Applicability of Yeast Genetics to Neurologic Disease
... dent on that function in yeast, providing an assay for genetic studies. It is particularly easy to create a synthetic phenotype if the gene of interest alters transcription of another gene, either directly as a transcription factor, or indirectly through a signaling pathway. To construct such a phe ...
... dent on that function in yeast, providing an assay for genetic studies. It is particularly easy to create a synthetic phenotype if the gene of interest alters transcription of another gene, either directly as a transcription factor, or indirectly through a signaling pathway. To construct such a phe ...
Relationship between expression amount and codon usage bias
... We examined the relationship between codon usage biases, expression and Ks data from the yeast 2 gene family, multiple gene family and big gene family. We found that in the gene pairs of yeast 2 gene & multiple gene family, if one gene in the pair has a significant large codon usage bias, then the c ...
... We examined the relationship between codon usage biases, expression and Ks data from the yeast 2 gene family, multiple gene family and big gene family. We found that in the gene pairs of yeast 2 gene & multiple gene family, if one gene in the pair has a significant large codon usage bias, then the c ...
Molecular biology of prions
... intracerebral injection of a synthetic 55-residue peptide corresponding to region 89-143 of mouse PrP with a P101L substitution can induce neurological, prion-like disease, however this is achieved only in transgenic mice expressing PrP with the same mutation (Kaneko et al. 2000). The caveats here a ...
... intracerebral injection of a synthetic 55-residue peptide corresponding to region 89-143 of mouse PrP with a P101L substitution can induce neurological, prion-like disease, however this is achieved only in transgenic mice expressing PrP with the same mutation (Kaneko et al. 2000). The caveats here a ...
Do gametes woo? Evidence for non-random unions at
... facilitate comparison with observed genotype distributions (Tables 1,2), calculated TR, the ratio of heterozygotes to WT. In intercrosses without TRD, this ratio should be 2 (= 2 heterozygotes to 1 WT). Results for one sex- and both sex-TRD are remarkably similar with an excess of heterozygotes aris ...
... facilitate comparison with observed genotype distributions (Tables 1,2), calculated TR, the ratio of heterozygotes to WT. In intercrosses without TRD, this ratio should be 2 (= 2 heterozygotes to 1 WT). Results for one sex- and both sex-TRD are remarkably similar with an excess of heterozygotes aris ...
L-Lysin-Production with Corynebacterium glutamicum
... Metabolite sensors as a high-throughput tool. a)The principle of the L-lysine sensor is based on the transcription factor LysG recognizing its effector L-lysine and the fusion of the LysG-target gene with eYFP asreporter. b)Cells accumulating higher intracellular L-lysine concentrations and carrying ...
... Metabolite sensors as a high-throughput tool. a)The principle of the L-lysine sensor is based on the transcription factor LysG recognizing its effector L-lysine and the fusion of the LysG-target gene with eYFP asreporter. b)Cells accumulating higher intracellular L-lysine concentrations and carrying ...
ESEfinder: a Web resource to identify exonic splicing enhancers
... proteins cause exon skipping in several genes (11-18). In some contexts, ESEfinder appears to be remarkably accurate. For example, using a BRCA1-derived three-exon minigene system, which is very responsive to point mutations within a critical ESE, we showed that when multiple SF2/ASF-dependent ESEs ...
... proteins cause exon skipping in several genes (11-18). In some contexts, ESEfinder appears to be remarkably accurate. For example, using a BRCA1-derived three-exon minigene system, which is very responsive to point mutations within a critical ESE, we showed that when multiple SF2/ASF-dependent ESEs ...
Prof. Kamakaka`s Lecture 16 Notes
... for the regulation of this operon. Input from other environmental factors, such as the presence of glucose, could not be accounted for. Eventually it was realized that some catalytic breakdown product of glucose prevented the activation of the lac operon even in the presence of lactose. This effect ...
... for the regulation of this operon. Input from other environmental factors, such as the presence of glucose, could not be accounted for. Eventually it was realized that some catalytic breakdown product of glucose prevented the activation of the lac operon even in the presence of lactose. This effect ...
