Point mutations in BCL6 DNA-binding domain reveal distinct
... respectively) on B6(9)-SV40-Luc. Thus, these two proteins have the ability to bind to the reporter and to inhibit transcription to the same extent as the wild type protein. By contrast, BCL6 proteins carrying a mutation in any one of the remaining ZFs (mutants 3–6) exhibited a dramatic loss in their ...
... respectively) on B6(9)-SV40-Luc. Thus, these two proteins have the ability to bind to the reporter and to inhibit transcription to the same extent as the wild type protein. By contrast, BCL6 proteins carrying a mutation in any one of the remaining ZFs (mutants 3–6) exhibited a dramatic loss in their ...
KIR3DL1 Phenotype Variation?
... (high, low, and null) on the NK cell surface (9), a phenomenon due at least in part to variation in the extracellular domains (14). Because DX9 blocks the interaction between KIR3DL1 and Bw4, enabling NK cells to kill Bw4⫹ targets (15), the quantity of KIR3DL1 on the cell surface could affect the in ...
... (high, low, and null) on the NK cell surface (9), a phenomenon due at least in part to variation in the extracellular domains (14). Because DX9 blocks the interaction between KIR3DL1 and Bw4, enabling NK cells to kill Bw4⫹ targets (15), the quantity of KIR3DL1 on the cell surface could affect the in ...
Ch15-Computational_Approaches_in_Comparative_Genomics
... By comparing genomes to gain a better understanding of the similarities & differences between genomes over evolutionary times ...
... By comparing genomes to gain a better understanding of the similarities & differences between genomes over evolutionary times ...
PDF
... alleles of the PEGs. However, a deletion on the paternal chromosome does not have this effect (Lin et al., 2003). The mechanism by which the IG-DMR regulates Dlk1-Gtl2 imprinting is unclear. It is likely that the IG-DMR acts as a positive regulator activating Gtl2 transcription and its downstream no ...
... alleles of the PEGs. However, a deletion on the paternal chromosome does not have this effect (Lin et al., 2003). The mechanism by which the IG-DMR regulates Dlk1-Gtl2 imprinting is unclear. It is likely that the IG-DMR acts as a positive regulator activating Gtl2 transcription and its downstream no ...
Molecular Plant-Microbe Interactions
... strain N33 (Cloutier et al. 1996a). By Southern hybridization, with the nodABC genes from Bradyrhizobium japonicum as a probe on total genomic DNA of strain N33, we showed previously that this probe hybridized with a 4.1-kb EcoRI fragment (pJC1) coding potentially for the nodA gene (Cloutier et al. ...
... strain N33 (Cloutier et al. 1996a). By Southern hybridization, with the nodABC genes from Bradyrhizobium japonicum as a probe on total genomic DNA of strain N33, we showed previously that this probe hybridized with a 4.1-kb EcoRI fragment (pJC1) coding potentially for the nodA gene (Cloutier et al. ...
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... transposition affords an opportunity to seal chromosome breaks. Other possible benefits have not been excluded. Thus the relationship between transposable elements and their hosts may be as much symbiotic as parasitic. Resolving these issues is an interesting challenge for future research. Discovery ...
... transposition affords an opportunity to seal chromosome breaks. Other possible benefits have not been excluded. Thus the relationship between transposable elements and their hosts may be as much symbiotic as parasitic. Resolving these issues is an interesting challenge for future research. Discovery ...
Assembly of additional heterochromatin distinct from centromere
... used (Ikeno et al., 1998). To investigate how transcriptional activity and resulting chromatin structures affect de novo centromere-chromatin assembly and HAC formation, we first constructed the basic alphoid BAC (7C5-basic BAC). It contains 70 kb of type-I alphoid (␣21-I) array, inverted human telo ...
... used (Ikeno et al., 1998). To investigate how transcriptional activity and resulting chromatin structures affect de novo centromere-chromatin assembly and HAC formation, we first constructed the basic alphoid BAC (7C5-basic BAC). It contains 70 kb of type-I alphoid (␣21-I) array, inverted human telo ...
c-Myc co-ordinates mRNA cap methylation and ribosomal RNA
... The enzymes that catalyse mRNA cap synthesis are configured in a species-specific manner [6]. In mammals, the triphosphatase and guanylyltransferase are contained in one protein, CE/RNGTT (capping enzyme/RNA guanylyltransferase and 50 -triphosphatase). The methyltransferase, RNMT (RNA guanine-7 methyl ...
... The enzymes that catalyse mRNA cap synthesis are configured in a species-specific manner [6]. In mammals, the triphosphatase and guanylyltransferase are contained in one protein, CE/RNGTT (capping enzyme/RNA guanylyltransferase and 50 -triphosphatase). The methyltransferase, RNMT (RNA guanine-7 methyl ...
A Genetic Linkage Map for the Zebrafish
... of making both haploid embryos and parthenogenetic diploid fish facilitate the identification and analysis of mutations (3). Saturating the genome with mutations that affect various aspects of the early development of zebrafish seems to be an attainable goal (2). The ability to make stable lines of ...
... of making both haploid embryos and parthenogenetic diploid fish facilitate the identification and analysis of mutations (3). Saturating the genome with mutations that affect various aspects of the early development of zebrafish seems to be an attainable goal (2). The ability to make stable lines of ...
From genomes to function: haloarchaea as model organisms
... environments, i.e. they are not only osmotolerant but typically require molar salt concentrations for cellular integrity and growth. This is explained by the mechanism of osmoadaptation that involves at least equimolar salt concentration in the cytoplasm compared to their environment. The question h ...
... environments, i.e. they are not only osmotolerant but typically require molar salt concentrations for cellular integrity and growth. This is explained by the mechanism of osmoadaptation that involves at least equimolar salt concentration in the cytoplasm compared to their environment. The question h ...
