Pathobiology of Aspergillus fumigatus, a saprotrophic pathogenic
... toxin secreted by the mycelium of this fungus do not play a role in the pathogenesis of A. fumigatus in experimentally induced infections. In contrast, the melanin layer of the conidial cell wall efficiently scavenges reactive oxygen species and plays a role in protecting the fungus against the phag ...
... toxin secreted by the mycelium of this fungus do not play a role in the pathogenesis of A. fumigatus in experimentally induced infections. In contrast, the melanin layer of the conidial cell wall efficiently scavenges reactive oxygen species and plays a role in protecting the fungus against the phag ...
B cell fate following immunization: from memory B cells to plasma cells
... understood. Thus, a better understanding of how to modulate Env-induced responses by using different immunogens, immunization regimens and adjuvants is needed. In this thesis, I used rhesus macaques to investigate several of these questions. ...
... understood. Thus, a better understanding of how to modulate Env-induced responses by using different immunogens, immunization regimens and adjuvants is needed. In this thesis, I used rhesus macaques to investigate several of these questions. ...
Correlations among measles virus
... correlates of protection against measles. Vaccine failure has been defined in terms of antibody response alone, and the markers of measles virus-specific cellular immunity after vaccination have been poorly characterized. Although the role and relative contribution of cellular immunity in imparting ...
... correlates of protection against measles. Vaccine failure has been defined in terms of antibody response alone, and the markers of measles virus-specific cellular immunity after vaccination have been poorly characterized. Although the role and relative contribution of cellular immunity in imparting ...
Cytokines That Promote Periodontal Tissue Destruction
... process involving innate and adaptive immune responses. PD is characterized by the host-mediated destruction of soft tissue caused by the induced production and activation of lytic enzymes and stimulated osteoclastogenesis.1 Although it is widely recognized that PD is chronic, the nature of the chro ...
... process involving innate and adaptive immune responses. PD is characterized by the host-mediated destruction of soft tissue caused by the induced production and activation of lytic enzymes and stimulated osteoclastogenesis.1 Although it is widely recognized that PD is chronic, the nature of the chro ...
Naked RNA immunization with replicons derived from poliovirus and
... immunization. These results demonstrate that naked RNA immunization with self-replicating molecules can effectively induce both humoral and cellular immune responses and constitutes an alternative strategy to DNA immunization. ...
... immunization. These results demonstrate that naked RNA immunization with self-replicating molecules can effectively induce both humoral and cellular immune responses and constitutes an alternative strategy to DNA immunization. ...
Treatment-dependent Loss of Polyfunctional CD8+ T
... setting is a matter of debate more so than the generally well tolerated ART. In particular, IS regimens including thymoglobulin (ATG), have been associated with an accelerated long-term CD4+ T-cell depletion and increased risk of non-opportunistic infections and may thus hamper overall clinical outc ...
... setting is a matter of debate more so than the generally well tolerated ART. In particular, IS regimens including thymoglobulin (ATG), have been associated with an accelerated long-term CD4+ T-cell depletion and increased risk of non-opportunistic infections and may thus hamper overall clinical outc ...
White blood cells, C-reactive protein and erythrocyte sedi
... WBC, ANC, CRP and ESR, reflect the severity of the acute phase reaction. In acute infections, they measure the tissue damage caused by microbes. Accordingly, they are expected to be higher in bacterial than in viral infections. In the present study, CRP, ESR and ANC were higher in patients with PNC ...
... WBC, ANC, CRP and ESR, reflect the severity of the acute phase reaction. In acute infections, they measure the tissue damage caused by microbes. Accordingly, they are expected to be higher in bacterial than in viral infections. In the present study, CRP, ESR and ANC were higher in patients with PNC ...
crosstalk between epithelial cells and macrophages - DORAS
... In order to cope with the overwhelming amount of commensal bacteria, dietary and environmental antigens, homeostasis in the intestine relies upon the fine tuned crosstalk between the immune cells and their environment. One of the key regulators of homeostasis in the intestine are macrophages. Unlike ...
... In order to cope with the overwhelming amount of commensal bacteria, dietary and environmental antigens, homeostasis in the intestine relies upon the fine tuned crosstalk between the immune cells and their environment. One of the key regulators of homeostasis in the intestine are macrophages. Unlike ...
Inducible Activation of TLR4 Confers Resistance to
... Production and identification of transgenic mice The CD4hTLR4 plasmid construct (see Fig. 1) was linearized with XbaI; the DNA ends were filled in by treatment with Pfu Turbo polymerase (Stratagene) for 15 min at 72°C in the presence of 1 mM dNTPs. A 2-kb ClaI fragment was recovered by agarose gel e ...
... Production and identification of transgenic mice The CD4hTLR4 plasmid construct (see Fig. 1) was linearized with XbaI; the DNA ends were filled in by treatment with Pfu Turbo polymerase (Stratagene) for 15 min at 72°C in the presence of 1 mM dNTPs. A 2-kb ClaI fragment was recovered by agarose gel e ...
Chronic inflammation
... their phagolysosomes. In a modified form of the antigen re-emerge on the macrophage plasma membrane, where they enter into a comprehensive communication with specific proteins. Only in such a combination the antigen recognized by T-lymphocytes. The interaction of macrophage and T-lymphocytes in chro ...
... their phagolysosomes. In a modified form of the antigen re-emerge on the macrophage plasma membrane, where they enter into a comprehensive communication with specific proteins. Only in such a combination the antigen recognized by T-lymphocytes. The interaction of macrophage and T-lymphocytes in chro ...
meriones shawi - ISI International Scientific Indexing
... the environment. Accordingly, there is ample evidence indicating a bidirectional relationship between the neuroendocrine and immune systems, in which the immune system acts on the neuroendocrine system through its cytokines, and the neuroendocrine system, in return modulates the immune system throug ...