Abundance of an mRNA is the average number of molecules per cell
... Constitutive heterochromatin describes the inert state of permanently nonexpressed sequences, usually satellite DNA. Constitutive mutations cause genes that usually are regulated to be expressed without regulation. Contractile ring is a ring of actin filaments that forms around the equator at the en ...
... Constitutive heterochromatin describes the inert state of permanently nonexpressed sequences, usually satellite DNA. Constitutive mutations cause genes that usually are regulated to be expressed without regulation. Contractile ring is a ring of actin filaments that forms around the equator at the en ...
ces-1 ces-2 - Development - The Company of Biologists
... NSM sisters. Because ces-l(n703) maps much closer to fer-1 than it does to unc-29 (only 1/33 recombination events in this interval separated fer-1 and ces-1 (see above, also unpublished data)), one or both of the two lin-10 daf-8(+) fer-1 (+) unc-29 recombinant chromosomes probably carried the cesl( ...
... NSM sisters. Because ces-l(n703) maps much closer to fer-1 than it does to unc-29 (only 1/33 recombination events in this interval separated fer-1 and ces-1 (see above, also unpublished data)), one or both of the two lin-10 daf-8(+) fer-1 (+) unc-29 recombinant chromosomes probably carried the cesl( ...
Is targeted modification of cytokinin regulatory gene activity in Rapid
... supplied cytokinin may be required during early pod development. None of IPT1, 3, 5 or 7 expressed specifically in developing pods and/or seeds, so may not be ideal targets for breeding. Metabolism of cytokinins is complex and involves irreversible deactivation by CKX as well as a complex array of g ...
... supplied cytokinin may be required during early pod development. None of IPT1, 3, 5 or 7 expressed specifically in developing pods and/or seeds, so may not be ideal targets for breeding. Metabolism of cytokinins is complex and involves irreversible deactivation by CKX as well as a complex array of g ...
Delivering copper within plant cells Edward Himelblau* and
... sequence of RAN1 revealed that it is the Arabidopsis CCC2/MNK homolog, and it has been shown that RAN1 can rescue ccc2 mutant yeast [3••]. The metal-binding, membrane-spanning and ATPase domains of RAN1 are similar to those of CCC2/MNK, yet both RAN1 and CCC2 do not appear to have an important targe ...
... sequence of RAN1 revealed that it is the Arabidopsis CCC2/MNK homolog, and it has been shown that RAN1 can rescue ccc2 mutant yeast [3••]. The metal-binding, membrane-spanning and ATPase domains of RAN1 are similar to those of CCC2/MNK, yet both RAN1 and CCC2 do not appear to have an important targe ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Grantham JJ 1996). There were three genetic mutations in PKD -1, PKD -2 and recently PKD – 3 also included but not yet proven. Gene PKD – 1 is located on chromosome 16p13.3, and encodes a large(460kD) protein named polycystin 1(The International polycystic kidney disease consortium 1995) for protein ...
... Grantham JJ 1996). There were three genetic mutations in PKD -1, PKD -2 and recently PKD – 3 also included but not yet proven. Gene PKD – 1 is located on chromosome 16p13.3, and encodes a large(460kD) protein named polycystin 1(The International polycystic kidney disease consortium 1995) for protein ...
Biological Molecules
... haploid cells and are produced through the process of meiosis. Meiosis is the type of cell division that occurs in reproductive tissues. During meiosis two cellular divisions occur. In the first division, homologous chromosomes with two sister chromatids are separated, reducing the number of chromos ...
... haploid cells and are produced through the process of meiosis. Meiosis is the type of cell division that occurs in reproductive tissues. During meiosis two cellular divisions occur. In the first division, homologous chromosomes with two sister chromatids are separated, reducing the number of chromos ...
Am. J. Physiol. 1989, 257, L47
... D7S8 and thus lie closer to the CF gene. Two clones were identified in this manner by the absence of recombination in informative families. The two DNA segments were found to be 10 kb apart and were located -500 kb from the met locus by the use of pulsed-field mapping (46). They could thus be used a ...
