Complexity of complement activation in sepsis
... Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA ...
... Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA ...
Stress and Glucocorticoids Affect the Expression of Brain
... ticoids hasten the loss of hippocampal neurons that normally occurs during aging (Landfield, 1987). As the hippocampus is important in cognitive processes such as learning and memory, neuronal damage to this structure may be linked to the cognitive impairments that occur during aging and chronic str ...
... ticoids hasten the loss of hippocampal neurons that normally occurs during aging (Landfield, 1987). As the hippocampus is important in cognitive processes such as learning and memory, neuronal damage to this structure may be linked to the cognitive impairments that occur during aging and chronic str ...
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... neurotransmitter. When dopamine is either elevated or low – we can have focus issues such as not remembering where we put our keys, forgetting what a paragraph said when we just finished reading it or simply daydreaming and not being able to stay on ...
... neurotransmitter. When dopamine is either elevated or low – we can have focus issues such as not remembering where we put our keys, forgetting what a paragraph said when we just finished reading it or simply daydreaming and not being able to stay on ...
Deep Insight Section Th17 cells: inflammation and regulation in Oncology and Haematology
... IL-17-producing CD4+ T cells (Th17 cells) are understood to be a distinct lineage of CD4+ T helper (Th) cells, which play an important role in the host defense, tissue inflammation and autoimmunity. The identification of Th17 cells collapsed the concept of the previously held Th1/Th2 paradigm in inf ...
... IL-17-producing CD4+ T cells (Th17 cells) are understood to be a distinct lineage of CD4+ T helper (Th) cells, which play an important role in the host defense, tissue inflammation and autoimmunity. The identification of Th17 cells collapsed the concept of the previously held Th1/Th2 paradigm in inf ...
DOPAMINE
... neurotransmitter. When dopamine is either elevated or low – we can have focus issues such as not remembering where we put our keys, forgetting what a paragraph said when we just finished reading it or simply daydreaming and not being able to stay on ...
... neurotransmitter. When dopamine is either elevated or low – we can have focus issues such as not remembering where we put our keys, forgetting what a paragraph said when we just finished reading it or simply daydreaming and not being able to stay on ...
Progress in Autoimmune Diseases Research
... autoimmune diseases, patients face a lifetime of illness and treatment. They often endure debilitating symptoms, loss of organ function, reduced productivity at work, and high medical expenses. And, because most of these diseases disproportionately afflict women, and are among the leading causes of ...
... autoimmune diseases, patients face a lifetime of illness and treatment. They often endure debilitating symptoms, loss of organ function, reduced productivity at work, and high medical expenses. And, because most of these diseases disproportionately afflict women, and are among the leading causes of ...
Chapter 2: Chemistry, Matter, and Life
... • Protect, support, and nourish nervous tissue • Aid in cell repair • Remove pathogens and impurities • Regulate composition of fluid around cells Examples of Neuroglia • Schwann cells ...
... • Protect, support, and nourish nervous tissue • Aid in cell repair • Remove pathogens and impurities • Regulate composition of fluid around cells Examples of Neuroglia • Schwann cells ...
The Role of Staphylococcus aureus Virulence Factors in Skin
... important during skin and respiratory site infections, but may be less important during systemic infection. Similarly, mice deficient in interleukin-17A (IL-17A) and IL-17F showed no difference in pathology compared to the wild type strain following systemic infection, however, they had increased su ...
... important during skin and respiratory site infections, but may be less important during systemic infection. Similarly, mice deficient in interleukin-17A (IL-17A) and IL-17F showed no difference in pathology compared to the wild type strain following systemic infection, however, they had increased su ...
among HLA-G, myeloid APCs, and regulatory cells
... molecules, and activate T cells. Professional APCs also provide a set of additional signals that modulate the activation of the responding cell. The most important professional APCs are dendritic cells (DCs), which play a major role as APCs in inducing adaptive immune responses and are critically in ...
... molecules, and activate T cells. Professional APCs also provide a set of additional signals that modulate the activation of the responding cell. The most important professional APCs are dendritic cells (DCs), which play a major role as APCs in inducing adaptive immune responses and are critically in ...
