Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD S-L. Cheng
... possible contribution of environmental or genetic cofactors to the development of COPD. Although cofactors, such as childhood viral infection and environmental and occupational pollution, play important roles in pathogenesis [3], genetic susceptibility may be a factor of major importance [4]. The on ...
... possible contribution of environmental or genetic cofactors to the development of COPD. Although cofactors, such as childhood viral infection and environmental and occupational pollution, play important roles in pathogenesis [3], genetic susceptibility may be a factor of major importance [4]. The on ...
Article A Molecular Evolutionary Reference for the Human Variome
... each possible residue state at a given position in a species (species 1 in fig. 1), where the multispecies alignment is modified to replace the residue at the focal position with a missing data symbol (see Materials and Methods). Then, we compute multiple PP values by progressively pruning evolution ...
... each possible residue state at a given position in a species (species 1 in fig. 1), where the multispecies alignment is modified to replace the residue at the focal position with a missing data symbol (see Materials and Methods). Then, we compute multiple PP values by progressively pruning evolution ...
Quantitative expression of cholera toxin mRNA in Vibrio cholerae
... respectively. The differences between arrangements C and A are: (i) the presence of two copies of the complete CTX in arrangement C, and (ii) the position of RS1 downstream of CTXW in arrangement C compared with upstream in arrangement A. The data support the suggestion that the position of RS1 may ...
... respectively. The differences between arrangements C and A are: (i) the presence of two copies of the complete CTX in arrangement C, and (ii) the position of RS1 downstream of CTXW in arrangement C compared with upstream in arrangement A. The data support the suggestion that the position of RS1 may ...
Ingenuity Pathway Analysis of metabolomics data including cross
... Data is taken from Connor et al 2008. Urine samples were collected over a 6 hour period from adult male db/db and db/+ mice at 8 weeks and again at 9 and 10 weeks of age (n=10 per group). Samples were buffered to pH 7 and NMR data acquired on a 700 MHz Bruker spectrometer using standard experiments ...
... Data is taken from Connor et al 2008. Urine samples were collected over a 6 hour period from adult male db/db and db/+ mice at 8 weeks and again at 9 and 10 weeks of age (n=10 per group). Samples were buffered to pH 7 and NMR data acquired on a 700 MHz Bruker spectrometer using standard experiments ...
How can we best detect hereditary non
... colorectal cancer (HNPCC) — sometimes known as Lynch syndrome. Both are inherited as autosomal dominant traits. Familial adenomatous polyposis can usually be readily diagnosed on the basis of clinical findings alone, when an individual develops CRC at a relatively young age on a background of colore ...
... colorectal cancer (HNPCC) — sometimes known as Lynch syndrome. Both are inherited as autosomal dominant traits. Familial adenomatous polyposis can usually be readily diagnosed on the basis of clinical findings alone, when an individual develops CRC at a relatively young age on a background of colore ...
Chromatin Domain Boundaries: Defining the Functional Domains in
... are separated by centrifugation and analyzed by gel electrophoresis and autoradiography [16, 17]. In another version of in vitro MAR assay nuclei are similarly treated with high salt to extract proteins and digested exhaustively with DNaseI. DNA and histone depleted nuclear matrices are incubated wi ...
... are separated by centrifugation and analyzed by gel electrophoresis and autoradiography [16, 17]. In another version of in vitro MAR assay nuclei are similarly treated with high salt to extract proteins and digested exhaustively with DNaseI. DNA and histone depleted nuclear matrices are incubated wi ...
TheraGuide 5-FU
... – Three common variations account for the majority of known 5-FU toxicity to date • IVS14+1 G>A, D949V, and I560S ...
... – Three common variations account for the majority of known 5-FU toxicity to date • IVS14+1 G>A, D949V, and I560S ...
Floral Symmetry - Coen Lab
... be produced without any apparent effect on the rest of the plant. The mutations were clearly affecting genes with very specific and fundamental roles in flower development. I had previously done a Ph.D on Drosophila with Gabby Dover, on the evolution and genetic behaviour of ribosomal DNA (Coen et a ...
... be produced without any apparent effect on the rest of the plant. The mutations were clearly affecting genes with very specific and fundamental roles in flower development. I had previously done a Ph.D on Drosophila with Gabby Dover, on the evolution and genetic behaviour of ribosomal DNA (Coen et a ...
Comparative Analysis of Structural Diversity and
... cleavage sites. Results of the targeting prediction programs are shown in supplementary table S2, Supplementary Material online. We considered a sequence to be mitochondrially targeted if two or more of the prediction programs predicted mitochondrial targeting. In addition to mitochondrial targeting ...
... cleavage sites. Results of the targeting prediction programs are shown in supplementary table S2, Supplementary Material online. We considered a sequence to be mitochondrially targeted if two or more of the prediction programs predicted mitochondrial targeting. In addition to mitochondrial targeting ...
Meristematic sculpting in fruit development
... cells of the corpus can divide in all planes. Superimposed on this layer structure, the SAM can be divided into three functional zones. The central zone is maintained by a low cell division rate that generates cells for the peripheral zone and the rib meristem. The peripheral zone is responsible for ...
... cells of the corpus can divide in all planes. Superimposed on this layer structure, the SAM can be divided into three functional zones. The central zone is maintained by a low cell division rate that generates cells for the peripheral zone and the rib meristem. The peripheral zone is responsible for ...
Analysis of a Controlling-Element Mutation at the Adh Locus of Maize
... such qustions, we have selected for controlling-element mutations at the Adh locus, which specifies alcohol dehydrogenase, an enzyme readily amenable to biochemical analyses and characterization (SCHWARTZ 1971, 1973). This paper deals with the analysis of one such Adh mutation. It is stable in the a ...
