Herpes simplex virus and varicella zoster virus, Open Access
... naïve host and is controlled by an innate immune responses, followed by eventual development of adaptive immunity. However, recurrent HSV-1 and VZV disease is initiated in the face of a primed adaptive immune response, by a virus that is antigenically identical to that inducing immunity during the p ...
... naïve host and is controlled by an innate immune responses, followed by eventual development of adaptive immunity. However, recurrent HSV-1 and VZV disease is initiated in the face of a primed adaptive immune response, by a virus that is antigenically identical to that inducing immunity during the p ...
the Complete 2016 Summit Summary
... Dr. Ali Jabbari, from Columbia University Medical Center, reported on the utility of the Alopecia Areata Disease Activity Index (ALADIN) biomarker tool to track disease status and potentially predict disease response early in the course of treatment. He discussed its utility predicting and tracking ...
... Dr. Ali Jabbari, from Columbia University Medical Center, reported on the utility of the Alopecia Areata Disease Activity Index (ALADIN) biomarker tool to track disease status and potentially predict disease response early in the course of treatment. He discussed its utility predicting and tracking ...
Presence of vesicular glutamate transporter-2 in
... stimulate dose-dependently GH secretion from perifused somatotrophs (Lindstrom & Ohlsson, 1992; Niimi et al., 1994). Several lines of evidence also indicate that glutamate exerts central actions on GH secretion in which GHRH neurons play a crucial role. In accordance with this idea, the N-methyl-D,l ...
... stimulate dose-dependently GH secretion from perifused somatotrophs (Lindstrom & Ohlsson, 1992; Niimi et al., 1994). Several lines of evidence also indicate that glutamate exerts central actions on GH secretion in which GHRH neurons play a crucial role. In accordance with this idea, the N-methyl-D,l ...
Welcome to the Nature Immunology Immune Evasion Web Focus
... (a frequent genotype plus its epidemiologically associated descendents) that have been responsible for three pandemic waves of disease since the 1960s17. The authors argue convincingly that loci under positive selection are highly antigenic and represent immune escape from herd immunity17. Many of t ...
... (a frequent genotype plus its epidemiologically associated descendents) that have been responsible for three pandemic waves of disease since the 1960s17. The authors argue convincingly that loci under positive selection are highly antigenic and represent immune escape from herd immunity17. Many of t ...
primer on brain facts - Chicago Society of Neuroscience
... drives behavior, and forms the foundation for the mind. Research is also essential for the development of therapies for more than 1,000 nervous system disorders that affect more than 1 billion people worldwide. As these strides occur, it is crucial that scientists communicate with the general public ...
... drives behavior, and forms the foundation for the mind. Research is also essential for the development of therapies for more than 1,000 nervous system disorders that affect more than 1 billion people worldwide. As these strides occur, it is crucial that scientists communicate with the general public ...
Vaccination - The Open University
... vaccinia can be expected to occur in a minority of individuals – particularly those with immunodeficiency. In the 1960s, smallpox vaccination led to an estimated 1–3 deaths per million doses, but today's population now has very much larger numbers of people whose immune system is suppressed by HIV i ...
... vaccinia can be expected to occur in a minority of individuals – particularly those with immunodeficiency. In the 1960s, smallpox vaccination led to an estimated 1–3 deaths per million doses, but today's population now has very much larger numbers of people whose immune system is suppressed by HIV i ...
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific
... members are Toll like receptors (TLRs) and C type lectin receptors (CLRs, Clec) [22]. TLRs are type I integral membrane glycoproteins and well characterized members of the PRR family. They are localized in the plasma membrane (TLRs 1, 2, 4, 5, 6, 11) or in endosomal compartments (TLRs 3, 7, 8, 9) [1 ...
... members are Toll like receptors (TLRs) and C type lectin receptors (CLRs, Clec) [22]. TLRs are type I integral membrane glycoproteins and well characterized members of the PRR family. They are localized in the plasma membrane (TLRs 1, 2, 4, 5, 6, 11) or in endosomal compartments (TLRs 3, 7, 8, 9) [1 ...
