thesis - KI Open Archive
... Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addresse ...
... Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addresse ...
The Role of Complement in Tumor Growth Chapter 11
... 2007). CRIg has recently been identified as a complement receptor. It is expressed on a restricted subset of tissue-resident macrophages and may play an important role in phagocytosis (Helmy et al. 2006; He et al. 2008). ...
... 2007). CRIg has recently been identified as a complement receptor. It is expressed on a restricted subset of tissue-resident macrophages and may play an important role in phagocytosis (Helmy et al. 2006; He et al. 2008). ...
Basophils contribute to TH2-IgE responses in vivo via IL
... Basophils induce the development of TH2 cells in vitro We first examined the ability of splenic basophils from naive mice and mice infected with Strongyloides venezuelensis30 to produce TH2 cytokines and to induce the development of naive CD4+ cells into TH2 cells in vitro. We prepared non–T cell, n ...
... Basophils induce the development of TH2 cells in vitro We first examined the ability of splenic basophils from naive mice and mice infected with Strongyloides venezuelensis30 to produce TH2 cytokines and to induce the development of naive CD4+ cells into TH2 cells in vitro. We prepared non–T cell, n ...
Lipid rafts facilitate LPS responses - Journal of Cell Science
... recruitment of multiple signalling molecules at the site of CD14-LPS ligation, within the lipid rafts. In order to test this hypothesis we investigated the existence of receptors identified as mediators of the innate immune recognition of LPS in lipid rafts. Using biochemical and fluorescence imagin ...
... recruitment of multiple signalling molecules at the site of CD14-LPS ligation, within the lipid rafts. In order to test this hypothesis we investigated the existence of receptors identified as mediators of the innate immune recognition of LPS in lipid rafts. Using biochemical and fluorescence imagin ...
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... replication and liver inflammation but do not lead to a cure. The interferon-α treatments modulate immune responses that may lower viral levels. It is given for a finite time (usually 12 months) due to its toxic side effects [5,6]. The nucleo(t)side analogues are administered for many years (and som ...
... replication and liver inflammation but do not lead to a cure. The interferon-α treatments modulate immune responses that may lower viral levels. It is given for a finite time (usually 12 months) due to its toxic side effects [5,6]. The nucleo(t)side analogues are administered for many years (and som ...
Antibodies and IL-3 support helminth-induced basophil
... occurs in the bone marrow, and to some extent within the spleen, and indicate that antibodies likely function to promote expansion and maturation of basophil progenitor cells located at these sites. H. polygyrus bakeri-Induced Basophil Expansion Requires IL-3. We have previously shown that H. polygy ...
... occurs in the bone marrow, and to some extent within the spleen, and indicate that antibodies likely function to promote expansion and maturation of basophil progenitor cells located at these sites. H. polygyrus bakeri-Induced Basophil Expansion Requires IL-3. We have previously shown that H. polygy ...
Excludes Superantigen-Like Recognition Complementarity
... main-chain atoms of amino acids in peptides or proteins (19, 20). These coordination complexes are rather stable and, therefore, a noncovalent interaction of Ni21 ions with MHC-embedded peptides was suggested as a hapten-like epitope for Ni-reactive T cells (21, 22). However, the definitive structur ...
... main-chain atoms of amino acids in peptides or proteins (19, 20). These coordination complexes are rather stable and, therefore, a noncovalent interaction of Ni21 ions with MHC-embedded peptides was suggested as a hapten-like epitope for Ni-reactive T cells (21, 22). However, the definitive structur ...
Differential fitness effects of immunocompetence and
... a key role in the evolution of polymorphism (Sinervo & Calsbeek 2003). Correlational selection may build genetic correlations within individuals that express different forms of the polymorphism (hereafter ‘morphs’) and may therefore play a crucial part in the maintenance of genetically based polymor ...
... a key role in the evolution of polymorphism (Sinervo & Calsbeek 2003). Correlational selection may build genetic correlations within individuals that express different forms of the polymorphism (hereafter ‘morphs’) and may therefore play a crucial part in the maintenance of genetically based polymor ...
