Aminobutyric Acid (GABA)-A Function and Binding in
... A role for GABA has been strongly implicated in hypertension. Administration of GABA agonists intraventricularly causes a greater fall in blood pressure in hypertensive animals.21,22,30 Muscimol microinjection into the dorsomedial hypothalamus causes an augmented fall in blood pressure in spontaneou ...
... A role for GABA has been strongly implicated in hypertension. Administration of GABA agonists intraventricularly causes a greater fall in blood pressure in hypertensive animals.21,22,30 Muscimol microinjection into the dorsomedial hypothalamus causes an augmented fall in blood pressure in spontaneou ...
Immune recognition and rejection of allogeneic skin grafts
... leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate the recipient’s draining lymph nodes where they present donor antigens via two mechanisms: the direct ...
... leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate the recipient’s draining lymph nodes where they present donor antigens via two mechanisms: the direct ...
Encephalomyelitis Experimental Autoimmune System Regulates
... Extracellular adenosine has an important role in regulating the severity of inflammation during an immune response. Although there are four adenosine receptor (AR) subtypes, the A2AAR is both highly expressed on lymphocytes and known as a prime mediator of adenosine’s anti-inflammatory effects. To d ...
... Extracellular adenosine has an important role in regulating the severity of inflammation during an immune response. Although there are four adenosine receptor (AR) subtypes, the A2AAR is both highly expressed on lymphocytes and known as a prime mediator of adenosine’s anti-inflammatory effects. To d ...
Genetic susceptibility to infectious disease: lessons from
... two inbred strains and carry all chromosomes except one from the same inbred strain (the background strain) and a single chromosome from the second parental strain (the donor strain), which provides an immediate assignment of QTLs to specific chromosomes121. Establishing map positions requires the a ...
... two inbred strains and carry all chromosomes except one from the same inbred strain (the background strain) and a single chromosome from the second parental strain (the donor strain), which provides an immediate assignment of QTLs to specific chromosomes121. Establishing map positions requires the a ...
The Role of Mechanistic Target of Rapamycin (mTOR) Complexes
... 2. mTOR Signaling Pathway Recent studies have implicated mTOR as a central regulator of metabolism, growth, cellular proliferation, and cell cycle progression [2,15,16]. Further, compelling evidence revealed that the dysregulation of mTOR is linked to the development of chronic diseases including in ...
... 2. mTOR Signaling Pathway Recent studies have implicated mTOR as a central regulator of metabolism, growth, cellular proliferation, and cell cycle progression [2,15,16]. Further, compelling evidence revealed that the dysregulation of mTOR is linked to the development of chronic diseases including in ...
Aging of the hematopoietic system
... leading to leukemia [1]. Furthermore, the lower incidence of lymphoid malignancies originating from developing B and T cells in the aged compared with the young [21] may be caused by impaired lymphopoiesis. The fact that the most prevalent hematological malignancy in the elderly is chronic lymphocyt ...
... leading to leukemia [1]. Furthermore, the lower incidence of lymphoid malignancies originating from developing B and T cells in the aged compared with the young [21] may be caused by impaired lymphopoiesis. The fact that the most prevalent hematological malignancy in the elderly is chronic lymphocyt ...
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"
... deteriorate the host9s ability to eradicate an intracellular pathogen, such as Chlamydia pneumoniae, which requires a properly functioning cell-mediated (T-helper-1-type) immune response to be cleared. These drugs are also able to reactivate persistent Chlamydia to an active growth phase, which, by ...
... deteriorate the host9s ability to eradicate an intracellular pathogen, such as Chlamydia pneumoniae, which requires a properly functioning cell-mediated (T-helper-1-type) immune response to be cleared. These drugs are also able to reactivate persistent Chlamydia to an active growth phase, which, by ...
13 Nervous System
... Transmission of the nerve impulse from one neuron to another takes place at a synapse when a neurotransmitter molecule is released from an axon bulb into a synaptic cleft. The binding of the neurotransmitter to receptors in the postsynaptic membrane causes either excitation or inhibition. Synaptic I ...
... Transmission of the nerve impulse from one neuron to another takes place at a synapse when a neurotransmitter molecule is released from an axon bulb into a synaptic cleft. The binding of the neurotransmitter to receptors in the postsynaptic membrane causes either excitation or inhibition. Synaptic I ...
ANS MCQ
... 3- Sensory neurons are ….. neurons, while …… neurons carry motor impulses, and the most common type of neuron is the …… which communicates from one neuron to another. 4- The cell body of the neuron is known as the ….. 5- The branch of the ANS that induces the "fight or flight" response is in the ……. ...
... 3- Sensory neurons are ….. neurons, while …… neurons carry motor impulses, and the most common type of neuron is the …… which communicates from one neuron to another. 4- The cell body of the neuron is known as the ….. 5- The branch of the ANS that induces the "fight or flight" response is in the ……. ...
