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Mechanisms of Autoimmunity
Mechanisms of Autoimmunity

Chapter 43: Immune System
Chapter 43: Immune System

... 29. Explain the difference between a primary and secondary immune response. ! The production of effector cells from a clone of lymphocytes during the first exposure to an antigen is the basis for the primary immune response. The primary response peaks about 10–17 days after the initial exposure. Dur ...
Spring 2015-Chapter 18
Spring 2015-Chapter 18

... Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system. The role NK cells play is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response. NK cells provide rapid responses to viral-infected cells and respond to tumor formati ...
10_12_immuno~2
10_12_immuno~2

... immune system can recognize and respond to infectious agents vigorously and with such great specificity. • It is clear that the immune system can act as an integrative system, analogous to the endocrine or nervous systems, in that it can receive information from the local and systemic environment, a ...
Cellular Immunity - ADAM Interactive Anatomy
Cellular Immunity - ADAM Interactive Anatomy

...  Class II MHC proteins are expressed by antigen-presenting cells (dendritic cells, macrophages, and B cells). They present antigens to CD4 lymphocytes.  Antigen-presenting cells phagocytize exogenous antigens, break them down, bind them to class II MHC proteins, and display portions of them on the ...
The Immune System Game
The Immune System Game

... • put the steps of immune system response in the appropriate order; • distinguish between primary and secondary immune responses; and • describe why an infected person will feel sick shortly after infection and why this feeling of sickness will dissipate. In most cases, when a new infectious agen ...
Allergy. Immunodeficiency conditions
Allergy. Immunodeficiency conditions

... their appearing are the specific peculiarities of the environment and state of organism reactivity. • Allergen – is a substance that causes development of an allergic reaction. • Allergens have all properties of antigens (macromolecularity, mainly protein nature, foreign for a particular organism). ...
Immune System Boosters for Increased Overall Health Our body`s
Immune System Boosters for Increased Overall Health Our body`s

... Our body’s immune system has to be functioning well in order to maintain health. It is like an army of soldiers fighting off foreign invaders such as bacteria, fungus, viruses etc. Our everyday lives can serve to strengthen this army and allow it to work smarter or drag it down and make us more susc ...
Presentation
Presentation

... innate immunity • This problem is solved in part by a) targeting molecules that viruses have a hard time changing (dsRNA especially), and b) having multiple mechanisms, making it harder for a virus to evade all of them • Viruses are amazingly good at evasion of immune defenses, but often the most le ...
Chapter 19: Blood
Chapter 19: Blood

... – jaundice is caused by bilirubin buildup – converted by intestinal bacteria to urobilins and stercobilins which account for the yellow brown to brown color of stool. ...
Clinical immunology
Clinical immunology

... lymphocyte proliferation by treatment with polyclonal mitogens or specific bacterial antigen, measurements of apoptosis, ELISA tests for cytokines identification, phagocytosis evaluation techniques. The second part of the course will include lectures on clinical immunology (starting next year). The ...
target cells
target cells

... – are white blood cells that spend most of their time in the tissues and organs of the lymphatic system, – are responsible for adaptive immunity, and ...
Raulet, D. H. 2009. Natural Killer Cells: Remembrances of Things Past. Curr Biol 19:R294-296.
Raulet, D. H. 2009. Natural Killer Cells: Remembrances of Things Past. Curr Biol 19:R294-296.

... time that NK cells display some features of adaptive immune cells [4]. For example, different NK cell clones display different sets of stimulatory and inhibitory receptors, creating a repertoire of specificities that is normally considered a feature of adaptive immunity; also, NK cells show specific ...
Helper T cells
Helper T cells

... Other cytokines chemically attract specific cell types. These so-called chemokines are released by cells at a site of injury or infection and call other ...
Evolutionary aspects of allorecognition
Evolutionary aspects of allorecognition

... that end up, launching alloaggression reactions. Second, several phyla use combinatorial associations to somatically generate, repertoires of large numbers of specific receptors (that exceed the number of genes encoding them!) that can provide adaptive individual responses during ontogeny. The assoc ...
Ch15AdaptiveImmuneF13
Ch15AdaptiveImmuneF13

... In the secondary lymph organs, B-cells, T-cells, and Dendritic cells exchange information. T-cells activate B-cells into plasma cells that make antibodies. T-cells also activate Dendritic cells and Macrophages to kill cells. T-cells also inactivate cells that present antigens from self – healthy bod ...
Cells of the Immune Response
Cells of the Immune Response

... differenBaBon  and  selecBon  and  finally  migrate  via  circulaBon  to  the   secondary  lymphoid  organs/  Bssues  where  they  are  able  to  respond  to   microbial  anBgens.   Most  (95%)  of  the  thymocytes  generated  each  day  in ...
Hygiene hypothesis and allergic pathologies
Hygiene hypothesis and allergic pathologies

... • Allergic diseases are caused by harmless antigens such as Pollen in allergic rhinittis (hayfever) via Th2 • Many bacteria and viruses elicit a Th1-mediated immune response, which down-regulates Th2 responses. • Insufficient stimulation of the Th1 arm, leads to an overactive Th2 arm, stimulating th ...
0-AB system of antigens
0-AB system of antigens

ETP: The Immune System
ETP: The Immune System

... concentration of a solute. The approximate concentration should be known at the start of the experiment before the appropriate number and amount of dilutions can be made. In order to arrive at the desired concentration, use serial dilutions, instead of making one big dilution, in order to finally ar ...
Ch15AdaptiveImmuneF13HO
Ch15AdaptiveImmuneF13HO

... Dendritic cells that have gathered antigen in the periphery present it to naïve T cells; co-stimulatory molecules are expressed if the ...
"Immunity to Infection". In: Encyclopedia of Life Sciences (ELS)
"Immunity to Infection". In: Encyclopedia of Life Sciences (ELS)

... coated with IgG1 or IgG3, it can also be destroyed by antibody-dependent cell-mediated cytotoxicity (ADCC). In this process, NK cells bearing the Fc receptor FcgRIII (CD16) bind the Fc domain, and this triggers a cytotoxic attack that destroys the target. See also: Antibodydependent Cell-mediated Cy ...
The Teaching of Immunology Using Educational Gaming Paradigms
The Teaching of Immunology Using Educational Gaming Paradigms

1 Continue… 2nd part Morphology Primary Tuberculosis. In
1 Continue… 2nd part Morphology Primary Tuberculosis. In

... and proliferation followed by intimal fibrosis. The regional nodes are usually enlarged and may show nonspecific acute or chronic lymphadenitis, plasma cell-rich infiltrates, or focal epithelioid granulomas. In secondary syphilis, widespread mucocutaneous lesions involve the oral cavity, palms of th ...
Hypersensitivity - TOP Recommended Websites
Hypersensitivity - TOP Recommended Websites

... 5 tuberculin units of liquid tuberculin admistered intradermally ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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