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Aqueous Solutions
Aqueous Solutions

... In the balanced molecular equation for the neutralization of sodium hydroxide with sulfuric acid, the products are: 1) NaSO4 + H2O 2) NaSO3 + 2H2O 3) 2NaSO4 + H2O 4) Na2S + 2H2O 5) Na2SO4 + 2H2O ...
Package `DART`
Package `DART`

... the steps in DART and are provided as explicit functions to allow user flexibility. DoDART is the main user function which will automatically and sequentially run through the following internal functions: (1) BuildRN: This function builds a relevance correlation network of the model pathway signatur ...
Sequence Analysis
Sequence Analysis

... Here we consider the access and analysis of data and information items rather than their generation, storage or annotation ...
Nutrition and Food Science
Nutrition and Food Science

... survey which is ideal for life science research and development. This offering provides the most extensive coverage of the metabolome. Most any sample type is feasible for study, but typically 500-1000 biochemicals can be identified and measured in human plasma and tissue samples in the TrueVision™ ...
Stochastic Modeling of Chemical Reactions (and more
Stochastic Modeling of Chemical Reactions (and more

... It is possible to find a function ϕ such that for every initial population xinit ...
Combination of Neuro-Fuzzy Network Models with Biological
Combination of Neuro-Fuzzy Network Models with Biological

... CSD2/CHS3, CDC8, DPB3, PRI1 and RAD17 are in G1 phase, CWP2 and TIR1 are their strong regulators. CWP2 and TIR1 were calculated by the neuro-fuzzy network model from their regulator sets which consists of 53 regulators. CWP2 and TIR1 are in S/G2 phase, HCM1 is their strong regulator which was calcul ...
Cell Metabolism - Cathkin High School
Cell Metabolism - Cathkin High School

... (a) Name the 3-carbon compound and the 6-carbon compound. 3C _______________________________________________________ 6C _______________________________________________________ ...
Presentazione standard di PowerPoint
Presentazione standard di PowerPoint

... anticlockwise, respectively (gray, conserved in all eight other sequenced E. coli strains; red, conserved only in the B2 phylogroup; yellow, variable distribution; blue, E2348/69 specific), the fifth circle shows the tRNA genes (red), the sixth circle shows the rRNA operons (blue), the seventh circl ...
Download paper (PDF format)
Download paper (PDF format)

... cluster of genes or between clusters? What is the nature of the interaction between genes (e.g does gene A inhibit gene B)? To infer such finer relations from perturbed gene expression profiles we use the framework of Friedman et al. (2000). In this framework, we treat the measured expression level ...
Redox Reactions in Metabolism Supplemental Reading Key
Redox Reactions in Metabolism Supplemental Reading Key

... In redox reactions, we use the term reduction potential (E), measured in volts (V), to represent the electron affinity of a given conjugate redox pair. Analogous to biochemical standard conditions that define Gibbs Free Energy, Gº', (25ºC, pH 7 and 1 M initial concentration of substrates and product ...
Nonenzymatic glycolysis and pentose phosphate
Nonenzymatic glycolysis and pentose phosphate

... that the origin of life could have been facilitated by the geochemical formation of cellular constituents in the reducing environment of the early earth (Oparin, 1938; Miller et al, 1997). Experimental support for this hypothesis was provided by the Miller–Urey experiment that demonstrated the non-b ...
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... enter the mitochondrial matrix to be broken down and are exported to adipose tissue to be stored as fat. But when malonyl CoA is low (fasting state) the fatty acids are broken down into ketone bodies. ...
Homologous and Nonhomologous Rearrangements: Interactions
Homologous and Nonhomologous Rearrangements: Interactions

Properties of Enzymes
Properties of Enzymes

... • Rate of reaction is independent of concentration of the reactants. • Change in concentration of [S] has no effect on rate v = ko • This occurs in catalyzed reactions when they are saturated with the substrate. • Under this conditions, the enzyme is operating at its maximum velocity. • In addition ...
Balancing Redox Cofactor Generation and ATP Synthesis: Key
Balancing Redox Cofactor Generation and ATP Synthesis: Key

... ABSTRACT: Geobacillus thermoglucosidasius is a Gram-positive, thermophilic bacterium capable of ethanologenic fermentation of both C5 and C6 sugars and may have possible use for commercial bioethanol production [Tang et al., 2009; Taylor et al. (2009) Trends Biotechnol 27(7): 398–405]. Little is kno ...
Disturbances of fluid and electrolyte balance
Disturbances of fluid and electrolyte balance

... pH = - log [H+]= pK+log [anion/undissociated acid] • Extracellular space: 7.38pH  7.42 • Intracellular space: pH ~ 6.8 • Source of H+: intake, metabolism (50 mmol/d), CO2: 12500 ,mmol/d) • Elimination of H+: kidney, lung (CO2), gastrointestinal tract, liver ...
Functional genomics in chickens
Functional genomics in chickens

ALLOMETRIC SCALING IN CENTRARCHID FISH Enzyme Levels in Muscles
ALLOMETRIC SCALING IN CENTRARCHID FISH Enzyme Levels in Muscles

... consumed in all cells for basic cellular processes, like protein synthesis and maintaining membrane potential. During maximal exercise, the majority of oxygen demands are made by skeletal muscle. In mammals, maximal metabolic rate scales with the same scaling coefficient as skeletal muscle mitochond ...
Biol 1406 notes Ch 8 8thed - Chemistry
Biol 1406 notes Ch 8 8thed - Chemistry

... Metabolism is an emergent property of life that arises from interactions between mole cules within the orderly environment of the cell. The chemistry of life is organized into metabolic pathways.  A metabolic pathway begins with a specific molecule, which is then altered in a ser ies of defined ste ...
Class: Protein functional Annotation and Family Classification
Class: Protein functional Annotation and Family Classification

... this protein and its possible function from available data Especially important for poorly characterized or uncharacterized (“hypothetical”) proteins More challenging for large sets of sequences generated by large-scale proteomics experiments The quality of this assessment is often critical for inte ...
Related Metabolic Processes
Related Metabolic Processes

... • Not all the organic molecules of food are completely oxidized to make ATP. • Intermediaries in glycolysis and the Krebs cycle can be diverted to anabolic pathways. • For example, a human cell can synthesize about half the 20 different amino acids by modifying compounds from the Krebs cycle. ...
PP - Chemistry Courses: About
PP - Chemistry Courses: About

... Know overall reaction and stages Explain chemical logic of each step Enzyme mechanisms presented in book ...
CHAPTER 9 CELLULAR RESPIRATION: HARVESTING CHEMICAL
CHAPTER 9 CELLULAR RESPIRATION: HARVESTING CHEMICAL

... • Not all the organic molecules of food are completely oxidized to make ATP. • Intermediaries in glycolysis and the Krebs cycle can be diverted to anabolic pathways. • For example, a human cell can synthesize about half the 20 different amino acids by modifying compounds from the Krebs cycle. • Gluc ...
Hybrid Functional Petri Nets to Model the Canonical Wnt Pathway
Hybrid Functional Petri Nets to Model the Canonical Wnt Pathway

... • This model is then input into a commercial program – Cell IllustratorTM by Gene Networks Inc • Simulation is then conducted using that program • [Demonstration] ...
Functional Analysis of A Novel Splicing Mutation in The Mutase
Functional Analysis of A Novel Splicing Mutation in The Mutase

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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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