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11th B Hypersensitivity reactions
11th B Hypersensitivity reactions

... (Type IV)  Delayed type hypersensitivity reactions are mediated by CD4+ or CD8+ CTLs  A result of autoimmunity or a response to environmental antigens  Usually restricted to a tissue, not systemic. However, chronic and progressive ...
Autoimmunity
Autoimmunity

... While he had to admit that auto-antibodies could form, as had been demonstrated with animal sperm, he firmly denied the possibility of autoimmune diseases And his influence was so pervasive, that autoimmune diseases were not generally recognized until the 1960’s Now, autoimmunity isn’t entirely a ba ...
Document
Document

... survive inside cells. Macrophages are a common targets for intracellular bacteria (e.g. Salmonella spp.) that live inside cell compartments. These bacteria cannot be detected by complement or antibody but, instead, are eliminated using a cell-mediated response. Infected macrophages present bacterial ...
Natural Killer (NK) Cells and Human Immunodeficiency Virus (HIV
Natural Killer (NK) Cells and Human Immunodeficiency Virus (HIV

... Human Immunodeficiency Virus (HIV) infection has become a serious problem of public health. Recently, it is observed cellular immunity is involved in HIV infection and disease progression, especially the Natural Killer (NK) cells, which are important part of innate immunity. In order to clearly unde ...
File
File

Human Biology
Human Biology

... Chemicals (allow communication between cells): • Cytokines – stimulate and regulate the immune response • Interferons – anti-viral proteins, stimulate immune response • Chemokines – involved with the inflammatory response – They lead to chemotaxis and activation ...
Document
Document

... the disease that the sick and the dying found most compassion. These knew what it was from experience, and had now no fear for themselves; for the same man was never attacked twice -never at least fatally. And such persons not only received the congratulations of others, but themselves also, in the ...
The Body’s Defenses - Falmouth Schools in Falmouth Maine
The Body’s Defenses - Falmouth Schools in Falmouth Maine

... • Memory cells do not express antibodies, stay in circulation for years with immunoglobulin expression for that bacteria on surface. • If same (or related) pathogen invades again, memory cells recognize it and provide rapid response, replicating and producing new plasma cells. ...
Tumor immunity
Tumor immunity

... presents a target for immune attack). The cell-mediated immune responses that affect tumor cells in vitro include natural killer (NK) cells, which act without antibody; killer (K) cells, which mediate antibody-dependent cytolysis (antibody-dependent cellular cytotoxicity); cytotoxic T cells; and act ...
Document
Document

... c. The internalized antigen is digested into fragments, linked to MHC proteins, and displayed. This alerts helper T cells to become active. d. A helper factor stimulates the B cell to divide repeatedly into a battalion of identical cells in a process known as clonal selection. e. Most cells of a clo ...
31.1 Pathogens and Human Illness
31.1 Pathogens and Human Illness

... Many body systems work to produce nonspecific responses. • Nonspecific responses are the same for every pathogen. • In inflammation, blood vessels become leaky. – white blood cells move extracellular capillary wall toward infection and space damaged tissue – characterized by swelling, redness, and w ...
Acting Out the Immune Response
Acting Out the Immune Response

... tissues. The human immune system is a complex collection of physical barriers, cells, and signaling systems that helps a human to respond to a pathogen invasion. The immune system can be thought of as two parts: the innate immune system that works nonspecifically against any invader, and the adaptiv ...
Specific Defenses of the Host
Specific Defenses of the Host

... and present the Antigens to a type of T-cell called a T-Helper cell (TH-cell). • The TH-cell becomes activated and secretes a cytokine called interleukin 2. • Interleukin 2 from the TH-cell, binds to T Tc-cell and has 2 effects. – 1. Activates Tc-cells causing them to produce perforin molecules. The ...
Human immunodeficiency virus (HIV)
Human immunodeficiency virus (HIV)

... Humoral response to HIV. The humoral immune response occurs later in infection; therefore, the level of antibodies during the acute infection is very low. Non-neutralising antibodies to structural proteins (i.e. P17 and P24) are first to appear and generally do not persist. Later neutralising antibo ...
No Slide Title
No Slide Title

... There is structural variation in antibody heavy chain constant regions. These variations are critical for effector functions and are achieved in two different ways, RNA splicing and DNA switch recombination. The signals regulating these changes come from antigen binding to the B cell receptor and an ...
Lecture notes
Lecture notes

Worm therapy: Multiple Sclerosis
Worm therapy: Multiple Sclerosis

... Prevalence (and exposure) of parasites in highlysanitized countries might indeed explain low prevalence of MS Links between some steps of the immune mechanisms Role of genetics? Diet? ...
File
File

... response)and are found in the lymphoid organs (except the thymus) ...
T cells
T cells

... • Acquired immunity is the third line of defense in vertebrates. – Can produce millions of different pattern-recognition receptors (PRRs) from relatively few genes – Once one variant is activated by a particular invader, it is amplified to high concentrations ...
GenomeWeb Qu Companion Diagnostics 23MAR17
GenomeWeb Qu Companion Diagnostics 23MAR17

0-AB system of antigens
0-AB system of antigens

Document
Document

... Once triggered it becomes a huge reaction in its successive steps ...
CELLS AND TISSUES OF THE ADAPTIVE IMMUNE SYSTEM
CELLS AND TISSUES OF THE ADAPTIVE IMMUNE SYSTEM

... A major function of macrophages in host defense is to ingest and kill microbes ingest dead host cells as part of the cleaning up process after infection or sterile tissue injury Activated macrophages secrete proteins, called cytokines, Macrophages serve as APCs promote repair of damaged tissues by s ...
Chp.7 Immune Lec
Chp.7 Immune Lec

... 7.3 Nonspecific Defenses ...
Class: 12 Subject: Biology Topic: Human Health and
Class: 12 Subject: Biology Topic: Human Health and

... (i) Papaver somniferum (Poppy plant) and the addictive drug extracted from its latex is morphine. It is widely used as a sedative and an anxiolytic agent. It is widely used in small doses to relieve pain and induce sleep in cases of serious injuries, burns, fractures and surgeries. Its ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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