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On the Evolution of Chemical Organizations
On the Evolution of Chemical Organizations

... Chemical evolution (i.e., prebiotic evolution) is concerned with the period of life’s history that precedes the arrival of the first living organism [17]. Since Miller’s pioneering work [19, 20], prebiotic chemistry has been studied in various laboratory experiments [16]. On the other hand, there ar ...
Metal ions in biological system and Potential Medicine
Metal ions in biological system and Potential Medicine

... Manganese(II) ions function as cofactors for a number of enzymes and the element is thus a required trace mineral for all known living organisms. Biological role: The classes of enzymes that have manganese cofactors are very broad and include such classes as oxidoreductases, transferase, hydrolases, ...
Chem 150 quiz #6
Chem 150 quiz #6

... 17. What is the total net yield of ATP obtained when 5 glucose molecules are catabolized through glycolysis? (Note: The end product of glycolysis has not entered the TCA cycle yet.) a. 2 ATP b. 28 – 29 ATP c. 30 – 32 ATP d. 18 ATP e. none of the above 18. How many molecules of pyruvate would be obta ...
multiscale modeling of the organizations of receptor transmembrane
multiscale modeling of the organizations of receptor transmembrane

Kinetic, Mechanistic, and Structural aspects of the cis
Kinetic, Mechanistic, and Structural aspects of the cis

... IPP are classified as cis- and trans-types according to the stereochemistry of the double bonds formed by IPP condensation. The complete kinetics of the multiple-step IPP condensation reactions by both types of enzymes has been determined using steady-state and pre-steady-state approaches. As a resu ...
Chapter 11 Chemical Reactions
Chapter 11 Chemical Reactions

... Atoms not created or destroyed (Law of Conservation of Mass)  rxn described in a: ...
Monte Carlo Simulations of HIV Capsid Protein
Monte Carlo Simulations of HIV Capsid Protein

... proteins in the simulations is directly related to the dissociation constant Kd in macroscopic systems. Our simulations can thus be used to estimate the binding affinity of the CA homodimer. Specifically, we define the bound and unbound states based on the contact strength introduced earlier. For each f ...
ELEM_CouvC_V1n3 copy
ELEM_CouvC_V1n3 copy

... organic molecules called alkane thiols, which were generated in a very different experiment. To test one of Wächtershäuser’s central postulates, Heinen and Lauwers (1996) performed a series of reactions using FeS, H2S, and water, blanketed by an atmosphere of N2/CO2 or pure CO2, and demonstrated the ...
Energy, Catalysis, and Biosynthesis
Energy, Catalysis, and Biosynthesis

... they may exchange or barter eggs for milk. But in a more complex economy, money serves as a mediator for the exchanges of goods or services. For instance, the cow owner with excess milk may not need other goods until three months from now, or may want goods from someone who does not need milk. In th ...
Enzymes in Action Kit – In Brief
Enzymes in Action Kit – In Brief

... enzymatic action by binding to another part of the enzyme. This second site, known as the allosteric site, is the place on an enzyme where a molecule that is not a substrate may bind, thus changing the shape of the enzyme and influencing its ability to be active. ...
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as a PDF

... permit more configurational sampling, while others use higherlevel quantum methods at the expense of sampling. The ONIOM method,3-6 with its separation of a system into layers, with higher-level methods used for inner and lower-level methods used for outer layers, is an attempt to reduce the cost of ...
Lecture 10, molecular diversity - Cal State LA
Lecture 10, molecular diversity - Cal State LA

... •Mostly cyclic, complex, resemble natural products, lots of stereochem •few synthetic steps Potential role of diversity-oriented synthesis and combinatorial chemistry in more efficient drug discovery: ...
Class: 11 Subject: Chemistry Topic: Equilibrium No. of
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... 11. Assertion (A) The pH of an aqueous solution of acetic acid remains unchanged on the addition of sodium acetate. Reason (R) The ionisation of acetic acid is suppressed by the addition of sodium acetate. A. Both (A) and (R) are true and (R) is the correct explanation of (A). B. Both (A) and (R) ar ...
Object Detection II COS 429 Princeton University
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“Synthesis, characterization and biomedical applications of microbial polymalic and polyglutamic acids derivatives.”
“Synthesis, characterization and biomedical applications of microbial polymalic and polyglutamic acids derivatives.”

