Adverse Reactions to Contrast Material
... for the Radiologic Decision-Making series. Send submissions to Jay Siwek, M.D., following the guidelines provided in “Information for Authors.” ...
... for the Radiologic Decision-Making series. Send submissions to Jay Siwek, M.D., following the guidelines provided in “Information for Authors.” ...
Metabolism IV
... Thymidylate derived from uridylate in a 5,10methylenetetrahydrofolate dependent reaction: uridylate + 5,10-meTHF thymidylate + dihydrofolate Catalyzed by thymidylate synthase Rest of cycle gets DHF reconverted into 5,10-meTHF ...
... Thymidylate derived from uridylate in a 5,10methylenetetrahydrofolate dependent reaction: uridylate + 5,10-meTHF thymidylate + dihydrofolate Catalyzed by thymidylate synthase Rest of cycle gets DHF reconverted into 5,10-meTHF ...
treatment guidelines for salicylate poisoning
... 4.) Vd = 0.1 to 0.3 L/kg; dependent on protein binding and physiologic pH. Acidosis increases Vd because of enhanced tissue penetration by unionized salicylic acid in a more acidic environment. 5.) The biologic half-life of Acetyl Salicylic Acid (ASA) is only 20 minutes since both the stomach and bl ...
... 4.) Vd = 0.1 to 0.3 L/kg; dependent on protein binding and physiologic pH. Acidosis increases Vd because of enhanced tissue penetration by unionized salicylic acid in a more acidic environment. 5.) The biologic half-life of Acetyl Salicylic Acid (ASA) is only 20 minutes since both the stomach and bl ...
First genomic insights into members of a candidate bacterial
... For COGs, RPS-BLAST against COG PSSMs from the CDD database (Marchler-Bauer et al., 2013) was performed using an e-value cutoff of 0.01, with the top hit retained for each protein domain. The amino acid sequences were also searched for conserved motifs with PFAM (Punta et al., 2012) using HMMR3 (Edd ...
... For COGs, RPS-BLAST against COG PSSMs from the CDD database (Marchler-Bauer et al., 2013) was performed using an e-value cutoff of 0.01, with the top hit retained for each protein domain. The amino acid sequences were also searched for conserved motifs with PFAM (Punta et al., 2012) using HMMR3 (Edd ...
Ube2W conjugates ubiquitin to α-amino groups of protein N
... was employed. A 1 % FDR (false discovery rate) was required at both the protein and peptide level. Spectra were annotated using the MaxQuant spectral annotation system as well as the ‘Expert system’ [12]. cDNA cloning ...
... was employed. A 1 % FDR (false discovery rate) was required at both the protein and peptide level. Spectra were annotated using the MaxQuant spectral annotation system as well as the ‘Expert system’ [12]. cDNA cloning ...
Scott et al. 2006
... reactions involved in amino acid biosynthesis can be used to distinguish amino acids formed by life from those formed by nonbiological processes. The unique patterns of 13C imprinted by life on amino acids produced a biological bias. We also showed that, by applying discriminant function analysis t ...
... reactions involved in amino acid biosynthesis can be used to distinguish amino acids formed by life from those formed by nonbiological processes. The unique patterns of 13C imprinted by life on amino acids produced a biological bias. We also showed that, by applying discriminant function analysis t ...
Peroxyl free radicals: potential mediators of tumor initiation and
... induced cells because the yield of jy/i-dihydrodiolepoxide in j3naphthoflavone-induced cells is — 10 times higher than the yield of a/jtt-dihydrodiolepoxide in control cells. We attempted to investigate the source of peroxyl radicals in the epidermal cells. The high prostaglandin biosynthetic capaci ...
... induced cells because the yield of jy/i-dihydrodiolepoxide in j3naphthoflavone-induced cells is — 10 times higher than the yield of a/jtt-dihydrodiolepoxide in control cells. We attempted to investigate the source of peroxyl radicals in the epidermal cells. The high prostaglandin biosynthetic capaci ...
as a PDF
... including this irnportant revision seemed essentially to be correct. However, this revised view was criticized (11) because the glutamine-derived oxoglutarate metabolism, which indeed will yield HCOJ production by the kidney, will not affect total body bicarbonate homeostasis, because the oxoglutara ...