ACTIVATION OF HUMAN NATURAL KILLER CELLS BY
... approximately 10 about every two to three days. Of the four types of Plasmodium that infect humans, namely P. ovale, P. malariae, P. vivax and P. Jalciparum, our research focuses on P. Jalciparum as it is the most virulent and pathogenic of the four and accounts for the vast majority of malaria case ...
... approximately 10 about every two to three days. Of the four types of Plasmodium that infect humans, namely P. ovale, P. malariae, P. vivax and P. Jalciparum, our research focuses on P. Jalciparum as it is the most virulent and pathogenic of the four and accounts for the vast majority of malaria case ...
Red blood cells
... Exposure to fetal red blood cell antigens generally occurs during delivery, when bleeding takes place at the placenta and uterus. Such mixing of fetal and maternal blood can stimulate the mother’s immune system to produce anti-Rh antibodies, leading to ...
... Exposure to fetal red blood cell antigens generally occurs during delivery, when bleeding takes place at the placenta and uterus. Such mixing of fetal and maternal blood can stimulate the mother’s immune system to produce anti-Rh antibodies, leading to ...
... out cellular immune responses. For the final differentiation of a B-cell, other cells besides the competent virgin B-cell are required. In most cases, T-lymphocytes called helper cells are also present. They interact with antigens by using their T-cell receptors. The antigens have been taken up and ...
Cross-Talk between Cancer Cells and the Tumour
... block cancer-related inflammation and immune escape. 2. 5-Lipoxygenase Pathway in Cancer The pronounced pro-inflammatory role of metabolites of the 5-LO pathway has been identified in a number of different pathological states including atherosclerosis, Alzheimer’s disease, type 2 diabetes and cancer ...
... block cancer-related inflammation and immune escape. 2. 5-Lipoxygenase Pathway in Cancer The pronounced pro-inflammatory role of metabolites of the 5-LO pathway has been identified in a number of different pathological states including atherosclerosis, Alzheimer’s disease, type 2 diabetes and cancer ...
The age-dependent expression of the F18 E. coli receptor
... correlates positively with F18+ E. coli adhesion It was suggested before that H-2 histo-blood group antigens (H-2 HBGAs) are involved in F18+ E. coli adhesion by Snoeck et al. (2004). In the porcine AO blood group system, the H-2 sugar, which corresponds to what is termed blood group O, can be furth ...
... correlates positively with F18+ E. coli adhesion It was suggested before that H-2 histo-blood group antigens (H-2 HBGAs) are involved in F18+ E. coli adhesion by Snoeck et al. (2004). In the porcine AO blood group system, the H-2 sugar, which corresponds to what is termed blood group O, can be furth ...
The Inherent Premise of Immunotherapy for
... concurrently induce apoptosis and inhibit tumor cell proliferation. This dual function of cancer therapies is apparent because of the heterogeneity of the tumor cells differentially responding to treatment, that is, cell death versus growth inhibition. In fact, residual surviving tumor cells that es ...
... concurrently induce apoptosis and inhibit tumor cell proliferation. This dual function of cancer therapies is apparent because of the heterogeneity of the tumor cells differentially responding to treatment, that is, cell death versus growth inhibition. In fact, residual surviving tumor cells that es ...
Slowing of wound healing by psychological stress
... wound repair. Proinflammatory cytokines such as interleukin-1, interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activation.1 Furthermore, cytokines released by the recruited cells regulate the ...
... wound repair. Proinflammatory cytokines such as interleukin-1, interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activation.1 Furthermore, cytokines released by the recruited cells regulate the ...
Molecular basis of the CRAC channel - Cahalan Lab-Home
... protein translation. These considerations enhance the feasibility of conducting a high-throughput RNAi-based screen in S2 cells. Since the Drosophila genome is much smaller and was better examined at the time than the human genome, S2 cells provided the ideal model system to test the role of candida ...
... protein translation. These considerations enhance the feasibility of conducting a high-throughput RNAi-based screen in S2 cells. Since the Drosophila genome is much smaller and was better examined at the time than the human genome, S2 cells provided the ideal model system to test the role of candida ...
