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Psoriasis and Stress–Psoriasis Aspect of Psychoneuroendocrinology
Psoriasis and Stress–Psoriasis Aspect of Psychoneuroendocrinology

... and CRH-R2 (Grammatopoulos et al., 2002) (Hillhouse et al., 2002). Both receptor types belong to the group II subfamily of G protein-coupled receptors (GPCRs). In human skin, CRH-R1 is the major receptor, expressed in both epidermal, dermal and subcutis with CRHR1 being the most prevalent isoform. T ...
R e v i s i ó n
R e v i s i ó n

... of lymphocytes to peripheral lymph nodes LFA-1 is expressed on lymphocytes, monocytes, granulocytes, and bone marrow cells. Its natural ligands include ICAM-1, -2, and –3 and it has been suggested to play roles during the immune response, lymphocyte recirculation, and inflammation. Its role in homin ...
Intestinal mucosal barrier function in health and disease
Intestinal mucosal barrier function in health and disease

Early steps regulating proliferation and activation in macrophages Ester Sánchez Tilló 2006
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How Does the Endocrine System Work?
How Does the Endocrine System Work?

... hypothalamus, is considered the most important part of the endocrine system. It's often called the "master gland" because it makes hormones that control several other endocrine glands. The production and secretion of pituitary hormones can be influenced by factors such as emotions and seasonal chang ...
STUDIES OF MUCOSAL IMMUNE REGULATION ANNE LAHDENPERÄ
STUDIES OF MUCOSAL IMMUNE REGULATION ANNE LAHDENPERÄ

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... egeneration of the human intervertebral disk (IVD) is a widespread and debilitating disorder characterized by pronounced anatomic and biological changes in a process that is strongly associated with aging.1 Low back pain in humans, which is an increasingly common and costly health problem, is mainly ...
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... Mannans is a non-digestible protein carbohydrate, this means when it is added to an animal’s total feed it’s complex nature prohibits it being digested by the animal, this makes it available to be used as a nutrient by the good bacteria or flor in the gut. The good bugs grow rapidly in the gut and ...
Chapter 15 The Lymphatic System and Immunity
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... – Group of proteins normally present in blood in inactive state – Complement cascade • Important mechanism of action for antibodies – Complement-binding sites on antibody are exposed after attaching to antigen – Complement triggers a series (cascade) of reactions that produce tiny protein rings that ...
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... for the continuation of IRIS.1,19 There is also an alteration or imbalance in the proinflammatory T-helper cells (including the Th1 cells, which help clear intracellular pathogens, and the Th17 cells, which help sustain inflammatory responses by producing certain cytokines) and regulatory T-cells, w ...
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... they are injected back to the patient these cells could still be able to migrate in periphery or in the lymphoid organs and/or to stimulate T-cells. So, we evaluated the expression of molecules involved in these processes on control or PUVA - monocytes. Moreover, for an optimal T-lymphocytes stimula ...
NIAID Biodefense Research Agenda for Category B and C Priority
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... and does not require ATP. Oncosis usually instigates a local immune/inflammatory response [16], and rapidly destroys damaged cells. Thus it is very useful in stopping the spread of pathogens and preventing damaged cells from lingering. In the past, the term ‘necrosis’ has been incorrectly used to al ...
The Very Young Patient - Advances in Inflammatory Bowel Diseases
The Very Young Patient - Advances in Inflammatory Bowel Diseases

Licentiate thesis from the Department of Immunology,
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... period between March 2000 and July 2001. An additional 19 long-standing type 1 diabetic patients were recruited during the same period from the King’s College Hospital Diabetes Service (courtesy of Professor S.A. Amiel). Also, 20 healthy donors were recruited from laboratory and hospital staff durin ...
Immune-related functions of the Hivep gene family in East African
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... Interferons (IFNs) are attractive biological response modifiers for use as therapeutic agents in infectious diseases because they have both antiviral and immunomodulatory activity. Their name even comes from the fact that they can “interfere” with viral replication.[1] IFN-α (“leukocyte interferon”) ...
Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are
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... and characterized 3 distinct subsets of DCs in murine Peyer’s patches (17,18): 1) CD11b⫹,CD8␣⫺ DCs with a myeloid lineage, residing in the subepithelial region; 2) CD11b⫺,CD8␣⫹ DCs with a lymphoid lineage, residing in the T cell–rich interfollicular region; and 3) DCs lacking expression of both CD11 ...
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... Immunity: The ability of the body to defend itself against infectious agents, foreign cells and even abnormal body cells. Specific immunity: Also known as acquired immunity, effective against particular identified foreign agents and develops in response to contact with that agent. Autoimmunity: Occu ...
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... States, affecting up to 40 million adults and children each year.  Allergic rhinitis costs the nation approximately $5.3 billion in direct and indirect costs (including time lost from work and school) and accounts for about 10,000 absences from school. ...
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... lowered fitness is an effect exerted by the pathogens. Neglect of variability in susceptibility might also result in erroneous interpretation of laboratory data, especially if these interpretations are used to draw conclusions about natural populations. Individuals from captive colonies are usually ...
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Induction of inhibitory central nervous system-derived and

... Monocytes, macrophages and dendritic cells constitute the so-called mononuclear phagocyte system and are increasingly recognized as a highly plastic continuum of cells able to adopt many different phenotypes involved in the initiation and regulation of immune responses, as well as in inflammation, h ...
Thèse de doctorat
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... Tumors grow within a complex microenvironment composed of immune cells, fibroblasts, endothelial cells and other non-malignant cells. The study of the composition of tumor microenvironments has led to classifications with prognostic and theranostic values, as well as the discovery of treatments modu ...
A Review Part-1 (Experimental Studies)
A Review Part-1 (Experimental Studies)

... Marked elevation in Natural Killer cells activity strongly suggests that DCP possesses considerable immunostimulatory activity. b. Evaluation of Immunomodulatory activity of DCP against Dendritic Cells12, 13 Dendritic cells are professional antigen-presenting cells that play pivotal role in the deve ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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