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... with any other significant events and options for new work. TILLING (Targetted Local Lesions IN Genomes) offers a route for carrying out what is termed a ‘reverse genetics’ approach to investigate whether a specific ‘candidate gene’ has an effect on a trait of interest. A TILLING approach requires t ...
... with any other significant events and options for new work. TILLING (Targetted Local Lesions IN Genomes) offers a route for carrying out what is termed a ‘reverse genetics’ approach to investigate whether a specific ‘candidate gene’ has an effect on a trait of interest. A TILLING approach requires t ...
Integrating Gene Expression Analysis into Genome-Wide
... study population may appear uniform across affected individuals, its genetic basis may not be. The detection ...
... study population may appear uniform across affected individuals, its genetic basis may not be. The detection ...
An Introduction to Genetic Analysis Chapter 23 Developmental
... which tissues and at what developmental times the gene is transcribed and how much of the gene product is synthesized. From a geneticist's point of view, all developmental programming that controls an organism's protein profiles is determined by the regulatory information encoded in the DNA. We can ...
... which tissues and at what developmental times the gene is transcribed and how much of the gene product is synthesized. From a geneticist's point of view, all developmental programming that controls an organism's protein profiles is determined by the regulatory information encoded in the DNA. We can ...
The Plant Cell
... 2002). miRNAs that have a significant number of mismatches and bulges when aligned to their targets are predicted to cause translational regulation, as in the cases of lin-4 and let-7. On the other hand, a miRNA with perfect or nearly perfect complementarity with its target is predicted to cause RNA ...
... 2002). miRNAs that have a significant number of mismatches and bulges when aligned to their targets are predicted to cause translational regulation, as in the cases of lin-4 and let-7. On the other hand, a miRNA with perfect or nearly perfect complementarity with its target is predicted to cause RNA ...
Leukaemia Section t(11;14)(p15;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... might facilitate protein-protein interaction which modulates transcription via intermolecular competitive binding between LIM domain and certain DNAbinding-transcription factors. The LDB1/NLI is a phosphoprotein and binds to LMO1 in its phophorylated state and essentially all the LMO1 and LDB1 prote ...
... might facilitate protein-protein interaction which modulates transcription via intermolecular competitive binding between LIM domain and certain DNAbinding-transcription factors. The LDB1/NLI is a phosphoprotein and binds to LMO1 in its phophorylated state and essentially all the LMO1 and LDB1 prote ...
Presentation
... Hepatitis B virus is associated with liver cancer, but some gene mutations may also be necessary for tumor formation. ...
... Hepatitis B virus is associated with liver cancer, but some gene mutations may also be necessary for tumor formation. ...
Human, yeast and hybrid 3-phosphoglycerate kinase gene
... essentially identical at 10 percent of the cell protein. By comparison with expression unit b, protein levels of all hPGK containing expression units are significantly decreased. Differences in migration of the various PGKs are due to differences in amino acid compositions (15). The above results ar ...
... essentially identical at 10 percent of the cell protein. By comparison with expression unit b, protein levels of all hPGK containing expression units are significantly decreased. Differences in migration of the various PGKs are due to differences in amino acid compositions (15). The above results ar ...
Responses-to-Referee2
... for 50% of the total number of transcripts around the mean. Thus, 25% transcripts have values above the upper boundary of the central box -- i.e. it is the 75% or top quartile line. Similarly, 25% transcripts have values below the lower boundary of the central box -- i.e. it is the 25% or bottom qua ...
... for 50% of the total number of transcripts around the mean. Thus, 25% transcripts have values above the upper boundary of the central box -- i.e. it is the 75% or top quartile line. Similarly, 25% transcripts have values below the lower boundary of the central box -- i.e. it is the 25% or bottom qua ...
POB3 Is Required for Both Transcription and Replication
... Nittis 1999; Wittmeyer et al. 1999), suggesting that Spt16-Pob3 acts in DNA replication. These results do not contradict studies that infer a role for Spt16-Pob3 in transcription, but instead suggest a similar or additional role for this factor in DNA replication. Since chromatin is the substrate fo ...
... Nittis 1999; Wittmeyer et al. 1999), suggesting that Spt16-Pob3 acts in DNA replication. These results do not contradict studies that infer a role for Spt16-Pob3 in transcription, but instead suggest a similar or additional role for this factor in DNA replication. Since chromatin is the substrate fo ...
