Conservation of the metabolomic response to starvation across two divergent microbes.
... widely divergent organisms (1). The prokaryote Escherichia coli and the eukaryote Saccharomyces cerevisiae share essentially the same metabolic network (2) despite radically different compartmentation. The concentrations and fluxes of metabolites depend on the interactions among this conserved netwo ...
... widely divergent organisms (1). The prokaryote Escherichia coli and the eukaryote Saccharomyces cerevisiae share essentially the same metabolic network (2) despite radically different compartmentation. The concentrations and fluxes of metabolites depend on the interactions among this conserved netwo ...
FinalPresentation_ccb2012_marc_shangying_yan
... Measurement of concentrations within small time scale before and after treatment will help to understand the whole signaling process and validate the model. ...
... Measurement of concentrations within small time scale before and after treatment will help to understand the whole signaling process and validate the model. ...
Question
... found to have a serum potassium of 3.2 mEq/L and a bicarbonate level of 19 mEq/L during a hospitalization for a D and C. She was treated with oral potassium and bicarbonate supplements and then weaned these off after 4 months of therapy. Six weeks later, she developed myalgias and collapsed due to p ...
... found to have a serum potassium of 3.2 mEq/L and a bicarbonate level of 19 mEq/L during a hospitalization for a D and C. She was treated with oral potassium and bicarbonate supplements and then weaned these off after 4 months of therapy. Six weeks later, she developed myalgias and collapsed due to p ...
Multiomics of tomato glandular trichomes reveals
... Metabolomics Central metabolites are mostly polar. Therefore, to better understand the connection between primary and secondary metabolism in glandular trichomes, non-targeted profiling for polar and semi-polar metabolites was carried out separately using two LC-MS methods and one GC ...
... Metabolomics Central metabolites are mostly polar. Therefore, to better understand the connection between primary and secondary metabolism in glandular trichomes, non-targeted profiling for polar and semi-polar metabolites was carried out separately using two LC-MS methods and one GC ...
Metabolic Applied Research Strategy
... bariatric surgery. But there is also a need for more effective ...
... bariatric surgery. But there is also a need for more effective ...
BIRMINGHAM CHILDREN’S HOSPITAL NHS FOUNDATION TRUST PAEDIATRIC LABORATORY MEDICINE
... We do not routinely analyse high-risk specimens without prior discussion. Please contact the Duty Metabolic Biochemist before sending any such specimens. Consent It is the responsibility of the requesting doctor to obtain consent for the specimen collection and the tests requested. It is implicit in ...
... We do not routinely analyse high-risk specimens without prior discussion. Please contact the Duty Metabolic Biochemist before sending any such specimens. Consent It is the responsibility of the requesting doctor to obtain consent for the specimen collection and the tests requested. It is implicit in ...
Enzyme Mechanisms
... unrelated settings Subtilisin: externals very different from mammalian serine proteases; triad same ...
... unrelated settings Subtilisin: externals very different from mammalian serine proteases; triad same ...
Radiocontrast Media Allergic Reactions and Interventional Pain
... fashion, rather than as its primary concern or focus, were excluded. ...
... fashion, rather than as its primary concern or focus, were excluded. ...
- Wiley Online Library
... We assess the use to which bioinformatics in the form of bacterial genome sequences, functional gene probes and the protein sequence databases can be applied to hypotheses about obligate autotrophy in eubacteria. Obligate methanotrophy and obligate autotrophy among the chemo- and photo-lithotrophic ...
... We assess the use to which bioinformatics in the form of bacterial genome sequences, functional gene probes and the protein sequence databases can be applied to hypotheses about obligate autotrophy in eubacteria. Obligate methanotrophy and obligate autotrophy among the chemo- and photo-lithotrophic ...
Chapter 23 Gluconeogenesis Gluconeogenesis, con`t.
... • Substrates include anything that can be converted to phosphoenolpyruvate . • Many of the reactions are the same as those in glycolysis. • All glycolytic reactions which are near equilibrium can operate in both directions. ...
