Intrinsically Disordered Proteins as Drug Targets
... and a lot of efforts are put on it [62]. The flexibility of proteins has been widely studied both experimentally and computationally. There exist a wide range of experimental techniques suitable to explore different time scales and resolutions. In IDPs the number of useful techniques is reduced beca ...
... and a lot of efforts are put on it [62]. The flexibility of proteins has been widely studied both experimentally and computationally. There exist a wide range of experimental techniques suitable to explore different time scales and resolutions. In IDPs the number of useful techniques is reduced beca ...
Predicting enzyme targets for cancer drugs by profiling
... reaction by analyzing its fluxes in different cellular environments such as NCI-60 cancer cell lines. Thus, each reaction can be represented as its reaction fluxes in the different cells. This is the reaction representation method what we call reaction profiling. By this method, we can construct the ...
... reaction by analyzing its fluxes in different cellular environments such as NCI-60 cancer cell lines. Thus, each reaction can be represented as its reaction fluxes in the different cells. This is the reaction representation method what we call reaction profiling. By this method, we can construct the ...
Mechanistic model of cardiac energy metabolism predicts
... concentrations of these metabolites in the cytosol and mitochondria when studying mechanisms controlling glycolysis and lactate metabolism from normal to ischemic conditions. Furthermore, it has been observed that key glycolytic enzymes are bound together in specific intracellular structures to form ...
... concentrations of these metabolites in the cytosol and mitochondria when studying mechanisms controlling glycolysis and lactate metabolism from normal to ischemic conditions. Furthermore, it has been observed that key glycolytic enzymes are bound together in specific intracellular structures to form ...
c Syun-Ru Yeh‡ and Denis L. Rousseau
... The off pathway intermediates (Di) are dead-end products that may form deep kinetic traps during folding and have been reported to be linked to human pathogenesis (10, 11). To unify the kinetic studies from a large variety of proteins, a “new view” of protein folding has been postulated in which uni ...
... The off pathway intermediates (Di) are dead-end products that may form deep kinetic traps during folding and have been reported to be linked to human pathogenesis (10, 11). To unify the kinetic studies from a large variety of proteins, a “new view” of protein folding has been postulated in which uni ...
Mittenthal, J.E., Clarke, B., Waddell, T., and Fawcett, G.
... The g-reactions of a C-paranet redistribute the carbon atoms in the reacting metabolites. Each of these metabolites is only speci"ed by the number of carbon atoms it contains. Conversion of a Cto an R-paranet proceeds through the following stages, here as in our work on the pentose phosphate pathway ...
... The g-reactions of a C-paranet redistribute the carbon atoms in the reacting metabolites. Each of these metabolites is only speci"ed by the number of carbon atoms it contains. Conversion of a Cto an R-paranet proceeds through the following stages, here as in our work on the pentose phosphate pathway ...
Document
... Hess’s Law of Heat Summation For a chemical equation that can be written as the sum of two or more steps, the enthalpy change for the overall equation equals the sum of the enthalpy changes for the individual steps. ...
... Hess’s Law of Heat Summation For a chemical equation that can be written as the sum of two or more steps, the enthalpy change for the overall equation equals the sum of the enthalpy changes for the individual steps. ...
High resolution crystal structures of unliganded
... The amino acid sequences of the ACBPs of known structure, including the sequence of the human ACBP (hLACBP), are listed in Figure 1. All known structures have the same four-helix bundle fold (helices A1, A2, A3, and A4), with a 13-residue loop insertion between the parallel helix-pair of A2 and A3. ...
... The amino acid sequences of the ACBPs of known structure, including the sequence of the human ACBP (hLACBP), are listed in Figure 1. All known structures have the same four-helix bundle fold (helices A1, A2, A3, and A4), with a 13-residue loop insertion between the parallel helix-pair of A2 and A3. ...
Experiment 7 (Lab Period 8) Quantitative Determination of
... seedling. Other phosphatases occur in the lysosomes of phagocytic cells and help to digest particulate matter captured during phagocytosis. Still others are active in the cytoplasm and serve to recycle phosphorus in metabolism or to remove phosphate groups from proteins whose activities are regulate ...