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... and occurs independently of the concentrations of lac (NRRL deposit no. B-l8292) was cloned as a 4.5 Kbp tose or glucose present in the cell. For example, in the BamHI to PstI fragment in the vector pTJ S260. Not all presence or absence of IPTG or lactose, a new protein the sequence of pTJS260 or of ...
... and occurs independently of the concentrations of lac (NRRL deposit no. B-l8292) was cloned as a 4.5 Kbp tose or glucose present in the cell. For example, in the BamHI to PstI fragment in the vector pTJ S260. Not all presence or absence of IPTG or lactose, a new protein the sequence of pTJS260 or of ...
The Sexual Nature of the Eukaryote Genome
... In bacteria, the parasitic nature of conjugation has long been apparent and is well understood mechanistically at a molecular level. Cells bearing an F plasmid transmit a copy of this plasmid to an uninfected partner, through the ability of the plasmid to encode partial cell fusion and gene transmis ...
... In bacteria, the parasitic nature of conjugation has long been apparent and is well understood mechanistically at a molecular level. Cells bearing an F plasmid transmit a copy of this plasmid to an uninfected partner, through the ability of the plasmid to encode partial cell fusion and gene transmis ...
Chapter 14: Mendel and the Gene Idea
... What is the probability that a couple will have a girl, a boy, a girl, and a boy in this specific order? ...
... What is the probability that a couple will have a girl, a boy, a girl, and a boy in this specific order? ...
Evaluation of the Water Stress-Inducible
... (Valliyodan and Nguyen, 2006), with water deficit stresses such as drought and high salinity being major contributors. Globally, water deficit stresses have been estimated to be responsible for over $10 billion in lost crop yield each year (Xu et al., 2014). It is estimated that by the year 2050, th ...
... (Valliyodan and Nguyen, 2006), with water deficit stresses such as drought and high salinity being major contributors. Globally, water deficit stresses have been estimated to be responsible for over $10 billion in lost crop yield each year (Xu et al., 2014). It is estimated that by the year 2050, th ...
Presentation
... Chromosome/chromatid assays • Micronucleus formation - classic assay especially in occupational exposure • Chromosome/ chromatid aberration - classic exposure dosimetric assay ...
... Chromosome/chromatid assays • Micronucleus formation - classic assay especially in occupational exposure • Chromosome/ chromatid aberration - classic exposure dosimetric assay ...
Solid Tumour Section Thyroid: Papillary carcinoma with inv(7)(q21q34) in Oncology and Haematology
... of all cases. The only known etiologic factor for this type of tumor is exposure to ionizing radiation, although the history of radiation exposure is found in less than 10% of all cases. In the last year it became evident that alterations in the MAPK pathway, an intracellular cascade that regulates ...
... of all cases. The only known etiologic factor for this type of tumor is exposure to ionizing radiation, although the history of radiation exposure is found in less than 10% of all cases. In the last year it became evident that alterations in the MAPK pathway, an intracellular cascade that regulates ...
Name: Date: Title: Problem Solving Techniques. Introduction. The
... If multiple loci are involved, what are their linkage arrangements? ...
... If multiple loci are involved, what are their linkage arrangements? ...
Statistical Analysis of Microarray Data
... Simple normalization of microarray data. The difference between the raw fluorescence is a meaningless number. Computing ratios allows immediate visualization of which genes are higher in the red channel than the green channel, but logarithmic transformation of this measure on the base 2 scale result ...
... Simple normalization of microarray data. The difference between the raw fluorescence is a meaningless number. Computing ratios allows immediate visualization of which genes are higher in the red channel than the green channel, but logarithmic transformation of this measure on the base 2 scale result ...
Yeast genome evolution-the origin of the species
... be needed under certain conditions that were not studied in the laboratory [14,15]. Given that truly redundant genes are unlikely to exist and assuming that a gene is initially present in all individuals in a population, there are three circumstances that could allow it to become lost: (a) if the se ...
... be needed under certain conditions that were not studied in the laboratory [14,15]. Given that truly redundant genes are unlikely to exist and assuming that a gene is initially present in all individuals in a population, there are three circumstances that could allow it to become lost: (a) if the se ...
Review packet for Biology Keystone Exam
... brown eyes" is a really big, powerful gene. Whenever it gets into a cell, it overshadows anything else that's there and makes sure it gets expressed. On the other hand, the copy that says "Don't make brown eyes" is a little, quiet gene that allows the "Make brown eyes" gene to be expressed. The only ...
... brown eyes" is a really big, powerful gene. Whenever it gets into a cell, it overshadows anything else that's there and makes sure it gets expressed. On the other hand, the copy that says "Don't make brown eyes" is a little, quiet gene that allows the "Make brown eyes" gene to be expressed. The only ...
What unique chromosomal events lead to the formation of a haploid
... Meiosis is a unique and defining event of gametogenesis serving at least two functions in the reproductive life cycle: it reduces chromosome number to the haploid state in the gamete (thus allowing diploidy to be restored at fertilization), and it shuffles gene allele combinations, giving rise to ge ...
... Meiosis is a unique and defining event of gametogenesis serving at least two functions in the reproductive life cycle: it reduces chromosome number to the haploid state in the gamete (thus allowing diploidy to be restored at fertilization), and it shuffles gene allele combinations, giving rise to ge ...
Slide 1
... Cells, Chromosomes and DNA 2. Genetic characteristics are handed down by simple rules – There are patterns and processes in inheritance ...
... Cells, Chromosomes and DNA 2. Genetic characteristics are handed down by simple rules – There are patterns and processes in inheritance ...