Biology Junction
... DNA Fingerprinting DNA fingerprinting analyzes sections of DNA that have little or no known function but vary widely from one individual to another. Only identical twins are genetically identical. DNA samples can be obtained from blood, sperm, and hair strands with tissue at the base. ...
... DNA Fingerprinting DNA fingerprinting analyzes sections of DNA that have little or no known function but vary widely from one individual to another. Only identical twins are genetically identical. DNA samples can be obtained from blood, sperm, and hair strands with tissue at the base. ...
XML
... Lymphoma represents a heterogeneous group of neoplastic blood disorders involving monoclonal proliferation of malignant lymphocytes. Historically, lymphomas have been divided in two basic categories: Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL) (DeVita et al., 2015). Different subtypes were ...
... Lymphoma represents a heterogeneous group of neoplastic blood disorders involving monoclonal proliferation of malignant lymphocytes. Historically, lymphomas have been divided in two basic categories: Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL) (DeVita et al., 2015). Different subtypes were ...
Distinct and stage specific nuclear factors regulate the expression of
... proteases, we carefully analyzed the 5'upstream regions of falcipain genes. Firstly, we identified the transcriptional start site of all the falcipains (Fig. 2A). The location of the transcriptional start site for each of the falcipains was determined by 5'RACE analysis using gene specific primers a ...
... proteases, we carefully analyzed the 5'upstream regions of falcipain genes. Firstly, we identified the transcriptional start site of all the falcipains (Fig. 2A). The location of the transcriptional start site for each of the falcipains was determined by 5'RACE analysis using gene specific primers a ...
14–3 Human Molecular Genetics
... DNA fingerprinting analyzes sections of DNA that have little or no known function but vary widely from one individual to another. Only identical twins are genetically identical. DNA samples can be obtained from blood, sperm, and hair strands with tissue at the base. ...
... DNA fingerprinting analyzes sections of DNA that have little or no known function but vary widely from one individual to another. Only identical twins are genetically identical. DNA samples can be obtained from blood, sperm, and hair strands with tissue at the base. ...
Grade 10 Science Unit Template Unit III Genetics and Biotechnology
... 6. Meiosis is the production of sex cells (gametes). The production and release of these gametes is controlled by hormones. In meiosis, the number of chromosomes is reduced by one-half and chromosomes may randomly exchange homologous parts to create new chromosomes with combinations not necessarily ...
... 6. Meiosis is the production of sex cells (gametes). The production and release of these gametes is controlled by hormones. In meiosis, the number of chromosomes is reduced by one-half and chromosomes may randomly exchange homologous parts to create new chromosomes with combinations not necessarily ...
Brief Summary of Unit - Delaware Department of Education
... 6. Meiosis is the production of sex cells (gametes). The production and release of these gametes is controlled by hormones. In meiosis, the number of chromosomes is reduced by one-half and chromosomes may randomly exchange homologous parts to create new chromosomes with combinations not necessarily ...
... 6. Meiosis is the production of sex cells (gametes). The production and release of these gametes is controlled by hormones. In meiosis, the number of chromosomes is reduced by one-half and chromosomes may randomly exchange homologous parts to create new chromosomes with combinations not necessarily ...
Meiosis and Reproduction
... • Some combinations of alleles, produced during meiosis and fertilization might be more advantageous • This is what leads to natural selection. Individuals with more advantageous traits will survive to reproduce and pass on those traits. • Darwin realized that slow changes in inherited traits, due t ...
... • Some combinations of alleles, produced during meiosis and fertilization might be more advantageous • This is what leads to natural selection. Individuals with more advantageous traits will survive to reproduce and pass on those traits. • Darwin realized that slow changes in inherited traits, due t ...
Contextual Genetic Algorithms: Evolving Developmental Rules
... 2. RNA Editing The discovery of messenger RNA (mRNA) molecules containing information not coded in DNA, first persuaded researchers in molecular biology that some mechanism in the cell might be responsible for posttranscriptional alteration of genetic information; this mechanism was called 'RNA Edit ...
... 2. RNA Editing The discovery of messenger RNA (mRNA) molecules containing information not coded in DNA, first persuaded researchers in molecular biology that some mechanism in the cell might be responsible for posttranscriptional alteration of genetic information; this mechanism was called 'RNA Edit ...