Bell DC et al. Atopic eczema/skin barrier/immune
... hydration[15]. However, in all but the mildest cases emollients are insufficiently effective so a combination therapy is used with another agent targeting the inflammatory response. Topical corticosteroids act through the corticosteroid-receptor complex to downregulate synthesis of the proteins invo ...
... hydration[15]. However, in all but the mildest cases emollients are insufficiently effective so a combination therapy is used with another agent targeting the inflammatory response. Topical corticosteroids act through the corticosteroid-receptor complex to downregulate synthesis of the proteins invo ...
Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins
... One important exception to the generalization that CRP concentrations correlate with the extent and severity of inflammation is SLE. Many patients with active SLE, particularly if they present without serositis, do not have elevated CRP (or serum amyloid A) concentrations but do have marked increase ...
... One important exception to the generalization that CRP concentrations correlate with the extent and severity of inflammation is SLE. Many patients with active SLE, particularly if they present without serositis, do not have elevated CRP (or serum amyloid A) concentrations but do have marked increase ...
Endoplasmic Reticulum Stress Is Important for the Manifestations ofα
... ␣-synucleinopathies. However, how ␣S causes neurodegeneration is unresolved. Because cellular accumulation of misfolded proteins can lead to endoplasmic reticulum stress/unfolded protein response (ERS/UPR), chronic ERS could contribute to neurodegeneration in ␣-synucleinopathy. Using the A53T mutant ...
... ␣-synucleinopathies. However, how ␣S causes neurodegeneration is unresolved. Because cellular accumulation of misfolded proteins can lead to endoplasmic reticulum stress/unfolded protein response (ERS/UPR), chronic ERS could contribute to neurodegeneration in ␣-synucleinopathy. Using the A53T mutant ...
Thesis - KI Open Archive
... KIR via bidirectional promoters (32). This multifaceted system endows humans with complex and unique KIR repertoires, comprising NK cells expressing 0, 1, 2 or more KIRs. Expression of KIRs has been determined to largely follow the product rule (%KIR-A+KIR-B+ = %KIR-A+ x %KIR-B+) (33). At steady sta ...
... KIR via bidirectional promoters (32). This multifaceted system endows humans with complex and unique KIR repertoires, comprising NK cells expressing 0, 1, 2 or more KIRs. Expression of KIRs has been determined to largely follow the product rule (%KIR-A+KIR-B+ = %KIR-A+ x %KIR-B+) (33). At steady sta ...
Curriculum Vitae - Institute of Experimental Immunology
... (HLA)-G molecules inhibit NKAT3 expressing natural killer cells“, Journal of Experimental Medicine (1997), 185(3): 385-392. 3. Reinhard Obst, Christian Münz, Stefan Stevanović and Hans-Georg Rammensee, "Generation of allo- and self-restricted cytotoxic T lymphocytes against a peptide library: eviden ...
... (HLA)-G molecules inhibit NKAT3 expressing natural killer cells“, Journal of Experimental Medicine (1997), 185(3): 385-392. 3. Reinhard Obst, Christian Münz, Stefan Stevanović and Hans-Georg Rammensee, "Generation of allo- and self-restricted cytotoxic T lymphocytes against a peptide library: eviden ...
Read More - D5Pharma
... No inhibition of TNFα-induced NO release by RAW264.7 cells was observed when treated with control aptamers cApt(VR) and VR20. This sequence thus represents a template that may be useful for modifications that may yield a suitable product for use in vivo. Structural Features of DNA Aptamer VR11. The s ...
... No inhibition of TNFα-induced NO release by RAW264.7 cells was observed when treated with control aptamers cApt(VR) and VR20. This sequence thus represents a template that may be useful for modifications that may yield a suitable product for use in vivo. Structural Features of DNA Aptamer VR11. The s ...
