis-sites When a gene is active the TF interaction strength on the cis-sites will determine the onset and duration values Affinity Based Model of Temporal Regulation ...
... factors with the cis-sites When a gene is active the TF interaction strength on the cis-sites will determine the onset and duration values Affinity Based Model of Temporal Regulation ...
Plant Molecular Biology
... activities (Freemont, 2000). For several RING proteins, a ubiquitin ligase activity has been observed (Joazeiro and Weissman, 2000). E3 ubiquitin ligases recognize and interact with degradation substrates, and in this way are responsible for the specificity of protein degradation by the ubiquitin pa ...
... activities (Freemont, 2000). For several RING proteins, a ubiquitin ligase activity has been observed (Joazeiro and Weissman, 2000). E3 ubiquitin ligases recognize and interact with degradation substrates, and in this way are responsible for the specificity of protein degradation by the ubiquitin pa ...
SMAD proteins of oligodendroglial cells regulate transcription of JC
... type 1 (HIV-1) has also been established. The Tat protein of HIV-1 has been implicated in activation of the cytokine transforming growth factor (TGF)-b in HIV-1-infected cells and in stimulating JCV gene transcription and DNA replication in oligodendroglia, the primary central nervous system cell ty ...
... type 1 (HIV-1) has also been established. The Tat protein of HIV-1 has been implicated in activation of the cytokine transforming growth factor (TGF)-b in HIV-1-infected cells and in stimulating JCV gene transcription and DNA replication in oligodendroglia, the primary central nervous system cell ty ...
Mendelian Traits
... and the breakdown of cellular proteins and enzymes into their basic amino acids; hence arrows are drawn from diet and tissue proteins into phenylalanine in the figure. Three things occur to the phenylalanine in our system: (1) it is used to build peptide chains, depicted in the figure by the arrow f ...
... and the breakdown of cellular proteins and enzymes into their basic amino acids; hence arrows are drawn from diet and tissue proteins into phenylalanine in the figure. Three things occur to the phenylalanine in our system: (1) it is used to build peptide chains, depicted in the figure by the arrow f ...
AP LAB # 3: MITOSIS AND MEIOSIS
... As you have seen, mitosis maintains the chromosome number (and DNA content) from one generation of cells to the next. A second type of nuclear division is required in the life cycles of sexually reproducing organisms. Consider a sexually reproducing animal with 2 chromosomes, A and B. An animal of t ...
... As you have seen, mitosis maintains the chromosome number (and DNA content) from one generation of cells to the next. A second type of nuclear division is required in the life cycles of sexually reproducing organisms. Consider a sexually reproducing animal with 2 chromosomes, A and B. An animal of t ...
Nucleolar Dominance - Indiana University Bloomington
... sequencing ladders used as size markers. Note that 5-aza-20 deoxycytosine and trichostatin A together are not signi®cantly more effective at derepressing the B. oleracea genes than is either chemical alone, suggesting that DNA methylation and histone deacetylation are partners in the same repression ...
... sequencing ladders used as size markers. Note that 5-aza-20 deoxycytosine and trichostatin A together are not signi®cantly more effective at derepressing the B. oleracea genes than is either chemical alone, suggesting that DNA methylation and histone deacetylation are partners in the same repression ...
Reversing Chromatin Accessibility Differences that Distinguish
... Large-scale chromatin reorganization from interphase to metaphase is driven by mitotic-specific condensation factors [1, 2]. Broadly speaking, this is thought to include histone proteins undergoing post translational modifications and interaction of histone tails with neighboring nucleosomes [1]. Th ...
... Large-scale chromatin reorganization from interphase to metaphase is driven by mitotic-specific condensation factors [1, 2]. Broadly speaking, this is thought to include histone proteins undergoing post translational modifications and interaction of histone tails with neighboring nucleosomes [1]. Th ...
Transcriptional Repression of Hox Genes by C. elegans HP1/HPL
... repressive function. We showed that HIS-24 acts synergistically with HPL to allow normal reproduction, somatic gonad development, and vulval cell fate decision. Furthermore, the hpl-2; his-24 double mutant animals displayed abnormal development of the male tail and ectopic expression of C. elegans H ...
... repressive function. We showed that HIS-24 acts synergistically with HPL to allow normal reproduction, somatic gonad development, and vulval cell fate decision. Furthermore, the hpl-2; his-24 double mutant animals displayed abnormal development of the male tail and ectopic expression of C. elegans H ...
Why teach a course in bioinformatics?
... arrays, filter arrays, macroarrays, small molecule microarrays, suspension arrays, tiling arrays, transcript arrays. Related terms include arrayed library. See also chips, microarrays. ...
... arrays, filter arrays, macroarrays, small molecule microarrays, suspension arrays, tiling arrays, transcript arrays. Related terms include arrayed library. See also chips, microarrays. ...
Evolution
... genomes can be quickly compared in order to detect genetic similarities and differences. An extremely powerful bioinformatics tool is BLAST, which stands for Basic Local Alignment Search Tool. Using BLAST, you can input a gene sequence of interest and search entire genomic libraries for identical or ...
... genomes can be quickly compared in order to detect genetic similarities and differences. An extremely powerful bioinformatics tool is BLAST, which stands for Basic Local Alignment Search Tool. Using BLAST, you can input a gene sequence of interest and search entire genomic libraries for identical or ...
chromosome - OnMyCalendar
... genetically identical offspring by mitosis. • A clone is a group of genetically identical individuals from the same parent. • In sexual reproduction, two parents give rise to offspring that have unique combinations of genes inherited from the two parents. ...
... genetically identical offspring by mitosis. • A clone is a group of genetically identical individuals from the same parent. • In sexual reproduction, two parents give rise to offspring that have unique combinations of genes inherited from the two parents. ...
Factor V Leiden (FVL) / Activated Protein C (APC) Resistance And
... damage to limbs or other organs. Veins are thinner, collapsible blood vessels that carry blood back from the tissues to the heart. Venous blood clots are often associated with surgery, pregnancy, birth control pills, IV lines or other external factors. Other common risks of thrombosis include cigare ...
... damage to limbs or other organs. Veins are thinner, collapsible blood vessels that carry blood back from the tissues to the heart. Venous blood clots are often associated with surgery, pregnancy, birth control pills, IV lines or other external factors. Other common risks of thrombosis include cigare ...
Bioinformatics - University of Colorado Denver
... take a phosphate from ATP, then put that phosphate on other proteins. This “phosphorylation” turns on (in this case, Src), or can turn off another protein. 5. Once turned on, Src phosphorylates the gamma form of Phospholipase C (PLC-γ). 6. PLC-γ breaks down a lipid called PIP2 to make IP3 and DAG. I ...
... take a phosphate from ATP, then put that phosphate on other proteins. This “phosphorylation” turns on (in this case, Src), or can turn off another protein. 5. Once turned on, Src phosphorylates the gamma form of Phospholipase C (PLC-γ). 6. PLC-γ breaks down a lipid called PIP2 to make IP3 and DAG. I ...
