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Innate immune recognition
Innate immune recognition

... Triggering of PRRs on macrophage or dendritic cells can induce a LARGE variety of events including: Increased phagocytosis Production of cytokines and inflammatory mediators: Interferons to induce anti-viral state Chemokines to attract migrating cells Etc, etc. Increased cell migration Changes in e ...
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... circulation. It removes microbes, dead or dysfunctional cells and cell debris. If any present antigens activate B & T-cells then you have an immune response! The lymph nodes are clustered in a few strategic areas…the cervical nodes, axillary nodes and inguinal nodes. They are also found along the me ...
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... radiation treatment and some forms of leukemia. Reduced counts are found with immunodeficiency diseases, severe sepsis, systemic lupus, bone marrow failure, medication reactions and the late stages HIV infection. Monocyte (Monos) Monocytes are the largest of the white blood cells. Monocytes digest d ...
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... Innate immunity which constituted the most ancient first line of immune protection is vital for invertebrate host defense and has become conserved through the animal kingdom. Even if invertebrates lack such critical elements of adaptive immunity as antibodies and lymphocytes, they can resist infecti ...
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... a. Both class I and class II MHC molecules consist of two protein chains and are transmembrane proteins in the plasma membrane b. Both class I and class II MHC molecules fold into similar shapes, each having a deep groove into which a short peptide or other antigen fragment can bind c. The presence ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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