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Recessive mutations
Recessive mutations

... Characteristics of Mutations at the DNA Level • Expanding Trinucleotide Repeats – may arise as a result of formation of hairpin structures during DNA replication – could also be due to unequal crossing over when repeated regions do not align properly ...
STB 221 THEORY - Unesco
STB 221 THEORY - Unesco

... Humans produce only humans. However, the resulting offspring need not and most often do not totally resemble the parent. Several characteristic differences may occur between individuals belonging to the same species. The similarities and differences among the members of a species are not coincidenta ...
Complete mitochondrial genome of a natural triploid
Complete mitochondrial genome of a natural triploid

... ATP synthases (ATP6 and ATP8). The total length of those genes was 11,429 bp, accounting for 68.95% of the whole mitogenome. In accordance with other bony fishes, overlapping protein-coding genes were found in the C. auratus var. pingxiangnensis mitogenome. There were three cases of reading-frame ov ...
The Mobile Genetic Element Alu in the Human Genome
The Mobile Genetic Element Alu in the Human Genome

... part of peptides in some cases (Makalowski et al. 1994). As part of proteins, the amino acids corresponding to Alu sequences provide raw genetic material for evolution. Reverse transcription. The first event involved in reverse transcription is priming. It has been postulated that the uracil residue ...
Proposal Submission Form
Proposal Submission Form

... NA (no rDNA) Will the insertion: 1) affect oncogenes, regulation of transcription or cell activators, tumor suppressors, cell cycle or cell division OR 2) integrate into the genome of any host OR 3) generate replication-competent viruses? If yes, please give details as well as explain if it will cau ...
Solid Tumour Section Nervous system: Astrocytic tumors Atlas of Genetics and Cytogenetics
Solid Tumour Section Nervous system: Astrocytic tumors Atlas of Genetics and Cytogenetics

... The epidermal growth factor receptor (EGFR) coded by the EGFR cellular oncogene is located on human chromosome 7 at locus 7p12-p14; EGRF is amplified in 40-60% of glioblastomas; it constitues a hallmark: primary glioblastomas rarely contain EGFR overexpression; patients with anaplastic astrocytomas ...
Full Text  - Iranian Red Crescent Medical Journal
Full Text - Iranian Red Crescent Medical Journal

... Specifically, when the G allele of the rs2232365 FOXP3 gene exists, GATA-3 cannot bind to the promoter region of FoxP3 (32). Therefore, the gene expression of FOXP3 is diminished, along with a decreased number of T-regs. T-reg cells modulate the Th1/Th2 cell balance toward Th2 cells. Hence, we deduc ...
Ontologies
Ontologies

... Jan 2009: 20 billion bases (or letters) of highquality human DNA sequence – seven-times the length of a human genome – in 10 days. Computer analysis of the genome took another 10 days. ...
complex patterns of inheritance
complex patterns of inheritance

... Because quantitative traits are polygenic and greatly influenced by environmental conditions, the phenotypes among different individuals may vary substantially in any given population. As an example, let’s consider skin pigmentation in people. This trait is influenced by several genes that tend to i ...
Neutral and Non-Neutral Evolution of Duplicated Genes with Gene
Neutral and Non-Neutral Evolution of Duplicated Genes with Gene

... protein sequence identity [35]. In order to explain these observations, they proposed the following hypothesis. According to their hypothesis, the ribosomal duplicates have subfunctionalized at the expression level due to mutations in the regulatory non-coding regions. Nevertheless, there is still v ...
March 12 lecture presentation
March 12 lecture presentation

... Genes specific to the pathogens are organized into islands, islet, atolls. That is, specific regions that are unique to the pathogens. Pathogenicity islands encode those functions needed for the pathogen to causes a successful infection. It still needs the rest of the chromosome! Pathogenicity islan ...
Phenotype and gene ontology enrichment as guides for
Phenotype and gene ontology enrichment as guides for

... dimensionality of the data via enrichment analyses of ontologies [3], which helps researchers understand The last decade has seen an explosion of techniques what terms are overrepresented beyond random levcapable of genome-wide measurements. Some examels. By analyzing overrepresented terms in aggrep ...
Li 2001 Cancer Res
Li 2001 Cancer Res