Influenza: A case study
... niche that enabled influenza, as well as a number of other infectious agents such as the viruses that cause measles and smallpox, to move from animals and adapt to a human host. Influenza as a disease has been recognised for centuries, even though the viruses which cause it were not correctly identi ...
... niche that enabled influenza, as well as a number of other infectious agents such as the viruses that cause measles and smallpox, to move from animals and adapt to a human host. Influenza as a disease has been recognised for centuries, even though the viruses which cause it were not correctly identi ...
Specific Control of Immunity by Regulatory CD8 T Cells
... lymphoblasts induced unresponsiveness to transplantation antigens (37). Later experiments expanded this earlier work towards antigen specificity, showing that allospecific T lymphoblasts can specifically immunize against graft versus host disease (GVHR) by induction of an anti-idiotypic response (38 ...
... lymphoblasts induced unresponsiveness to transplantation antigens (37). Later experiments expanded this earlier work towards antigen specificity, showing that allospecific T lymphoblasts can specifically immunize against graft versus host disease (GVHR) by induction of an anti-idiotypic response (38 ...
Non‐invasive imaging of allogeneic transplanted skin graft by 131I
... As the induction and maintenance of donor-specific tolerance is a central aim in solid organ transplantation, a reliably biomarker is essential for clinicians to identify and monitor tolerance accurately. CD4+CD25+Foxp3+Treg is the first choice which associates with allograft tolerance induction. Al ...
... As the induction and maintenance of donor-specific tolerance is a central aim in solid organ transplantation, a reliably biomarker is essential for clinicians to identify and monitor tolerance accurately. CD4+CD25+Foxp3+Treg is the first choice which associates with allograft tolerance induction. Al ...
Amino acid-derived hormones
... The Endocrine System: Hormones An animal's endocrine system controls body processes through the production, secretion, and regulation of hormones. Hormones serve as chemical "messengers" that function in cellular and organ activity to maintain the body's homeostasis. Maintaining homeostasis within ...
... The Endocrine System: Hormones An animal's endocrine system controls body processes through the production, secretion, and regulation of hormones. Hormones serve as chemical "messengers" that function in cellular and organ activity to maintain the body's homeostasis. Maintaining homeostasis within ...
The evolution within us - Philosophical Transactions of the Royal
... cause hypothyroidism in Hashimoto’s thyroiditis [15]. Ribonucleoprotein and other nuclear antigens are frequent targets in primary Sjögren’s syndrome and systemic lupus erythematosus [16,17], conditions associated with widespread inflammation. A frustrating feature of autoimmune disorders involving ...
... cause hypothyroidism in Hashimoto’s thyroiditis [15]. Ribonucleoprotein and other nuclear antigens are frequent targets in primary Sjögren’s syndrome and systemic lupus erythematosus [16,17], conditions associated with widespread inflammation. A frustrating feature of autoimmune disorders involving ...
A dissection of T cell receptor signaling pathways
... astronauts to spend extended periods in the absence of gravity, and require careful consideration of the long-term impact of spaceflight on astronaut health. Orbital missions of up to approximately one-year in length have shown that microgravity can have profound effects on astronaut physiology incl ...
... astronauts to spend extended periods in the absence of gravity, and require careful consideration of the long-term impact of spaceflight on astronaut health. Orbital missions of up to approximately one-year in length have shown that microgravity can have profound effects on astronaut physiology incl ...
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... 445). It has been further shown that the skin has the intrinsic capability to actually produce POMC as well as CRH peptides and to also express the corresponding receptors. Cutaneous modulation of CRH and POMC production could be mediated by proinflammatory cytokines, as is the case at the systemic ...
... 445). It has been further shown that the skin has the intrinsic capability to actually produce POMC as well as CRH peptides and to also express the corresponding receptors. Cutaneous modulation of CRH and POMC production could be mediated by proinflammatory cytokines, as is the case at the systemic ...
