Vaccines
... • A live or inactivated substance capable of producing an immune response Single constituent,e.g.,, polysaccharide or tetanus, ...
... • A live or inactivated substance capable of producing an immune response Single constituent,e.g.,, polysaccharide or tetanus, ...
Really Essential Medical Immunology Arthur Rabson
... (figure 1.2a), finally settle in the tissues as mature macrophages where they constitute the mononuclear phagocyte system (figure 1.2d). They are present throughout the connective tissue and around the basement membrane of small blood vessels and are particularly concentrated in the lung (figure 1.2 ...
... (figure 1.2a), finally settle in the tissues as mature macrophages where they constitute the mononuclear phagocyte system (figure 1.2d). They are present throughout the connective tissue and around the basement membrane of small blood vessels and are particularly concentrated in the lung (figure 1.2 ...
Module Two- The biology of cancer Overview Key concepts
... substances.23 Foreign antigens may be exogenous microbes or endogenous altered or virally transformed cells.24 The immune system, which recognises foreign micro-organisms as 'non-self' and mounts a response to destroy these disease-causing agents, plays a similar a role in protecting the body from m ...
... substances.23 Foreign antigens may be exogenous microbes or endogenous altered or virally transformed cells.24 The immune system, which recognises foreign micro-organisms as 'non-self' and mounts a response to destroy these disease-causing agents, plays a similar a role in protecting the body from m ...
A role of the adaptive immune system in glucose homeostasis
... and that their expression increases in adipocytes on introduction of a HFD.24 25 Collectively, these results support the hypothesis that one role of the adaptive immune system in glucose homeostasis is maintaining levels of macrophage-stimulating cytokines and preventing disruption in glucose homeos ...
... and that their expression increases in adipocytes on introduction of a HFD.24 25 Collectively, these results support the hypothesis that one role of the adaptive immune system in glucose homeostasis is maintaining levels of macrophage-stimulating cytokines and preventing disruption in glucose homeos ...
(From the Variety Club Heart Hospital Pediatric Research
... Mammalian hosts, as well as simpler organisms, rely on complex mechanisms to provide resistance against infection and invasion. Such protective factors as lysozymes in body fluids, polyelectrolytes, complement, non-specific bactericidal substances, and phagocytosis are among the innate mechanisms of ...
... Mammalian hosts, as well as simpler organisms, rely on complex mechanisms to provide resistance against infection and invasion. Such protective factors as lysozymes in body fluids, polyelectrolytes, complement, non-specific bactericidal substances, and phagocytosis are among the innate mechanisms of ...
The dynamics of acute inflammation
... IL-8 and High Motility Group Box-1 (HMGB-1) that activate more immune cells and recruit them to the sites of the infection (Cross and Opal, 2003). In addition, anti-inflammatory mediators such as IL-10 and Transforming Growth Factor-b (TGF-b) are also released which inhibit the production of the pro- ...
... IL-8 and High Motility Group Box-1 (HMGB-1) that activate more immune cells and recruit them to the sites of the infection (Cross and Opal, 2003). In addition, anti-inflammatory mediators such as IL-10 and Transforming Growth Factor-b (TGF-b) are also released which inhibit the production of the pro- ...
Immunology of Viral Disease, How to Curb Persistent Infection Simone C. Zimmerli
... Publication #2: The second article (section 4.2, page 81) explores new strategies to trigger CD8 T cell immunity against specific HIV-1 proteins believed to be processed and exposed as "infection signal" at the surface of infected cells. Such signals consist of peptide fragments (813 amino acids) or ...
... Publication #2: The second article (section 4.2, page 81) explores new strategies to trigger CD8 T cell immunity against specific HIV-1 proteins believed to be processed and exposed as "infection signal" at the surface of infected cells. Such signals consist of peptide fragments (813 amino acids) or ...
From carbohydrate leads to glycomimetic drugs
... A large, synthetically produced polymer in which the atoms are arranged in many branches and subbranches radiating out from a central core. ...
... A large, synthetically produced polymer in which the atoms are arranged in many branches and subbranches radiating out from a central core. ...