... the environment. Accordingly, there is ample evidence indicating a bidirectional relationship between the neuroendocrine and immune systems, in which the immune system acts on the neuroendocrine system through its cytokines, and the neuroendocrine system, in return modulates the immune system throug ...
Day, M. J. (2016). Cats are not small dogs: Is there an
... consistently failed to demostrate differences between normal and inflamed canine intestine [52, 53], but in cats, increased expression of proinflammatory, Th1- and Tregrelated cytokines has been shown [54]. Canine IBD more clearly has a genetic component with strong breed predispositions and genetic ...
... consistently failed to demostrate differences between normal and inflamed canine intestine [52, 53], but in cats, increased expression of proinflammatory, Th1- and Tregrelated cytokines has been shown [54]. Canine IBD more clearly has a genetic component with strong breed predispositions and genetic ...
Piperine inhibits cytokine production by human peripheral blood
... A major alkaloid and active component of most Piper spp is piperine. Black pepper and piperine have been reported to exhibit central nervous system depression (Virinder et al., 1997), anti-pyretic (Virinder et al., 1997), anti-microbial (Kumar et al., 2007), and anti-inflammatory activities (Virinde ...
... A major alkaloid and active component of most Piper spp is piperine. Black pepper and piperine have been reported to exhibit central nervous system depression (Virinder et al., 1997), anti-pyretic (Virinder et al., 1997), anti-microbial (Kumar et al., 2007), and anti-inflammatory activities (Virinde ...
Delivery strategies to enhance oral vaccination against
... through contaminated water and food, resulting from poor sanitation. In the developed world, diarrhoeal diseases account for significant morbidity whereas in the developing world, where sanitation systems are often sub-optimal, it is associated with high levels of mortality [1], especially in childre ...
... through contaminated water and food, resulting from poor sanitation. In the developed world, diarrhoeal diseases account for significant morbidity whereas in the developing world, where sanitation systems are often sub-optimal, it is associated with high levels of mortality [1], especially in childre ...
Lymphatic system.pps - Elizabeth Bauer Consults
... When the body is fighting an infection, lymphocytes multiply rapidly and produce a characteristic swelling of the lymph nodes. ...
... When the body is fighting an infection, lymphocytes multiply rapidly and produce a characteristic swelling of the lymph nodes. ...
Workshop summary Primary immunodeficiency diseases: An update
... Furthermore, nomenclature of class-switch recombination defects, previously known as hyper-IgM (HIGM) syndromes and classified according to progressive numbers (eg, HIGM1 and HIGM2), has been revised, with direct reference to the gene defect. This change takes into account the variability of serum I ...
... Furthermore, nomenclature of class-switch recombination defects, previously known as hyper-IgM (HIGM) syndromes and classified according to progressive numbers (eg, HIGM1 and HIGM2), has been revised, with direct reference to the gene defect. This change takes into account the variability of serum I ...
Sequence analysis of T-cell repertoires in health and disease
... Box 1 T-cell repertoire biology In the genome, there are no loci that have greater complexity or extend a deeper and broader reach into human biology than those encoding the antigen receptors of T cells and B cells. The choreographed programs of stochastic recombination that unfold at these loci dur ...
... Box 1 T-cell repertoire biology In the genome, there are no loci that have greater complexity or extend a deeper and broader reach into human biology than those encoding the antigen receptors of T cells and B cells. The choreographed programs of stochastic recombination that unfold at these loci dur ...
Article
... Pathogen-associated molecular pattern (PAMP)triggered immunity (PTI) serves as a primary plant defense response against microbial pathogens, with MEKK1, MKK1/MKK2, and MPK4 functioning as a MAP kinase cascade downstream of PAMP receptors. Plant Resistance (R) proteins sense specific pathogen effecto ...
... Pathogen-associated molecular pattern (PAMP)triggered immunity (PTI) serves as a primary plant defense response against microbial pathogens, with MEKK1, MKK1/MKK2, and MPK4 functioning as a MAP kinase cascade downstream of PAMP receptors. Plant Resistance (R) proteins sense specific pathogen effecto ...
English - SciELO Costa Rica
... Typhus group Rickettsia grow until they burst the host cell74 while spotted fever group Rickettsia rapidly spread from cell to cell75 due to their actin propulsion. Of course, host cells are damaged in the process;76 the mechanisms may involve the production of free radicals77,78 and phospholipase a ...
... Typhus group Rickettsia grow until they burst the host cell74 while spotted fever group Rickettsia rapidly spread from cell to cell75 due to their actin propulsion. Of course, host cells are damaged in the process;76 the mechanisms may involve the production of free radicals77,78 and phospholipase a ...
Please click here to view the article from the Peninsula Clarion
... volunteers were able to start construction on Landon's swing set right away. Kelly Kneaper, a member of the organization's board of directors, said that with the help of more than 12 volunteers in Kenai and more in Anchorage as well as help from Era Aviation, Landon was able to play on his swing set ...
... volunteers were able to start construction on Landon's swing set right away. Kelly Kneaper, a member of the organization's board of directors, said that with the help of more than 12 volunteers in Kenai and more in Anchorage as well as help from Era Aviation, Landon was able to play on his swing set ...
Full-Text PDF
... The local production of complement components by MNP has been shown to alter their function [46]. C1q enhances the receptor-mediated uptake of disease-associated PrP by classical dendritic cells (see section 2.4.2 below) [47]. The association of C1q with PrPSc may alter the downstream processing by ...
... The local production of complement components by MNP has been shown to alter their function [46]. C1q enhances the receptor-mediated uptake of disease-associated PrP by classical dendritic cells (see section 2.4.2 below) [47]. The association of C1q with PrPSc may alter the downstream processing by ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