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informe tecnológico de patentes
informe tecnológico de patentes

... disorder caused by the expression of mutant huntingtin protein (Htt). Suppression of Htt expression, using RNA interference, might be an effective therapy. However, if reduction of wild-type protein is not well tolerated in the brain, it may be necessary to suppress just the product of the mutant al ...


... of rice blast depends on the use of chemically synthesized fungicides. However, the repeated use of such chemicals has several drawbacks, such as their lack of specificity, increased incidence of development of resistance upon prolonged application, and the adverse impact on human health and environ ...
A mutation in the Arabidopsis mTERFrelated plastid protein
A mutation in the Arabidopsis mTERFrelated plastid protein

... SOLDAT10 encodes a protein related to the human mitochondrial transcription termination factor mTERF (Fernandez-Silva et al., 1997). The mTERF proteins have in common a modular architecture with a variable number of an approximately 30 amino acid signature termed the mTERF motif (Roberti et al., 200 ...
Course Objectives
Course Objectives

... one unexcused absence. Students who miss more than fifteen (15) minutes of a class will be marked absent. A student who leaves the classroom without the instructor’s permission will be marked absent. HCC recognizes two types of excused absences: those for personal emergencies, and those for officia ...
Efficient Delivery of Dharmacon SMARTpool® siRNA
Efficient Delivery of Dharmacon SMARTpool® siRNA

... 2) Negative control: Negative siRNA control reagents are bioinformatically designed to have no known target in the cell line of choice. These reagents are important for distinguishing sequence-specific silencing from sequence-independent effects that are associated with the delivery of siRNA into th ...
frequency distribution of antimalarial drug
frequency distribution of antimalarial drug

... Deduced haplotypes in pfcrt genet ...
(1977) New Genes for Resistance to the Brown Planthopper in Rice
(1977) New Genes for Resistance to the Brown Planthopper in Rice

... Twenty-eight rice cultivars that IRRI entomologists (9) identified as resistant to brown planthopper were studied (Table 1). All were crossed with ’TNI’, which is highly susceptibie to the brown planthopper; the F1 and F2 progenies were studied to determine the mode of inheritance. Wealso studied F~ ...
Biochemistry Lecture 23 THE LAST ONE!
Biochemistry Lecture 23 THE LAST ONE!

... • “Activated” • This intermediate links to aa arm – Forms high energy ester linkage ...
About the origins of Molecular Biology and of our Department at UTD
About the origins of Molecular Biology and of our Department at UTD

... the E. coli chromosome map is given by the threonine marker that is transferred first in a cross when the male strain is E. coli HfrH, where Hfr stands for high frequency of recombination (due to F) and H stands for Hayes. This and subsequent work made Bill Hayes and Roy Clowes the leading experts o ...
org.Mm.eg.db
org.Mm.eg.db

... assigned in the literature, users are cautioned that this map may produce multiple matching results for a single gene symbol. Users should map back from the entrez gene IDs produced to determine which result is the one they want when this happens. Because of this problem with redundant assigment of ...


... 4. An organism’s gene type, or allele combination (shown with 2 letters) is known as its ______________ a. phenotype b. genotype c. heterotype d. notmytype 5. An organism’s physical appearance, or what it looks like is called its… a. phenotype b. genotype c. heterotype d. notmytype Match the correct ...
A Novel PCR Detection Method for Major Fish Pathogenic Bacteria
A Novel PCR Detection Method for Major Fish Pathogenic Bacteria

... This bacterium has been identified as the main cause of fish vibriosis, which has caused severe economic losses in the fish farming industry (Ganzhorn, 2005; Actis et al., 2011). To control and monitor the outbreak of vibriosis in fish farms, development of a method for rapid diagnosis is important. ...
A long-term demasculinization of X
A long-term demasculinization of X

... noncoding RNAs from novel exons of protein-coding genes or nondegraded intronic transcripts (we provide the chromosomal distribution of intronic ncRNAs in Supplemental Fig. S2). In all three comparisons performed using male/female adult transcriptome profiles derived from either whole body or reprod ...
Translational control of regA, a key gene controlling
Translational control of regA, a key gene controlling

... Karin Babinger1, Armin Hallmann2 and Rüdiger Schmitt1,* The complete division of labour between the reproductive and somatic cells of the green alga Volvox carteri is controlled by three types of genes. One of these is the regA gene, which controls terminal differentiation of the somatic cells. Here ...
Molecular Evolution of Overlapping Genes
Molecular Evolution of Overlapping Genes

... Chapter Seven: Summary ...
Journal of Bacteriology
Journal of Bacteriology

... Construction of psoA::gfp transcriptional fusions. A 1.2-kb HindIII fragment containing the luxI promoter and the gene encoding green fluorescent protein (gfp) from pJBA89 (1) was cloned into the broad-host-range vector pBBR1MCS-5 (23), resulting in pMP4670. Subsequently the SphI fragment containing ...
The somatic-visceral subdivision of the embryonic mesoderm is
The somatic-visceral subdivision of the embryonic mesoderm is

... balancer chromosome. Mutants also possess an expanded cephalic furrow. The details of the 2xPE-sna fusion gene are described by Ip et al. (1994). It includes the entire sna genomic coding region and 1.6 kb of the 5′ flanking sequences. This genomic fragment was placed downstream of two tandem copies ...
A Haploid System of Sex Determination in the Brown Alga - Hal-CEA
A Haploid System of Sex Determination in the Brown Alga - Hal-CEA

... male V are expected to be under similar evolutionary pressures not only because they function independently in different individuals but also because neither the U nor the V SDR haplotype recombines [8, 9]. As a result, both haplotypes are expected to exhibit the effects of loss of recombination, su ...
High-resolution melting analysis of the single nucleotide
High-resolution melting analysis of the single nucleotide

LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs
LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

... homozygosity region, together with the c.1552A>T mutation, were genotyped and tested for association from 28 BFJE cases and 112 healthy controls. doi:10.1371/journal.pgen.1002194.t001 Next we studied segregation of the sequence change in the pedigree. Of the 28 affected dogs from which we had sample ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics

... MLL (11q23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. ...
Multi-petal cyclamen flowers produced by
Multi-petal cyclamen flowers produced by

... Chimeric repressor gene-silencing technology (CRES-T) provides a powerful tool for dominant negative genetic modification of a transcription factor. In CRES-T, a short but strong, plant-specific transcriptional repression domain (SRDX) is fused to the coding sequence of transcription factor of inter ...
The whole paper can be downloaded here if you like.
The whole paper can be downloaded here if you like.

... past 100 years. The development of antibiotics was and is still a weapon of massive importance to the prevention of disease. However, bacteria have many methods to create resistance to adapt to the onslaught of microscopic assassins thrown at them. Bacteria have many dynamic characteristics, which e ...
Ectocarpus
Ectocarpus

... no heterozygous sex comparable to XY males or ZW females. This difference between UV and XY/ZW systems should have important implications for SDR evolution [8, 9]. In particular, the female U and male V are expected to be under similar evolutionary pressures not only because they function independen ...
14-31 - McGraw Hill Higher Education
14-31 - McGraw Hill Higher Education

... Slides prepared by Karen Burke da Silva, Flinders University ...
< 1 ... 39 40 41 42 43 44 45 46 47 ... 1045 >

Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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