Supplementary Information
... ratio threshold = 0.8, deletion log2 ratio threshold = -0.5, baseline distribution (smoothing window size) = 10kbp, and p-value threshold = 0.05. The output of FACADE is list of copy number alterations in each sample profiled. Gene expression profiling RNA extracted from each PDAC line and HPDE was ...
... ratio threshold = 0.8, deletion log2 ratio threshold = -0.5, baseline distribution (smoothing window size) = 10kbp, and p-value threshold = 0.05. The output of FACADE is list of copy number alterations in each sample profiled. Gene expression profiling RNA extracted from each PDAC line and HPDE was ...
Genetics Vocabulary 2014-2015
... recessive allele – an allele that is masked when a dominant allele is present hybrid – an organism that has two different alleles for a trait phenotype – an organism’s physical appearance or visible traits gentotype – an organism’s genetic makeup or allele combinations homozygous – having two identi ...
... recessive allele – an allele that is masked when a dominant allele is present hybrid – an organism that has two different alleles for a trait phenotype – an organism’s physical appearance or visible traits gentotype – an organism’s genetic makeup or allele combinations homozygous – having two identi ...
microRNA: microRNA
... CLL pts, and in 16-1 causes decreased miRNA miR-15a and miR-16-1 directly target bcl2, and their absence may contribute to the pathogenesis of CLL miRNA or miRNA-like sequences may be used therapeutically to target bcl2 or other oncogenes in the future ...
... CLL pts, and in 16-1 causes decreased miRNA miR-15a and miR-16-1 directly target bcl2, and their absence may contribute to the pathogenesis of CLL miRNA or miRNA-like sequences may be used therapeutically to target bcl2 or other oncogenes in the future ...
Protein Synthesis (Transcription and Translation)
... • A point mutation is a change in a single base pair in DNA. • A change in a single nitrogenous base can change the entire structure of a protein because a change in a single amino acid can affect the shape of the protein. ...
... • A point mutation is a change in a single base pair in DNA. • A change in a single nitrogenous base can change the entire structure of a protein because a change in a single amino acid can affect the shape of the protein. ...
GENOME SEQUENCING AND OBJECTIVES
... millions of individual molecules. It expects to apply this technology to sequencing an individual human genome much more quickly and cheaply than can be done with current methods: The arrays could also be applied to studying interactions between other large sets. ...
... millions of individual molecules. It expects to apply this technology to sequencing an individual human genome much more quickly and cheaply than can be done with current methods: The arrays could also be applied to studying interactions between other large sets. ...
lecture 03b
... DNA replication Complementary base-pairing allows for a mechanism for 1 DNA molecule to be copied to produce two identical molecules. Because each new double-stranded molecule is made of one old strand and one new strand, this is called “semi-conservative” replication. ...
... DNA replication Complementary base-pairing allows for a mechanism for 1 DNA molecule to be copied to produce two identical molecules. Because each new double-stranded molecule is made of one old strand and one new strand, this is called “semi-conservative” replication. ...
Document
... • Upon completion of this lesson, the student will be able to identify the basic cellular processes, which influence our health. compare and contrast cellular adaptation processes. describe the processes associated with aging and list the current theories. determine syndromes associated with ...
... • Upon completion of this lesson, the student will be able to identify the basic cellular processes, which influence our health. compare and contrast cellular adaptation processes. describe the processes associated with aging and list the current theories. determine syndromes associated with ...
Genetics
... – Silent mutation: the strict definition = a change in the codon does not change the encoded amino acid; a more broad definition = a change that does not change the function of the encoded protein • by this definition a silent mutation could be any of these types of base substitions, as long as the ...
... – Silent mutation: the strict definition = a change in the codon does not change the encoded amino acid; a more broad definition = a change that does not change the function of the encoded protein • by this definition a silent mutation could be any of these types of base substitions, as long as the ...
BIOLOGY CONTENT STANDARDS REVIEW
... 16. Draw and label a DNA molecule with nine base pairs, the transcribed mRNA molecule, and the resulting protein molecule. 17. Describe the three main types of RNA. Where is each found in the cell? Draw a picture of each. Base-pairing rules explain precise copying of DNA during semi-conservative rep ...
... 16. Draw and label a DNA molecule with nine base pairs, the transcribed mRNA molecule, and the resulting protein molecule. 17. Describe the three main types of RNA. Where is each found in the cell? Draw a picture of each. Base-pairing rules explain precise copying of DNA during semi-conservative rep ...
answers
... Which kind of RNA has an ANTICODON? __t-RNA____ What kind of molecules make up ribosomes? ___PROTEINS______ & ___r-RNA__________ Which cell part makes r-RNA? ___NUCLEOLUS__ Which cell part makes proteins? _RIBOSOMES______________ The ribosome makes sure the amino acid is put in the right spot by mat ...
... Which kind of RNA has an ANTICODON? __t-RNA____ What kind of molecules make up ribosomes? ___PROTEINS______ & ___r-RNA__________ Which cell part makes r-RNA? ___NUCLEOLUS__ Which cell part makes proteins? _RIBOSOMES______________ The ribosome makes sure the amino acid is put in the right spot by mat ...
Identification of disease genes Mutational analyses Monogenic
... No families, no linkage studies available (mutations cause low reproductive fitness). ...
... No families, no linkage studies available (mutations cause low reproductive fitness). ...
1. DNA (genetic info is passed down through DNA and RNA) A
... 7. incomplete dominance- red X white pink; both protein product are expressed and blended 8. codominance- red x white red and white; both protein products are equally expressed ex.AB blood types 9. multiple alleles- blood types- ABO 10. epistasis- one gene affects expression of another 11. linke ...
