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1 - contentextra
1 - contentextra

... The Eubacteria have wide diversity of shape. They can be rods, spheres or helices. They can also be divided into two groups – Gram-positive or Gram-negative – based on their cell wall structure (Figure 12.3, page 386). ...
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T cells

... T Cells Cytotoxic T cells -Naïve TC cells are activated upon TCR recognition of foreign peptide displayed on self-MHC class I protein on dendritic cells -Clonal expansion and differentiation into activated cells and memory cells -Activated cells induce apoptosis in cells with same specificity as fi ...
Chapter 14: Lymphatic System and Immunity Introduction The is
Chapter 14: Lymphatic System and Immunity Introduction The is

... T cell activation requires the presence of an ______________________________________ cell, such as a B cell or macrophage that has already encountered the antigen In order for a ______________________ T cell to become activated, it must first encounter a macrophage displaying the antigen on its majo ...
7-8 lectureTCR_L
7-8 lectureTCR_L

... Capture of an Ag-Specific T Cell by an Ag-Bearing DC Bone-marrow derived DCs (yellow) were pulsed with 1 µM Ova 4 peptide and 10 µM Ova for 1 hour at 37oC, then injected into the footpad of a C57BL/6 recipient. This was followed 6 hours later by i.v. co-injection of CD8+ T cells (green) and CD4+ T c ...
21_22_Tumor_immunology_immunotherapy
21_22_Tumor_immunology_immunotherapy

... NK CELL-MEDIATED ADCC Antibodies bind to a cell-surface antigen of the tumor cells, for example CD20. The Fc regions of the antibodies engage FcγRIII on an NK cell, which then becomes activated to kill the tumor cell. ...
The MHIRT Newsletter-Week 3: June 11-17, 2015
The MHIRT Newsletter-Week 3: June 11-17, 2015

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The First and Second Lines of Defense Against Disease
The First and Second Lines of Defense Against Disease

... -some cells contain cilia which helps to filter out pathogens or other particles 2nd LINE OF DEFENSE: NON-SPECIFIC RESPONSE: -these are generalized, and random responses to pathogen infection -they consist of various plasma proteins and WBC’s such as: neutrophils, eosinophyls, basophils, mast cells, ...
Med Chem 535P – Diagnostic Medicinal Chemistry Hematology
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... Macrophages can recognize and phagocytize pathogens. They digest the particle and “present” peptides on their surface (antigen presenting cell). The peptide is recognized by a T-lymphocyte, which is then activated. C. Lymphocytes (Lymphs). Normal Range: 20 – 40% Lymphocytes make up the second major ...
Helper T cells - Morgan Community College
Helper T cells - Morgan Community College

... MHC II proteins tell T helper cells to start an immune response against the antigen MHC I proteins tell T cytotoxic cells to kill the infected cell before it can infect other cells ...
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Slide 1

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CHAPTER 24

... The immune system recognizes foreign materials in the body: - foreign invaders are called antigens - can include certain molecules on the surfaces of ...
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17 Unit 1 - Cloudfront.net

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S. Typhi-specific CD8+ T EM responses

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MACROPHAGE - immunology.unideb.hu

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I. Lymphatic System A. Lymphatic Vessels 1. Lymph Capillaries a

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Scientific Glossary

... Interleukins: Glycoproteins secreted by a variety of leukocytes which have effects on other leukocytes. Internal image: A spatial configuration of the combining site of an anti-idiotype antibody which resembles the epitope to which the idiotype is directed. Intron: A segment of DNA that does not cod ...
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17_18 pathology-deficiency_short

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Defences: the immune system

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IMMUNE SYSTEM
IMMUNE SYSTEM

... greatly increases the # of B and T cells 4. there is a stronger & more rapid response to agn previously encountered – immunological memory occurs after mature lymphocyte encounters & binds to a specific agn ...
Lecture3 - Cell Mediated Immunity
Lecture3 - Cell Mediated Immunity

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lecture3-Cell Mediated Immunity (2014)

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HERE - WordPress.com

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Antibodies - INAYA Medical College

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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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