Novel drug therapies in myeloid leukemia
... mediated by activation of NK cells through binding of the FcR CD16a (FcγRIIIA), but neutrophils (through CD64 (FcγRI), CD32 (FcγRII) and CD16 (FcγRIIIB)), macrophages and eosinophils also participate in ADCC. Once binding of the FcR occurs, the natural killer (NK) cell releases cytokines, such as IF ...
... mediated by activation of NK cells through binding of the FcR CD16a (FcγRIIIA), but neutrophils (through CD64 (FcγRI), CD32 (FcγRII) and CD16 (FcγRIIIB)), macrophages and eosinophils also participate in ADCC. Once binding of the FcR occurs, the natural killer (NK) cell releases cytokines, such as IF ...
Back to Basics: Regulation of the Gastrointestinal Functions
... cells of the gut respond to antigenic stimulation similar to any other immune cells in the body including the creation of antigenic memory, neutralization, and the synthesis of antibodies and recruitment of killer cells. Second, the immune cells of the gut respond by secreting inflammatory mediators ...
... cells of the gut respond to antigenic stimulation similar to any other immune cells in the body including the creation of antigenic memory, neutralization, and the synthesis of antibodies and recruitment of killer cells. Second, the immune cells of the gut respond by secreting inflammatory mediators ...
Anti-Aging Benefits of Bovine Colostrum
... cancers, chemotherapy, compromises the body’s natural immune function, thereby creating a situation of increased risk for opportunistic infections. The diverse combination of immune and growth factors in colostrum can protect against invading pathogens and toxins as well as inhibit the spread of can ...
... cancers, chemotherapy, compromises the body’s natural immune function, thereby creating a situation of increased risk for opportunistic infections. The diverse combination of immune and growth factors in colostrum can protect against invading pathogens and toxins as well as inhibit the spread of can ...
Characterization of a surface antigen of Type="Italic
... E. nieschulzi sporozoites, we conclude that mcab 3C3 recognizes a surface antigen on these organisms. This was also confirmed by immunoprecipitation data, since mcab 3C3 immunoprecipitates a radioactive protein comigrating with polypeptide found by iodinating sporozoites via the lactoperoxidase proc ...
... E. nieschulzi sporozoites, we conclude that mcab 3C3 recognizes a surface antigen on these organisms. This was also confirmed by immunoprecipitation data, since mcab 3C3 immunoprecipitates a radioactive protein comigrating with polypeptide found by iodinating sporozoites via the lactoperoxidase proc ...
Virology: Research and Treatment
... SDJ, WKA, BUF, LEJ, LEW) regardless of age at transmission, the production of HTLV-1 antibodies differed significantly among strain and age at the time of transmission.61,62 Multiple studies concluded that HTLV-1-infected WistarKing-Aptekman (WKA) strain of rats not only produced an antibody respons ...
... SDJ, WKA, BUF, LEJ, LEW) regardless of age at transmission, the production of HTLV-1 antibodies differed significantly among strain and age at the time of transmission.61,62 Multiple studies concluded that HTLV-1-infected WistarKing-Aptekman (WKA) strain of rats not only produced an antibody respons ...
Lineage Commitment During T cell Development
... in gd T cells. Its KO, decreases gd development. Its over-expression in DN thymocytes impairs DN -> DP transition and ab T cell development. Bcl11b, a zinc finger transcription factor, is preferentially expressed in ab lineage T cells and is induced in DN2a-DN2b. It is low in the gd lineage. The KO ...
... in gd T cells. Its KO, decreases gd development. Its over-expression in DN thymocytes impairs DN -> DP transition and ab T cell development. Bcl11b, a zinc finger transcription factor, is preferentially expressed in ab lineage T cells and is induced in DN2a-DN2b. It is low in the gd lineage. The KO ...
EIR 14
... events gated based on forward- vs sidescatter the high-affinity heterotrimeric IL-2 receptor complex, which provides this characteristics. subset an advantage of responding to very low concentrations of IL-2 (7). IL-2-induced activation of CD56bright cells results in the production of relatively lar ...
... events gated based on forward- vs sidescatter the high-affinity heterotrimeric IL-2 receptor complex, which provides this characteristics. subset an advantage of responding to very low concentrations of IL-2 (7). IL-2-induced activation of CD56bright cells results in the production of relatively lar ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