Significance of the MHC Significance of the MHC
... T cells are MHC-restricted i.e. they must recognize antigen presented on MHC. CD4+ T cells are class II MHC-restricted i.e. they must recognize antigen presented on class II MHC. CD8+ T cells are class I MHC-restricted i.e. they must recognize antigen presented on class I MHC. A particular T cell cl ...
... T cells are MHC-restricted i.e. they must recognize antigen presented on MHC. CD4+ T cells are class II MHC-restricted i.e. they must recognize antigen presented on class II MHC. CD8+ T cells are class I MHC-restricted i.e. they must recognize antigen presented on class I MHC. A particular T cell cl ...
The role of the cerebellum in classical conditioning of
... terminals indicate excitatory neurons. Stars indicate sites of plasticity based on current evidence. See text for details. (Modified from Thompson, 1986.) ...
... terminals indicate excitatory neurons. Stars indicate sites of plasticity based on current evidence. See text for details. (Modified from Thompson, 1986.) ...
Infusion Reactions - Chemotherapy
... is helpful to comprehend the origin of an infusion reaction. Essentially, the administration of any foreign drug is likely to elicit some response from the immune system; most often, the response is a minor, subclinical, and transient reaction. Serious symptoms or issues arise when the immune system ...
... is helpful to comprehend the origin of an infusion reaction. Essentially, the administration of any foreign drug is likely to elicit some response from the immune system; most often, the response is a minor, subclinical, and transient reaction. Serious symptoms or issues arise when the immune system ...
Bledsoe_V1_ch08c
... Bledsoe et al., Paramedic Care Principles & Practice Volume 1: Introduction © 2006 by Pearson Education, Inc. Upper Saddle River, NJ ...
... Bledsoe et al., Paramedic Care Principles & Practice Volume 1: Introduction © 2006 by Pearson Education, Inc. Upper Saddle River, NJ ...
Essential role of Toll-like receptor 2 in
... we revealed that glycogen activated RAW264.7, murine macrophage cell line, to induce the production of nitric oxide (NO) and inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and that the molecular weight of glycogen was strongly related to its macrophage-stimula ...
... we revealed that glycogen activated RAW264.7, murine macrophage cell line, to induce the production of nitric oxide (NO) and inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and that the molecular weight of glycogen was strongly related to its macrophage-stimula ...
Regulatory T cells
... -Check in which conditions the extended models conserve the key dynamical features of the original cross-regulation model. -Compare models of different hypotheses about the specific role of IL2 in T cell mediated suppression ...
... -Check in which conditions the extended models conserve the key dynamical features of the original cross-regulation model. -Compare models of different hypotheses about the specific role of IL2 in T cell mediated suppression ...
Modeling the interactions of bacteria and Toll-like
... mucus layer, intestinal macrophages, and blood macrophages are three important defense mechanisms that help to maintain homeostasis in the gut. However, the inflammatory response by which macrophages eliminate bacteria also can cause collateral tissue damage and must be moderated by anti-inflammatory ...
... mucus layer, intestinal macrophages, and blood macrophages are three important defense mechanisms that help to maintain homeostasis in the gut. However, the inflammatory response by which macrophages eliminate bacteria also can cause collateral tissue damage and must be moderated by anti-inflammatory ...
Sinusoid-lining cells are novel myeloid- endothelial innate cells that form splenic
... novel, more efficacious and less expensive vaccine strategies against encapsulated bacteria, including antibiotic-resistant bacteria. However, this task is hampered by our poor knowledge of the mechanisms underlying antibody production by MZ B cells in humans5. Growing evidence shows that TI antibod ...
... novel, more efficacious and less expensive vaccine strategies against encapsulated bacteria, including antibiotic-resistant bacteria. However, this task is hampered by our poor knowledge of the mechanisms underlying antibody production by MZ B cells in humans5. Growing evidence shows that TI antibod ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.