... seedling. Other phosphatases occur in the lysosomes of phagocytic cells and help to digest particulate matter captured during phagocytosis. Still others are active in the cytoplasm and serve to recycle phosphorus in metabolism or to remove phosphate groups from proteins whose activities are regulate ...
George Facer`s A level Chemistry
... The reaction involves nucleophilic attack on the carbon atom joined to the halogen by the lone pair of electrons on the oxygen in water. Since water is not as good a nucleophile as hydroxide ions, the reaction is much slower than that with aqueous potassium hydroxide. The halide ion formed then reac ...
... The reaction involves nucleophilic attack on the carbon atom joined to the halogen by the lone pair of electrons on the oxygen in water. Since water is not as good a nucleophile as hydroxide ions, the reaction is much slower than that with aqueous potassium hydroxide. The halide ion formed then reac ...
ppt
... Then further analyze the performance on phosphorylation information extraction using the PIR evidence-tagged abstracts as the benchmark standard. ...
... Then further analyze the performance on phosphorylation information extraction using the PIR evidence-tagged abstracts as the benchmark standard. ...
3.5 Empirical Formulas - Mayfield City Schools
... 8. Epsom salts, a strong laxative used in veterinary medicine, is a hydrate, which means that a certain number of water molecules are included in the solid structure. The formula for Epsom salts can be written as MgSO4•xH2O, where x indicates the number of moles of H2O per mole of MgSO4. When 5.061 ...
... 8. Epsom salts, a strong laxative used in veterinary medicine, is a hydrate, which means that a certain number of water molecules are included in the solid structure. The formula for Epsom salts can be written as MgSO4•xH2O, where x indicates the number of moles of H2O per mole of MgSO4. When 5.061 ...
Introduction
... Converts “<“ to “|” in string citations Checks isozyme sequence similarity Fixes references between polypeptides and genes Changes compound names to ids in a variety of slots Matches physiological regulators to other regulators Cross-references compounds to reactions Checks pathways predecessors/rea ...
... Converts “<“ to “|” in string citations Checks isozyme sequence similarity Fixes references between polypeptides and genes Changes compound names to ids in a variety of slots Matches physiological regulators to other regulators Cross-references compounds to reactions Checks pathways predecessors/rea ...
doc - DePaul University
... the overall stability of the protein while the non-core amino acids play a significant role in determining the tertiary structure. The results were encouraging, demonstrating that it was possible to repack the core alone with novel sequences. Unfortunately, the potential sequences were limited by th ...
... the overall stability of the protein while the non-core amino acids play a significant role in determining the tertiary structure. The results were encouraging, demonstrating that it was possible to repack the core alone with novel sequences. Unfortunately, the potential sequences were limited by th ...
Chapter 5: chemical reactions in the living cell
... and algae, and ultimately converted into other types of energy, most prominently into the formation of new covalent bonds of sugar molecules during photosynthesis (see Chapter 7) - the importance of sugar molecules produced by agricultural plants for human nutrition and food supply proves the prime ...
... and algae, and ultimately converted into other types of energy, most prominently into the formation of new covalent bonds of sugar molecules during photosynthesis (see Chapter 7) - the importance of sugar molecules produced by agricultural plants for human nutrition and food supply proves the prime ...
Outline
... 3A Electrochemical cells 1 Show how any redox reaction can be separated into oxidation and reduction half-reactions. 2 Describe how a cell can be constructed using a redox reaction in which halfreactions are contained in half-cells joined by a salt bridge or separated by a ...
... 3A Electrochemical cells 1 Show how any redox reaction can be separated into oxidation and reduction half-reactions. 2 Describe how a cell can be constructed using a redox reaction in which halfreactions are contained in half-cells joined by a salt bridge or separated by a ...
Supplementary Notes - Word file
... effects of these mutations on bioluminescence color are not fully understood at the current level of our structural study, but do not exclude the possibility of general and integral role of Ile288 in the firefly luciferases. ...