... 7. incomplete dominance- red X white pink; both protein product are expressed and blended 8. codominance- red x white red and white; both protein products are equally expressed ex.AB blood types 9. multiple alleles- blood types- ABO 10. epistasis- one gene affects expression of another 11. linke ...
FACS RNA
... The optimal volume of RNAlater and limit of dilution is 10%. Therefore, 15 mL conical tubes containing 9 mL of RNAlater should be provided to the Flow Core and 1 mL of so ...
... The optimal volume of RNAlater and limit of dilution is 10%. Therefore, 15 mL conical tubes containing 9 mL of RNAlater should be provided to the Flow Core and 1 mL of so ...
`RNA world`.
... With RNA we throw away many of the rules! If DNA is straight-laced and uniform, RNA is freewheeling and audacious. RNA is the non-conformist. It has ceded primacy as the repository of genetic information to DNA but it has gained versatility. It is a master architect, forming complex, threedimension ...
... With RNA we throw away many of the rules! If DNA is straight-laced and uniform, RNA is freewheeling and audacious. RNA is the non-conformist. It has ceded primacy as the repository of genetic information to DNA but it has gained versatility. It is a master architect, forming complex, threedimension ...
Introduction and Review
... Transcription ends (termination) when RNA polymerase reaches a terminator sequence, usually located several bases upstream from where transcription actually stops Some terminators require a termination factor protein called the rho factor (); these are rho-dependent. Others are rhoindependent. Mess ...
... Transcription ends (termination) when RNA polymerase reaches a terminator sequence, usually located several bases upstream from where transcription actually stops Some terminators require a termination factor protein called the rho factor (); these are rho-dependent. Others are rhoindependent. Mess ...
Alternative Splicing
... • mutations in the Alu can create a 5’ or 3’ site in an intron causing it to be an exon • This mutation doesn’t impact existing exons • It only has effect when it is alternatively spliced in ...
... • mutations in the Alu can create a 5’ or 3’ site in an intron causing it to be an exon • This mutation doesn’t impact existing exons • It only has effect when it is alternatively spliced in ...
From Gene to Protein
... • Facilitate mRNA export from the nucleus • Separated from the stop codon by trailer sequence ...
... • Facilitate mRNA export from the nucleus • Separated from the stop codon by trailer sequence ...
A grand challenge for nutrigenomics
... Doll, 1992), diabetes is a nutritional/metabolic disorder, we are all familiar with the cholesterol–cardiovascular disease relationship, and obesity is a pressing nutritional problem, with a majority of Americans overweight and expanding rapidly (Ogden et al., 2007). If genetic scientists are lookin ...
... Doll, 1992), diabetes is a nutritional/metabolic disorder, we are all familiar with the cholesterol–cardiovascular disease relationship, and obesity is a pressing nutritional problem, with a majority of Americans overweight and expanding rapidly (Ogden et al., 2007). If genetic scientists are lookin ...
3rd of 7 Review Packets
... 7. incomplete dominance- red X white pink; both protein product are expressed and blended 8. codominance- red x white red and white; both protein products are equally expressed ex.AB blood types 9. multiple alleles- blood types- ABO 10. epistasis- one gene affects expression of another 11. linke ...
... 7. incomplete dominance- red X white pink; both protein product are expressed and blended 8. codominance- red x white red and white; both protein products are equally expressed ex.AB blood types 9. multiple alleles- blood types- ABO 10. epistasis- one gene affects expression of another 11. linke ...
Legends for Supplementary Materials Figure S1. Schematic
... Figure S3. Expression levels of LOG genes in wild type and log septuple mutant. (a) PCR for genotyping with genomic DNA prepared from wild type (WT), log1log2log3log4log5log7log8 septuple mutant (1234578), log1log2log3log4log5log7 (123457), and log1log2log3log4log5log8 (123458) with a pair of gene-s ...
... Figure S3. Expression levels of LOG genes in wild type and log septuple mutant. (a) PCR for genotyping with genomic DNA prepared from wild type (WT), log1log2log3log4log5log7log8 septuple mutant (1234578), log1log2log3log4log5log7 (123457), and log1log2log3log4log5log8 (123458) with a pair of gene-s ...
SEGMENTAL VARIATION
... deal of human phenotypic variability including disease • Depth-of-coverage methods can detect many CNVs but not inversions and translocations. Variation from sample to sample limits sensitivity and specificity. ...
... deal of human phenotypic variability including disease • Depth-of-coverage methods can detect many CNVs but not inversions and translocations. Variation from sample to sample limits sensitivity and specificity. ...
Gene Section PRAME (preferentially expressed antigen in melanoma) Atlas of Genetics and Cytogenetics
... LRR family proteins, some of which are known to have functions in cell immunity and signal transduction. It has been suggested that, like TLRs, PRAME may be upregulated in response to encounters with microbial pathogens, and may be involved in targeting intracellular PAMPs to the Golgi for ubiquityl ...
... LRR family proteins, some of which are known to have functions in cell immunity and signal transduction. It has been suggested that, like TLRs, PRAME may be upregulated in response to encounters with microbial pathogens, and may be involved in targeting intracellular PAMPs to the Golgi for ubiquityl ...
In meiosis, what is the difference between metaphase 1 and
... 6. Explain what is meant by crossing-over (recombination). Be sure and mention at what time it is taking place within the cell. An exchange of corresponding segments between two homologous chromosomes at the chiasma. Occurs during prophase I of meiosis. ...
... 6. Explain what is meant by crossing-over (recombination). Be sure and mention at what time it is taking place within the cell. An exchange of corresponding segments between two homologous chromosomes at the chiasma. Occurs during prophase I of meiosis. ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.