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Slide set - Mediterranean Group for the Study of Diabetes
Slide set - Mediterranean Group for the Study of Diabetes

T. caerulescens
T. caerulescens

... and excess T. caerulescens were chosen • Extreme conditions chosen because it would show the most altered expression of genes • Genes that are expected to be found would deal with zinc transporters, homeostasis, and lignin biosynthesis • Each gene has its own function which ultimately helps the plan ...
on the MGED OWG from the Fourth Annual Bio
on the MGED OWG from the Fourth Annual Bio

... – behavioral stimulus: The organism is forced to respond to a stimulus with some behavior (e.g., avoidance, obtaining a reward, etc.) – agent-based treatment: The treatment is effected by a defined chemical, biological, or physical agent. ...
Metabolic Energy - Metabolism Foundation
Metabolic Energy - Metabolism Foundation

... Metabolic Energy for Dummies: A quick look at Cellular Metabolism (Energetics) ...
Metabolism - Princeton Chiropractic Wellness Center
Metabolism - Princeton Chiropractic Wellness Center

Analysis of tissue-specific co-expression networks Somaye
Analysis of tissue-specific co-expression networks Somaye

... types. Thus, the reconstruction and analysis of the gene co-expression networks provides an approach to understanding tissue-specific mechanisms in health and disease. In this study, we reconstructed and analytically assessed tissue-specific co-expression networks in order to identify and characteri ...
ClickThisLinkForEntries
ClickThisLinkForEntries

... Cofactors are nonproteins assisting the process of catalytic activity. They can be inorganic or organic; examples are vitamins. They can either bind tightly and permanently (covalently) to enzymes or loosely and reversibly to substrates with weaker bonds; either way of interacting with these two wil ...
PPT3 - Ycmou
PPT3 - Ycmou

... are abundantly made available by catabolic pathways. Sugar, amino acids, fatty acids and nitrogenous bases are precursors utilized in anabolic reactions. ...
Gokul Das, Ph.D. - Roswell Park Cancer Institute
Gokul Das, Ph.D. - Roswell Park Cancer Institute

... pyruvate, which can then be oxidized in the mitochondria or converted into lactate. Cells containing enhanced expression of the enzyme phosphoglycerate dehydrogenase (PHGDH), either as the result of genomic amplification of its gene on chromosome 1p12 or through other mechanisms, divert 3-phosphogly ...
Biochemistry with Elements of Chemistry - Collegium Medicum
Biochemistry with Elements of Chemistry - Collegium Medicum

... Assessment is based on the presence at the lectures, passing all tests as well as completing and passing all tutorials. Assessment form and regulations of tutorials 1. Students should attend all classes and be prepared for every practical task based on an programme posted on the notice board of the ...
Summary of Metabolism
Summary of Metabolism

... Allosteric regulation • Typically associated with enzymes that catalyze irreversible reactions • Allosteric regulators can cause feed back or feedforward regualtion ...
Vilar et al. 2006, PLoS Computational Biology
Vilar et al. 2006, PLoS Computational Biology

... •Models clarify systemic and dynamic properties of the investigated object. •Models allow simulating processes independent of the experiment. •Modeling reveals regulatory properties of cellular networks ...
Metagenomic investigation of deep
Metagenomic investigation of deep

... and lipid transporters, and both rTCA and CBB carbon fixation cycles were detected in the genomes, highlighting key and shared functions with symbiont metagenomes of Riftia, Tevnia, and Ridgeia from the Pacific. The potential for a second hydrogen oxidation pathway (via a bidirectional hydrogenase), ...
Fifth dimension of life and the 4/5 allometric scaling law for human
Fifth dimension of life and the 4/5 allometric scaling law for human

... biology, but this is not the case. He and Chen (2003) pointed out that the law holds only for three-dimensional organisms. Riisgard (1998) considered that there is no foundation for a ‘‘3/4 power scaling law’’ for respiration in biology; and White and Seymour (2003) concluded that mammalian basal me ...
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(acid)…

... Types of Imbalances • Respiratory acidosis ...
Structures and mechanisms
Structures and mechanisms

... such as individual amino acid residues, a group of amino acids, or even an entire protein domain. These movements occur at various time-scales ranging from femtoseconds to seconds. Networks of protein residues throughout an enzyme's structure can contribute to catalysis through dynamic motions.[46][ ...
Chapters 13 and 16
Chapters 13 and 16

... **Note: The values of 3 and 2 are “consensus values.” Because they may not reflect actual values and because these ratios may change depending on metabolic conditions, these estimates of ATP yield are approximate. TCA Intermediates See figure 16.16 in book The TCA cycle provides intermediates for ma ...
Cell Metabolism
Cell Metabolism

... One type of biochemical pathway regulation is referred to as feedback inhibition. This means that as the A. cell produces more quantity of product through a biochemical pathway, the build up of that product will inhibit the activity of that product’s production B. cell produces more quantity of prod ...
SG 7,8,9,10
SG 7,8,9,10

... What is the Cori cycle? What is the relationship between muscle and liver in the Cori cycle? Describe the Pentose Phosphate Pathway; importance in production of NADPH and 5C sugars, reaction pathway, enzymes involved. List other important sugars for vertebrates and their metabolism. Describe glycoge ...
IntroToBioinformatics
IntroToBioinformatics

... How can Bioinformatics help make scientific discoveries? Bioinformatics is not just the storage of data ...
Study Guide - PEP 535 Exam#1
Study Guide - PEP 535 Exam#1

... What are the sources of protons during muscle contraction? What are the sources of proton buffering/utilization/removal in skeletal muscle? Is it correct to interpret lactate production as the cause of muscle acidosis? Why? Why does ATP hydrolysis release a proton? How would you explain the biochemi ...
Evolution & organisation of metabolic Pathways
Evolution & organisation of metabolic Pathways

... mixtures of proteins, lipids, carbohydrates: fixed composition Reserve(s) do complicate model & implications & testing Reasons to delineate reserve, distinct from structure • metabolic memory • biomass composition depends on growth rate • explanation of respiration patterns (freshly laid eggs don’t ...
Amino Acid Regulation of RNA Synthesis
Amino Acid Regulation of RNA Synthesis

...  The carrier molecules act like enzymes catalysing group-transfer reactions using the solute as substrate.  Group translocation can be envisaged as consisting of two separate activities: 1- the entrance process and 2- the exit process.  The exit process increases in rate with the accumulation of ...
Enzymes
Enzymes

... and control the rates of chemical reactions. • In enzymatic reactions, the molecules at the beginning of the process are called substrates, and the enzyme converts them into different molecules, the products. • Almost all processes in a biological cell need enzymes in order to occur at significant r ...
Citric Acid Cycle Catalysts
Citric Acid Cycle Catalysts

... acid catabolism and ATP production. It is clear how important it is to keep this sequence of key biochemical reactions as efficient as possible for both the catabolic and anabolic aspects of cell function. Patients with chronic degenerative diseases, which are those we encounter most frequently toda ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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