... • Substrates include anything that can be converted to phosphoenolpyruvate . • Many of the reactions are the same as those in glycolysis. • All glycolytic reactions which are near equilibrium can operate in both directions. ...
Pentose P Path
... Regulation of Glucose-6-phosphate Dehydrogenase: Glucose-6-phosphate Dehydrogenase is the committed step of the Pentose Phosphate Pathway. This enzyme is regulated by availability of the substrate NADP+. As NADPH is utilized in reductive synthetic pathways, the increasing concentration of NADP+ ...
... Regulation of Glucose-6-phosphate Dehydrogenase: Glucose-6-phosphate Dehydrogenase is the committed step of the Pentose Phosphate Pathway. This enzyme is regulated by availability of the substrate NADP+. As NADPH is utilized in reductive synthetic pathways, the increasing concentration of NADP+ ...
![[U-13C]propionate, phenylacetate, and acetaminophen](http://s1.studyres.com/store/data/002254284_1-9ecb94e9c5e6c14c57ae26d63989e9aa-300x300.png)
[U-13C]propionate, phenylacetate, and acetaminophen
... stomach after ingestion, in a manner similar to aspirin. These features suggest that oral administration of propionate may be an effective method for noninvasive analysis of hepatic gluconeogenesis in humans. Although deployment of more hepatophilic tracers has minimized labeling contributions from ...
... stomach after ingestion, in a manner similar to aspirin. These features suggest that oral administration of propionate may be an effective method for noninvasive analysis of hepatic gluconeogenesis in humans. Although deployment of more hepatophilic tracers has minimized labeling contributions from ...
The co-ordination of central plant metabolism by the circadian clock
... plants. The second hypothesis that could explain the underlying circadian oscillator that co-ordinates CAM involves the pathway being coupled with the autoregulatory negativefeedback gene loops that form a circadian oscillator in the nucleus of every plant cell. The components of this oscillator are ...
... plants. The second hypothesis that could explain the underlying circadian oscillator that co-ordinates CAM involves the pathway being coupled with the autoregulatory negativefeedback gene loops that form a circadian oscillator in the nucleus of every plant cell. The components of this oscillator are ...
Enzyme
... Stored at high concentration, as lyophilized powders, or in a concentrated (NH4)2SO4 solution Some proteases may go through autolysis during storage. Some enzymes are easier to subject to denaturation at low concentrations. Stored at low temperatures Be careful: freeze-thaw cycles would inac ...
... Stored at high concentration, as lyophilized powders, or in a concentrated (NH4)2SO4 solution Some proteases may go through autolysis during storage. Some enzymes are easier to subject to denaturation at low concentrations. Stored at low temperatures Be careful: freeze-thaw cycles would inac ...
12-Glycolysis2016-11-15 13:225.6 MB
... short, intense exercise, providing energy for a period ranging from 10 seconds to 2 minutes. ...
... short, intense exercise, providing energy for a period ranging from 10 seconds to 2 minutes. ...
"Using the KEGG Database Resource". In: Current Protocols in
... The items on the pathway map are represented by various symbols (Fig. 1.12.1). Most of the nodes of a pathway map are rectangles that represent gene products, usually proteins. Small circles represent chemical compounds and other molecules. Large ovals represent links to other pathway maps, and a cl ...
... The items on the pathway map are represented by various symbols (Fig. 1.12.1). Most of the nodes of a pathway map are rectangles that represent gene products, usually proteins. Small circles represent chemical compounds and other molecules. Large ovals represent links to other pathway maps, and a cl ...
medical chemistry and biochemistry
... 5. Derive units of measurement and conclude which units are used in which formulas. 6. Differentiate electrolytes and non electrolytes. 7. Predict the number of ions to which an electrolyte ionises. 8. Solve gas laws and problem tasks relating to colligative properties of solutions, on their own. 9. ...
... 5. Derive units of measurement and conclude which units are used in which formulas. 6. Differentiate electrolytes and non electrolytes. 7. Predict the number of ions to which an electrolyte ionises. 8. Solve gas laws and problem tasks relating to colligative properties of solutions, on their own. 9. ...
Metabolic network modelling
Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