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PGC-1α: a key regulator of energy metabolism
PGC-1α: a key regulator of energy metabolism

... members of a relatively large family of nuclear receptors, all of which are subject to transcriptional coactivation by PGC-1␣. PPAR-␥ is essential for adipogenesis and differentiation (31), whereas PPAR-␣ and PPAR-␦ play important roles in the control of fatty acid oxidation (61). In addition, PPAR- ...
De novo Structure Variations of the Y Chromosome in a 47,XXY
De novo Structure Variations of the Y Chromosome in a 47,XXY

... completely failed. Although the patient denied a family history of ovarian failure, the karyotypes of her family members were analyzed using G-banding. Intriguingly, chromosome analysis revealed a 47,XXY karyotype only in the patient (fig. 1a), whereas the karyotypes of her parents and younger broth ...
Biomarkers for Epithelial Ovarian Cancers
Biomarkers for Epithelial Ovarian Cancers

... tumors are re ected in a high level of CA 125 antigen. However, it is not a good marker for early stage tumors, and may yield false positives. Clearly, there is a need for better understanding of the molecular pathogenesis of epithelial ovarian cancer, so that new drug targets or biomarkers that fac ...
Heredity Quiz 2017 Self-Testing Guide DUE day of quiz! ANSWERS
Heredity Quiz 2017 Self-Testing Guide DUE day of quiz! ANSWERS

... Genes and Dominance-. Remember when we learned about trait inheritance and dominance by putting leaves on a tree and created adorable baby caterpillars to practice our knowledge of the 4 rules of inheritance, 5. Who are your genes inherited from? Our genes are inherited from our parents. We receive ...
Restriction Enzyme Digest and Plasmid mapping
Restriction Enzyme Digest and Plasmid mapping

... On the other hand, separation of very small (less than 1 kb) can be better achieved in higher percentage agarose gel, such as a 1.5-2% gel. Making DNA Visible DNA is colorless so DNA fragments in the gel cannot be seen during electrophoresis. The loading dye (or loading buffer) does not stain the DN ...
CD99 and CD99L2 are Mediators of Homotypic Adhesion in Human
CD99 and CD99L2 are Mediators of Homotypic Adhesion in Human

... – H3K79: ambiguous, but known to activate Hoxa9 transcription – Bivalence: both activating and silencing modifications present. ...
A plant dialect of the histone language
A plant dialect of the histone language

... transcriptional regulation and methyl transferases contain well conserved domains among different organisms. In contrast to other modifications, no histone demethylases have thus far been identified, although theoretical studies recently predict their existence [23]. Histone methylation is correlate ...
Isolation of Dynein Light Chains and determination of
Isolation of Dynein Light Chains and determination of

... • The erythrocytic stages of the parasite life cycle are responsible for all symptoms and pathologies of the disease. • The symptoms are; fever, ...
Host genetics and disease resistance
Host genetics and disease resistance

BB - Life Science Classroom
BB - Life Science Classroom

... harmful chemicals, radiation form nuclear bomb explosions are some of the causes of mutated genes. The offspring will inherit the mutated gene ...
Genetic manipulation and quantitative
Genetic manipulation and quantitative

... 2000) has recently been investigated. However, overexpression of either GOGAT gene has not been reported in plants, including rice. In the first chapter of this review, recent transgenic work expressing sense RNA for NADH-GOGAT in an indica rice is described. Conventional approaches that involve who ...
Asilomar - University of Notre Dame
Asilomar - University of Notre Dame

... capabilities include: ...
Chapter 1. Fundamental Properties of Genes
Chapter 1. Fundamental Properties of Genes

... In 1902, Sutton and Boveri independently realized that the behavior of genes in Mendelian crosses mimics the movement of chromosomes during meiosis and fertilization. They surmised that the two alleles of each gene correlated with the homologous pair of chromosomes. The equal segregation of alleles ...
Bacterial Gene Expression—Lac Operon
Bacterial Gene Expression—Lac Operon

... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
as a PDF
as a PDF

... neighbors that share a common ancestry. The expression of Fragilis, an interferoninducible transmembrane protein, marks the beginning of germ cell competence. Using single-cell gene expression profiles, these authors demonstrated that the cells, at 7.25 days post coitum (dpc), show the highest expre ...
"Engineering Large Animal Species to Model Human Diseases". In
"Engineering Large Animal Species to Model Human Diseases". In

... alone, the nuclease initiates a DSB, which is repaired by the error-prone nonhomologous end joining (NHEJ) process. This process results in variable sized insertions or deletions (indels), which can yield frameshift mutations, effectively knocking out the targeted gene. Alternatively, if the nucleas ...
Polymorphism of the CTNNB1 and FOXL2 Genes is not
Polymorphism of the CTNNB1 and FOXL2 Genes is not

... (CFA23). Interestingly, two important genes for ovarian development are located on this chromosome: CTNNB1 (Catenin [Cadherin-Associated Protein], Beta 1) and FOXL2 (forkhead box L2). The CTNNB1 gene is activated by two signaling molecules: RSPO1 (R-spondin 1) and WNT4 (wingless-type MMTV integratio ...
Course leader - University of Warwick
Course leader - University of Warwick

... timetable changes by email with at least 24 hours notice. Failure to note timetable changes will result in loss of credit for attendance.  IAMBEC students to submit all work to Mrs. Christina Forbes.  MOAC students to submit all work to Mrs. Monica Lucena.  Plagiarism policy: Any text directly cu ...
Lac Operon - Faculty Web Pages
Lac Operon - Faculty Web Pages

... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
References - Plant Developmental Biology
References - Plant Developmental Biology

... Confocal laser scanning microscopy (CLSM) represents one of the most significant advances in optical microscopy ever developed. This technique enables visualization deep within both living and fixed cells and tissues and affords the ability to collect sharply defined images of cellular components or ...
R - Genetics
R - Genetics

... either with the specific DNA (from a capsule-deficient strain) responsible for their production or with the DNA extracted from cells of their own strain (clone). This finding suggests genotypic identity of the capsule-deficient transformants with the capsule-deficient donor cells. The spontaneous ca ...
Full Text PDF - Journal of Integrative Plant Biology
Full Text PDF - Journal of Integrative Plant Biology

... mut ants, have b een found, and ph enoty pes of them are controlled by a single ressesive gene. Khu sh and Librojo (1985) reported op, nsr and lhs1 gene are allelic. Furthermore, Thakur and Roy (1975) isolated lp-1 and lp-2 (long palea-1, lon g palea-2) genes. In o ur exp eriment, th e effects o f l ...
Complete Sequence of the Mitochondrial DNA of
Complete Sequence of the Mitochondrial DNA of

... However, phylum Mollusca is the marked exception to the rule, and the mitochondrial genomic structure is unusually variable. Complete mitochondrial gene organizations have been determined for five molluscan species (representing three different classes): the blue mussel Mytilus edulis, of the class ...
Type-2 fuzzy Approach for Disease-Associated Gene Identification on Microarrays  Yan-Fei Wang
Type-2 fuzzy Approach for Disease-Associated Gene Identification on Microarrays Yan-Fei Wang

... Ten best-ranked genes of diabetes identified by the type2 FM-test and the original FM-test are shown in Table II. From this table we see that the results of the two methods are not much different. We identified gene U61734 and gene Z26491 by the type-2 FM-test instead of gene U06452 and gene X57959 ...
FROM PEAS TO PUPS
FROM PEAS TO PUPS

... egg cell, with its new set of 39 chromosomes, a fertilized cell or zygote is formed. A new puppy starts from this single cell, which now contains 39 chromosomes from the sire and 39 chromosomes from the dam. At this point, each puppy’s conformation and temperament are going to result from a double s ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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