... such qustions, we have selected for controlling-element mutations at the Adh locus, which specifies alcohol dehydrogenase, an enzyme readily amenable to biochemical analyses and characterization (SCHWARTZ 1971, 1973). This paper deals with the analysis of one such Adh mutation. It is stable in the a ...
Genetic Inheritance in Humans | Principles of Biology from Nature
... environment plays a strong role in determining phenotype and that some phenotypes can be inherited through mechanisms other than gene sequence variations (known as epigenetics). Asthma, for example, is an inflammatory disease that researchers believe involves both inherited genes and environmental ...
... environment plays a strong role in determining phenotype and that some phenotypes can be inherited through mechanisms other than gene sequence variations (known as epigenetics). Asthma, for example, is an inflammatory disease that researchers believe involves both inherited genes and environmental ...
Epigenetic differences arise during the lifetime of
... personnel to complete the questionnaire about their health, nutritional habits, physical activities, pharmacological treatments, and tobacco, alcohol, and drug consumption. Weight and height were measured, and a family tree of genetic history was drawn up by the interviewer. The data collected in th ...
... personnel to complete the questionnaire about their health, nutritional habits, physical activities, pharmacological treatments, and tobacco, alcohol, and drug consumption. Weight and height were measured, and a family tree of genetic history was drawn up by the interviewer. The data collected in th ...
A systematic screen for genes expressed in definitive endoderm by
... of both pan-endodermal and endodermal region-specific genetic markers, since the majority of DE markers are also expressed in the visceral endoderm and/or other germ layers. Devising screens to identify genes specifically expressed in DE will contribute to studies of DE development. Several groups h ...
... of both pan-endodermal and endodermal region-specific genetic markers, since the majority of DE markers are also expressed in the visceral endoderm and/or other germ layers. Devising screens to identify genes specifically expressed in DE will contribute to studies of DE development. Several groups h ...
Inheritance of Retinal Degenerations
... When only one member of a family has a retinal degeneration, as we see in about 40 percent of families affected by RP, it is impossible to determine how the disease is inherited in that family. Nevertheless, to assess the risk of retinal degeneration occurring in other family members, it must be ass ...
... When only one member of a family has a retinal degeneration, as we see in about 40 percent of families affected by RP, it is impossible to determine how the disease is inherited in that family. Nevertheless, to assess the risk of retinal degeneration occurring in other family members, it must be ass ...
Estrogen receptor β gene polymorphisms and susceptibility to
... alter protein function, whereas SNPs in the gene promoter can modify gene expression levels [16–22]. Thus, SNPs may lead to altered expression of growth controlling genes, thereby promoting tumor initiation and proliferation [17,21]. Polymorphisms in genes involved in estrogen biosynthesis, metaboli ...
... alter protein function, whereas SNPs in the gene promoter can modify gene expression levels [16–22]. Thus, SNPs may lead to altered expression of growth controlling genes, thereby promoting tumor initiation and proliferation [17,21]. Polymorphisms in genes involved in estrogen biosynthesis, metaboli ...
5 Genetic Analysis of Kidney Disease in Mice
... genes in these small regions were tested using two expression databases to determine if the genes were expressed in the tissues relevant to the phenotype. Those genes meeting this criterion were then examined for coding sequence differences using first a database and then actual sequencing. These ge ...
... genes in these small regions were tested using two expression databases to determine if the genes were expressed in the tissues relevant to the phenotype. Those genes meeting this criterion were then examined for coding sequence differences using first a database and then actual sequencing. These ge ...
Genetics- Ch. 5 text notes
... • An individual carries two alleles for each gene • A population can have many alleles among the individual members • Examples – PKU gene has over 300 alleles resulting in four basic phenotypes – CF gene has over 1000 alleles ...
... • An individual carries two alleles for each gene • A population can have many alleles among the individual members • Examples – PKU gene has over 300 alleles resulting in four basic phenotypes – CF gene has over 1000 alleles ...
lab 4: genetic analysis of the maize plant - UTSC
... chiasmata (an X-shaped connection, where reciprocal genetic exchange occurs). Nonhomologous chromosomes are not connected in any way like homologous chromosomes, so non-homologous chromosomes do not have any influence on other homologous pairs, thus the alleles sort independent of each other. Howeve ...
... chiasmata (an X-shaped connection, where reciprocal genetic exchange occurs). Nonhomologous chromosomes are not connected in any way like homologous chromosomes, so non-homologous chromosomes do not have any influence on other homologous pairs, thus the alleles sort independent of each other. Howeve ...
INHERITANCE OF RETINAL DEGENERATIONS
... When only one member of a family has a retinal degeneration, as we see in about 40 percent of families affected by RP, it is impossible to determine how the disease is inherited in that family. Nevertheless, to assess the risk of retinal degeneration occurring in other family members, it must be ass ...
... When only one member of a family has a retinal degeneration, as we see in about 40 percent of families affected by RP, it is impossible to determine how the disease is inherited in that family. Nevertheless, to assess the risk of retinal degeneration occurring in other family members, it must be ass ...
Document
... polyploidy is common in plants - but not animals polyploids are more normal in appearance than aneuploids large-scale chromosomal alterations in humans and other mammals often lead to spontaneous abortions (miscarriages) or cause a variety of developmental disorders – plants tolerate such genetic ch ...
... polyploidy is common in plants - but not animals polyploids are more normal in appearance than aneuploids large-scale chromosomal alterations in humans and other mammals often lead to spontaneous abortions (miscarriages) or cause a variety of developmental disorders – plants tolerate such genetic ch ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.