... D7S8 and thus lie closer to the CF gene. Two clones were identified in this manner by the absence of recombination in informative families. The two DNA segments were found to be 10 kb apart and were located -500 kb from the met locus by the use of pulsed-field mapping (46). They could thus be used a ...
Salmonella typhimurium
... addition to UniProt IDs, this database provides the following proper gene ID systems that were cross-referenced by the UniProt data: OrderedLocusNames, GeneId (NCBI), and RefSeq (protein IDs of the form NP_###### or YP_#########). It also supplies UniProt-derived annotation links from the following ...
... addition to UniProt IDs, this database provides the following proper gene ID systems that were cross-referenced by the UniProt data: OrderedLocusNames, GeneId (NCBI), and RefSeq (protein IDs of the form NP_###### or YP_#########). It also supplies UniProt-derived annotation links from the following ...
Molecular mechanisms of sex determination and gonadal sex
... (Matsuda et al. 2002). Taken together, the loss-offunction mutant and the depressed expression mutant strongly indicate that DMY is required for normal testicular development. More recently, we demonstrated that a genomic DNA fragment carrying DMY, containing about 56 kb of the coding region, about ...
... (Matsuda et al. 2002). Taken together, the loss-offunction mutant and the depressed expression mutant strongly indicate that DMY is required for normal testicular development. More recently, we demonstrated that a genomic DNA fragment carrying DMY, containing about 56 kb of the coding region, about ...
Chapter 14 Notes - Parkway C-2
... One human trait in which epistasis may occur is in the occurrence of deafness in a child Question: Assume that this trait is controlled by 3 pairs of genes and that normal hearing occurs when an individual has the genotype A_ or B_. The presence of DD, however, causes deafness, no matter what other ...
... One human trait in which epistasis may occur is in the occurrence of deafness in a child Question: Assume that this trait is controlled by 3 pairs of genes and that normal hearing occurs when an individual has the genotype A_ or B_. The presence of DD, however, causes deafness, no matter what other ...
PANTHER version 11: expanded annotation data from Gene
... They can also upload a custom reference list for calculating overrepresentation by clicking on the ‘Change’ button. The Reactome pathways are accessible to both statistical test types in PANTHER: the overrepresentation tool (shown here) that takes a user-uploaded gene list as input, and the enrichme ...
... They can also upload a custom reference list for calculating overrepresentation by clicking on the ‘Change’ button. The Reactome pathways are accessible to both statistical test types in PANTHER: the overrepresentation tool (shown here) that takes a user-uploaded gene list as input, and the enrichme ...
"Silencing of Gene Expression in Cultured Cells Using Small
... initiated a new wave of reverse genetics in mammalian systems. The siRNA-mediated silencing provides fast, target-specific down-regulation of gene expression. The extent to which one can successfully carry out the silencing for determination of gene function depends on the potency of siRNAs, transfe ...
... initiated a new wave of reverse genetics in mammalian systems. The siRNA-mediated silencing provides fast, target-specific down-regulation of gene expression. The extent to which one can successfully carry out the silencing for determination of gene function depends on the potency of siRNAs, transfe ...
Archaeal Transcription Initiation - IMBB
... an area of considerable research interest. Bacteria contain “histone-like” proteins (Schmid, 1990), but despite this designation, these are not histone-like and do not form DNA–protein complexes structurally related to the nucleosome. Bacterial RNA polymerases do not, therefore, appear to face the s ...
... an area of considerable research interest. Bacteria contain “histone-like” proteins (Schmid, 1990), but despite this designation, these are not histone-like and do not form DNA–protein complexes structurally related to the nucleosome. Bacterial RNA polymerases do not, therefore, appear to face the s ...
Word file (37 KB )
... Not all genes are retained in the clustering analysis, only 5,000 significant genes with more than two-fold regulation and significance of regulation p < 0.01 in more than 5 experiments were kept. This focusses the attention to the most informative genes, yet does not bias the clustering result towa ...
... Not all genes are retained in the clustering analysis, only 5,000 significant genes with more than two-fold regulation and significance of regulation p < 0.01 in more than 5 experiments were kept. This focusses the attention to the most informative genes, yet does not bias the clustering result towa ...