the role of muscle damage in the etiology of overtraining syndrome
... effects of the growth hormone may result from a growth hormonestimulated increase in IGF-I production (Elloumi et al., 2005; de GraafRoelfsema et al., 2007; de Graaf-Roelfsema et al., 2009. IGF-I simulate amino acid transportation, which is essential to tissue growth. Autocrine/paracrine processes i ...
... effects of the growth hormone may result from a growth hormonestimulated increase in IGF-I production (Elloumi et al., 2005; de GraafRoelfsema et al., 2007; de Graaf-Roelfsema et al., 2009. IGF-I simulate amino acid transportation, which is essential to tissue growth. Autocrine/paracrine processes i ...
The Aryl Hydrocarbon Receptor in Barrier Organ Physiology
... because of the toxicity associated with its activity in adverse drug–drug interactions and generation of carcinogenic metabolites from polycyclic aromatic hydrocarbons (PAHs). Especially in the field of toxicology and pharmacology, the AhR is viewed as a protein that has developed during evolution t ...
... because of the toxicity associated with its activity in adverse drug–drug interactions and generation of carcinogenic metabolites from polycyclic aromatic hydrocarbons (PAHs). Especially in the field of toxicology and pharmacology, the AhR is viewed as a protein that has developed during evolution t ...
Immune Recognition HLA-E, F, and G in Maternal
... 1.2 g/ml, and plates were incubated overnight at 4°C. After the uncoupled sites were blocked with 5% skim milk in PBS, 100 l of hybridoma supernatant was added to each well. HRP-goat anti-mouse was added at 1/2000 dilution in PBS/Tween 20, and 3⬘,3⬘,5⬘,5⬘-tertramethyl benzidine was used as a subst ...
... 1.2 g/ml, and plates were incubated overnight at 4°C. After the uncoupled sites were blocked with 5% skim milk in PBS, 100 l of hybridoma supernatant was added to each well. HRP-goat anti-mouse was added at 1/2000 dilution in PBS/Tween 20, and 3⬘,3⬘,5⬘,5⬘-tertramethyl benzidine was used as a subst ...
human monoclonal antibody technology.
... Antigen-specific mouse hybridomas have been selected using this approach shortly after somatic cell fusion, reducing efforts involved in the cloning procedure (Horton et al., 1989; Ossendorp et a l . , 1989). The selection of mouse x human heterohybridomas by this technique has been unsuccessful, ho ...
... Antigen-specific mouse hybridomas have been selected using this approach shortly after somatic cell fusion, reducing efforts involved in the cloning procedure (Horton et al., 1989; Ossendorp et a l . , 1989). The selection of mouse x human heterohybridomas by this technique has been unsuccessful, ho ...
Recent developments in basophil research
... Thymic stromal lymphopoietin (TSLP), produced by epithelial cells, stromal cells and mast cells, ...
... Thymic stromal lymphopoietin (TSLP), produced by epithelial cells, stromal cells and mast cells, ...
Food Lectins in Health and Disease: An Introduction
... someone receives the wrong blood type during a blood transfusion. In fact, red blood cell agglutination specific to each person or groups of people is the basis for testing for blood types. The attachment or binding of certain food lectins can initiate a variety of cell specific effects. These react ...
... someone receives the wrong blood type during a blood transfusion. In fact, red blood cell agglutination specific to each person or groups of people is the basis for testing for blood types. The attachment or binding of certain food lectins can initiate a variety of cell specific effects. These react ...
SECTION A.1 – ELECTRICAL IMBALANCE IN AUTISM A. Evidence
... A question arises as to, if electrical imbalances is at the core of autism, why don’t all children show abnormal EEG’s all the time. What may be happening is that the autistic brain is not always overstimulated. It has the potential for overstimulation, but it may be relaxed and quiescent at many ti ...
... A question arises as to, if electrical imbalances is at the core of autism, why don’t all children show abnormal EEG’s all the time. What may be happening is that the autistic brain is not always overstimulated. It has the potential for overstimulation, but it may be relaxed and quiescent at many ti ...
A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade
... CD206+, CD64+, CD68+, CD11c+ CD115low, and CD102+, confirming they were macrophages but were different from Kupffer cells (Figure S1). Furthermore, CD102 has been identified as a specific marker for resident peritoneal macrophages and was present on macrophages in injury but not on Kupffer cells (Ok ...
... CD206+, CD64+, CD68+, CD11c+ CD115low, and CD102+, confirming they were macrophages but were different from Kupffer cells (Figure S1). Furthermore, CD102 has been identified as a specific marker for resident peritoneal macrophages and was present on macrophages in injury but not on Kupffer cells (Ok ...
Kokatla_Wiley_2014
... strength of the salt-bridge of the C2-amine with Asp543, as well as ππ interactions with Phe405. We therefore synthesized N3- butylquinoline and 3-(butylthio)quinoline analogues (9 and 12, respectively), as well as the 3-alkylquinolin-2-amines 14a-f (Scheme 1). Accessing the N3-butylquinoline 9 by c ...
... strength of the salt-bridge of the C2-amine with Asp543, as well as ππ interactions with Phe405. We therefore synthesized N3- butylquinoline and 3-(butylthio)quinoline analogues (9 and 12, respectively), as well as the 3-alkylquinolin-2-amines 14a-f (Scheme 1). Accessing the N3-butylquinoline 9 by c ...