Humabody fragments: Small and perfectly formed
... Multivalent products There is increasing recognition of the advantages that small biologics have in tumor penetration, resulting in potential improvement in therapeutic efficacy and safety. At the same time, there is growing demand for product modalities with multiple functions. Humabodies, with sup ...
... Multivalent products There is increasing recognition of the advantages that small biologics have in tumor penetration, resulting in potential improvement in therapeutic efficacy and safety. At the same time, there is growing demand for product modalities with multiple functions. Humabodies, with sup ...
J Comp Physiol (1982) 149: 179 193
... lamina monopolar cell, which were recorded under the same conditions, but in a different animal. In all records, the transient increase of activity decays with approximately the same time course. That is to say that an instantaneous perturbation does not seem to elicit longlasting reverberations, wh ...
... lamina monopolar cell, which were recorded under the same conditions, but in a different animal. In all records, the transient increase of activity decays with approximately the same time course. That is to say that an instantaneous perturbation does not seem to elicit longlasting reverberations, wh ...
MSH-induced inhibition of oxytocin cells
... train during the identified periods. To assess changes in responses, the same poststimulus periods were used to quantify response amplitudes as those identified in control PSTHs. For the experiment with intracerebroventricular injection of ␣-MSH, firing rate in 30-s bins in the 5 min before injectio ...
... train during the identified periods. To assess changes in responses, the same poststimulus periods were used to quantify response amplitudes as those identified in control PSTHs. For the experiment with intracerebroventricular injection of ␣-MSH, firing rate in 30-s bins in the 5 min before injectio ...
HLA-A*02 AND ITS PROGNOSTIC TRAITS IN CANCER.
... HLA-A*02 negative. In the second paper, blood samples were collected from 32 patients with advanced epithelial ovarian cancer (EOC) to determine HLA-A, -B, -Cw and -DRB1. The results showed an unusual representation of HLA alleles in EOC compared to healthy Swedish bone-marrow donors where HLA-A*02 ...
... HLA-A*02 negative. In the second paper, blood samples were collected from 32 patients with advanced epithelial ovarian cancer (EOC) to determine HLA-A, -B, -Cw and -DRB1. The results showed an unusual representation of HLA alleles in EOC compared to healthy Swedish bone-marrow donors where HLA-A*02 ...
UPMC Eye Center Highlights
... The department had the privilege of hosting our third annual Fox Center Conference for Vision Restoration in 2013, which brought together more than 150 multidisciplinary scientists, clinicians, engineers, and other professionals in the fields of ophthalmology and regenerative medicine. The departmen ...
... The department had the privilege of hosting our third annual Fox Center Conference for Vision Restoration in 2013, which brought together more than 150 multidisciplinary scientists, clinicians, engineers, and other professionals in the fields of ophthalmology and regenerative medicine. The departmen ...
Fine tuning of vestibular apparatus in terrestrial snail at Earth and
... Retrieval of memory (reminding) is followed either by reconsolidation that maintains the memory, or by extinction that results in weakening of existing memory or formation of a competing memory. In our study we analyzed the behavior and responses of identified neurons involved in the network underly ...
... Retrieval of memory (reminding) is followed either by reconsolidation that maintains the memory, or by extinction that results in weakening of existing memory or formation of a competing memory. In our study we analyzed the behavior and responses of identified neurons involved in the network underly ...
T cell coinhibition in prostate cancer: new immune evasion pathways and
... immune evasion mechanisms that allow them to escape the immune responses generated by the body as well as those employed in immunotherapy. Although many cancer vaccines are designed to bolster tumor antigen presentation, most do not address the immune evasion pathways that suppress T cell function. ...
... immune evasion mechanisms that allow them to escape the immune responses generated by the body as well as those employed in immunotherapy. Although many cancer vaccines are designed to bolster tumor antigen presentation, most do not address the immune evasion pathways that suppress T cell function. ...
Autonomic Nervous System
... Innervate organs through specific axon bundles called autonomic plexuses. Communication by chemical messengers, called neurotransmitters. specific in each division of the autonomic nervous system Usually all organs are innervated by both divisions of the autonomic nervous system. Maintains homeostas ...
... Innervate organs through specific axon bundles called autonomic plexuses. Communication by chemical messengers, called neurotransmitters. specific in each division of the autonomic nervous system Usually all organs are innervated by both divisions of the autonomic nervous system. Maintains homeostas ...
A Comparison of Injected and Orally Administered β
... other cells, and subsequent secretion of cytokines and other substances initiating inflammation reactions (e.g., interleukins IL-1, IL-2, IL-6, and TNF-α).22-24 We found that all tested glucans stimulated splenocytes to produce IL-2, with #300 and Krestin showing the strongest and longest effects. O ...
... other cells, and subsequent secretion of cytokines and other substances initiating inflammation reactions (e.g., interleukins IL-1, IL-2, IL-6, and TNF-α).22-24 We found that all tested glucans stimulated splenocytes to produce IL-2, with #300 and Krestin showing the strongest and longest effects. O ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.