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Vaksin dan sera
Vaksin dan sera

... This genetically engineered plasmid comprises the DNA vaccine which is then injected into the host. Within the host cells, the foreign gene can be expressed (transcribed and translated) from the plasmid DNA, and if sufficient amounts of the foreign protein are produced, they will elicit an immune re ...
Slide Presentation (Powerpoint)
Slide Presentation (Powerpoint)

... Increased replication potential ...
1.9mb ppt - UCLA.edu
1.9mb ppt - UCLA.edu

... Bone marrow cells from donor determine negative selection Host DC die from irradiation Replaced by DC from donor marrow Positive selection is on host thymic epithelium Negative selection occurs on donor-derived DC ...
Diapositive 1 - Fondazione ARCO
Diapositive 1 - Fondazione ARCO

... 5FU-Cisplatin chemotherapy in Head&Neck cancer Analysis of intra-patient cell count evolution at 2-month relative to baseline showed that 5FU+platinum alone negatively significantly modulated both T, NK, NKT and invNKT cells, with a median decrease of 44% to 66% relative to baseline (p values compri ...
innate immuni̇ty
innate immuni̇ty

...  Innate immunity does not reat against the host  İnnate immunity respond in the same way to repeated invasions ...
The immune system consists of a variety of white blood cells and
The immune system consists of a variety of white blood cells and

... Immunity - is a term that we have all heard on survivor, but what does it really mean? Immunity is the ability to resist a disease after being exposed to it in the past. Non-Specific Defences - guard against a wide variety of pathogens (disease-causing agents). > Effectiveness does not depend on pre ...
Text S1 Description of expression correlated pathogen defence
Text S1 Description of expression correlated pathogen defence

... these syntaxins, AtWAKL10 expression is also correlated with genes encoding other essential proteins of the SNARE (SOLUBLE-NSF (N-ETHYLMALEIMIDESENSITIVE FACTOR) PROTEIN ATTACHMENT PROTEIN RECEPTOR) machinery including SYNAPTOSOMAL-ASSOCIATED PROTEIN (SNAP)-33 (r = 0.722, At5G61210) and VESICLE-ASSO ...
What Causes Infectious Diseases
What Causes Infectious Diseases

... The most common disease-causing fungi invade mainly deep tissues of the hair, nails, and skin. Ringworm and athletes foot are the two most common fungal ...
Kuby Immunology 6/e - Dr. Jennifer Capers
Kuby Immunology 6/e - Dr. Jennifer Capers

... Complement deficiencies ○ Fairly common ○ Mostly associated with bacterial infections or ...
Nicotinic receptor signaling in nonexcitable
Nicotinic receptor signaling in nonexcitable

... protein kinase signaling cascades to upregulation of NF-␬B expression (10). This study has exciting clinical and biological implications on the nonneuronal activity of the peripheral cholinergic system. These include the following two major points and other considerations (Fig. 1). The nAChRs mediat ...
Micro 532 Exam 1995
Micro 532 Exam 1995

... long half-lives of the activated complement components. very low concentrations of the inactivated complement components in serum. the inability to activate the system in the presence of IgG antibodies. once activated, the destructive activities of complement are non-specific. none of the above ...
Reminder: Answer all questions, and strive to be both brief and
Reminder: Answer all questions, and strive to be both brief and

... a. Are double chain antibodies with cancer-specific idiotypes b. Are transplantation-immune lobules with a lytic capacity c. Are white blood cells recovered from a tumor that can be activated by cytokines before reinjection into that patient d. Are single chain antibodies with no lytic capacity e. A ...
Ch15 - Morgan Community College
Ch15 - Morgan Community College

... MHC II proteins tell T helper cells to start an immune response against the antigen MHC I proteins tell T cytotoxic cells to kill the infected cell before it can infect other cells ...
Ch. 43 immune system
Ch. 43 immune system

... 2 Types of immune responses • Humoral immunity • B cell activation • Production of antibodies • Microbes circulating in blood and lymph (body fluids) • Defend against free bacteria, toxins, and viruses in body fluids. • Cell-mediated immunity • Tc cell activation • Binds to and/or lyses cells • Def ...
Science News Discarded Immune Cells Induce the
Science News Discarded Immune Cells Induce the

... Neutrophils are leukocytes (white blood cells) that defend the body against attack from bacteria and other disease organisms. To perform their function, these cells release toxic substances when they come into contact with microorganisms. However, release of these substances in the wrong place by da ...
Innate lymphoid cells: identification of their role in allergic asthma
Innate lymphoid cells: identification of their role in allergic asthma

... transcription factor binding landscapes at GREs were markedly different between ILC2s and Th2 cells. Importantly, shared and ILC2-specific - but few Th2-specific - GREs reside in asthma-associated loci in human and murine cells, prioritizing GREs potentially relevant for asthma and supporting a path ...
Harnessing the immune system to combat cancer
Harnessing the immune system to combat cancer

... detailing receptor interactions that downmodulate the activation of T cells that recognize antigen presented on MHC molecules. Blocking such immune checkpoints results in enhanced, nonspecific T cell activation and/or T cell survival. CTLA4–B7 interactions are important during the induction phase of ...
Programmed Cell Death / Apoptosis
Programmed Cell Death / Apoptosis

... Steps in cell death process identified by mutants: Decision: ced-9, egl-1 Execution: ced-3, ced-4 Engulfment: ced-1, ced-2 Digestion of DNA: nuc-1 Vertebrates have similar proteins: bcl-2 is homolog of ced-9 ...
Chapter 13 Diseases of White Blood Cells, Lymph Nodes, Spleen
Chapter 13 Diseases of White Blood Cells, Lymph Nodes, Spleen

... Histologic examination is required for diagnosis Most of the time, antigen receptor gene rearrangement preceded transformation: hence all of daughter cells share the same antigen receptor gene configuration Vast majority are of B cell origin ( 85-90%) Often associated with immune abnormalities Neopl ...
late onset
late onset

Our Body`s Defense
Our Body`s Defense

... multiply when they encounter a pathogen • Killer cells-stop the spread of disease • Helper cells-aide in the activation of B-cells and Killer T-cells and control the body’s immune system ...
chapter 1
chapter 1

... The body's first line of defense against pathogenic organisms (including bacteria, fungi and viruses) is the physical barrier provided by the skin, by the epithelium and mucus secretions of the alimentary tract and lungs, etc. This level of protection, however, is relatively non-specific; it disting ...
Anti-Bcl-2 antibodies mouse
Anti-Bcl-2 antibodies mouse

... 11. Resuspend cell pellet in a suitable amount of buffer for analysis by flow cytometry or fluorescence microscopy. ...
Chapter 18: Blood
Chapter 18: Blood

... leukocytes Platelets are pieces of cells also called thrombocytes ...
White blood cells and their disorders
White blood cells and their disorders

... Important in immunity and allergy ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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