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Knudson - Memorial University
Knudson - Memorial University

... drawn to pediatrics. I was disappointed in the first two preclinical years because of the excessive memorization required, in great contrast to Caltech’s theme of problem solving. To my pleasant surprise, the clinical years brought me back to problem solving. Despite the fact that I was at a great m ...
G 1 - University of Queensland
G 1 - University of Queensland

... Two Groups in Two Dimensions. All cluster information would be lost by collapsing to the first principal component. The principal ellipses of the two groups are shown as solid curves. ...
38.1. Bone: Appendicular Skeleton, Trunk, Skull and Facial Bones
38.1. Bone: Appendicular Skeleton, Trunk, Skull and Facial Bones

... CIC–DUX4–positive SRC/SCTs. CIC–DUX4 fusions are emerging as the most prevalent genetic event in EWSR1-negative SRC/SCTs, accounting for two thirds of cases in this group. CIC–DUX4 fusion results from two possible translocation events, either a t(4;19)(q35;q13) or t(10;19)(q26.3;q13). In contrast to ...
Analysis of Similarities/Dissimilarities of DNA Sequences Based on a
Analysis of Similarities/Dissimilarities of DNA Sequences Based on a

... -501that most of the 11 sequences are rich in dinucleotide of TG, while lack of TA and CG, information of other dinucleotides can also be inspected intuitively according to the colorbar. In addition, we can see that Gorilla and Chimpanzee have the most similar compositions and densities of dinucleo ...
Gene Section USF1 (upstream transcription factor 1) Atlas of Genetics and Cytogenetics
Gene Section USF1 (upstream transcription factor 1) Atlas of Genetics and Cytogenetics

... factors. The bHLH-ZIP domains are important for DNA binding and dimerization. USF homo- and heterodimers activate transcription of target genes through binding either at distal E-box elements or at pyrimidine-rich Inr elements in the core promoter (Roy et al., 1997). Whole genome ChIP-chip analysis ...
Transgenic Alteration of Sow Milk to Improve Piglet Growth and...
Transgenic Alteration of Sow Milk to Improve Piglet Growth and...

... The amount and composition of milk that a sow produces has a significant impact on the growth, health and development of her offspring. Piglet growth and health influences all subsequent aspects of pork production. In swine, 44% of the growth of suckling pigs is accounted for by the volume and solid ...
Supplementary Table S1: Published information about
Supplementary Table S1: Published information about

... The nudel gene, which is expressed in follicle cells covering the oocyte encodes an unusual mosaic protein resembling an extracellular matrix protein with a central serine protease domain and has been proposed to function in locally triggering a protease cascade that produces the ventral signal. The ...
Screening for homozygosity by descent in families with autosomal
Screening for homozygosity by descent in families with autosomal

... from an adequate sample size. An initial screen was conducted with DNA from parents and one affected offspring. There were 10 sets of genotypes (one set for each family) per marker. Seven markers did not give clearly interpretable results and were not taken into account. For the remaining 34 markers ...
journal - Bradon Smith
journal - Bradon Smith

... of ‘contaminated’ popular science as a crucial corollary of the maintenance of the ideal of ‘pure’ scientific knowledge, shoring up ‘an idealised view of genuine, objective, scientifically-certified knowledge’ and also placing the judgement of which popularizations are ‘“appropriate” [...] and which ...
Gene Section FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase))
Gene Section FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase))

... variants were reported to encode polypeptides containing 575, 446, 308 and 169 amino acid residues. The 575 residue protein is a fully active alpha1,6fucosyltransferase, which was first of the variants to be identified. ...
Cowboy Genetics
Cowboy Genetics

... homozygous normal, known carrier is heterozygous and the PHA affected individual is homozygous for the opposite allele as the normal individual) are documented and examined further. Each mutation you examine is another panel of DNA samples from different types of animals. All the calves with PHA sho ...
Polyploidy and genome evolution in plants
Polyploidy and genome evolution in plants

... Arabidopsis suecica, soybean, and tobacco, have become experimental systems for addressing questions in younger allopolyploids. Even more recent are allopolyploids in Tragopogon, Spartina and Senecio that were formed within the past 200 years [29,30,31,32]. These situations provide a rich opportun ...
Microarrays - Consortium for Mathematics and its Applications
Microarrays - Consortium for Mathematics and its Applications