Chapter 1: Masters Thesis Literature Review
... rather than the low bacterial load latent infection seen in humans [18]. Despite this discrepancy the availability of many well characterized mouse strains, including knockouts and overexpressors, and the wide array of immunological tools available make the murine model a great animal for research [ ...
... rather than the low bacterial load latent infection seen in humans [18]. Despite this discrepancy the availability of many well characterized mouse strains, including knockouts and overexpressors, and the wide array of immunological tools available make the murine model a great animal for research [ ...
Fundamentals of Immunology
... 2. Rates of infectious disease and general ill health correlated with lowered IQ. (Figure ...
... 2. Rates of infectious disease and general ill health correlated with lowered IQ. (Figure ...
JAK3 deficiency, (SCID T-B+)
... pediatric emergency and affected child will not survive beyond infancy in the absence of successful reconstitution of their immune system by allogeneic BMT (bone marrow transplantation). Treatment The treatment of choice for JAK3 deficiency is allogeneic BMT that has been demonstrated to be life-sav ...
... pediatric emergency and affected child will not survive beyond infancy in the absence of successful reconstitution of their immune system by allogeneic BMT (bone marrow transplantation). Treatment The treatment of choice for JAK3 deficiency is allogeneic BMT that has been demonstrated to be life-sav ...
Hypothyroidism in Children
... The thyroid is a small, butterfly-shaped gland that lies just under the Adam’s apple in the neck. There are two lobes to the gland, and they lie just in front and at either side of the windpipe (trachea). The thyroid is part of the body’s endocrine system, which consists of glands that secrete horm ...
... The thyroid is a small, butterfly-shaped gland that lies just under the Adam’s apple in the neck. There are two lobes to the gland, and they lie just in front and at either side of the windpipe (trachea). The thyroid is part of the body’s endocrine system, which consists of glands that secrete horm ...
A Neural Network of Adaptively Timed Reinforcement
... One of the main tasks of the present work is to show how processes such as adaptive timing, reinforcement learning, attention, and motor learning differ, yet are linked in the control of behavior. Thus the exposition needs to describe several different types of circuits that form part of a larger ne ...
... One of the main tasks of the present work is to show how processes such as adaptive timing, reinforcement learning, attention, and motor learning differ, yet are linked in the control of behavior. Thus the exposition needs to describe several different types of circuits that form part of a larger ne ...
Mast Cell Activation and Migration to Lymph Nodes during
... inhibited in 3% H2O2 for 10 min. Sections were then incubated with primary antibodies; goat anti–mouse MIP-1a or MIP-1b (R&D Systems), and affinity-purified polyclonal rabbit anti–mouse mast cell protease-5 (mMCP-5) (40), for 1 h at room temperature, followed by HRP-conjugated donkey anti–goat IgG ( ...
... inhibited in 3% H2O2 for 10 min. Sections were then incubated with primary antibodies; goat anti–mouse MIP-1a or MIP-1b (R&D Systems), and affinity-purified polyclonal rabbit anti–mouse mast cell protease-5 (mMCP-5) (40), for 1 h at room temperature, followed by HRP-conjugated donkey anti–goat IgG ( ...
thesis - KI Open Archive
... Natural Killer (NK) cells are cytotoxic cells of the innate immune system. They have been found to be critical in the defense against infections and also against some tumors. Recent studies have shown that NK cells require signals from accessory cells to induce their recruitment and activation at th ...
... Natural Killer (NK) cells are cytotoxic cells of the innate immune system. They have been found to be critical in the defense against infections and also against some tumors. Recent studies have shown that NK cells require signals from accessory cells to induce their recruitment and activation at th ...
Stress, serotonin, and hippocampal neurogenesis
... development of the nervous system (Kendler et al., 2002, 2006; Kendler et al., 2004). The effect of stress, on the other hand, can be modulated by many other factors such as personality, intrapsychic conflict, and presence (or absence) of social support, which could affect how stressful events are pe ...
... development of the nervous system (Kendler et al., 2002, 2006; Kendler et al., 2004). The effect of stress, on the other hand, can be modulated by many other factors such as personality, intrapsychic conflict, and presence (or absence) of social support, which could affect how stressful events are pe ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.