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reprint - Oleg Igoshin
reprint - Oleg Igoshin

... The effects of intrinsic noise on operon maintenance are not well characterized, but covariance between protein levels arising from intrinsic noise depends on transcriptional coupling (coexpression from an operon) of the corresponding genes [15]. The order of genes within an operon may also affect n ...
Candidate interactions EDITORIAL
Candidate interactions EDITORIAL

... Gly16 allele (or Gly16Gln27 haplotype), which is functionally associated with enhanced receptor function, has a protective role towards subphenotypes of asthma in relation to age, specific expression of the disease, such as nocturnal symptoms, and interaction with environmental factors. The conceptu ...
Comparative study of overlapping genes in bacteria, with special
Comparative study of overlapping genes in bacteria, with special

... means of compressing the maximum amount of information into short sequences of structural genes and may be a result of evolutionary pressure to minimize genome size and increase the density of genetic information; and (2) as a mechanism for regulating gene expression through translational coupling o ...
Survival of the Sickest Reading Guide
Survival of the Sickest Reading Guide

... 48. How does streptococcus cause your body to attack itself? 49. Define xenophobia and how does it affect the spread of disease? 50. What is virulence? 51. Describe three ways microbes move from host to host. 52. How can we treat pathogens by changing their evolutionary path? 53. What does vaccine l ...
GENECLEAN® Kit
GENECLEAN® Kit

... The best method for checking yields of DNA isolated by GENECLEAN® is to run an aliquot on an agarose gel using known quantities in adjacent lanes as controls. OD260 and fluorescent readings can also be used to estimate yields, but these methods are affected by trace amounts of salts and silica matri ...
Duplication and Inherited Susceptibility of Chromosome 15q11
Duplication and Inherited Susceptibility of Chromosome 15q11

... social impairment. This approach is likely to identify genetically more homogeneous groups of families; analysis of these families should reveal more significant findings for gene locus variants that specifically affect a particular phenotype domain. Support for this strategy is found in efforts to ide ...
Project Summary The single nucleotide polymorphisms (SNPs) are
Project Summary The single nucleotide polymorphisms (SNPs) are

... disorders,  and  infertility.  However,  the  effects  of  SNPs  on  biological  clock  and  the  related  disorders   are  not  well  understood.  CLOCK/BMAL1  heterodimers  bind  DNA  of  clock  target  genes  at  E-­‐boxes  and   initiat ...
Clamp loader structure predicts the architecture of DNA polymerase
Clamp loader structure predicts the architecture of DNA polymerase

... should be somewhat destabilized by the spring tension between internal domains. In other words, these ‘springs’ would exert an opening force on the interface, weakening them. This should make it easier to open the first interface. Now consider the remaining interface after the first has opened. The ...
Presentation - Cloudfront.net
Presentation - Cloudfront.net

... different positions in the other genomes, some are inverted and appear on the bottom strand of the double stranded genome ...
as a PDF
as a PDF

... human clock-gene variation reported to affect human circadian rhythmicity (8). Katzenberg et al. discovered this variation by comparing the sequence alignment of expressed sequence tags of the Clock gene recorded in the public database. They also administered the HorneOstberg (H-O) questionnaire, wi ...
Genetically Modified Crops and Soil
Genetically Modified Crops and Soil

... enormously the biomass of resistance genes. We cannot predict what the effect of such amplification will be.…It is considered that the growth and use of transgenic plants [containing a particular gene] will increase significantly the number of resistance genes in the environment and could create new ...
Biomarker Detection for Hexachlorobenzene Toxicity Using Genetic
Biomarker Detection for Hexachlorobenzene Toxicity Using Genetic

... goal in finding diagnostic markers is to minimize the number of needed data without affecting accuracy. If the toxin causes a response in gene expression level, microarray technology is very powerful for biomarker discovery [4-5]. The entire human genome can be contained on a single microchip, enabl ...
Chromosomal Amplification Is Associated with
Chromosomal Amplification Is Associated with

