Eyeblink Conditioning During an Interstimulus Interval Switch in
... et al., 2002), we decided to use a lower dose that has a demonstrated efficacy in unmasking short-latency responses in welltrained rabbits for a period of time that is approximately equal to the length of our training session (Garcia & Mauk, 1998). We undertook the present investigation, in part, to ...
... et al., 2002), we decided to use a lower dose that has a demonstrated efficacy in unmasking short-latency responses in welltrained rabbits for a period of time that is approximately equal to the length of our training session (Garcia & Mauk, 1998). We undertook the present investigation, in part, to ...
Olfaction and the Chemical Senses
... system in the selection of receptors is very different from most other processes of chemical detection in the brain. Possibly by virtue of forming part of the earliest sensory system, cells of the olfactory cortex send and receive information from more brain regions than any other sensory system (Ge ...
... system in the selection of receptors is very different from most other processes of chemical detection in the brain. Possibly by virtue of forming part of the earliest sensory system, cells of the olfactory cortex send and receive information from more brain regions than any other sensory system (Ge ...
Phagocytosis: a repertoire of receptors and Ca as a key second
... Of interest, Caenorhabditis elegans appears to use a common mechanism, utilizing the same set of genes, to engulf apoptotic and necrotic cells [52], whether this is also true for ‘higher’ organisms remains to be seen. In common with FcR- and CR-mediated phagocytosis, phagocytosis mediated by this di ...
... Of interest, Caenorhabditis elegans appears to use a common mechanism, utilizing the same set of genes, to engulf apoptotic and necrotic cells [52], whether this is also true for ‘higher’ organisms remains to be seen. In common with FcR- and CR-mediated phagocytosis, phagocytosis mediated by this di ...
Monoclonal Antibodies for Therapeutic Use: Specific Characteristics
... 3.3. Limitations of animal models The use of animal models during the development of MoAb is difficult due to the between-species differences of the “partners” of the MoAb, i.e. target antigen and immune effectors (including FcγR receptors).[19] MoAb do not usually recognise target antigens in the m ...
... 3.3. Limitations of animal models The use of animal models during the development of MoAb is difficult due to the between-species differences of the “partners” of the MoAb, i.e. target antigen and immune effectors (including FcγR receptors).[19] MoAb do not usually recognise target antigens in the m ...
B-Lymphocyte-Mediated Delayed Cognitive Impairment following
... stroke are at increased risk of developing dementia, and approximately one-third will eventually suffer from vascular dementia (Barba et al., 2000; Leys et al., 2005; Béjot et al., 2011). In many of these patients, dementia might be caused by an associated comorbidity, but even after controlling fo ...
... stroke are at increased risk of developing dementia, and approximately one-third will eventually suffer from vascular dementia (Barba et al., 2000; Leys et al., 2005; Béjot et al., 2011). In many of these patients, dementia might be caused by an associated comorbidity, but even after controlling fo ...
Autoimmunity to glomerular antigens in
... [l8], and mesangial IgA deposits are usually clinically silent in hepatic cirrhosis and coeliac disease [19,20]. These anomalies have focused attention on other factors, such as a role for an antigen in immune aggregates in sera, and on the possibility that mesangial IgG or IgM deposits may be a nec ...
... [l8], and mesangial IgA deposits are usually clinically silent in hepatic cirrhosis and coeliac disease [19,20]. These anomalies have focused attention on other factors, such as a role for an antigen in immune aggregates in sera, and on the possibility that mesangial IgG or IgM deposits may be a nec ...
Bacillus anthracis Protective Antigen Bound by Neutralizing Antibodies *
... where distinct subunits are involved in the different steps at which it can act. The B subunit (PA) is involved in receptor binding and cellular internalization into the cytoplasm, whereas the A subunit (EF and/or LF) bears the enzymatic activity (1). Anthrax can occur naturally in animals by spore ...
... where distinct subunits are involved in the different steps at which it can act. The B subunit (PA) is involved in receptor binding and cellular internalization into the cytoplasm, whereas the A subunit (EF and/or LF) bears the enzymatic activity (1). Anthrax can occur naturally in animals by spore ...
Leptin: A metabolic signal affecting central regulation of
... that numerous genes, i.e., relaxin, interleukins and other cytokines and biologically active substances such as leptin, insulin-like growth factor-I (IGF-I), IGF-II and Agouti protein are produced by porcine adipose tissue, which could have a profound effect on appetite and the reproductive axis. Hy ...
... that numerous genes, i.e., relaxin, interleukins and other cytokines and biologically active substances such as leptin, insulin-like growth factor-I (IGF-I), IGF-II and Agouti protein are produced by porcine adipose tissue, which could have a profound effect on appetite and the reproductive axis. Hy ...
TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation
... that NOD2 was readily degraded in a time-dependent manner (Figure 4A, upper panel), whereas NOD1 was not subjected to rapid protein turn-over (Figure S3A). TRIM27 WT overexpression only very slightly influenced the kinetic of NOD2 degradation (Figures 4A, upper panel, and S3B). However, overexpressi ...
... that NOD2 was readily degraded in a time-dependent manner (Figure 4A, upper panel), whereas NOD1 was not subjected to rapid protein turn-over (Figure S3A). TRIM27 WT overexpression only very slightly influenced the kinetic of NOD2 degradation (Figures 4A, upper panel, and S3B). However, overexpressi ...
Receptive Fields and Binaural Interactions for Virtual
... insertion of acoustic assemblies. A small hole was drilled into each bulla, and a 60-cm plastic tube (0.9 mm ID) was inserted to prevent static pressure build-up in the middle ear. The animal was placed in a double-walled, electrically shielded, sound-proof room. The dorsal surface of the IC was exp ...