... the manufacture of nanoparticles with a diameter in the 200 nm range and a fairly narrow size distribution. These nanoparticles are readily hydrodegradable following almost linear profiles and taking place within periods of time of 15 to 40 days. The degradation rate is depending of both the length ...
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... residues, we observed no evident change of peak intensity, suggesting the fast exchange between conformational states. On the other hand, some residues showed a decrease in peak intensity above pH 6 without changing the chemical shift, suggesting a contribution of slow conformational change. ...
The Physiological Roles of Enzymes
The Physiological Roles of Enzymes

... A. Enzymes use a variety of strategies to catalyze reactions, and individual enzymes often use more than one strategy. B. Substrate binding by an enzyme helps catalyze the reaction by bringing the reactants into proximity with the optimal orientation for reaction. C. Amino acid side chains within ac ...
enzyme - iGEM 2014
enzyme - iGEM 2014

... • An increased interaction of the enzyme and substrate occurs in the transition-state (ES‡) • The enzyme distorts the substrate, forcing it toward the transition state • An enzyme must be complementary to the transition-state in shape and chemical character • Enzymes may bind their transition states ...
Enzyme Activity
Enzyme Activity

... The effects of change in temperature. Temperature: enzymes work best at an optimum temperature. Below this, an increase in temperature provides more kinetic energy to the molecules involved. The numbers of collisions between enzyme and substrate will increase so the rate will too. Above the optimum ...
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ligand design and selection: using 3d fragments with

... This MED-Ligand application is about to generate potential hits of egfr (the Epidermal Growth Factor Receptor) from a pool of prealigned fragments of the PDB that are combined in the 3D pocket of egfr (PDB code 1xkk). Our MED-SuMo/MEDP-Fragmentor technology were used first to cross-mine the PDB with ...
Chapter 12 Review “Stoichiometry”
Chapter 12 Review “Stoichiometry”

... g water, 2.24 L of hydrogen gas forms (at STP). How would the amount of hydrogen produced change if the volume of water was decreased to 440 mL (440 g)?  When two substances react to form products, the reactant which is used up is called the ____. ...
FINAL EXAM Spring 2012
FINAL EXAM Spring 2012

... The last page of this examination is a periodic table [Gas constant = 8.314 J/mol K; 0.08206 L*atm/mole*K,1 faraday = 96500 J/V mol e-; at 25oC] 1) The reaction has the rate law, Rate = k[A][B]2. Which will cause the rate to increase the most? A) doubling [A] B) doubling [B] C) tripling [B] D) quadr ...
Biological Molecules – Carbohydrates Carbohydrate – molecules
Biological Molecules – Carbohydrates Carbohydrate – molecules

... These are examples of simpler diagrams. Diagrams can go as simple as only having the “lines” and the molecules that are at each “corner” that are not carbon (as shown in these ones). Carbohydrates have five characteristics about them: ...
Nanotechnology
Nanotechnology

... with biological and biochemical applications or uses. Nanobiotechnology often studies existing elements of nature in order to fabricate new devices. Nanobiotechnology usually refers to the use of nanotechnology to further the goals of biotechnology, while bionanotechnology might refer to any overlap ...
An introduction to enzyme structure and function
An introduction to enzyme structure and function

... A more recent explanation to the fitting of enzymes is the induced-fit hypothesis. This hypothesis still states that one substrate fits one active site, this is scientific fact. But this hypothesis suggests that the enzyme molecule slightly changes shape when it collides with substrate, making the a ...
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Multi-state modeling of biomolecules

Multi-state modeling of biomolecules refers to a series of techniques used to represent and compute the behaviour of biological molecules or complexes that can adopt a large number of possible functional states.Biological signaling systems often rely on complexes of biological macromolecules that can undergo several functionally significant modifications that are mutually compatible. Thus, they can exist in a very large number of functionally different states. Modeling such multi-state systems poses two problems: The problem of how to describe and specify a multi-state system (the ""specification problem"") and the problem of how to use a computer to simulate the progress of the system over time (the ""computation problem""). To address the specification problem, modelers have in recent years moved away from explicit specification of all possible states, and towards rule-based formalisms that allow for implicit model specification, including the κ-calculus, BioNetGen, the Allosteric Network Compiler and others. To tackle the computation problem, they have turned to particle-based methods that have in many cases proved more computationally efficient than population-based methods based on ordinary differential equations, partial differential equations, or the Gillespie stochastic simulation algorithm. Given current computing technology, particle-based methods are sometimes the only possible option. Particle-based simulators further fall into two categories: Non-spatial simulators such as StochSim, DYNSTOC, RuleMonkey, and NFSim and spatial simulators, including Meredys, SRSim and MCell. Modelers can thus choose from a variety of tools; the best choice depending on the particular problem. Development of faster and more powerful methods is ongoing, promising the ability to simulate ever more complex signaling processes in the future.
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