EMEA/536810/2008 - EMA
... Transport across the blood brain barrier by both passive diffusion and by active transporters is agerelated and undergoes constant maturational changes in the neonate. This may contribute to a significantly altered distribution of active substances or metabolites into the CNS with a potential impact ...
... Transport across the blood brain barrier by both passive diffusion and by active transporters is agerelated and undergoes constant maturational changes in the neonate. This may contribute to a significantly altered distribution of active substances or metabolites into the CNS with a potential impact ...
Intact skin and not stripped skin is crucial for the
... Figure 1 a-Study design for the evaluation of peanut protein passage into blood stream after epicutaneous application on intact or stripped skin. Naive mice were divided into 3 groups (n=10 for each). One group received a ViaskinW loaded with 500μg (ViaskinW-500) applied on intact skin (EPIT), anoth ...
... Figure 1 a-Study design for the evaluation of peanut protein passage into blood stream after epicutaneous application on intact or stripped skin. Naive mice were divided into 3 groups (n=10 for each). One group received a ViaskinW loaded with 500μg (ViaskinW-500) applied on intact skin (EPIT), anoth ...
The physiology of blood platelets and changes of their biological
... mechanisms that play a role in hemostasis and thrombosis facilitate platelets the participation in other physiological and pathological processes, particularly in the inflammation, the immune response and central nervous system disorders. Platelets are involved in pathophysiology of central nervous ...
... mechanisms that play a role in hemostasis and thrombosis facilitate platelets the participation in other physiological and pathological processes, particularly in the inflammation, the immune response and central nervous system disorders. Platelets are involved in pathophysiology of central nervous ...
Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are
... their phenotype and their localization in lymphoid tissues (16). Iwasaki and Kelsall have recently identified and characterized 3 distinct subsets of DCs in murine Peyer’s patches (17,18): 1) CD11b⫹,CD8␣⫺ DCs with a myeloid lineage, residing in the subepithelial region; 2) CD11b⫺,CD8␣⫹ DCs with a ly ...
... their phenotype and their localization in lymphoid tissues (16). Iwasaki and Kelsall have recently identified and characterized 3 distinct subsets of DCs in murine Peyer’s patches (17,18): 1) CD11b⫹,CD8␣⫺ DCs with a myeloid lineage, residing in the subepithelial region; 2) CD11b⫺,CD8␣⫹ DCs with a ly ...
CNB12 Plus
... Few substances have been shown to regenerate nerves in humans with peripheral neuropathies. However, a study in the Journal of Neurological Science (1994 Apr. 122[2]:140-143) postulated that methylcobalamin could increase protein synthesis and help regenerate nerves. The scientists showed that very ...
... Few substances have been shown to regenerate nerves in humans with peripheral neuropathies. However, a study in the Journal of Neurological Science (1994 Apr. 122[2]:140-143) postulated that methylcobalamin could increase protein synthesis and help regenerate nerves. The scientists showed that very ...
TLR2 and TLR4 expression on CD14++ and CD14+ monocyte
... Still, a wealth of gene and protein expression data points to increased monocytic activity in type 1 diabetic patients compared to healthy controls5,8-10. Monocytes exert their crucial role in immune defence through toll-like receptors (TLRs), a type of pattern recognition receptors. Activation of T ...
... Still, a wealth of gene and protein expression data points to increased monocytic activity in type 1 diabetic patients compared to healthy controls5,8-10. Monocytes exert their crucial role in immune defence through toll-like receptors (TLRs), a type of pattern recognition receptors. Activation of T ...
Modulation of immune responses by the tumor suppressor p53
... intracellular ROS/NOS levels to aid in appropriate balance of the inflammatory responses. In addition, since p53 is subject to modifications in the presence of reactive compounds, it can be considered a cellular sensor of redox changes [23]. Modulations of the p53 redox state can affect cell signali ...
... intracellular ROS/NOS levels to aid in appropriate balance of the inflammatory responses. In addition, since p53 is subject to modifications in the presence of reactive compounds, it can be considered a cellular sensor of redox changes [23]. Modulations of the p53 redox state can affect cell signali ...
Tumor necrosis factor-alpha in normal and diseased brain
... CNS and thus act directly on brain parenchyma by crossing the blood-brain barrier (BBB), either by active transport mechanisms or passive diffusion in the circumventricular organs, including areas of the hypothalamus, pituitary, and pineal gland (Sternberg, 1997). Although much of this action occurs ...
... CNS and thus act directly on brain parenchyma by crossing the blood-brain barrier (BBB), either by active transport mechanisms or passive diffusion in the circumventricular organs, including areas of the hypothalamus, pituitary, and pineal gland (Sternberg, 1997). Although much of this action occurs ...
Latent toxoplasmosis is clinically asymptomatic, but usually life
... cell activity [9]. Progesterone has also clinical studies have noted differences been shown to decrease production of in the incidence and severity of NO and nitrite by macrophages [10]. parasitic diseases between males and Gay-Andrieu et al.[11] showed females. Although in some instances that proge ...
... cell activity [9]. Progesterone has also clinical studies have noted differences been shown to decrease production of in the incidence and severity of NO and nitrite by macrophages [10]. parasitic diseases between males and Gay-Andrieu et al.[11] showed females. Although in some instances that proge ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.