DNA Sequence Analysis Using Boolean Algebra
... regarding the characteristics of these sequences arise. Life represents order. It is not chaotic or random [7]. Thus, we expect the DNA sequences that encode life to be non random. In other words, they should be very compressible. There are also strong biological evidences that support this claim: i ...
... regarding the characteristics of these sequences arise. Life represents order. It is not chaotic or random [7]. Thus, we expect the DNA sequences that encode life to be non random. In other words, they should be very compressible. There are also strong biological evidences that support this claim: i ...
Chapter 11 : BIOTECHNOLOGY-PRINCIPLES
... the nucleotides provided in the reaction and the genomic DNA as template. If the process of replication of DNA is repeated many times, the segment of DNA can be amplified to approximately billion times, i.e., 1 billion copies are made. Such repeated amplification is achieved by the use of a thermos ...
... the nucleotides provided in the reaction and the genomic DNA as template. If the process of replication of DNA is repeated many times, the segment of DNA can be amplified to approximately billion times, i.e., 1 billion copies are made. Such repeated amplification is achieved by the use of a thermos ...
Kartagener`s Syndrome: a relentless triad
... Bouvagnet, P. 2001. Axonemal Dynein Intermiediate-Chain Gene (DNAI1) Mutations Result in Situs Inversus and Primary Ciliary Dyskinesia (Kartagener Syndrome). Am. ...
... Bouvagnet, P. 2001. Axonemal Dynein Intermiediate-Chain Gene (DNAI1) Mutations Result in Situs Inversus and Primary Ciliary Dyskinesia (Kartagener Syndrome). Am. ...
Putative GTPase Gtr1p genetically interacts with the RanGTPase
... on chromatin in a ratio of one molecule per 1 to 10 nucleosomes (Dasso et al., 1992). On the other hand, Ran/TC4 has a 25-fold molar excess over RCC1 in HeLa cells (Bischoff and Ponstingl, 1991a) and is located within the nucleoplasm (Ren et al., 1993). In contrast with other Ras-family members, Ran ...
... on chromatin in a ratio of one molecule per 1 to 10 nucleosomes (Dasso et al., 1992). On the other hand, Ran/TC4 has a 25-fold molar excess over RCC1 in HeLa cells (Bischoff and Ponstingl, 1991a) and is located within the nucleoplasm (Ren et al., 1993). In contrast with other Ras-family members, Ran ...
Impact of epigenetics in the management of cardiovascular disease: a review
... regulation, RNA-based mechanisms are relatively the most recently described and much works needs to be done to gain clear understanding of these mechanisms. Current research focuses on noncoding RNAs and small RNAs (i.e., RNAs that do not code for any particular protein) that function in the nucleus ...
... regulation, RNA-based mechanisms are relatively the most recently described and much works needs to be done to gain clear understanding of these mechanisms. Current research focuses on noncoding RNAs and small RNAs (i.e., RNAs that do not code for any particular protein) that function in the nucleus ...
DNA sequence representation by trianders and determinative
... specified by more than one codon (Lewin, 1983; Stent and Kalindar, 1981). From 64 possible codons one can extract 16 families each defined by the first two nucleotides. Let we denote a triplet (5′-1-2-3-3′) by XYZ. Then the codon sense can be fully determined by the first two nucleotides X and Y ind ...
... specified by more than one codon (Lewin, 1983; Stent and Kalindar, 1981). From 64 possible codons one can extract 16 families each defined by the first two nucleotides. Let we denote a triplet (5′-1-2-3-3′) by XYZ. Then the codon sense can be fully determined by the first two nucleotides X and Y ind ...
Primary transcript
A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. The primary transcripts designated to be mRNAs are modified in preparation for translation. For example, a precursor messenger RNA (pre-mRNA) is a type of primary transcript that becomes a messenger RNA (mRNA) after processing.There are several steps contributing to the production of primary transcripts. All these steps involve a series of interactions to initiate and complete the transcription of DNA in the nucleus of eukaryotes. Certain factors play key roles in the activation and inhibition of transcription, where they regulate primary transcript production. Transcription produces primary transcripts that are further modified by several processes. These processes include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found in cells. The modifications of primary transcripts have been further studied in research seeking greater knowledge of the role and significance of these transcripts. Experimental studies based on molecular changes to primary transcripts the processes before and after transcription have led to greater understanding of diseases involving primary transcripts.