... respectively), and smoking status (90 and 91% ever-smokers, respectively). Although more cases reported to have smoked in the last 24 h (26%) and a family history of cancer in a first-degree relative (67%) compared with controls (20 and 63%, respectively), these differences were not statistically si ...
The tightly regulated promoter of the xanA gene of
The tightly regulated promoter of the xanA gene of

... 2001). For both xanA and uapA, xprD1 results in derepression, but also in an elevated basal level of message in both the presence and absence of inducer. Is the promoter of the psxA region active? As reported above, no transcript corresponding to psxA could be detected. We investigated whether the p ...
The uSe of mAnnoSe SeleCTion SySTem foR gene
The uSe of mAnnoSe SeleCTion SySTem foR gene

... amplified by PCR from the transgenic samples. The sequence obtained was subjected to BLAST analysis against deposited sequences in the GenBank database (Figure 7). Based on PCR analaysis of pmi gene on transgenic tobacco leaf sampels, it could be suggested that around 75% of the transformed plants s ...
Extensions to Mendel`s Law
Extensions to Mendel`s Law

... Genetics 2011 ...
here - Genomes Unzipped
here - Genomes Unzipped

... Li et al.[1] sequenced cDNA from lymphoblastoid cell lines derived from 27 individuals whose genomes have been sequenced at low coverage [2], and identified 10,210 sites of mismatches between an individual’s mRNA and DNA sequences (RDD sites, for RNA-DNA difference). RDD sites included all possible ...
Running head: GENETICALLY MODIFIED ORGANISMS 1
Running head: GENETICALLY MODIFIED ORGANISMS 1

... added to it, so it would be able to help prevent vitamin A deficiency. A specific rice has milk proteins that can be used to treat infant diarrhea. Corn is also used to treat cystic fibrosis, duckweed to treat hepatitis, and safflower to treat diabetes (Reece, 2012). But, even though there are many ...
Multiplex PCR NZYTaq 2× Green Master Mix
Multiplex PCR NZYTaq 2× Green Master Mix

... primers. In general, primers should range in length from 20– 34 bases and should contain 40–60% of GC residues. Minimize the number of consecutive G’s in the primers. Preferably, G and C residues should be distributed uniformly along the primer. Avoid sequences that might produce internal secondary ...
The Genetic Control and Cytoplasmic Expression of "Inducibility" in
The Genetic Control and Cytoplasmic Expression of "Inducibility" in

... Let UB emphasize that this sketch of the Lac region is preliminary and very incomplete, and that the results concerning the relationshipe of certain markers are not understood. For instance, the i marker recombines rather freely with all the other mutants shown (both y and .) yet, by cotransduction ...
Familial Mediterranean Fever (FMF) factsheet for patients
Familial Mediterranean Fever (FMF) factsheet for patients

... like hair colour, eye colour and ...
Congenital hyperinsulinism caused by a de novo mutation in the
Congenital hyperinsulinism caused by a de novo mutation in the

... One possible event is a paternally inherited mutation in the ABCC8 or KCNJ11 gene that would remain silent, but if there is an acquired somatic deletion of the maternal allele, focal CHI will develop because of the loss of heterozygosity. The ABCC8 and KCNJ11 containing chromosome region also contai ...
1. dia
1. dia

... 4: long arm, 5: satellite, 6: secondary constriction. A (not ordered) karyogram ...
Matthew Kwong - GEP Community Server
Matthew Kwong - GEP Community Server

... The final exon in contig 10 (exon 4 for isoforms ey-PA, ey-PC and exon 5 for isoform eyPD) likely does not represent the end of the gene since ey has eleven unique exons with either eight or nine being expressed (depending on the isoform). Thus, the ey gene likely extends past contig 10. The final e ...
The common bean growth habit gene PvTFL1y is a
The common bean growth habit gene PvTFL1y is a

... greenhouse with natural day length and an average temperature of 24°C. Arabidopsis was grown in a growth chamber at 24°C under the condition of 16 h of 120 lE m-2 s-1 light and 8 h of darkness. Arabidopsis was chosen for the transformation species because the PvTFL1y gene was initially identified du ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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