... including this irnportant revision seemed essentially to be correct. However, this revised view was criticized (11) because the glutamine-derived oxoglutarate metabolism, which indeed will yield HCOJ production by the kidney, will not affect total body bicarbonate homeostasis, because the oxoglutara ...
XTalkDB: a database of signaling pathway crosstalk
... papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents crosstalk between specific pairs of signaling pathways. We have developed XTALKDB (http://www.xtalkdb.org) to fill this very important gap. XTALKDB contains curated information for ...
... papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents crosstalk between specific pairs of signaling pathways. We have developed XTALKDB (http://www.xtalkdb.org) to fill this very important gap. XTALKDB contains curated information for ...
Chapter 4
... In Summary Oxygen uptake increases in a linear fashion during incremental exercise until VO2 max is reached. The point at which blood lactic acid rises systematically during graded exercise is termed the lactate threshold or anaerobic threshold. Controversy exists over the mechanism to explain ...
... In Summary Oxygen uptake increases in a linear fashion during incremental exercise until VO2 max is reached. The point at which blood lactic acid rises systematically during graded exercise is termed the lactate threshold or anaerobic threshold. Controversy exists over the mechanism to explain ...
Berleman, J. Analysis of inter-species interactions and
... Firmicutes, and the furanosyl borate diester (commonly called autoinducer 2, or AI-2) which is dependent on activity of the LuxS protein and present in many domains of bacteria. However, analysis of 818 currently available complete bacterial genomes indicates that only 322 (39%) of these genomes con ...
... Firmicutes, and the furanosyl borate diester (commonly called autoinducer 2, or AI-2) which is dependent on activity of the LuxS protein and present in many domains of bacteria. However, analysis of 818 currently available complete bacterial genomes indicates that only 322 (39%) of these genomes con ...
Metabolic Pathways and Energy Production
... • NADH (Complex I) oxidation for 3 ATPs. NADH + 3 ADP + 3Pi NAD+ + 3 ATP • FADH2 (Complex II) oxidation for 2 ATPs. FADH2 + 2 ADP + 2Pi FAD + 2 ATP ...
... • NADH (Complex I) oxidation for 3 ATPs. NADH + 3 ADP + 3Pi NAD+ + 3 ATP • FADH2 (Complex II) oxidation for 2 ATPs. FADH2 + 2 ADP + 2Pi FAD + 2 ATP ...
Decreased expression of plastidial adenylate kinase in potato tubers
... were directly targeted at pathway enzymes/proteins—the overexpression of a bacterial ADPglucose pyrophosphorylase (AGPase) (Stark et al., 1992) and the overexpression of an amyloplastidial adenylate transporter from Arabidopsis (Tjaden et al., 1998)—while others were targeted at co-factors or effect ...
... were directly targeted at pathway enzymes/proteins—the overexpression of a bacterial ADPglucose pyrophosphorylase (AGPase) (Stark et al., 1992) and the overexpression of an amyloplastidial adenylate transporter from Arabidopsis (Tjaden et al., 1998)—while others were targeted at co-factors or effect ...
Slide 1
... other mitochondrial uncoupling proteins) which are activated by calcium coming in through the calcium uniporter. Also note that electron carriers can autooxidize directly to oxygen, creating oxygen radicals (Co-Q is the major site of autooxidation) with as much as 5% of resting oxygen use due to thi ...
... other mitochondrial uncoupling proteins) which are activated by calcium coming in through the calcium uniporter. Also note that electron carriers can autooxidize directly to oxygen, creating oxygen radicals (Co-Q is the major site of autooxidation) with as much as 5% of resting oxygen use due to thi ...