... insertion of acoustic assemblies. A small hole was drilled into each bulla, and a 60-cm plastic tube (0.9 mm ID) was inserted to prevent static pressure build-up in the middle ear. The animal was placed in a double-walled, electrically shielded, sound-proof room. The dorsal surface of the IC was exp ...
Exhibit N. a general information booklet on vaccine safety for parents titled VACCINE SAFETY AND YOUR CHILD, Separating Fact from Fiction , an excerpt from the book Vaccines and Your Child. (PDF: 2.20MB/34 pages)
... performed by different groups of investigators working on several different continents all showed the same thing: MMR didn’t cause autism. Although no epidemiological study is perfect, they can be quite powerful, capable of determining whether a vaccine caused a problem in as few as one in a million ...
... performed by different groups of investigators working on several different continents all showed the same thing: MMR didn’t cause autism. Although no epidemiological study is perfect, they can be quite powerful, capable of determining whether a vaccine caused a problem in as few as one in a million ...
Nlrp3-inflammasome activation in non-myeloid- derived cells aggravates diabetic nephropathy
... Diabetic nephropathy is the leading cause of end-stage renal disease in adults, putting an enormous burden on affected individuals and health-care systems. Current therapies are insufficient, necessitating the search for new therapeutic strategies in diabetic nephropathy. Inflammatory processes have ...
... Diabetic nephropathy is the leading cause of end-stage renal disease in adults, putting an enormous burden on affected individuals and health-care systems. Current therapies are insufficient, necessitating the search for new therapeutic strategies in diabetic nephropathy. Inflammatory processes have ...
the role of zinc in the pathogenesis and treatment of central nervous
... This metal is a component of many structural as well as regulatory and catalytic proteins. The precise regulation of zinc homeostasis is essential for central nervous system and for the whole organism. Zinc plays a significant role in the brain development and in the proper brain function at every s ...
... This metal is a component of many structural as well as regulatory and catalytic proteins. The precise regulation of zinc homeostasis is essential for central nervous system and for the whole organism. Zinc plays a significant role in the brain development and in the proper brain function at every s ...
The relation of emotions to placebo responses
... more frequently in the future, termed positive reinforcement [37]. The pleasant stimulus produced by the behaviour is called a ‘reinforcer’, and is any stimulus that the organism will behave in a way to obtain. Typical primary reinforcers are food, sex and drugs of abuse. Similarly, negative reinfor ...
... more frequently in the future, termed positive reinforcement [37]. The pleasant stimulus produced by the behaviour is called a ‘reinforcer’, and is any stimulus that the organism will behave in a way to obtain. Typical primary reinforcers are food, sex and drugs of abuse. Similarly, negative reinfor ...
The relation of emotions to placebo responses
... more frequently in the future, termed positive reinforcement [37]. The pleasant stimulus produced by the behaviour is called a ‘reinforcer’, and is any stimulus that the organism will behave in a way to obtain. Typical primary reinforcers are food, sex and drugs of abuse. Similarly, negative reinfor ...
... more frequently in the future, termed positive reinforcement [37]. The pleasant stimulus produced by the behaviour is called a ‘reinforcer’, and is any stimulus that the organism will behave in a way to obtain. Typical primary reinforcers are food, sex and drugs of abuse. Similarly, negative reinfor ...
7 CHAPTER Diverging effects of classically (M1) and alternatively (M2)
... RNA was isolated using TRIzol (Invitrogen) as described by the manufacturer. After 2 days in vitro, macrophages were washed with phosphate buffered saline (PBS) and one ml of TRIzol was added to 2 million cells. Phase Lock Gel-Heavy tubes (Invitrogen) were pre-spun briefly (1500 g for 30 seconds). T ...
... RNA was isolated using TRIzol (Invitrogen) as described by the manufacturer. After 2 days in vitro, macrophages were washed with phosphate buffered saline (PBS) and one ml of TRIzol was added to 2 million cells. Phase Lock Gel-Heavy tubes (Invitrogen) were pre-spun briefly (1500 g for 30 seconds). T ...
Thiol-Reactive Metal Compounds Inhibit NF
... of many inflammatory genes. NF-B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory IB (inhibitory protein that dissociates from NF-B) proteins, and a multisubunit IB kinase (IKK) has been identified previously. We tested the effect of various gold compounds ...
... of many inflammatory genes. NF-B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory IB (inhibitory protein that dissociates from NF-B) proteins, and a multisubunit IB kinase (IKK) has been identified previously. We tested the effect of various gold compounds ...
Studies on the antimicrobial defence of human hair follicle epithelium
... jedermann benutzt werden dürfen. This document is protected by copyright law. No part of this document may be reproduced in any form by any means without prior written authorization of the publisher. ...
... jedermann benutzt werden dürfen. This document is protected by copyright law. No part of this document may be reproduced in any form by any means without prior written authorization of the publisher. ...
... in wasted children underfives in Peneleh Puclic Health Center Surabaya City. Crossectional comparative design was done in 28 wasting children. Underfive children were randomized to observed CRP and IgA level. At the end of the study there were no significant differences in serum CRP level (p > 0.05) ...
Effects of antigenic challenge on growth and composition of
... Refining health-management programs requires a greater understanding of the underlying biological mechanisms by which diseases reduce lean growth rate. Different health management programs produce differences in health status, Le., differences in both the duration and intensity of individual and com ...
... Refining health-management programs requires a greater understanding of the underlying biological mechanisms by which diseases reduce lean growth rate. Different health management programs produce differences in health status, Le., differences in both the duration and intensity of individual and com ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.