... indicate threshold values of 0.80 and 1.20 for loss and gain, respectively. resistant tumors. These data, therefore, comprise the first evidence of chromosomal amplification in GCTs associated with resistance. Among the other sites amplified that were restricted to resistant tumors, several are of f ...
PDF
PDF

... We do not seriously doubt the hypothesis that the first metamerically segmented ancestors of the arthropods were homonomous - though there is at present no way of knowing where to place that ancestor on the phylogenetic tree. We do question whether homonomy is generally a primitive trait among extan ...
Dominant/Recessive
Dominant/Recessive

... code for how a certain molecule can be made. The molecules produced by the genes can generally be sorted into two different types: ones that run the chemical reactions in your body, and ones that will be the structural components of your body. How an organism looks and functions is a result of the c ...
answers
answers

... expression pattern. Therefore, when you inject the [Hom-enh]-Ubx construct into Artemia or the [Art-enh]-Ubx into Homarus, the UBX expression domain will be determined by the cis-regulatory element that you are introducing. Thus, the transformed Artemia will have the Ubx expression pattern of Homaru ...
Dominant
Dominant

... In this case, the heterozygote is expressing both proteins. Therefore, with regards to expression of LM and LN protein on the RBC surface these alleles are co-dominant ...
Autosomal monoallelic expression in the mouse
Autosomal monoallelic expression in the mouse

... cell sorting (Materials and methods; Table S1 in Additional file 1), and cultured them to create clonal cell lines. Use of this cell type allows for comparison with the analyses of human RMAE, which primarily involved B-lymphoblastoid cells [10]. We also used SV-40 large T antigen transformed fibrob ...
Protein Design
Protein Design

... • needs some strong binding like streptavidin+biotin ...
Three-letter Symbols - Online Open Genetics
Three-letter Symbols - Online Open Genetics

... have their cell membranes modified by sugar tags that give rise to our blood type. One allele of I gives rise to blood type A and is therefore called IA. An enzyme encoded by IB modifies sugars to create blood type B. A heterozygote IAIB demonstrates both sugar tags because those alleles are express ...
Clustering of mandibular organ-inhibiting hormone and moult
Clustering of mandibular organ-inhibiting hormone and moult

... genes, we sequenced l12 in the region downstream of the MO-IH-2 gene to see at what point it ceased to be approximately 99% identical to l1. Downstream of the poly(A) signal the genes remain almost identical for about 1200 bp, there being a progressive increase in base changes and short insertions/d ...
Phevor Combines Multiple Biomedical Ontologies for
Phevor Combines Multiple Biomedical Ontologies for

... the landscape of clinical genetics, but it also presents a host of challenges. Every sequenced exome presents the clinical geneticist with thousands of variants, any one of which might be responsible for the person’s illness. One approach to making sense of these data is to employ a whole-genome and ...
rpoB gene sequence-based characterization of emerging non
rpoB gene sequence-based characterization of emerging non

... Over the past 10 years, 16S rRNA gene sequencing has contributed to the establishment of more than 45 novel species of non-tuberculous mycobacteria and to the description of emerging mycobacterial infections. Cumulative experience has indicated that this molecular tool underestimates the diversity o ...
Microarray data normalization and data transformation
Microarray data normalization and data transformation

... There are a number of schools of thought regarding the estimation of background for DNA microarrays (1) Not to calculate a background value • But rather to try to estimate it using statistical techniques • Argument – subtracting background introduces significant variance into the estimation of hybri ...
Exploration of PAR2-like Proteins present in Culex Mosquitoes
Exploration of PAR2-like Proteins present in Culex Mosquitoes

... sperm have a unique motility pattern, specifically the sperm cycle through three separate and distinctive waveforms (Thaler et al 2014). The three wave forms consist of a low amplitude, long wavelength form (Wave A), a double waveform with two superimposed waveforms over the length of the flagellum ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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