... spots will have both colors. Also, some cDNAs may not bind to any of the 6 genes and can be placed off to the side. You set to work. Since your DNA biology is a little rusty, you are not as fast as your friend Shiv. After finding a few cDNAs that match you start to see some patterns and pick up you ...
Gene Section FAT1 (FAT tumor suppressor homolog 1 (Drosophila))
Gene Section FAT1 (FAT tumor suppressor homolog 1 (Drosophila))

... Expressed in epithelial, endothelial and smooth muscle cells. ...
Biology Keystone Review Packet
Biology Keystone Review Packet

... Nitogenous bases can be cytosine (C), thymine (T), uracil (U), adenine (A), or guanine (G) ...
Mutational Analysis of a Patient with Concomitant
Mutational Analysis of a Patient with Concomitant

... From mutational analysis, we were able to establish a genetic and biochemical configuration of CTX in our patient. No mutations were found on the DHCR7 gene. According to Krakowiak et al., to date, all individuals with SLOS have been shown to have mutations in the sterol ∆7-reductase gene [7]. We we ...
Induced neural stem/precursor cells for fundamental studies and
Induced neural stem/precursor cells for fundamental studies and

... instability while retaining the self-renewing capacity. This iNSC/iNPC technology has fueled much excitement in regenerative medicine, as these cells can be differentiated into target cells for re placement therapy for neurodegenerative diseases. Patients’ somatic cell-derived iNSCs/iNPCs have also ...
Lecture 21: Gene Set Enrichment Analysis
Lecture 21: Gene Set Enrichment Analysis

... • Increase sum when gene in set, decrease it otherwise. • Magnitude of increment depends on correlation of gene with phenotype. • Record the maximum deviation from zero as the ...
ppt檔案
ppt檔案

... old) and forager bees (28 to 32 days old) showed significant differences in the expression of many genes  The gene expression patterns reflect the bee’s behavior, not its age  The gene expression profile in the brain of a honeybee nurse differs from that of the forager brain, even if the nurse and ...
The dual nature of homologous recombination in plants
The dual nature of homologous recombination in plants

... metabolic activities. Numbers are not available for plants, but it has been estimated that 5–10% of first passage primary fibroblasts from mice or humans have a chromosome break (discussed in Ref. [33]). In plants and vertebrates most of these breaks are repaired by nonhomologous-end joining (NHEJ), ...
Usage Mitochondrial 16S rRNA Gene as Molecular Marker in
Usage Mitochondrial 16S rRNA Gene as Molecular Marker in

... and 6.5 µl distilled water. This means component concentration 25 ng of template DNA, 5pmoles of primer, 0.1 mM of each dNTPs, 4 mM MgCl2, 0.5 U of Taq polymerase and master mix buffer solution. The reaction conditions were one cycle at 95o C for 5 min., 35 cycle at 95o C for 1 min., 58o C for 1 min ...
In vitro translation with non
In vitro translation with non

... to the 20 natural aa’s (total 32 aa’s). The GTA will contribute to that greater goal, via individual subprojects with Drs Collighan and Spickett. The Collighan research group has extensive experience of working with firefly luciferase. They have generated mutations that improve thermostability or de ...
GENETICS OF BACTERIOCINS BIOSYNTHESIS BY LACTIC ACID
GENETICS OF BACTERIOCINS BIOSYNTHESIS BY LACTIC ACID

... regulation of the gene expression). This is not unexpected because in the simplest case the bacteriocin expression needs at least two genes: one structural gene and another one that encodes an immunity protein specific to the produced bacteriocin. In most cases bacteriocin production needs also a sp ...
thalassaemia mutations in Sardinians
thalassaemia mutations in Sardinians

... In the Sardinian population, one 1 thalassaemia mutation, namely a C-T substitution at the codon corresponding to amino acid 39 (1339), is widely prevalent accounting for the majority (95%) of cases of thalassaemia major and intermedia.' 2 Prenatal diagnosis in this population is therefore carried o ...
Slide 1
Slide 1

... chromosome 9 it is expressed only in liver cells in a cell cycle dependent fashion. The up gene contains two domains. Domain 1 contains a kinase which is important for cell proliferation. Domain 2 inhibits the kinase activity of domain 1 when it is phosphorylated. The beef gene contains 3 domains al ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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