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Chapter 1 Introduction
Chapter 1 Introduction

... If work-stress can lead to burnout, the question arises what the mediating mechanisms might be. For understanding this issue, it is crucial to study the physiological stressresponse as a potential mediator. Under stressful conditions, the body becomes activated to meet the increased demands of the e ...
Drug Addiction - Perelman School of Medicine at the
Drug Addiction - Perelman School of Medicine at the

... stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites ...
Stress as a Risk Factor for Cardiovascular Events - e
Stress as a Risk Factor for Cardiovascular Events - e

... Almost eight decades passed after the first definition of the term “stress”. In 1936 Hans Selye defined this term as “the nonspecific response of the body to any demand for change” which was later referred to as “general adaptation syndrome”. Simply put, this model suggests that all stimuli are “str ...
Endocrine System Outline
Endocrine System Outline

... 2. Medulla - The inner portion of the adrenal gland is the adrenal medulla. Here, some of your "Fight or Flight" hormones are made. They are released in response to an angry or fearful situation and exaggerate the fight or flight response. a. Epinephrine (Adrenaline) b. Norepinephrine 3. Cortex - Th ...
Biology Nervous System - Educational Research Center
Biology Nervous System - Educational Research Center

... − the somatic nervous system receives external stimuli that determine how it interacts with its environment under certain conditions. − the nervous system and the endocrine system are related such that both achieve communication among different body organs. − the speed of propagation depends on exte ...
Lecture 4 Antigen Recognition
Lecture 4 Antigen Recognition

... Each lymphocyte bears a single type of receptor of a unique specificity Interaction between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation The differentiated effector cells derived from an activated lymphocyte will bear ...
LECTURE 3. BLOOD AND LYMPH Of all the derivatives of the
LECTURE 3. BLOOD AND LYMPH Of all the derivatives of the

... Heparin, histamine and several other inflammatory substances are contained in the granules, closely resembling those of labrocytes. These substances are associated with polysaccharides. Since granules are positive to carbohydrate stains e.g. azure A and PAS stain with which they are metachromatic i. ...
Overview of the Lymphoid System
Overview of the Lymphoid System

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Topic 2 Protozoa
Topic 2 Protozoa

... which causes the characteristic symptoms the disease is named for. The patient becomes confused and the sleep cycle is disturbed with the patient alternating between manic periods and complete lethargy. Progressive mental deterioration is followed by coma and death. ...
The Essential Role of T cells in Multiple Sclerosis: A Reappraisal
The Essential Role of T cells in Multiple Sclerosis: A Reappraisal

... In 1986, Mosmann and Coffman[15] put forward the concept of distinct T helper cell subsets, in large part recipro‑ cally inhibitory, Th1 and Th2, the former producing inter‑ feron gamma (IFN‑g) and the latter, interleukin (IL)‑4 (and associated cytokines IL‑5 and IL‑13). These T‑cell subsets serve p ...
SialylTn-mAb17-1A Carbohydrate−Protein Conjugate Vaccine
SialylTn-mAb17-1A Carbohydrate−Protein Conjugate Vaccine

JSAS 2013
JSAS 2013

... Abstract. Since Medawar (1953), much attention has been given to the immunological paradox of the survival and growth of the semi-allogeneic fetus in the maternal uterus. Numerous studies, mainly on the human placenta, have established fundamental mechanisms of this phenomenon; however, many aspects ...
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Nervous_System__Ch_7__S2015

... The nervous system uses the nerve impulse to convey information. – Resting potential is the voltage level when an axon is not conducting an impulse. ...
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Phosphospecific Flow Cytometry Immunological Signaling Network

... The IL-2R signals through Stat5 and is primarily restricted to NK, activated T and B cells, and regulatory T cells. Finally, the IL-10R is similar to the IFN-␥R in sequence, but IL-10 modulates the immune responses of monocytes and macrophages to inhibit Th1 and is thought to enhance Th2 development ...
Probiotics for the Immune System
Probiotics for the Immune System

Document
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... lymphoid tissues, including the lymph nodes and spleen. To migrate to these locations, DCs travel via the blood or in lymph vessels. The primary function of DCs is to interact with lymphocytes and stimulate them, either to initiate or maintain an immune response against a pathogen, or to prevent res ...
BRAIN GLUCOSE-SENSING: AGE- AND ENERGY
BRAIN GLUCOSE-SENSING: AGE- AND ENERGY

... survival. It is achieved by matching food intake and energy expenditure, and failure to maintain this balance can be devastating. Excessive food intake can ultimately manifest as obesity, diabetes and other co-morbidities such as high blood pressure and certain forms of cancer. The other extreme is ...
Appendices Sample - Essentials Education
Appendices Sample - Essentials Education

... 6. Herd immunity is where the population has a certain level of immunity due to the fact that most or many individuals within the population are immune, therefore the disease is less likely to spread. This term only applies to contagious diseases as these are the only ones that can spread from one ...
Toxic Stress in the First Three Years
Toxic Stress in the First Three Years

... • Effects of stress depend on many factors – the type of stressor – the duration of the stress (acute vs. chronic) – the unpredictability or uncontrollability of the stress – the social environment of the stressed individual including caregiving in children and social support in adults – The timing ...
Macrophages in Kidney Injury and Repair
Macrophages in Kidney Injury and Repair

... studies indicate that Mφs can be polarized to phenotype M1 or M2 after activation by different cytokines. However in vitro studies are highly artificial and may not reflect the scenario in vivo. Not only are the cytokines IFNγ, LPS, IL-4, or IL-13 which generate different subpopulations of Mφs less ...
TABLE 3.1. Antigen Recognition by B and T Cells
TABLE 3.1. Antigen Recognition by B and T Cells

... Activates NK cells and promotes generation of TH1 CD4⫹ T cells Shares characteristics with IL-4 such as Ig switch to IgE synthesis, but does not affect T cells; growth factor for human B cells Involved in the development of memory B cells T-cell growth factor, similar to IL-2 Activates NK cells, mac ...
How T cells recognize antigen
How T cells recognize antigen

... 1) Naïve CD8 T cells have to be activated by professional APC, 2) Only cells that synthesize antigen themselves can present antigen to CD8 T cells, ⇒ CTL response possible only against viruses that infect DCs or tumors derived from DCs ...
Boundless Study Slides
Boundless Study Slides

... molecules; before a T cell can do so, it must be activated via interaction with an antigen presenting cell, or APC. • Once a cytotoxic T cell (TC) is activated, it will clone itself, producing many TC cells with the correct receptors; some portion of the cells are active and will help destroy infect ...
Part 1 MRCSI (Ophth) - Royal College of Surgeons in Ireland
Part 1 MRCSI (Ophth) - Royal College of Surgeons in Ireland

... work under Full or Temporary/Limited Registration in Ireland or the United Kingdom. ...
TETRAMER STAINING OF ANTIGEN SPECIFIC T CELLS
TETRAMER STAINING OF ANTIGEN SPECIFIC T CELLS

... tetramers are synthesised for the analysis of cellular immunity against viral infections in HIV infected individuals. Background Cells present part of their proteinaceous content to the immune system via the proteolytic generation of peptides which are transported to the lumen of the endoplasmic ret ...
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Psychoneuroimmunology



Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.
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