Deep Insight Section Th17 cells: inflammation and regulation in Oncology and Haematology
... CD4+ T cells play a pivotal role in host defense, but are also recognized to have pathogenic roles such as in autoimmunity, asthma, cancer and allergic responses (Zhu et al., 2010). On activation by co-stimulatory molecules and particular cytokines, naïve CD4+ T cells can differentiate into the dist ...
... CD4+ T cells play a pivotal role in host defense, but are also recognized to have pathogenic roles such as in autoimmunity, asthma, cancer and allergic responses (Zhu et al., 2010). On activation by co-stimulatory molecules and particular cytokines, naïve CD4+ T cells can differentiate into the dist ...
GWU Biology Department - The George Washington University
... The immune response of the model insect Drosophila melanogaster consist of a complex multi-layer structure of defensive mechanisms. The Drosophila immune response is highly specific, making immune reactions as diverse as the microbes infecting it; such as bacteria and parasitic nematodes (1). Xenorh ...
... The immune response of the model insect Drosophila melanogaster consist of a complex multi-layer structure of defensive mechanisms. The Drosophila immune response is highly specific, making immune reactions as diverse as the microbes infecting it; such as bacteria and parasitic nematodes (1). Xenorh ...
STACHYS OCYMASTRUM RETICULOENDOTHELIAL SYSTEM PHAGOCYTIC ACTIVITY Research Article
... anti-inflammatory action of many, but not all flavonoids, appears to be largely based on their antioxidant effect. They can scavenge active oxygen species including superoxide radicals, hydrogen peroxide and hydroxyl radicals [29]. However, oxygen radical formation by peripheral blood monocytes is s ...
... anti-inflammatory action of many, but not all flavonoids, appears to be largely based on their antioxidant effect. They can scavenge active oxygen species including superoxide radicals, hydrogen peroxide and hydroxyl radicals [29]. However, oxygen radical formation by peripheral blood monocytes is s ...
陶秘華 Mi-Hua Tao Institution Institute of Biomedical Sciences
... Chronic hepatitis B virus (HBV) infection is a serious global health problem, leading to high incidence of cirrhosis and hepatocellular carcinoma (HCC). In these patients, T cell responses to HBV are usually weak and accompanied with various levels of T-cell dysfunctions. The research focus of my la ...
... Chronic hepatitis B virus (HBV) infection is a serious global health problem, leading to high incidence of cirrhosis and hepatocellular carcinoma (HCC). In these patients, T cell responses to HBV are usually weak and accompanied with various levels of T-cell dysfunctions. The research focus of my la ...
Serum Dioxin and Immunologic Response in Veterans of Operation
... murine monoclonal antibodies. Antibodies to the following antigens were used: T-cell antigens (CD3, CD4, CD5, and CD8), B-cell antigens (CD20), NKcell antigens (CD 16 and CD56), and activation antigen (CD25). CD25 antigen expression was measured on total CD3+ cells. Row cytometric analyses were perf ...
... murine monoclonal antibodies. Antibodies to the following antigens were used: T-cell antigens (CD3, CD4, CD5, and CD8), B-cell antigens (CD20), NKcell antigens (CD 16 and CD56), and activation antigen (CD25). CD25 antigen expression was measured on total CD3+ cells. Row cytometric analyses were perf ...
VeriPrime Bulletin: Beta Glucans
... Natural products, useful in preventing and/or treating various diseases, have been sought after throughout the history of mankind. One main problem in characterizing natural products also occurred with glucans: in nature, they represent a complex mixture of ingredients, each of which might contribut ...
... Natural products, useful in preventing and/or treating various diseases, have been sought after throughout the history of mankind. One main problem in characterizing natural products also occurred with glucans: in nature, they represent a complex mixture of ingredients, each of which might contribut ...
Integrator Networks: Illuminating the Black Box Linking Genotype
... (Siegal and Bergman 2002). Prior selection may canalize traits such that no variation in the influence of the integrator persists within the network. An obvious example is differentiation of secondary sex characteristics, a process impacted by androgens and estrogens in all vertebrates. Other exampl ...
... (Siegal and Bergman 2002). Prior selection may canalize traits such that no variation in the influence of the integrator persists within the network. An obvious example is differentiation of secondary sex characteristics, a process impacted by androgens and estrogens in all vertebrates. Other exampl ...