... effects of these mutations on bioluminescence color are not fully understood at the current level of our structural study, but do not exclude the possibility of general and integral role of Ile288 in the firefly luciferases. ...
Document
... Designing an appropiate method in order to support or reject the proposed hypothesis and answer the given research question brought various problems with it. One of the biggest problems was the lack of chemicals. I did not have the all chemicals to synthesise all complexes in the spectrochemical ser ...
... Designing an appropiate method in order to support or reject the proposed hypothesis and answer the given research question brought various problems with it. One of the biggest problems was the lack of chemicals. I did not have the all chemicals to synthesise all complexes in the spectrochemical ser ...
Lab 5: Proteins and the small molecules that love them
... can be performed outside of the cell. Reaction rates can be accelerated through the addition of heat, altering the pH of the solution, or adding catalysts – a reagent(s) that speeds up a chemical reaction without being consumed. The first two options are not very readily available inside a cell. The ...
... can be performed outside of the cell. Reaction rates can be accelerated through the addition of heat, altering the pH of the solution, or adding catalysts – a reagent(s) that speeds up a chemical reaction without being consumed. The first two options are not very readily available inside a cell. The ...
The Wizard Test Maker
... 67. Why does an abrupt color change take place when phenolphthalein is used as an indicator in the titration of a strong acid and a strong base? (A) When enough base is added to the solution, phenolphthalein acts as a catalyst for the color change. (B) Phenolphthalein changes the rate of reaction, c ...
... 67. Why does an abrupt color change take place when phenolphthalein is used as an indicator in the titration of a strong acid and a strong base? (A) When enough base is added to the solution, phenolphthalein acts as a catalyst for the color change. (B) Phenolphthalein changes the rate of reaction, c ...
Supplementary Figures 1 - 5, Methods
... For inoculation into NSG mice, Globo-Hlow and Globo-Hhigh MCF-7 cells sorted by FACS Aria were suspended in serum-free MEM at a concentration of 5 × 106 cells in 100 μl with 2mg/ml matrigel, and injected subcutaneously (s.c.) into the mammary ...
... For inoculation into NSG mice, Globo-Hlow and Globo-Hhigh MCF-7 cells sorted by FACS Aria were suspended in serum-free MEM at a concentration of 5 × 106 cells in 100 μl with 2mg/ml matrigel, and injected subcutaneously (s.c.) into the mammary ...
Mini-Review Roles of Molecular Chaperones in Protein Degradation
... tetradecamer of the protease subunit, Clp P (14) assembled with a hexamer of regulatory ATPase subunits, ClpA or ClpX (8, 14). Molecular Chaperones and Proteolysis by Proteases La and Clp. Degradation of bulk abnormal proteins such as puromycyl peptides and proteins containing amino acid analogs is ...
... tetradecamer of the protease subunit, Clp P (14) assembled with a hexamer of regulatory ATPase subunits, ClpA or ClpX (8, 14). Molecular Chaperones and Proteolysis by Proteases La and Clp. Degradation of bulk abnormal proteins such as puromycyl peptides and proteins containing amino acid analogs is ...
Can correct protein models be identified?
... Residue–residue distances have been used in many statistical energy functions. The information can be represented in several different ways, including binary contact/noncontact information and distance-dependent functions. Furthermore, the sequence separation between two residues can be included. If ...
... Residue–residue distances have been used in many statistical energy functions. The information can be represented in several different ways, including binary contact/noncontact information and distance-dependent functions. Furthermore, the sequence separation between two residues can be included. If ...
Cavity cooling of the internal and external motion of molecules
... Iodoform in an optical potential properties calculated with ab intio methods (B3LYP/aug-cc-pVTZ) → C-H stretch is chosen as cooling transition → well localized vibration ...
... Iodoform in an optical potential properties calculated with ab intio methods (B3LYP/aug-cc-pVTZ) → C-H stretch is chosen as cooling transition → well localized vibration ...