The adaptive dynamics of function-valued traits
... that function-valued traits will rarely be selectively neutral: we must expect that some function shapes will amount to improved adaptation, so that variant phenotypes expressing such shapes will be able to invade and replace inferior resident types. In general, therefore, evolution will proceed to ...
... that function-valued traits will rarely be selectively neutral: we must expect that some function shapes will amount to improved adaptation, so that variant phenotypes expressing such shapes will be able to invade and replace inferior resident types. In general, therefore, evolution will proceed to ...
Luminaries - Oxford Academic
... Krebs observed a rapid oxidation of citrate, but interestingly, he identified that citrate was never fully consumed as a substrate, suggesting a capacity for citrate synthesis in this system (Figure 1). In addition, hypoxic conditions (low oxygen) resulted in large amounts of citrate formation in mi ...
... Krebs observed a rapid oxidation of citrate, but interestingly, he identified that citrate was never fully consumed as a substrate, suggesting a capacity for citrate synthesis in this system (Figure 1). In addition, hypoxic conditions (low oxygen) resulted in large amounts of citrate formation in mi ...
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3 Peter Meinhold,
... oxidizing an immense variety of organic molecules in vivo using atmospheric dioxygen as an oxidant.1,2 Conversion of even a small fraction of these P450 systems into useful synthetic catalysts, however, is limited by several factors, including the multicomponent nature of most of these enzymes, the ...
... oxidizing an immense variety of organic molecules in vivo using atmospheric dioxygen as an oxidant.1,2 Conversion of even a small fraction of these P450 systems into useful synthetic catalysts, however, is limited by several factors, including the multicomponent nature of most of these enzymes, the ...
Physiological meaning and potential for application of reductive
... dehalogenation by pure cultures of bacteria (Table 1). The bacteria involved range from strict anaerobic organisms such as methanogenic, sulfate-reducing, and fermenting bacteria to facultative anaerobic ones such as Escherichia coil or Pseudomonas putida. The first investigations which showed pure ...
... dehalogenation by pure cultures of bacteria (Table 1). The bacteria involved range from strict anaerobic organisms such as methanogenic, sulfate-reducing, and fermenting bacteria to facultative anaerobic ones such as Escherichia coil or Pseudomonas putida. The first investigations which showed pure ...
Science Course Outline Template
... By the end of this course, you will be able to: Describe and contrast the major metabolic pathways in humans. Explain the various mechanisms that control and regulate anabolic and catabolic processes simultaneously in the cells of living tissues. Discuss the integration of major metabolic path ...
... By the end of this course, you will be able to: Describe and contrast the major metabolic pathways in humans. Explain the various mechanisms that control and regulate anabolic and catabolic processes simultaneously in the cells of living tissues. Discuss the integration of major metabolic path ...
Propionate metabolism in Saccharomyces cerevisiae
... Aerobic, glucose-limited chemostat of Saccharomyces cerevisiae CBS 8066 cometabolized propionate when this compound was added t o the reservoir medium. Co-metabolism of propionate led to an increase of the biomass and protein yields. Attempts to grow 5. cerevisiae on propionate as a sole source of c ...
... Aerobic, glucose-limited chemostat of Saccharomyces cerevisiae CBS 8066 cometabolized propionate when this compound was added t o the reservoir medium. Co-metabolism of propionate led to an increase of the biomass and protein yields. Attempts to grow 5. cerevisiae on propionate as a sole source of c ...
Glycogen Earth organisms use three major forms of - Rose
... Phosphoglucomutase interconverts glucose-6-phosphate and glucose-1phosphate. This process is completely reversible. When glycogen is broken down, phosphoglucomutase converts the glucose-1-phosphate released to glucose-6phosphate, which can then be used for other processes. Phosphoglucomutase require ...
... Phosphoglucomutase interconverts glucose-6-phosphate and glucose-1phosphate. This process is completely reversible. When glycogen is broken down, phosphoglucomutase converts the glucose-1-phosphate released to glucose-6phosphate, which can then be used for other processes. Phosphoglucomutase require ...
Metabolic network modelling
Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